1. 5. Dr. Leblond experimented on himself, injecting drug under skin of abdomen. He abstained from coffee during his provings, and for a week before their commencement. Marey’s sphygmograph was used. 1 a. Pulse 76 – 80 (after repose), at 5:45 p. m. 10 centigr. were taken. 6:15, pulse 64; ascending line of curve straight, descending line undulating. 6:45, pulse 56; a marked plateau at summit of curve. 7, pulse 54; same curve, ascending line being quite abrupt. 1 b. After 4 hours exercise, pulse 80 – 84. At 6 p. m., took 20 centigr. 6:30, pulse 78; ascending line very abrupt and high. 7, pulse 72; same tracing. 7:30, pulse 64; plateau now apparent. 8, pulse 62, descending line undulating. 1 c. After 4 hours quiet, pulse 80, at 3:30 p. m. took 30 centigr. 4, pulse 70; 4:30, 62. 5, pulse 54; ascent abrupt, descent presents a series of undulations. 5:30, pulse 54. 6, pulse 52, filiform; tracing resembles that of mitral insufficiency. 6:30, pulse of better quality after 15 m. exercise, but still only 56. 6:40, pulse again filiform; it continued at 52 till 7.5, when it fell to 50 at 7:10, and 48 at 7:20. From 8 it began to regain force and frequency, and had become normal (after dinner) by 9:30. 1 d. After 40 centigr., similar results followed. Pulse, 74 – 78 at commencement, had fallen in 2 1/4 hours to 52. After 3 hours it was 56, but very feeble and filiform; at same time there were frequent fibrillary twitchings in muscles of arms and legs, which in 15 m. more had involved also masseters and tongue; face was pale. Re – action set in after 3 3/4 h. 1 e. Pulse 80, at 1 p. m. took 50 centigr. 1:30, pulse very weak, 64. 1:35, sense of emptiness in head and of weight over eyes, objects seem covered with a thin mist; pulse 60, slightly irregular, filiform at times and then again stronger. 2.5, after 5 m. walking about room, pulse rose a little, but on resting again fell to 56. It beat at same rate at 2:20, and was very feeble and compressible. It did not begin to regain fulness and force till 7:15, and even then was quite slow; during this time there had been coldness and some creeping in lower extremities; slight vertigo and some tremor on walking; and a little praecordial anxiety. At 7:30 a walk in room raised pulse to 70, but after a minute’s rest it fell to 58 again. After a late dinner pulse went up to 90, but therewith was extreme lassitude, some giddiness, and vomiting.
1 f. The experiments were now made with a view of ascertaining the changes in arterial pressure induced by C. After 24 centigr. it was found increased; there was also coldness of extremities. After 24 milligr. same increase was noted; and though pulse fell from 76 – 80 to 50, it lost power for a short time only.
1 g. The temperature was next observed. A thermometer closely held in left hand for 1/4 hours marked 35 – 35.5 o (Cent.), while that in mouth was 37 o. This was at 3:15, and 24 centigr. of C. were then injected. At 3:35 thermometers were replaced, and after 1/4 hours that in hand was 23.5 o, the other remaining at 37 o. At 5:50 the former was 21.8 o only, at which point it continued till 6:10, from, which time it gradually ascended till it reached 32 o. Pulse had fallen from 74 to 54.
1 h. On two other occasions similar results followed 36 centigr., peripheric temp. falling in former from 36.6 o to 27.8 o, in latter from 36.8 o to 26 o. In both experiments there were fibrillary twitchings, which in former were so intense in the masseters that there was fear of breaking the thermometer in the mouth. In the second trial sphygmographic tracings were taken every 5 m. Slowing of the heart followed promptly, with at first augmentation but later diminution of the force of its beats; later still, their energy became renewed. 1 i. After 2 injections of 24 centigr. each at 3.2 p. m., usual effects followed on pulse and temp. Therewith were in first 2 hours frequent yawnings, somnolence, and incessant desire to stretch the limbs. 5:25, slight dimness of sight on trying to fix an object; tracing showed very short ascent, slightly undulating descent (pulse at this time slow and filiform). 5:30, yawnings more frequent; general lassitude; nausea; inability for steady reading. 5:40, nausea increasing. After a minute’s walking, trembling in limbs, impatience, slight lachrymation and salivation. 6:15, efforts to vomit, nothing coming up but viscid and rather bitter matters; weakness of limbs. 6:30, some twitching in calves. 9, vomiting of a portion of dinner taken at 7:30. During evening, impossibility, alike in hand and mind, to play piano. 11, pulse 78, slight headache. N. was quiet. 1 j. In another experiment, the peripheric temp. was noted with a thermometer in each hand, and it was found to fall much lower on right side than on l. It was also noted that every time a cigarette was smoked while the effects lasted, a fresh fall of temp. occurred, though there was some acceleration of heart’s action. (Etude sur la Cafeine, Paris, 1883.)
CALENDULA [CALEN].
Introduction
Calendula officinalis, L. Marigold. Nat. Ord., Compositae.
Provings
1. Franz. (No information as to doses or repetitions.) Great irritability, he is easily frightened, hearing is very acute; fretful, sleepy, dreamy. Confusion of head, as after a night’s debauch, in m. heaviness of head as after a long illness; dull sensation, especially in upper occiput; aching in forehead, with sense of heat there, after eating; dull pressive sensation in occiput. Dryness and biting in margin of lids, as from smoke; white of eye inflamed, with pressive headache, now in forehead, now in temples, when lying down, not when sitting or standing. Drawing tensive pain in glands before left ramus of lower jaw, on moving head. Bitter taste of mucus in throat, before eating, – food, however, tastes natural; rheumatic drawing pain in right throat, increased on bending neck to right side, and on raising right arm, extending to shoulder (m. of 2nd d.); on 2nd day the submaxillary glands are painful to touch, as if swollen, and at times cause a tensive pain, which, especially on swallowing, becomes a pressure in the throat; on 4th day they are actually swollen, as if suppurating, and axillary glands also are tender. Hiccup after smoking; attacks of nausea at times; boring – digging pain deep in region of navel when walking; dull coarse stitches in middle of right abdomen, on moving, they go away during rest. M. stool preceded by griping and anxiety in abdomen, and accompanied by a chill; frequent micturition, urine as pale as water, is very hot and burning. Very deep inspiration, with heat in chest and face; pressive – drawing pain in left chest, and on sternum, with stitches in right chest (2nd d.); pressure and oppression in left chest, evening in bed; drawing pressure in left chest, when standing, during inspiration; pressive drawing pain between shoulder – blades; pressive pain beneath angle of right scapula, with sensation as if everything were suppurating and bruised. Drawing – pressive tension in wrists and ankles, during rest; pains in knees, while sitting, in outer side, as if bruised; burning – tearing pain in upper calf, and drawing – pinching pain at inner border of sole, when sitting. Very restless at n., he gets rest in no position, continually wakes, is obliged to urinate frequently, and drinks much. A wound becomes inflamed, sore, and painful as if it would suppurate; eruption of small vesicles, in left corner of lower lip. Chilly the whole m., and very sensitive to air (2nd d.); he feels shivery, and has a kind of goose – flesh, while skin seems warm to touch; shivering in back, with pressure in last true ribs of left side, with movements in epigastric region and abdomen as if he would faint; chilliness in hands and feet all forenoon, without thirst, together with drawing – pressive rheumatic pains through whole body, ribs aching as if squeezed together and bruised, some time after eating (m. of 2nd d.); during chill, anxious, morose, solicitous, and at times tearings in urethra; great heat all forenoon, with much sweat, he feels qualmish in chest, axillae are very hot; heat p. m., with creeping chills and great thirst, – drinking, however, causes every time shivering and a shaking chill; great heat, evening in bed, followed by sweat, feet especially burn and sweat; on one occasion, heat abated after 5 p. m., without shivering even in open air, head feels freer, breathing easier, and voice stronger and deeper, – on another heat continued unabated after this hours, but cold drinks caused shivering; flushes in forehead, evening (after 8 h.); sense of heat in face after eating, and of hands and feet, – an hours later, thirst; towards evening, feeling of heat in the otherwise cold hands and whole body, with creeping chills, without thirst and indeed with almost dread of drinking, while sitting (after 9 1/2 h.); (Archiv, xvii, 3, 169.)2. Dr. Price took a tablespoonful of the tinct. Immediately, sensation as if lips were swollen, from lips it spread to sides of nose, and increased rapidly in intensity. After 1 hours, lids were much swollen and pupils dilated; great effort had to be made to inflate lower lobes of lungs, and it could only be done sitting up; speech was hardly recognisable; pulse irregular and diminishing rapidly; tired weary feeling in lower extremities; hands and feet cold. (Amer. Obs., vi, 27.).
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.