During latter part of afternoon had very severe dull aching pains in heart, and feeling of a layer of hard substance in abdomen gave way to sensation of hard spots here and there; the feeling of hard spots over chest continued, but was much more severe. Was almost prostrated by effort of undressing. There was a great deal of buzzing in ears and difficulty in hearing, more especially in latter part of d. During early part of evening hawked a great deal, but did not raise as much as usual. 20th. Last n. tossed and twisted for 2 hours before sleep came, had to throw off bed clothing and could hardly bear to keep on my night – shirt, for it annoyed me to have anything touch my chest or abdomen. Sleep was very restless, but more satisfying than that of n. before. On rising this m. a dull frontal headache; not very much vertigo. Urine not so dark, and not so strong in odour as yesterday. Stool quite large, very dark greenish, and mixed with pieces of prunes (eaten yesterday). A few m. after stool an agonizing cramp came on; the griping lasted just 50 m. I did not move during this time, but lay ” stiffened out,” and so ” sick ” with the pain that, although I felt like it, I cold not cry out. Especially during latter part of d. I was much annoyed by the ” hard spots ” sensation in abdomen, but same feeling in chest is more severe and painful; now and then I will have dull aching pains in heart, but not so badly as before. Was not so drowsy this m., but the dull frontal headache continued throughout day, getting worse toward n., being aggravated by motion and accompanied by very marked throbbing through neck to occiput. Had some slight appetite at lunch – time, but did not relish food; at dinner I was hungry and enjoyed a very fair meal. Had a great deal of thirst during evening; towards e. I began to feel weak, and slightest exertion would tire me out, forcing me to remain absolutely quiet to regain my breath. On the whole, however, I am feeling much better to – day. I did not have very much buzzing in my ears to – day, but my hearing is still quite defective. Very little hawking of mucus to – day. 21st. – Last n. was annoyed by touch of bed clothing, but not to such an extent as heretofore, and, although quite restless, succeeded in sleeping much sooner and slept better than usual; woke rather refreshed, a slight frontal headache, but very little vertigo, being noted. Urine natural in quantity and colour, and of very little odour. Stool of natural brownish colour with spot of dark greenish matter, followed by cramps which lasted about 5 or 6 m., but were not unbearable in intensity. Appetite normal. Headache grew worse toward n., but even then was slight. Once in a while I would have the ” hard spots ” feeling in abdomen, and in chest it is still rather marked; the heart pains are seldom felt. Some fever and restlessness toward n., but thirst was not so fierce and weakness not so marked. 22nd. – Rested very well last n., fairly good sleep. Stool normal and followed by slight cramps. For past 5 or 6 day all sexual instinct seemed dead, but to – day there has been some excitement. My scalp has been very tender for a couple of weeks and has been getting worse, but in the past 2 day it has become hardened (to sensations of tenderness); I have lost considerable hair and a little from my face, which may not be due to the drug effects, but as I cannot account for it otherwise I note it. There are but two inflamed spots on my nose at present and very little acne about face. Very little restlessness this evening 23rd. – Slept very well during n. To – day accidentally pricked my finger with a needle; the blood, pale and thin, flowed in almost a stream, and fully 10 m. elapsed before I could stop it. Off and on I experience the ” hard spots ” sensation in my chest, but it is not so unbearable as formerly. 24th. – My weight to – day is 15 1/2 lbs. less than at the beginning; allowing a goodly amount for the hot weather there would still be an evident loss of flesh. (Trans. of N. Y. State Hom. Medorrhinum Soc., 1889.)
2. a. M. Cooke, M. D., on May 7th, 1988, took B. No symptoms. 8th. – Of C took three 4 gr. doses daily for 2 d. Throat slightly sore, left side, in e. On waking next m. throat feels swollen and stiff, deglutition painful, worse empty swallowing. Took no more of drug. Throat seemed gradually (>) during day, but head toward evening had dull ache and felt as if I were taking a cold. Next m. throat very much worse, nose running, and all the usual signs of a severe cold in head. Head ached so badly that at noon I took bry., which quickly removed the headache, and the cold disappeared in a day or two. One week later, feeling well, resumed C as before, and after 2 day had same sore throat, felt sided, worse a. m., wearing off during day, with symptoms of cold in head following heaviness in head, watery followed by mucopurulent bland discharge from nose. A year ago when taking the drug I had much the same symptoms, which I attributed to other causes than the drug.
2 b. D was taken in same manner. Stye began on lower margin, left eye, near outer canthus. I stopped drug when redness and swelling became marked. Some years ago was much troubled with styes on both eyes. Supposing this to be a return of the old trouble, I took bell., and by 24 hours the redness and swelling began to abate, and finally disappeared without suppurating as they had always done before. On recovery tried D as before; started another stye on left upper lid near outer canthus. Stopped drug and resolved the stye with bell., still being under the impression that it was the return of an old trouble. In a few day after resuming D a third stye appeared on lower left eyelid near inner canthus. This time I stopped the drug and took nothing else; the stye resolved without suppurating in about the same time as the other two.
2 c. Oct. 21st. – Feeling well in every way took B, 3 – 5 gr. doses for a week; no symptoms. Took C Oct. 29th, Nov. 2nd, 3rd, 4th – 6 doses a day 2nd. – Fulness, sensation in head as though too much blood there (weather warm and relaxing). 3rd. – Arose with same feeling in head, most in left frontal region, hardly amounts to an ache. Throat a little sore, raw, worse empty swallowing, worse left side. These feelings gradually wore away during day as weather grew more bracing (I remember that I sat in a draught yesterday). 4th. – Throat still a little raw; wrists ache, with loss of grasping power; pain among tendons of wrist on shaking hands.
2 d. Of D took, Nov. 5th, 5 doses. Symptoms of throat decreasing. 6th, 6 doses; 7th, 2 doses; 8th, 5 doses; 9th, 6 doses. 10th. – 4 doses. Continual aching pain about carpal head of right radius, worse on using fingers or thumb, especially thumb; certain amount of inability to grasp objects, with sudden darting pain on using force. Crampy pain (last e.) prevented my holding pen tight or pressing it on paper. 11th. – 3 doses. 12th. – 5 doses. Pain in wrist and weakness of prehension are disappearing; are most noticeable 10 to 12 a. m., and at 9 p. m.
2 e. Of E took, Nov. 13th, 6 doses. Nose feels very much stuffed up, worse right (not aware of any exposure to cold). 14th. – 4 doses, nose beginning to run. 15th. – 6 doses. Mucous discharge quite free; last evening took allium cepa. This a. m. less discharge, nostrils open. This p. m. severe dull headache over outer side of right eye. 16th. – 5 doses. Still have pain and loss of power in right wrist; pain worse from being kept long in one position, also when using; cannot lift as strongly as ordinarily. Drug finished. Nov. 25th. – Pains, &c., in wrist disappeared. No further symptoms. The wrist symptoms I do not remember to have had before. (Ibid.)
3. W. S. Rink, M. D. Began June 6th, 1887, with A, 10 gr. n. and m. for 4 or 5 d. No results. Then took B, 10 gr. n. and m. Took nearly whole bottle (Z). On 11th, papule on back of neck, very sore and itchy, hard base. In a few day there appeared over right eye (forehead) a sensitive swollen spot with red centre. Small papules (acne) with hard base, on forehead, very sensitive to touch; some of the papules becoming pustular. R. hemianopsia, transient, evening g. ” detach (ed).” This never before or since. Erysipelatous redness of tip of nose extending toward forehead on left side; it was shiny, swollen, hot, with aching pain worse on touch, very sensitive, especially just under tip, followed by removal of a small slough from just within and under the apex (l. side), (>) began after removal of slough. Bodily temperature was increased and I felt indisposed. I now stopped the drug; had begun C. (Never before had nasitis. Have had pustules occasionally, but never so sensitive or in such amount.) (Ibid.)4
4 a. D. Simmons, M. D. May 18th, 1887, took A for one week without getting any effect. 25th. – Took B for one week with like result. June 5th. – Took C. After five or six doses had an ache and soreness in right hip and thigh; very sore and painful when sitting so as to produce pressure on the part; could not sleep on right side while soreness remained. Urinated frequently day and night, copious, light lemon colour. Stopped proving until the ache in hip and thigh ceased and flow of urine returned to normal quantity and colour, which was about 36 h. After first 12 hours without the drug, there was a reaction and I only passed urine twice in 22 hours; then everything began to come right, so that in a few hours more the urine was normal in quantity and colour. After again taking five or six doses the trouble in hip and thigh and that with urine all returned; stopped proving for 36 hours, and the symptoms all left again. After taking it for the third time, for 3 day, a powder – 5 gr. – about every 3 hours, could get none of the symptoms again except a weakness or lameness in hip. 28th. – Took first dose of day with no other effect than the old pain and soreness in hip, and pain running down back part of thigh. Stopped taking medicine, and in 2 day pain left hip and leg, and in 4 day everything seemed to be in a normal condition.
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.