34.ZLATAROVICH began to proving March 19th, 1845 by taking 1 gr. 1st trit (5’95); no effects. 20th. – Took same dose. Sweet metallic unpleasant taste, especially at root of tongue and palate (immediately), worse from smoking. Slight indefinite painful sensation right side of face, especially malar bone and towards ear (after 1 h.). Later in forenoon unpleasant sweetish taste in mouth while smoking. 21st. – Took. 2 gr.. in 2 oz. water. forenoon, again a trace of sweetish taste. Afternoon, moderately cold air was very distressing so that I hurried to get into warm room, where contrary to habit, I had a desire for beer, which relieved me. 22nd. – Took same dose; breakfast soon afterwards; very disagreeable, sweetish metallic taste when smoking cigar (for 1 h.). Inflamed pimple on forehead. Towards noon slight threatening of burning pressive pain in stomach. At 2 p. m. a severe tearing pain on radial side of left hand. Burning in stomach 1 hour after dinner. Pimple has gone. Later, evening, roughness and slight burning in skin of forehead. 23rd. – Took 2 gr. pain in throat, at first between lower maxilla and hyoid extending to malar and behind ears (not lasting long). Later, metallic taste increased while smoking cigar. Burning in anus after second semi-fluid evacuation. 24th. – took 3 gr. in 2 oz. water at 10 a. m. Before taking dose troublesome sweetish metallic taste at root of tongue; desire for fresh water; tumbling in bowels with discharges of odourless flatus; several small inflamed pimples on forehead. Immediately after taking dose burning in oesophagus extending to stomach (for 1/2 h.). Slight drawing behind right ear. Slight pain in right groin and right hip – joint (short duration). Pappy evacuation. Later, sweet metallic taste while smoking cigar. 25th. – Took 4 gr. in m. Empty sensation in stomach soon afterwards. Accumulation of saliva in month. Nausea. No appetite repeated). Disagreeable sweetish taste. Vomiting (at 10) and creeping contractive sensation in scalp. Confusion of head (noon), especially frontal and parietal regions. Slight heartburn in afternoon (during 2 h.). Heaviness and tension in right leg. Symptoms disappeared after a short refreshing sleep. 26th. – Took 5 gr. Hoarseness on waking. Discomfort in throat (increased after taking dose). Hawking of thick mucus. Scanty knotty stool, followed by burning in anus. Distaste for cafe – au – lait at breakfast, and even during meal nausea, which continued along with accumulation of saliva in mouth, vomiting restrained with difficulty. Distension of abdomen. Sweet metallic taste (soon after breakfast) worse than ever, associated with nausea. While dressing inclination to vomit suddenly became violent, and all contents of stomach were forcibly ejected; vomiting was entirely without effort, left behind no disagreeable taste, and after it I felt quite well so that I was able to give my lecture. Excessively disagreeable sweet metallic taste (towards noon), returning after taking meat soup. Distaste for smoking whole forenoon. Transient tearing stitches right axilla and back of left thigh (at 1:30). Slight tenderness of teeth. Very sensitive to cold air in afternoon. Twitching frequently from; right axilla to upper arm and elbow. Disagreeable nauseous taste always recurs on attempting to smoke. Great sleepiness in e. Awakened often from sleep by twitching, now in upper part of body, now in whole body, now in separate muscles. 27th. – Slept well during n. and took breakfast with good appetite. While smoking cigar after breakfast recurrence of very disagreeable taste. Slight griping in bowels. Heat and pressure in eyes. Sweet taste again at noon soon after taking clear soup. Later, pressure in stomach. Burning in stomach 1 hour
after dinner. 28th. – Slight headache, frontal and parietal, on waking, in occiput after getting up. Burning in eyes. At noon, slight recurrence of pain in bones of face (as on 20th) but on l. side. Confusion of head after dinner. Heartburn in evening 29th. – Took 2 gr. and trit. in 2 oz. water. In m. before medicine sneezing as many as 10 times in succession (never happens to me). Soon after dose rumbling in bowels. Slight pressure in stomach for a short time in forenoon. 30th. – slept well. Troublesome pressive pain in heart (for 1 h.). 31st. – Medicine as on 29th. slept well. Immediately after dose while smoking cigar accumulation of water in mouth. slight inclination to vomit during breakfast. After breakfast while smoking sweetish metallic taste in mouth, more particularly on middle of tongue, especially on contact of tongue with hard palate. Pressive pain in heart e. (for short time) with peculiar sore feeling there. April 1st. – No symptoms. 2nd. 2nd. – Medicine as on 29th. Weakness in stomach and incipient nausea (immediately). No appetite for breakfast. Slight tearing in left half of face. Meteorism. later while smoking cigar disagreeable resinous, astringent taste in mouth. Rumbling in bowels. Occasionally during forenoon burning in stomach with accumulation of water in mouth (only for short time). Disagreeable taste lasting some hours violent itching in anus while walking. Slight drawing in bones of head E., after walking a good deal, severe tension and weight in r. leg. Burning in navicular fossa of urethra while urinating. Discharge of much offensive flatus. After a while cold feeling in thigh, rest of body being warm. 3rd. – Repeated dose. Slept very well. After dinner severe tension anterior surface of thigh. Drawing in left temple as if in sheath of muscles. Transient stitch through abdomen towards spine. Slight pain in stomach as if heartburn were coming on, subsiding in afternoon, appearing again in e. E., severe tension in right thigh. 4th. – Same dose. Immediately disgusting taste. Slight nausea. While smoking cigar taste became more disgusting, lastly burning, astringent. After 1 hour slight pressive pain l. axilla extending to chest when moving arm, aggravated by raising arm. Tearing in right thumb (for short time), afterwards in. arm and round thorax left side. After dinner pressive pain in heart for several hours. E., while walking, tension in left chest, more outwards. Later, lancinating pain right side of had in several paroxysms of short duration. 5th., m., two semifluid motions in rapid succession, followed by burning in anus for several m. Afternoon, burning in stomach, itching at anus. E., constriction of chest from stomach outwards, although I had eaten nothing. Urine passed in afternoon became cloudy and covered with thick mucoid deposit. 6th. – Repeated dose. Frequent short cough in m. until several lumps of tough mucus were loosened, afterwards tenderness of larynx for short time. Cough did not return during day soft stool. Usual cigar tasted unpleasantly bitter. There is a large vesicle on sole of right foot, and a pustule on the back. 7th. – Took same dose. Slept very well. Nothing except occasional hawking of mucus and slight pain in scalp. 8th. – Same dose. N. very restless, moaning and tossing about. M., rawness in throat, frequent hawking from larynx. Eyes slightly agglutinated. Mucous sediment in urine. Slight drawing in forearm and legs. At 11 a. m., pressure on vertex as if a weight were lying upon it. Drawing in limbs. Soreness of margins of eyelids; on moving them there was sensation as though they rubbed against eyeball. Afternoon and e., well., except slight feeling of fatigue. 9th. – Same dose. Slept well. On waking drawing and tearing at various parts of body, especially limbs, at chest and between shoulders. After breakfast eructations of flatus and slight nausea, sore pain right knee, especially on sitting down and rising. Forenoon, dryness of mouth, especially lips, without thirst. Symptoms subsided later. 10th. – Same dose. On waking slight drawing behind left ear and left side of lower jaw. Muscles on left side of neck seem stiff so that behind left ear and left side of lower jaw. Muscles on left side of neck seem stiff so that head does not move freely. After breakfast feeling of pressure in upper maxilla close to orbit. Disagreeable taste. Pressure in anus after normal stool. Slight sounding in head. 11th. – Well all d. Tearing in forearm and burning in eyes in evening 12th. – took a gr. 1st trit, in 1 or distilled water Slept well. Tearing pain in right tibia and right elbow. Later burning on outer surface of left. leg. At 10 a. m., slight burning in stomach. Pressure and burning in stomach after dinner. Pressive shooting and constrictive pain over spot size of half a crown in region of 7th rib, left side, as if in costal pleura. Gums bleed easily when sucking. 13th. – Took a gr. 2nd trit. in 2 oz. of water in m. Slept well. On waking same pain as yesterday but left thorax, spot being rather tender to touch, stitches recurring occasionally during forenoon. Slight tearing in hands and feet. Accumulation of water in mouth with incipient nausea. Afternoon, no symptoms except occasionally recurring tearing pain in hands and feet 14th. – Same dose. Slept well. Bad tearing pains in legs and feet, also forearms and hands. These pains were peculiar; they came by shocks and were circumscribed; it was as if a nerve – fibre or bundle were suddenly torn (lasting I h.). A few times during day acute pain in maxilla at lower margin of orbit. slight griping and twitching in bowels. Several tearing pains in hand and foot joints. Forenoon, burning in bulbous portion of urethra while urinating and at other times. Some burning in eyes. Dryness of mouth for 2 hours in forenoon, could scarcely speak. Good appetite for dinner. Metallic astringent taste afterwards. Some burning in eyes. Tensive pain right knee. Sensitiveness of facial bones. 16th. – Slept very well. Dryness and burning of lips in m. Eyelids slightly agglutinated. Rawness in throat, coughed up mucus several times. Tearing and drawing in right leg and tibia, at same time in periosteum, then in bones of forearm. Afternoon, some burning in margins of eyelids and slight burning in stomach. 17th. – took same dose. Slept well. Felt nothing of the catarrhal symptoms of yesterday e. Weakness in stomach, immediately. Accumulation of water in mouth with incipient nausea. Inclination to vomit after breakfast. Distension of abdomen. Rumbling in bowels. Later, dry sensation in nose, especially right nostril, although moisture comes from nose, Dull pain in bones of nose until noon. Burning in stomach after dinner. Flow of moisture from lower part of nose in evening; dryness towards upper part and ethmoid cells. Sensitiveness of teeth, especially upper incisors. 18th. – Same dose. Afternoon, heaviness of right leg and burning in skin of same. Burning in stomach. Sensitiveness of upper maxillary bone, especially under orbits. 19th. – Without medicine. Slept so well that I could hardly wake in m. Slight agglutination of eyelids. Peculiar wave like contraction of muscles of back, right side, on sitting down after great exertion in evening (for 1/4 h.). 20th. – without medicine. Pappy taste in mouth in m. 21st. – took 2 gr, 1st trit. in 2 oz. water. Immediately slight inclination to vomit. Tension in muscles of face with accumulation of water in mouth. the remainder of forenoon well except some urging pressure at anus. Sickness after drinking a glass of water about 2 p.m. inclination to vomit; slight griping in abdomen. Heaviness in legs; burning pain in corns on sitting down. Disagreeable taste of medicine distinctly noticeable at noon. 22nd. – Same dose. Immediately inclination to vomit. Twitching in bowels. Distension of abdomen. Slight burning in margin of eyelids. After breakfast very disagreeable bitter resinous taste. Burning in anus after scanty stool. Urging at anus while walking in forenoon. Burning and pressure in eyes. Slight pressive aching in forehead after dinner. fulness in haemorrhoidal vessels. Pustule (painful) on back. 1 hour later, frontal aching had gone, and contractive pain in vertex had taken its place. Feeling of general exhaustion in evening, especially lower limbs, Tension in temporal muscles. 23rd. – Same dose. Immediately weakness in stomach. Slight distension of abdomen. Rumbling in bowels. Burning of inner surface of eyelids. Breakfast not relished. After breakfast weakness of stomach; frequent eructations of flatus. Too much occupied during day to notice symptoms. Pain for 2 hours in circumscribed spot on upper third of right forearm (extensor side), partly in muscles, partly in periosteum; spot is tender to touch. One of the pustules on back (noticed on 14th is larger and has discharged sanious pus, also more painful than before Constriction and shooting stitches in lower portion of thorax. Slight sensitiveness in cranial bone here and there. 24th. – Same dose. Slept well. Urine passed during n. is cloudy and deposits copious sediment. Slight drawing in bones of face in m., also in bones of right hand. Discharge of scanty acrid mucus from nose, causing burning of septum. Slight burning on inner surface of upper lip. Forenoon, after great exertion cutting and burning on inner surface of upper lip. Forenoon, after great exertion urging and burning in haemorrhoidal vessels. Heaviness in right leg. Slight burning inner surface of eyelids Stitches in region of heart for short time in evening 25th. – Same done. Slept well. Soreness in throat in m. forenoon, burning and pressure in anus for short time. Afternoon, burning in eyes Eyelids felt thickened and sore on inner surfaces. 26th. – same dose. Slight burning of eyes in m. and eyelids agglutinated. Tension of fascia over back, especially felt on stooping and on moving arms. After breakfast, acrid disagreeable taste while smoking cigar. Pimple on back before mentioned still painful. Transient stitch through 1st phalanx middle finger of right hand. while sitting dead numbness and tingling right foot. Later, less burning in eyes and upper lip. At noon again more in margins of eyelids. In evening burning of lower end of parts of body, but everywhere near to bone, as if periosteum and adhering tendinous tissues were affected with it. Hawked up a goodish quantity of tenacious, thick phlegm. Soon after taking med. annoying pressure in back between shoulder – blades. After breakfast, which was not at all relished, gurgling and rumbling in bowels. Somewhat later, scratching and burning in throat. The pressure between shoulders along spine got worse again. After dinner tearing in all muscles of back extending to upper arms, loins, sacrum, even thighs; frequent short, dry cough. In evening tearing had subsided, only a certain discomfort remained at back between shoulder – blades. Before going to bed felt quite well, the pimple at back again filled with pus. 28th. – Same dose. In m. tearing in both forearms of same kind as yesterday. After awhile, tearing in left shoulder. During day well; in evening, although I had walked less than usual to – day, a quite peculiar lassitude and sleepiness, so that I was not able to stand, read or write, and while sitting eyelids drooped; even at supper nearly fell asleep. 29th. – same dose. On waking again, slight tearing pain in hands, feet, occiput, face (disappeared after 1/2 h.). After awhile pressure and tearing between shoulders. Before dinner some tension in muscles of chest. 30th. – Gr. iv of 2nd trit. with 2 oz. water. awoke with exceeding dryness of nose. After rising, burning of eyes; tobacco – smoke especially causes burning and lachrymation, which is usual, Slight pressure in r. nasal bone. These symptoms soon subsided. After awhile drawing in bone of right forearm, radial side. During day here and there drawing pain, especially in limbs. May 1st. – After rising, very troublesome drawing and pressing pain in different parts of body, especially bones of face, but also long bones of limbs. Burning of eyes. At noon more heaviness and tension right leg., especially knee. 2nd. – for an hour troublesome dryness and soreness in right nostril. 3rd. – Gr. iv of 2nd trit. with 2 oz water. Slight drawing in fascia of right forearm. 4th. – Gr. v. Tearing in l, forearm and right side of occiput. A few times mucous expectoration. 5th. – Same dose. Towards noon, slight drawing pain in left hand, forearm, and nape of neck. Burning eyelids, repeatedly a single, dull stitch edge of right thorax in region of liver, not increased either by deep inspiration or motion. After dinner this pain still lasts, but rather less, and sometimes leaves its place. I have at times more mucous discharge from more than usual; later, watery discharge. Whole abdomen is tense. In afternoon the drawing pain, and the pain in region of liver have disappeared. Flatulence of stomach and whole of lower part of thorax. In evening, slight burning in stomach going up to throat. 6th and 7th. – Gr. vij. Slept very well at n,; after rising, roughness in larynx necessitating frequent hawking. slight burning of margins of eyelids. Pressing pain right inner malleolus. After dinner tenderness of same place of right hypochondrium as yesterday, but much less (all these symptoms subsided in an h.) Much flatulent distension of abdomen. Some moisture discharging from right nostril. Towards a repeated stitches in metacarpal joint of middle discharging from right nostril. Towards evening repeated stitches in metacarpal joint of middle finger of right hand. On 7th, gr. x. Although I slept very well, yet I feel after rising great discomfort, knocked up feeling in all limbs (lessened after being up for some time). After breakfast very disagreeable taste in mouth, like beginning sickness. Taste sweetish – sour, astringent. Slight burning of margins of eyelids. Easy expectoration of thick phlegm. Towards noon, constrictive headache in temporal region. Later, drawing with paralysed feeling in right shoulder. 8th. – Same dose. Well all day except a few times slight mucous expectoration. In evening in room, while I was not smoking, a disagreeable tickling high up in left nostril, as if a hair was moving in it, so that I had automatic tickling high up in left nostril, as if a hair was moving in it, so that I had automatically to pick my nose with finger; but there was nothing in the nose, which was quite dry. (This tickle lasted for 1/4 h.). 9th. – same dose. In m. drawing pain in right shin, and slight drawing in right hand. For rest of day noticed nothing. 10th. – Gr. xv. Awoke with slight drawing in fasciae, now here, now there, in neck, back, limbs After rising in ceased. Slight burning of eyes; nose very dry. for 1/2 hour burning soreness in furrow between right alae nasi and cheek. 11th. – Same dose. Breakfast, 1/2 hour after taking it, relished; but immediately after, a disgusting, hot, sweet, metallic, resinous taste in mouth ensued, especially at entrance of throat, so that I nearly vomited. After a glass of water the taste got still more disgusting; even smoking a cigar does not dispel it. this m. no trace of drawing pains of last 2 d. Burning of skin either side of nose towards lower margin of orbit.. After an hours above – mentioned bad taste ceased. soft stool, followed by burning in anus. 12th. – Slept very well. After rising, general lassitude, especially in limbs. A few vesicles right lower lip. 13th. – Gr. xv. In m. burning of margins of eyelids, especially towards outer corner of eye. Burning inner surface of right leg. Pressing pain in right hip – joint. After breakfast an extremely nasty taste; forenoon, pressure and burning of chest in front about 5th and 6th ribs of left side, judging from feelings in costal pleura, lasting some h. In evening a similar feeling, but to a lesser degree, under right axilla. Went to dinner without any appetite, but enjoyed food. Twice stool, in m. and after dinner, very unusual with me, motions in each case scanty and not fluid. In evening drawing pain inner side of right thigh, not very acute, also much moist discharge from nose. 14th. – Slept very well at n., still after rising feeling as if I had not slept enough. Did not much relish breakfast. Some pressing pain under breast – bone. A few times mucous expectoration. In forenoon, a few times when drawing deep breath, tension in anterior wall of chest. In evening itching and burning of skin of forehead; feeling as if all bones of head would part asunder, as if brain was too large for cavity of skull, and was driving bones asunder. I cannot call this feeling exactly a pain, but it is very troublesome, and is felt chiefly at temporal bone, towards ears and parietal bone. External meatus of ear, especially of left side, is somewhat tender and obstructed. 15th. – Grt. xv. In m. on waking, for 1/2 hour, sharp, tearing, stitching pain, whole l. side of chest, from axillary cavity to hypochondrium, rather superficial as if in costal pleura later, dull pressure in bones of face, especially in infra-orbital region and nasal bones. Took breakfast without appetite; after breakfast the repeatedly mentioned nasty taste in mouth. Later in forenoon uncomfortable dryness of mouth, especially lips, without thirst. Did not enjoy dinner with usual appetite. After dinner drawing pain in right thumb. While smoking very disagreeably bitter taste. Towards evening violent burning and itching gets so violent that I feel inclined to rub my forehead constantly. tobacco-smoke causes burning in mouth. Obstruction of right ear and burning of concha. 16th. – – Same dose. Slept very well. After taking it slight pressive feeling in crown externally; not the slightest trace of feeling in skin over forehead noticed yesterday. 17th. – same dose after rising; dryness and burning in right nostril, wherefrom tensive, drawing pain extends to right meatus. Immediately after rising a stool, unusual for me at this time; after which sore feeling of anus. Pain in face stopped after an h. At noon, when I got home, pressure and burning in right nostril, wherefrom tensive, drawing pain extends to right meatus. Immediately after rising a stool, unusual for me at this time; after which sore feeling of anus. Pain face stopped after an h. At noon, when I got home, pressure and burning in eye, feeling as of sharp sand in eyes. Burning in nose especially right nostril, extending to frontal sinuses; m. m. quite dry with sore feeling. I notice to-day in albuginea of right eye, not far off cornea, brown spot size of pin’s head. After dinner more nasal secretion and sore pain at margin of nostril. toward evening again strong burning and feeling of increased warmth in right eye. Skin around eye feels also burning in spells. 18th. – On waking, pretty strong headache, especially in crown, disappearing after rising, but there remained for some time laziness, with feeling of not having slept enough. Burning of eyes; passing of flatus. A little later return of pain in crown. 19th. – Gr. xv. On waking, tearing pain in right elbow-bone; disappeared after awhile from there, and appeared in right shine-bone. After rising all these pains ceased. Frequent expectoration of thick phlegm. In right side of forehead several inflamed nodules. In forenoon for short time, slight stitches in interior of right car. Later, slight stitches here and there-in body. 20th. – Slept excellently, and after rising not the slightest trouble. Whole day without medicinal symptoms. 21st. – Gr. xx. slept very well. On waking, eyes slightly gummed. Some roughness in throat, with hawking up of mucus. After breakfast slight sickness; a few times sneezing; slug in bowels. In e. strong burning in eyes and especially margins of eyelids, which are very tender to motion and touch. Some pressing together of head from both temple. Burning in outer margin of right nostril 22nd. – In m. eyes gummed, otherwise quite well. After breakfast nasty taste, especially at root of tongue. Some itching vesicles on margin of lip. During day a few itching pimples have come out on upper and lower lips. The eye somewhat tender. In evening violent burning and itching of pimples. After supper, while smoking cigars, a very nasty, sharp astringent taste extending to throat. 23rd. – Repeated dose. On waking, heaviness of upper eyelids so that they have no be lifted with some effort (ceased after 1/2 h.). Violent stitch through right zygoma towards forehead. In e itching of eruption of lips, although it begins to dry up. 24th.-gr. j of 1st trit. with 2 oz. water. (As I made my triturations in the proportion 5:95, I gr. of 1st trit. is all to gr. xx of 2nd trit.). slept very well. On waking, and also after rising, a few short tearings in extremities, mostly towards hands and feet, which ceased after a while. Instead, a pressing pain came on under both axillae in muscles of the chest, which also lasted only a short time. Nose quite dry; passage of air through it quite easy. Burning of skin at inner surface of right leg. 25th.-gr. i) Immediately after for 1 hour (after breakfast) inclination to vomit. Heaviness and tension in hypogastrium, and general malaise and depression. Eruption in lips dried up Nauseous taste. After awhile less nausea, but disagreeable coolness all over. Towards noon, smoking, frequent spitting and slight nausea; former troubles having disappeared 26th. – Burning in skin of face and eyes in forenoon. Dryness of nose with pressure in bones of nose. On smoking cigars disagreeable taste. 27th. – Repeated dose. After scanty stool in m., burning in ano. After dinner again urging to stool, but passed flatus. 28th. – A few times stitches in right chest in forenoon, superficial and of short duration Burning margins of eyelids. Burning upper lip under nostrils. After breakfast again disagreeable taste as yesterday but less in degree. 29th. – Repeated dose. Burning margins of eyelids again pressure in head in m. A few times cough caused by irritation in windpipe. Short lasting tearing here and there in both axillae and in hand. Urging in anus, and forcing in sphincter at noon. Before dinner suddenly violent pain in anterior surface of stomach, burning, constrictive, with commencing nausea. Accumulation of saliva in mouth. External pressure increases pain. After 10 m. relief, but tension and drawing in mastication – muscles, with more salivation. Soon well again, dined with appetite; after dinner, violent ineffectual urging to stool. 30th. – Occasional return of forcing in ano, forenoon. Burning eyes. Soreness in right great toe in evening, inner side, where nail touches soft parts 31st. – No med. r. leg tender at n., especially hip; could not lie on right side. At inner side of right leg burning pain in m. Watery discharge from nose, first painless, later with caustic pain in outer subcutaneous part of septum. In evening after walk, tensive drawing pains in right leg. June Ist – Pretty strong stitches in region of left nipple in forenoon, after a few hours only when taking breath, in afternoon ceased entirely. e. soreness round anus. 2nd. – Repeated dose. On waking roughness of throat, hawking, slight burning of margins of eyelids. A vesicle containing clear fluid in right eyebrow. After dinner strong pressive pain in right hip. Frequent discharge of acrid caustic fluid from right nostril without causing so much soreness. 3rd. – No med. Slept well. Immediately after waking burning in margin of eyelids. tickling in nose. Painful tension in extensor surface of right thumb, diminishing towards noon, and only felt when moving hand. On external pressure also pain where radius joints carpal bones of thumb. After dinner, discharge of drops of water from right nostril. Burning of skin over forehead in e. Several itching points in occiput and scalp, as if pimples would form. Tenderness in part of thumb on external pressure and moving continues. 4th. – Awoke with violent pain in thumb, almost unable to hold pen. Every motion of arm or hand increases pain. Externally neither swelling nor redness. Eyelids agglutinated and burning. Burning in occiput, &c., disappeared. Dryness of mouth. Pains in thumb lasted all forenoon, sometimes very violent, extending up to elbow, without any external sign. Eyelid – margin burn and itch constantly. discharge of some acrid fluid from nose. Head somewhat confused. I feel as if some morbid diathesis, some “psora” had been excited in me by the medicine, producing all these symptoms. some brown spots at neck like those I had in eye, looking like freckles, which I never had before Less pain in thumb in evening, only tender when joint is touched. After chocolate, meteorism and heaviness in stomach, wore off towards evening, water flows unnoticed from right nostril. 5th, m., thumb free from pain. Watery discharge from nose causing burning of upper lip. Noon, no pain in thumb; hardly any tenderness on strong pressure. Less burning in eyelids. In evening occasionally watery discharge from nose, without burning; no other symptoms. 6th. – Repeated dose. Slept very well. In m. burning of eyes and watery discharge from nose although on waking nose was quite dry. Lip under right nostril slightly swollen and covered with small blisters. After medicine coolness in stomach. In open air strong burning and pressure in eyes forenoon; flow of water from right nostril, with sore feeling in nose. Slight tension and oppression of chest. Dryness of mouth and lips. Strong desire for beer. 7th. – After rising flow of water from right nostril. Later, pressure at root of nose (did not last long). After normal stool burning in ano. 8th. – slept very well; awoke well. Soon after rising slight tearing in 5th and 4th fingers of left hand, then in left side of face, and in right knee, nowhere lasting long. Discharge of water from left nostril, without feelings of coryza, and not until flowing over lip. 9th. – Notwithstanding the heat of yesterday (23 R.)constant discharge of water from right nostril
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.