24c. On 8th, 9th and 10th June took 300, 400 and 500 dr., each quantity in 4 doses. Except griping pain in abdomen, relieved by soft stool on m. of 9th, no symptoms first 2 d. On 10th, fine pricking pain in anterior (glandular) portion of urethra, lasting only a short time causing no desire to urinate or pain on doing so; urine normal. Later, drawing pain in r. great toe, coming on during rest, and passing away on moving. After this he noticed no mental or physical change whatever, and the pityriasis alluded to was unaffected drug. (Hygea, xxii, 446.)
25. Herr RUSCH, aet. 24, florid complexion, lymphatic temperament, took 3rd trit. from April 3rd to 15th, beginning with 2 gr. and increasing I gr. per diem. On 8th and 9th d. he had a pressive frontal headache, and this was the only departure from perfect health that he noticed. On the 20th he took 4 dr. of tinct., and increased 2 dr. a. d. for 10 day without any result. (Ibid.) [Dr. Genzke also experimented on five of his own children, boys and girls varying from 6 to 15 years of age, to whom he administered daily increasing dose of the 15th attenuation. No symptoms attributable to the drug resulted, and the same was the case after a 10 d. course of the 3rd trit. The negative results of these experiments on Herr Rusch and on his children, led him to question whether the symptoms noted in his own case were really attributable to the L.] (Ibid.)
26a. Dr. FR. SEGIN, on March 24th and 25th, while in perfect health, took gtt. ij of 18th dil. in m. fasting. He experienced only a little pain in abdomen, as from wind, and (instead of the usual single stool) had 2 evacuations of the bowels and an often- recurring dull pressure in the neighborhood of the temples. On 27th a similar dose. On 28th was obliged to go a 7 h. journey, and took at dinner a little wine, followed by coffee. Soon after dinner, while in earnest conversation, frequent momentary confusion; could not take in accurately what was being said, and (irrelevant) thoughts forced themselves into his mind against his will. For instance, he kept thinking of droughts, his favourite game at that time. He could not succeed in giving undivided attention to the conversation; he pictured the game and all its moves. This lasted all the afternoon and until he went to bed, but he woke up free from it the next m. On 29th, 30th, and 31st took 3 doses of same strength, and on April 8th, 2 dr. of the 30th. On this d. he took some coffee in m., and half a wine glassful of wine. Until 24th he felt an unusual liability to catching cold; had toothache, now on one side and then on the other, at first drawing, then extending to ears and temples, with painful sensitiveness of the scalp over l. ear. worse on touching it. Also on swallowing had stitches extending to l. ear. 26th. – Had some shocks from a voltaic battery. 27th. -No more pain.
26b. May 8th, 1835. M., fasting, took 10 gr. 3rd trit. On 10th, having obtained no results, took 10 dr. of 30th dill., and same on 11th. On 12th 50 dr. Papules on legs, with here and there sharp pricking, which compelled him to scratch. On 13th and 14th same dose; a sore pain in toes, lasting until 18th and hindering walking. Sweat between toes so softened a corn that he was able to remove it by scratching.
A feeling of hunger in m. at 10 a. m., quite unusual with the prover. Increased sexual desire, emissions in night; he wet the bed, while dreaming that he had got up to use the chamber utensil (this happened to him once before when a student). From 18th to 21st drank daily half a glass of wine and some coffee. Swelling and painfulness at tip of nose, a small red spot as if a pustule would form, with occasional severe shooting on edge of r. upper eyelid. April 4th. -The aforesaid pain in the toes, which had disappeared, returned. Increased sexual desire and nocturnal emissions, followed by marked lessening of desire; the emissions occurred also without previous erection. 26 c. Nov. 7th, 1842, in good health; 8 a. m., I h. after breakfast (chocolate), gtt. x. of Ist dil. of tinct. 11-12, griping pain in abdomen, as if diarrhoea would ensure. Frontal headache p. m., a pressing and squeezing pain, to which he is not subject, lasting several hours 8th. -Slept well; between 7 and 8 a. m., while sitting writing, severe pressing pain in back, now over a large extent, now as if her were pressed with a fist on lower dorsal vertebrae, at same time similar pressure at the end of sternum, so that he was obliged to hold his breath. At same time slight toothache, pressure outwards in forehead, with slight drawing sensation through right side of face, over shoulder, and in arm. Never had a similar pain before; it went off in great part while he was writing it down, and after 1/4 hours was only a painless sensation. 19th. -No symptoms since last date; took 10 dr. of tinct. while traveling, and, after drinking 3 oz. of white was and a little cafe au lait, much confusion of head and difficulty in collecting thoughts so as to differentiate between medicines. Without being painful, the feeling of irresolution was very disagreeable. This confusion lasted, though less severely, until 22nd. 24th. -Took a small quantity of the oily residue of some tinct. which had evaporated; the confusion of head came back at once, with a feeling as if a board lay across the forehead. 29th. -50 dr. of 3rd dil., m. fasting. Until Dec. 6th felt again periodically the confusion of head; at such times thinking and grasping a subject were especially difficult. Rheumatic tearing pain several times in right ear and temple; also once drawing pain in left shoulder; these may have been due to the weather- sudden changes between east and south-west wind, between clear and dry, and dull and cloudy weather, but prover consider this sensitiveness to the weather due to the drug. His mental condition prevented his continuing the experimentation. (Hygea, xix, 14.).
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.