Hydrogen iodide, (HI)2.
These were made with a I per cent. syrup 1. WALTER B. FARLEY took 2 dr. every 2 hours. Experienced first effects on evening of 2nd d. About 1 hours after supper had feeling of constriction in region of stomach, with great distress, as if food had disagreed. These symptoms recurred after each meal (most after supper) for 3 day more; smoking would relieve them in a few m. (Trans. of Amer. Inst. of Hom., 1889, p. 376.)
2. C. A. WAYLAND, aet. 23, took drop doses in water on Feb. 22nd, at 12, 2, 3:40, and 4:30 p. m. Pulse at first 45, temp. 97.7. About 15 m. after first dose, nauseating feeling with eructations, and dry hacking cough. After second, tickling sensation behind sternoclavicular articulation. At 5 p. m. pulse 54; temp. 98.2; chilly feeling up and down back. 23rd. – Took dose at 9:30 a. m., 12 m., 2:30 p. m.; after last, suddenly, while studying, felt cold all over. Doses at 4:30 and 9; then chilly feeling up back. Dose at 11:30; sharp shooting pains beneath left nipple. 25th. – Pains in region of heart, of griping nature; chilly feelings in all part of body. 26th. – Dose at 10 p. m. 10:30, sharp intermittent pains through transverse colon. 11, colicky pains in bowels, followed by stool. 27th. – 3 doses. March 1st. – After breakfast darting and stitching pains, dull beneath scapula, from right to 1. 2nd. – Dose at 8:30 a. m. 11 p. m., dull darting pain in left renal region; rust – coloured mucus from post. nares. (Ibid.)
3. A. QUACKENBUSH, aet. 26, at noon of Feb. 22nd put 6 dr. in 1/2 glass water, and took two sips. A few m. after, colicky pains, with eructations and slight desire to vomit; tickling behind sterno – clavicular articulation. Repeated dose at 2:30, 3:40, 4:30. At 6, hacking cough with tickling and strangling behind sterno – clavicular articulations, hands and feet cold, head hot, with slight hoarseness. Repeated dose at 6:30 and 11:30, 7, slight colicky pain in transverse colon, increased by sitting down quickly. 8:30, sharp cutting pain at neck of bladder. 11:30, slight colicky pain at hepatic flexure of colon, worse on lying on left side, better on lying on right 23rd. – Repeated dose at 9:30 and 11 a. m. After 2nd dose slight hacking cough, with tickling and strangling behind sternum. 1, chills down back and then over whole body, followed by desire to vomit, relieved by belching wind. At 3:30, mixed 30 dr. in a glass of water, and took this in 4 doses. 10:30, sharp pleuritic stitch at base of left lung, running round to region of left kidney, increased by quick movement. He took 2 similar doses on 24th, 26th, and 27th, 24th. – 4 p. m., pain in transverse colon, increased by lying down or by pressure. 8, a few m. after dose, sharp cutting pain in left renal region, also pain in outer side of left knee, worse on twisting leg. 25th. – 3:30 p. m., griping in bowels, followed by diarrhoea (stools dark yellow). 5:45, short, sharp, dry hacking cough, with tickling behind sternum. 12 p. m., right side of throat sore; submaxillary gland swollen; griping in bowels. 26th. – Griping in rectum, relieved by stool. 11 p. m., sharp pain in glans penis. 27th. – 3 p. m., profuse, watery, liver – coloured stool. 28th. – 10:30 a. m., throbbing pain in left ascending frontal convolution of brain, with skin very tender over spot as large as a florin. 6:15, hacking cough, with tickling behind sternum; no expectoration. March 1st. – Sharp pains in right iliac and umbilical region at 2 p. m. 2:30, sharp pain at apex of heart, continuous, worse at times, relieved by belching of wind having a sweetish taste. 2nd. – Oppressed feeling about heart, relieved for a few seconds by belching wind. 11:30 a. m., sharp cutting pain at umbilicus, worse lying on right side, better on 1. 6 p. m., eructations of undigested food, very acid. (Ibid.)
4. Dr. J. C. MORGAN, who reports the above provings, himself tasted the cork of an opened bottle of the syrup on Feb. 19th, 1889. On 21st symptoms began to appear, and continued to do until April, when, “as weather became milder,” they subsided. [We must content ourselves with referring to this observation. – EDS.] (Ibid.)
5. D. LA PLANT began with 5 dr., afterwards increased to 10 dr. doses of same syrup. Woke about 2 a. m. with rumbling and much movement in bowels, without pain. Next day continued taking medicine; no symptoms till evening, when he became drowsy unusually early, so that he was compelled to retire. Awoke again at 2 a. m. with same loud rumbling and gurgling in bowels, preventing sleep for some time. 3rd day – Breakfasted as usual and went to work, but did not feel well; had a dull headache. At 10 a. m. stiffness of jaws came on. which rapidly increased. At noon went to dinner, but could not eat on account of pain in maxillary joints. At 1 p. m. jaws were almost set, and any attempt to open them caused extreme pain. Alarmed, and thinking of tetanus, he took some aconite, with relieved at once. In evening face was sore and lame, and it remained so for several d. On 4th day, after dinner, was seized with colicky pain in epigastric region which continued for 30 hours; it was attended with frequent urination. On examination urine showed decrease of urea. During the proving bowels very much constipated (more so than usual). (Ibid., 1890, p. 228.)
ACIDUM OXALICUM (See vol, i, p.45.)
II. 9. B. K., aet, 19, took sixpenny worth of oxalic acid soon after a lunch of bread, cheese, beer and coffee. In 5 m. retching and copious vomiting, burning pains in throat and abdomen. The stomach was washed out several times; the vomit and washings were bloody. Half an hours later, grave collapse; pulse 48, small, irregular; respiration 10 – 12, superficial; skin covered with cold, clammy sweat; face livid and features sunken; pupils dilated. Patient opens his eyes when loudly spoken to and then falls back into his apathetic state; constant desire to vomit, but brings up mucus only – no blood. Hypodermics of camphor, hot coffee, brandy. At 8 p. m., 2 hours later, complains of great thirst, burning and stitching in abdomen, and then collapse returned in a most threatening manner, with cyanosis; dyspnoea; livid fingers and toes, and sensation altered in toes and tips of fingers. Stimulants relieved again, and pulse regained some volume; great restlessness with tonic and clonic spasms in upper and lower extremities. Patellar reflexes increased on both sides, a slight touch causing long – continued crampy motions. Achilles tendon reflex and periosteal reflex increased; when merely touching the left external malleolus, tendon of left tibialis anticus becomes prominent. Triceps tendon reflex and periosteal reflex of epiphyses of humerus also increased on both sides. Sensorium dull; patient reacts only on loud calls; pupils still dilated. At 9 p. m. spasms diminish in strength and frequency; sensorium more clear, realizes that he is in the hospital; severe pains in throat when talking or swallowing; pulse better; patient sleeps naturally, only interrupted by weak clonic spasms in upper and lower extremities. 10 p. m., abdomen soft; desires to urinate, but passes only 100 c. cm. of yellow, somewhat murky acid urine. Sensorium clear and replies freely, though with a hoarse voice and some exertion. 11:30, examination shows complete anaesthesia of tips of fingers and toes, of palmar surface of hands and plantar surface of feet. Incomplete sensibility of leg. Sensation in thighs and other parts of body normal, pulse 80; temp. 38.2 C. Pains in left lumber region and both legs: feet and hands feel as if asleep; great thirst, burning in mouth; sleeps but little during night. 2nd day – Passes spontaneously 150 c. cm. of acid urine, slightly bloody, leaving a thick Sediment; sp. gr. 1016; rich in albumen; epithelia and epithelial cylinders; red and white blood corpuscles; colouring matter of blood; no sugar; small quantities of oxalic acid crystals, amorphous, of envelope and so – called dumb – bell form. After standing 36 hours, microscope shows copious, whitish, shining crystals of oxalic acid and of oxalate of lime in many forms – insoluble in acetic, soluble in sulphuric acid. In evening pains in renal and vesical region, a crawling sensation over whole body, especially in both lower extremities. Several times during day painful spasms in muscles of left calf; no appetite; tendency to vomit; profuse perspiration on hands and feet; discharges 300 c. cm. of dark, jumentous urine; tongue heavily coated; pulse 84, temp. 38.6 C. 3rd. d. – Urine 400 c. cm., much albumen, many cylinders; sensory disturbances continue; no spasms; dulness in head, patient feels as if he had been drunk. Urine 600 c. cm. no crystals; temp. normal; feet and hands dry. 4th day – Urine 900 c. cm.; less albumen and fewer cylinders; general improvement; sensory and reflex phenomena disappear; slight gastric disturbances still, but well enough to be discharged. (The lunch taken before the suicidal attempt and the prompt washing out of stomach probably saved the patient’s life.) (KOHLER, transl. in Hom. Phys., Sept., 1889.)
ACIDUM SALICYLICUM (See vol.iv, p.15.)
In vol.i p.70, l 13 deom borrom, doe “SALICINUM” read “SALICYLICA”
1. 15. Dr. A. M. CUSHING took 5 gr. of 1x trit. daily for 5 day, when following symptoms appeared: – Nov. 23rd. – Distressing pain in middle dorsal vertebrae, with desire to press back against something. 24 th. – 0 Some distress in back burning day 2 p. m., sudden lame pain in left ankle when beginning to walk. Hard dull pain around body in epigastric region all afternoon. 5, lower bowels greatly distressed with flatulence, which soon passed off. 10, sharp pain in right eye – tooth, though perfectly sound. 25th. – 11 a. m., hard pain in right arm just above elbow, seemingly round bone, which soon passed off, same king of pain then coming below elbow. In n. hard pain in lumbar muscles, near spine. 26th. – In m. on waking from sleep hard lame pressing pain in chest on both sides, worse in region of nipples, also worse on right side, where nipple is sore. At n. 1. foot lame. 27th. – 7 a. m., sharp pain in region of floating ribs extending to liver and right iliac fossa. 8, pain and soreness in left breast, and in region of nipple. 28th. – 8 a. m., sore pain in both sides of chest just below nipple, with sense of tightness and desire to draw a long breath and more arms. 6 p. m., hard sudden pain in middle finger of left hand; sudden sharp pain in 3rd toe of left foot nearly compelling him to scream. At times pain in 3rd toe of left foot nearly compelling him to scream. At times pain in muscles of left thigh. For several day hard pain in right arm above elbow. During whole proving burning sensation in region of heart. A carbuncle appearing on back of neck led him to scream. At times pain in muscles of left thigh. For several day hard pain in right arm above elbow. During whole proving burning sensation in region of heart. A carbuncle appearing on back of neck led him to scream. At times pain in muscles of left thigh. For several day hard pain in right arm above elbow. During whole proving burning sensation in region of heart. A carbuncle appearing on back of neck led him to discontinue proving. (Publ. of Mass. Hom. Medorrhinum Soc., v, 30.)
11. 17. A young man of 22, convalescing from pneumonia, was given 5 gr. 3 times daily as a “tonic.” He was now taken with severe pain in right foot, seemingly in toe joint. He put foot into hot mustard and water, but it did not relieve; suffered all night; pain then went to above knee, then to shoulder and arm. The doctor gave Dover’s powders for the pain, continuing the “tonic.” Pain lessened, but at n. grew worse again, very severe and sharp in shoulders and both limbs above knees. Next forenoon pain in bowels, which more Dover’s powders did not relieve. At n., pain in left side about heart; distress for breath; palpitation; could not rest. Was very weak next day, and, beginning to be alarmed, Dr. Donaldson was sent for. He found “congestion of heart,” pulse very irregular. The acid was stopped, and nux vomica given, and patient began to improve at once. (Ibid.) Dr. Althaus describes a skin eruption, beginning like herpes but then assuming the appearance of pemphigus, spreading all over face and body, with aphthae in mouth and fauces, and haemorrhage from bowels, as resulting from the drug. He does not say how it was given or in what disease
ACONITINUM (See vol.
The cases of poisoning, Nos. 2 to 4, taken from the Berlin klin. Wochenschrift, are referred by that journal to a Dutch periodical, the Nederl. Tijdschrift voor Geneeskunde, 1880, No. 16. To this we have not been able to get access. In the Bull. de la Soc. de Therapeutique for 1883, however (p.3), Dr. Dujardin – Beaumetz mentions the cases, and gives an account of Dr. Meyer (s symptoms during life, which the German version omits. They were as follows: –
The toxic effects began to show themselves in 1/4 h. After 4 h. Dr. Tresling found him pale; pulse small and irregular, but not accelerated; skin cold; pupils contracted. There was sense of burning in mouth, and of constriction from throat to abdomen; patient complained of praecordial anxiety, and of heaviness and weakness of limbs, especially legs. Pupils suddenly dilated, and vision was lost, but it returned as they became once more contracted. Vomiting was excited, but there soon came on acute congestion of head, and therewith convulsions and stertorous breathing. M – then complained of deafness, and of humming now in one, and now in other, ear. After a subcutaneous injection of ether, pupils dilated again, and vision was lost; then vomitings recurred, and prolonged and violent convulsions. A second injection was made, but patient could not be restored to consciousness; pupils did not react to light; respiration became slow and laboured, and spite of electricity more and more difficult; heart grew feebler, and in 5 hours after taking poison M – was dead. P. M. showed great pallor of skin and muscles, while internal organs were strongly congested, save colon, rectum, and bladder, and bladder, which were anaemic. Heart was in diastole. At certain spots in arachnoid exudation was found, and there was in diastole. At certain spots in arachnoid exudation was found, and there was bloody serum in ventricles, and a sanguineous exudation on the choroid plexus.
ACONITUM (see vol.
i, pp. 72, 747.)
I. 40 J. F. B -, in full health, pulse 70 and regular, took 2 dr. of tinct. in water at 11 a. m. 11.5, pulse 78. 11:15, pulse 90, hard and thin; slight rigors along spine, internal heat with external coldness and pallor. 11:25, great restlessness, with numbness of left arm and oppression of breathing. 11:45, sharp pains in ears, with heat and redness of cheeks; felt anxious and uneasy; desired fresh air. 12, asthmatic breathing, with palpitation. 12:15, drawing pains in extremities; stinging pains in throat, with thirst. 12:30, sight of food causes nausea. 1:20, pulse 84; occasional stitches through chest during inspiration. 3, stitches and soreness in hepatic region, with heat in abdomen; soreness and stiffness of muscles all over. 3:15, pulse 80; perspiration on face and hands without cause; feeling as if diarrhoea would occur. 4:15, urging to urinate; urine scant. 6:30, pulse 75; urging to stool, which was copious, and attended by colic and tenesmus; perspiration increased after stool. 8:45, second call to stool, watery and copious, with relief of all symptoms. Slept well, and awoke in usual health next m. (IBID., Trans. of Int. Hom. Conv., 1881, p. 35.)
41. I have myself experienced violent palpitation of the heart, with much praecordial oppression, 1.1/2 hours after taking mx of tinct. It lasted about 15 m., and recurred at intervals during the following day (PHILLIPS, Mat. Medorrhinum, 2nd ed., p.
42. Dr. E. W. BEEBE, aet. 45; normal pulse 72, resp. 13. On March 26th took 10 gr. of 6x trit. 1/2 hours before breakfast. No effect. 27th. – At same hours took 10 gr. of 2x. At 10:30 a. m. pulse was 86, at noon 80, at 9 p. m. 86. 28th. – At 7 a. m. took same, pulse 70. 7:10, pulse 72; slight numbness of tongue and fauces. 7:30, pulse 68. 8, chilly while sitting near warm stove; pulse 68. 30th. – Took, at 7:30 a. m., 10 gr. of 1x; pulse 72. 8:45, pulse 92; slight headache; numbness of tongue and fauces. 10, pulse still 92; headache ceased in open air. 12, pulse 78. 1:20, feeling chilly; pulse 76. (Trans. of Amer. Inst. of Hom., 1885, p. 155.)
43. Dr. LEWIS SHERMAN, aet. 42, normal pulse 64. 1st day – At 8 a. m. took 10 gr. of 6x trit. without effect. 2nd day – 7:45 a. m., took 10 gr. of 2x dry on tongue. Soon after cool numb sensation on palate tongue and fauces. 8:15, pulse 76; surface of body cool and pale (these symptoms continued about 2 h.). 5th day – At 7:30 a. m., pulse normal, temp. 98.6, took 10 gr. of 2x. 8, pulse 74, temp. 98.24. Numbness in mouth an fauces more marked than before, and lasted temp. 98.24, resp. 17, took 10 gr. of 1x. I 8 m. pulse 66, resp. 15. After 5 m. more, gnawing nauseating sensation in stomach, followed by rumbling in bowels. At 8 a. m., before eating, pulse 84. 8:20, pulse 17, temp. 97.88. 9, pulse 64, temp. 98.24. All symptoms better after breakfast. Only mental symptom observed was a slight uneasiness, allied to fear. ( Ibid., p. 156.)
II. 14. The patient, Miss M -, aet. 24, took through mistake Zss of the tinct. aconiti red., which was followed i 20 or 30 m. by a sense of warmth in stomach, nausea, and oppression of breathing. Shortly after this followed numbness, tingling, and slight muscular weakness. She did to attribute her feelings to the drug, and in 1 hours from the time it was taken (4:30 p. m.) the dose was repeated. She started soon afterwards to walk a distance of two miles, and did not complain until about half way. On reaching her destination she began to stagger, and was soon completely prostrated. Her voice became different portions of body, but particularly in joints. I was set for, poisonous dose of aconite, I administered the usual emetic, which was quickly arrived. I found the patient in the following condition: Axillary T. 97.1/2; P. 32; right 10. Pupils dilated, extremities cold, loss of consciousness, extreme pallor of face with expression of great suffering, and there was a twitching of the mouth and eyelids. Emesis which had an odour of alcohol. The retching continued, and her condition each moment grew worse, the pulse becoming frequent and irregular, and respiration more difficult. By consent of Dr. S. I injected hypodermically fifteen mins. Magendie’s sol., just after which having slight convulsion. There was a spasmodic sol., just after which having a slight convulsion. There was a spasmodic contraction of the laryngeal muscles, respiration ceased, and the pulse was imperceptible. Dr. S. did not observe me inject the morphia, d remarked that if I woman; respiration had ceased, the feeblest pulsation could not be detected, the body was cold to the touch, and we had every evidence of impending dissolution. We had lost all hope in the case, but were endeavouring to detect a feeble impulse of the heart, when suddenly and to our surprise the pulse sprang up, about the rate of 40 per m. the laryngeal muscles were relaxed and respiration began. Very soon the cheeks were flushed, and heat returned gradually to the extremities. The thermometer was again placed in the axilla, and registered 98.1/2. The retching continued, and in 1/2 hours the pallor returned, there was general muscular tremor, and the pulse became frequent and irregular as before. Ten mins. Magendie’s sol. were injected, and an enema containing 20 gr. carbonate of ammonia and one ounce of brandy. She soon rallied as before, this time recovering consciousness; and complained of cephalalgia, burning sensation in the stomach, and severe pain in different parts of body. At 10 p. m. I injected ten mins. more Magendie’s sol., which seemed to quiet her, and at 12 she was asleep. The bladder had been evacuated four times since 8 o’clock. – 15th, 6 a. m., temp. 99; pulse 80. Has vomited only after the enemas, which were repeated at intervals of 2 h. She complained of great muscular soreness, and movement of the body is painful. She is very weak, her grasp being scarcely perceptible Champagne and mucilaginous drinks were given, and the enemas continued, but at longest intervals. 4 p. m., temp. 99.1/2; pulse 72. Vomiting has ceased, and but little nausea. Diuresis has continued, and she complain for the first time of pain in region of kidneys, paroxysmal in character, lasting but for a few moments at a time. – 16th, 10 a. m., temp. normal; pulse 80. Has rested well since evening before; diuresis diminished; no pain in region of the kidneys; cephalalgia and muscular soreness remaining. – 17th, 10 a. m., patient much improved; temp. normal, pulse 80. Has taken food in fluid form with relish. Muscular soreness diminished, and but slight cephalalgia, which remained for several days. Two day later she complained of a peculiar sensation at the roots of her teeth, and diarrhoea, which symptoms lasted but a short the roots of her teeth, and diarrhoea, which symptoms lasted but a short time. The patient gradually improved, the muscular soreness being last to disappear. (O’BRIEN, N. Y. Medorrhinum Record, Feb. 8th, 1879.)