27a. H. DWORZACK took 0.1 gramme of extract of root of acon. neomontanum. Felt peculiar sharp taste, followed by violent shooting pain from lips to stomach. Immediately violent eructation with rumbling in bowels, head and face very warm, pulse quick, lingual and buccal mucous membrane red, studded with small whitish-yellow vesicles, surround by bright red areola; salivation came on; eructation more severe; loathing; inclination to vomit; pulse slower; vomiting. On taking extract in a wafer so that it did not come in contact with mucous membrane of mouth there came on rumbling in bowels and eructation; head became confused; a tensive drawing sensation in course of trigeminus, which gave place to a shooting wandering pain, at first often interrupted,, but afterwards continued. Pulse begins to sink, becomes irregular, small, and weak; confusion of head increases; prostration, exhaustion, drowsiness, and dull pain within skull. Pupils, at first very mobile, became persistently dilated; vision dim, and he is not able to look at a highly-illuminated object without winking; near and distant objects seem to swim. About 40 morning afterwards a peculiar formicating sensation tongue as after taking peppermint. This spreads over lips, back parts of mouth, fauces, goes into tips of fingers and toes and into face, and thence spreads all over body. Increased secretion of saliva; skin becomes cold, harsh, dry. The formication always increased; excited sensation of distortion of features and extremities and constriction of body. Extreme restlessness; it seems as it were a tickling which compels him to constant movement; it is better in equable temperature, but is increased on coming from cold into heat and vice versa. The headache and confusion of head gradually diminished 2 hours after taking dose, but then came on uncommon exhaustion and weariness, oppression and anxiety; he must often yawn; respiration became more difficult and slow, with feeling as if throat and chest were constricted; pulse becomes always more irregular, and sinks to half the normal rate, often intermits, and is sometimes dicrotic. The exhaustion became so great that he could not stand, but is obliged to remain lying; anxiety increased, with apathy, in difference to all the world; pulse and heart’s beats are sometimes indiscernible for several seconds; respiration a gasping for air; skin always dry and icy cold; taste and sensibility diminished; on the parts where the formication had ceased occurs a furry feeling as in a finger tightly tied with a thread; subsultus tendinum; involuntary stretching out of limbs. At same time constant nausea; loathing; inclination to vomit, and at length (after 2 hours), repeated vomiting, with relief; pulse regular; respiration more frequent and regular; anxiety and oppression diminish; body becomes warmer. Formication goes off quite; instead there is a kind of insensibility of skin, furry feeling. Head not so painful and confused; rather dazed and empty, as in drunken somnolence; exhaustion continues; on rising up, vertigo; flickering before eyes, roaring in ears, head and face -ache, nausea, and such muscular weakness that he must lie down, else he would fall. Night passed without sleep in this state; some slumber for 2 hours about 4 a.m. Next day he went about from morning till night half asleep. Memory and attention quite deranged; pupils dilated; pulse sometimes quicker, sometimes slower; after mental or bodily exertion confusion of head, headache and faceache; tongue furred in morning; taste flat; skin of whole body cold and dry; urine much increased. (Ibid.)
27b. Took 0.1 gramme of extr. of A. ferox. Caused immediately violent burning in mouth and pharynx, [This was in spite of extract being enclosed in a capsule. (SCHROFF, Zeit, des Allg. Apoth. Verbascum iii, 173)] with warmth in stomach; in 5 morning salivation ensued, rumbling in bowels, pulse was found slowed by 11 beats; he drank much water to relieve burning. In 40 morning there was formication on upper surface of tongue, gradually involving whole mouth, which with cheeks, felt furry. In 80 morning there was confusion of head; troublesome formication, mostly over face; frequent eructations; general sick feeling at times, nausea and inclination to vomit; weakness and trembling of extremities; walking difficult, uncertain, fatiguing; general sick feeling; and sense of coldness. He was so tired and cold, objectively as well as subjectively, that he had to go to bed and be covered up warm.
In 2 hours pulse small, weak, 60; formication spread over whole body, but affected very slightly, or not at all, those parts that had been cold; worse by change of temperature and motion. Form 7 to 7:30 p.m. this annoying sensation, having changed from one nerve to another, reached its greatest severity; it caused a painful unrest, so that he could not possibly lie more than a few morning quietly, and constantly changed his position. The body was now, especially in extremities, icy cold; the skin dry and rustling; he was wrapped in his gown and doubled coverings, with three feather beds, and the room was kept very hot, without effect. Desiring warmth, he tired to reach stove, but there arose vertigo, flickering, trembling of limbs, inclination to vomit, and he had to lie down again. Dyspnoea now (4 hours) set in with great weakness and anxiety, increasing to such a degree that he was obliged to half sit up to breathe. Therewith feeling of constriction in throat, and color morbax on forehead, chest and hands, with sensation as if numerous glowing hot wires were stuck into him, also constant gurgling in bowels. Weakness, dyspnoea, restlessness, with anxiety, increased, with intervals of relief, during which he made merry over his condition; but when distress returned it seemed intolerable; he talked constantly; pupils were dilated, sluggish to light; tongue almost insensible, it felt like a piece of leather in mouth; respiration was accelerated; pulse weak and small sensation as though benumbed; on touching objects it seemed as though he had gloves on, no pain on pinching cheek. In order to promote perspiration, he flexed and extended arms as rapidly as possible; after a morning, copious sweat; then felt so weak he sank down exhausted, with palpitation. Slept 3/4 hour; on waking, violent burning in mouth and throat, warmth in stomach, dull sensation in head; weak, weary, relaxed. All this time (since 40 morning) there had been frequent (15 to 30 morning) and copious urination; this continued so that in 12 hours more than 5 quarts had been passed, at first straw-yellow, but after 8 hours dark. Had intervals of sleep only during night. On 2nd day rose at 6:30 a.m., with vertigo; tongue covered with a thick, yellowish white fur, taste flat and pasty, very little appetite; after breakfast, nausea, pressure in stomach, with pain; two half-watery, dark, not copious stools. Pulse was 70, small and weak; gait tottering, step regular but powerless, comprehension confused, was incapable of any mental work, even the simplest addition. During day lassitude and weariness suddenly attacked him, and temperature was objectively and subjectively lowered, so that he lay 1.1/2 hour by hot stove. Touch all this day and the two next blunted, as through gloves, and he seemed to walk on woolen carpets. On 3rd day he had transient nausea; remarkable weakness in lower extremities, especially right; violent drawing pain in region of stomach and in sacrum, which soon spread over whole abdomen; on pressure at epigastric region pain is increased. This pain recurred on 4th days also, and from now till 8th days there was pressure in stomach after eating, and internal dull aching was induced by compressing abdomen. On 4th day, without cause had sleepless night, and on 5th felt very prostrate in consequence. (Journ. f. Pharm., Tox. u. Theridion, i.)
28a. First degree of operation. – In the course of 20 minutes or 1/2 hours after the exhibition of 5 min. of the tincture, a feeling of warmth in the stomach is usually experienced, which is occasionally accompanied by slight nausea or oppression of the breathing. After the lapse of 30 or 40 morning, this sense of warmth is diffused throughout the body, and, in a few morning more, is attended by numbness, tingling and a sense of distention of the lips and tongue. There is also tingling at the tips of the fingers, and a peculiar sensation is felt at the roots of the teeth. The feeling of warmth soon disappears, but the numbness and tingling of the lips and fingers continue for a period varying from 1 to 3 hours. Slight muscular weakness is generally experienced, with indisposition for exertion, either mental or corporal. In about 1/2 hour more, the pulse is found to be diminished in strength; and in another hours both the pulse and the respiration have become less frequent. Thus, a pulse which in the normal state, beats 72 in the morning, will, by that time, have fallen to about 64, and the respirations, supposing them to have been 18, to 15 or 16.
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.