16c. 5th March. – 20 drops Soon afterwards chilly feeling from crown down back to coccyx. After 1/4 hour general agreeable feeling of warmth in skin and sensation of looseness of ligaments of joints, causing unsteady gait, with flying stitches in left patella and left shoulder-joint Burning when urinating recurred, flow more copious and a kind of anxiety at commencement of micturition. Next morning after breakfast pressure in gastric region, not lasting long; three soft stools with rumbling in bowels, as after purgative, and sensitiveness in sacral region; night restless. 8th. – 20 drops. Thereupon pressive pain in head, sometimes more felt in occiput, sometimes at root of nose. Headache, sometimes shooting, lasted all next day. Lastly, scraping in throat and constant tickling in larynx when smoking tobacco. Although accustomed to smoke, it always had a deadening effect during the proving 10th, night, the pain in throat increased, swallowing was difficult; in morning whole pharynx considerably reddened. Bruised pain in sacral region with pain in belly as from flatulence was pretty constant; evening, difficulty of swallowing and redness of throat declined; chilliness with marked exhaustion in lower extremities frequent; had to go to bed at 7 p.m. Slept well till midnight, after which had frequently starting out of dreamful sleep. At 5 a.m. great hawking of mucus with nausea, and lastly, twice vomiting of greenish-grey watery fluid. The weariness and exhaustion of limbs felt in bed. 11th. – On awaking heaviness on chest, and soon afterwards violent pricks in rapid succession in left half of chest from without inwards. During day shooting burning with hot feeling in region of coccyx and in haemorrhoidal vessels, which lasted till next day. 12th. – Stiffness with bruised feeling in left side of neck to shoulder- joint and part of back, aggravated in bed and when lying, ameliorated by movement and open air. This lasted 13th, 14th, and 15th, but alternated from 14th with similar feeling in lower and upper limbs, and then suddenly sprang back to first place. During whole proving had two or three times a day sudden congestion to head, with anxiety, whereupon the chilly feeling over back and extremities came on. A constant symptom was fatigue when walking, especially going up stairs, during which he must frequently rest on account of dyspnoea and hot feeling in lungs. Mind and disposition affected; sleepiness, dislike to mental work, crossness, anger about unimportant things, dislike to society and tendency to start were constantly recurring.
16d. 3rd April. – 30 drops. Immediately hot feeling in head, with chilliness over back; all day extraordinary exhaustion in whole body. 4th. – 40 drops. Pressing pain in forehead and occiput, increasing towards evening. The next night restless. 5th. – Headache relieved, but prostration of whole body, so great in evening that he must go to bed early. Next morning violent stitches in right half of chest with loss of breath, and during day repeated tinnitus aurium. 7th. – 50 drops. Shooting pressure in left half of chest, with anxiety and warm feeling in cardiac region, frequently recurring all day; night restless, disturbed by frequent starting. These symptoms returned twice the following day, but slighter. Towards evening tearing stitches in right knee-joint, and contused pain in right testicle. Next day nothing but tearing stitches in almost all joints, quickly changing, but very acute. (Ibid.)
17a. Dr. WATZKE took 10th January forenoon, 1 drop of acon. tinct, and continued till the 16th, increasing the daily dose by 1 drop. On 18th, 8 drops; 20th, 10 drops. Made no alteration in diet. 1 drop caused scraping in throat for several morning, and a peculiar derangement of the disposition. Could not, even in society, get rid of anxious, fearful thoughts. Had, too, transient pressive pain in patella. After 2 drops, scraping in throat for several morning, and a peculiar derangement of the disposition. Could not, even in society, get rid of anxious, fearful thoughts. Had, too, transient pressive pain in patella. After 2 drops, scraping in throat was more marked and lasted longer (all afternoon and evening) and there were repeated stitches in throat and dull pain in vertex. Oppression of chest and frequent stitches in back. After 3 and 4 drops, besides scraping, swollen feeling and stitches darting through throat, oppression of chest, and predominant sadness. After 5, 6, 7 drops, no throat symptoms, but pressure and acute stitches in vertex, pressive pain in patella and tendo Achillis, oppression of chest and feeling of weight in stomach, the latter lasting 1 minute, and recurring several times in day. 10 drops caused frequent violent eructation, increased thirst, feeling of weight in stomach with sense of compression in oesophagus (especially in forenoon), dull pain in vertex, extending to temples increased by stooping, aching and gnawing pain in patella, melancholy disposition. After eating, after wine and coffee, symptoms disappeared.
17b. 22nd, forenoon, 15 drops. Soon afterwards prickling burning in palate, throat, and along Eustachian tubes, increasing till noon, declining afternoon. Next night sleep very restless. 23rd. – Uvula much swollen, and with arch of fauces and posterior part of palate injected in a ramified manner. Saliva increased, compelling frequent swallowing; pain increased by swallowing. Therewith oppression of chest, dull pain behind sternum, frequent deep sighing, sometimes dry cough. Throat pain worse when walking in open air, accompanied by troublesome pain compounded of burning, itching, and shooting in both ears, relieved by eating, returning in evening with increased intensity. All these symptoms continued though slighter next day, and were quite gone on 25th.
17c. 6th, 7th, 8th, 9th February, morning, after breakfast, 20 drops. During these days the throat-pain was constant. It began soon after taking dose, was shooting and accompanied by feeling of swelling in throat; lasted all day. It was as if an angular, many-pointed body stuck in throat; uvula swollen, elongated, arch and posterior surface of palate greatly injected and dark red. At same time frequently during the day, for a morning at a time, very troublesome and acute pressive pain at both sides of vertex, forehead, lower jaw, most persistent and severe in right shoulder and right upper arm; feeling of exhaustion and heat in chest; frequent sighing, attacks of anxiety; sometimes dry cough and contractive shooting pain in right side of chest. In open air heaviness and stiffness of limbs, especially lower extremities; difficulty of moving; on treading heavily sensitiveness in lumbar region; occasionally when sitting sudden constrictive pain in region of gall-bladder, taking away breath. Every forenoon, some hour after taking medicine, increase of sexual desire, which went off about noon. After eating, chilly feeling, exhaustion, drowsiness; night, increased heat, frequent tossing about in bed; sleep very broken, full of vivid dreams, distinctly remembered. Frequent transient itching, prickling, burning scratching here and there in skin. Sometimes repeated going to sleep of right foot when sitting.
17d. 22nd. – 15 drops morning facing, same an hour later. During day painful drawing here and there, most frequently in different parts of thorax and arms, weariness in arms and thighs, confusion of head, continual but slight pressure in vertical region, scraping and constriction in throat, as if it were narrowed. Chest oppressed, must often sight. Sometimes stitches darted through chest. Occasionally violent eructation. Sexual desire much increased; evening, when passing from obscure room into street, flickering before eyes, lamp-lights trembled and swayed. Difficulty of seeing faces of passers-by; was anxious and giddy, feared to knock up against them. Thought he saw near objects worse, distant objects better than usual. Next night, sleep very restless, body felt hot tossed about much in bed, and had very vivid remembered drams. Dreamt he was playing whilst, and when awoke remembered all the cards in his hand. 23rd. Felt pressure and tension in vertical region; took, an hour after breakfast, 30 drops. All yesterday’s symptoms except those of eyes recurred, but less severely. 24th. – 40 drops, morning. Same symptoms. Oppression of chest was more persistent. When coming from open air into warm room, irritation to cough in larynx and dry cough. Feeling of fatigue in thighs and arms more distinct and troublesome. 25th and 26th. – 50 drops each morning at 9 a.m. Thorax painful externally in various parts, especially right side. Breathing sometimes very tight. Must sign often Deep breathing often hindered by feeling of compression in central anterior part of chest, or by persistent pinching together, especially in right side of chest interiorly, or by violent stitches deep in hepatic region. Change of temperature excited dry cough, accompanied by sore pain in chest. The feeling of weight in stomach came on more severely and was accompanied by constriction in throat, and attack of nausea. When walking in open air, troubled by acute pressing pain, which alternated for morning or 1/4 hour between left patella, right tendo Achillis, and back of left foot. Violent eructation of air, persistent pressive pain in vertex, restless night with vivid remembered dreams, anxiety, laziness, and prostration. The painful sensations of pinching, aching, pressing, gnawing on different parts of body, lasting a morning or more, were not unlike what is caused by a pretty strong electro-magnetic apparatus. 27th and 28th, each morning 50 drops. Soon afterwards feeling as if throat swelled, and as if a large quantity of mucus was there, which he could not get rid of by constant hawking; flow of frothy saliva into mouth; repeated violent eructation of air; frequent dry cough with sore feeling in chest, and sore pain in larynx; stitches in forehead, back, sides of chest, fingers, back of hand, and lower parts of body, as though he stood on the vibrating stool of an electric machine, and sparks were drawn from him. Pinching together as with blunt forceps in several parts of left arm, near bend of elbow, for 1/2 hour, frequently recurring during day. Twitching in various muscular parts, especially forearms, as though he had hold of the conductors of an electro-magnetic apparatus, only the pains came and went away more slowly. Fatigue as after a long walk in thighs and forearms; pain of sacral and lumbar regions, tensive aching, more felt when treading; violent very painful contraction about anus, but not resembling ordinary tenesmus; sometimes stitches darting through anus and urethra Continual itching and smarting on various portion of skin, compelling scratching; here and there papules the size of millet-seeds appeared, these again filled with yellowish lymph and dried. Afternoon, drowsiness, prostration, feeling of pressure and weight in crown, disinclination to mental work. When walking a peculiar stiffness and heaviness of lower extremities; could not go at his usual quick pace, but sauntered slowly along street. Night throughout very restless, next morning felt heavy pressure in vertical region, head heavy and giddy as after drinking strong wine the previous evening 29th. – 80 drops 2 hours after breakfast caused no new symptoms, but those of previous days came with greater intensity, and chest symptoms assumed a more serious aspect. Very frequent dry cough, especially on breathing deeply and in changes of temperature, combined with sore feeling behind sternum. The pressure and oppression on chest increased, especially towards evening, accompanied by drawing and stiffness in nape, and painfulness of scapula. Moderate wine drinking relieved chest symptoms, but aggravated those of head. Next day sleepless. Woke every 1/4 hour with confusion of head in vertical region, and dryness of mouth and gullet. Cutaneous temperature somewhat increased; drank much. 1st March. – Took 80 drops, half at 9:30 a.m., other half 3 hours later. Afternoon, violent pressure in vertical region, attack of vertigo, feeling in crown as if hair stood on end, that part was hot externally; chest symptoms as yesterday. Next night excessively restless. Great exhaustion after the restless night. The next 14 days same symptoms occurred as when taking the acon., only less intensely. Sleep during first week very disturbed. The most persistent symptom, besides the restless night, was the tiresome pressive pain in vertical region. Oppression of chest, and cough, generally dry, and only with slight mucous expectoration in morning occurred occasionally, then tiresome and frequent was the drawing, gnawing, shooting pains in limbs, especially forearms. Also the anxious sad humour came sometimes. The symptoms came in greater degree when walking in open air and towards evening; they were removed only for hours by wine and coffee.
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.