III. 1. a. I made an infusion with 18 gr. of the seeds to 3j of boiling water. Having secured a frog, I opened the thoracic cavity, freed heart from pericardium, and, after waiting till excitement had subsided, found its beats 90 per m. Ten dr. of infusion were now injected under skin of thigh, and in 4 m. pulsations were only 65. After 8 m. they were 60, and a little irregular; in 15 m. they had increased to 71. The contractions were very firm, forcing nearly all the blood out of the organ. In 20 m. from first injection 20 dr. were introduced into opposite thigh, and contractions became still firmer, ventricle looking almost white during systole, and heart seeming only 2/3 its natural size. Pulsations, after 12 m., were 60 per m.; after 18 m., 56. On removing heart from body, and making a section of it, no blood was to be found, save a little between the columnae carneae.
1 b. Another frog was treated in the same way, and heart – beats were found to be 95. In 4 m. after injecting 25 dr. they were 80; in 8 m., 70; in 15 m., 45; in 25 m., 40, and very firm. Similar results were obtained with 2 other frogs; while in a counter – experiment, where no drug was given, beats fell from 95 to 85 only, and heart was larger than in the other cases.
1 c. Into mouth of a large ‘bull – frog” 3ij of weak tinct. were introduced by a syringe. Heart, on being taken out an hours afterwards was found much contracted and empty. (E. A. GATCHELL, north Amer. Journ of Hom., Feb., 1877.)
IODOFORMUM (see vol.iii, p.i)
II. 11. A boy, aet. 10, had his leg amputated for strumous disease of knee. Sutures held well, save at outer border of wound, at which point Iodium was applied thickly. On 3rd day child was found sleepy; and nurse reported him restless during n., and sighing frequently. Dressing was changed, and Iodium renewed. On same day the child, not having eaten since previous day, was attacked by vomiting several times; this was bilious and easy. During next few day all these symptoms became more prominent; child was constipated, and seemed to suffer from its head. The nights were very restless, sleep interrupted by sighings and cries like those of meningitis; there was drowsiness during day; pupils were unequally contracted, and reacted slowly to light. Child was perfectly indifferent, and did not recognise those about him. Later, nocturnal agitation was replaced by tranquil delirium. Temp. oscillated between 37.5o and 38.2o. These symptoms continued until the 8th day, pulse being rapid, small but perceptible, and regular. From the 6th day the Iodium had been discontinued, and phenic acid substituted; on the 7th symptoms had diminished; on the 8th considerable improvement had set in, and all went well from the 9th day. (CAZIN, Frame Medicale, 18888, II, 1637.)
12. A child had tuberculous osteitis of tibia. Place was scraped, and Iodium gauze applied. Symptoms appeared on 1st night; child was very restless, and did not sleep; it complained of violent pains in head. Next day, at time of making rounds, child was drowsy, and responded with difficulty to questions asked. Pupils were unequally contracted. During day several attacks of bilious vomiting; pulse irregular and very frequent (100). These symptoms continued to get worse for 3 day, and with them was constipation. On 5th day the Iodium was left off, and the symptoms rapidly became much milder, disappearing completely after 3 day more. While symptoms continued to get worse for 3 day, and with them was constipation. On 5th day the Iod was left off, and the symptoms rapidly became much milder, disappearing completely after 3 day more. While symptoms lasted there was slight fever, with evening aggravation, – temp. oscillating during the 5 day between 37o and 38.5o (Ibid., p.)
IODUM (see vol.ii, pp.691 and 756)
II. 31. SIMON relates that having treated 11 children for tinea favosa by local applications of tinct., in 4 he observed albuminuria, which disappeared at each cessation of the treatment, and recurred with its resumption. Analysis revealed at the same time the presence in the urine of left itself. (France Medicale, Mai, 1876.)
32. HALLOPEAU reports a case of a child of 4 who took an iodised solution of horseradish. She exhibited a pemphigoid eruption of most singular character. Several of the bulbae were more than 4 centimetres in diameter, they were grayish and their contents were thick. There was no constitutional disturbance, and the eruption disappeared without leaving any traces. He mentions two other similar cases which had come under his observation. ( L’ Hom. Militante, iii, 414.)
33. About 5 hours after injection of a sol. of left into the sac of a lumbar abscess, patient had vertigo with impairment of vision; soon afterwards vomiting of serous mixed with chocolate like matter occurred with general malaise, skin moist, extremities cold, pulse small and thready, resp. hurried, prostration. He continued in this state during evening and succeeding n. Next day vomiting continued; he lay faint and groaning, palpebrae were greatly swollen and had a violent tint; he complained of a distressing sensation in throat. 22nd. – Expressed himself as better, though apparently in the same state. The throat looked dry merely, but breathing was impeded, especially during respiration. A rough croupy cough was present, and the voice was whispering. (NELATON, Journ de Chim. Medorrhinum, Jan. 1854.)
34. A patient with a cancerous ulcer towards root of tongue was ordered 3j of the iodide of starch, each drachm containing 1 gr. of left, m. and e. After 5 day, as he felt unwell, he was directed to take half the quantity. Early next m. he was seized with dyspnoea, which became very urgent. When seen countenance was sallow and anxious; pulse intermittent; on right side of neck, extending downwards from angle of jaw, there is considerable firm circumscribed swelling, apparently not interfering with larynx and trachea On right side of chest percussion is dull, especially posteriorly; respiratory murmur throughout is feeble and in front there is loud mucous rale. L. side is similarly, but less severely affected. In evening his pulse flagged; at 10 p. m. dyspnoea increased; and at midnight he died suddenly. The friends refused to allow body to be opened. (LAWRIE, Lond. Medorrhinum Gaz., N. S., ii, 588.) On p. 698, 1.3 from bottom for “b” read “3.”.
IPECACUANHA (see vol.iii, p.10)
II. 12. a. Early in m. of April 25th, m 1888 Chas. E. A., aet 18, came to my office in great distress. Both eyes were tightly bandaged, head hung down, and he was led in by his father. On day previous he had pulverised about 28 oz. of Ip. in an open iron mortar. He had gone to bed feeling as well as usual, but was awakened about 1 a. m. by intense pain in both eyes. There was profuse lachrymation and great photophobia; and therewith constant nausea but no vomiting. This state of affairs had continued from that time until I saw him. I found skin of lids and parts about eyes dusky red; margins of lids reddened; conjunctivae slightly injected, particularly on lids; faint circumcorneal redness; great photophobia and copious lachrymation, especially when lids were separated. Irides were somewhat contracted, not mobile, and apparently darkened in colour. Pain was constant and severe; it seemed to localize itself just over eyes, beneath brows, and was much worse over left eye. There was also slight dull headache in frontal region, just above inner canthus; and sensation of a foreign body being in eye. Nausea was constant and appetite gone.
12 b. Cocaine was instilled several times, without effect on pain or upon pupils. Atropine solution was equally powerless; and at last a few atropine crystals were placed in the conjunctival sacs. Even then dilatation wa slow; left pupil was more sluggish than r. As soon as pupils were dilated, photophobia and lachrymation was somewhat lessened; and during day all symptoms gradually abated a little. After 2 day they had disappeared. (HAROLD WILSON, hahn Monthly, Nov. 1888.).
IRIS MINOR [Iris -t] (see vol.iii, p.18).
Provings
1. In Oct. I prepared a tinct, from the small bulbs, by pounding them to a pulp, and to each oz of this adding 2 oz of alcohol, letting mixture stand 10 day in a dark cool room, shaking well n. and m. Of this I took, De. 1st, 5 dr. In 15 m. burning in mouth, which increased, mouth and throat seemed on fire; cold water did not relieve feeling which continued till midnight.. 3rd. – At 7 a. m. took 25 dr. In 15 m. terrible burning in throat, which at 9 was ver painful, he had to keep swallowing every second or two. Mouth dry and without saliva. 2 p. m. very gloomy and cast down At 8, feeling thus, went to bed; but could not sleep, and became more and more despondent. Fell asleep at 1; at 5; awoke with dull aching in temples and itching in eyes. Could not sleep again but kept turning pillow over, – cool side relieving pain of temples. The symptoms passed off at 8:30. 6th. – Took 30 dr. at 7 a. m. Burning still worse; cold water gave no relief, but sweet oil and camphor were comforting 11, passed urine of brownish colour, and continued to do so every 15 m. for 2 hours 1:30, pain in first left upper molar, which feels too long. 6, pain in tooth very severe; applied chloroform without benefit. Went to bed at 7, but owning to pain did not sleep till 2 a. m.,7th. – Awoke at 6:15, tooth still aching. Upon standing up, sinking “gone” feeling in stomach causing him to vomit up a quantity of greenish – yellow slime, not bitter: this symptom passed off on drinking a cup of tea. 10:25, pain in tooth increasing; hot and cold water, chloroform, camphor, failed to relieve it. Went to dentist and had it extracted, when all pain ceased Tooth was decayed, but not ulcerated. 8th. – Awoke at 6 a. m. with fearful itching all over head. At 7, brushed hair well with stiff brush; after 5 m. whole scalp was burning as if tinct. of capsicum had been rubbed over it; at same time eyes began to smart, – they did not water. Itching and burning passed off in evening, having lasted 11 hours 10th. – 9 a. m., took 60 dr. Burning was fearful. 10, cutting pain in abdomen, more severe on right than on left side; pressure on ileo – caecal region caused deathly sensation at pit of stomach. 11:40, courage all gone, could not help crying. 2 p. m., felt ill all over, and went to bed; pain in bowels increasing; headache in both temples; vomiting green bile. Hot applications relieved bowels, and at midnight there was copious evacuation. 11th. 8 a. m., so exhausted that he cannot leave bed, although pains have somewhat moderated. At 2 p. m. a hard chill came on, lasting 20 m., after which temp. ran up to 102o As it fell perspiration came on, though not very profuse. The acute pains passed off during night; but for 14 day there was a painful spot over – ileo – caecal region, as if an ulcer about the size of a quarter dollar (shilling) might be inside. The bowels did not act normally for 10 day (G. WIGG, St. Louis Periscope, Sept. 1886.)JABORANDI (see vol.iii, p. 26)
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.