20b. June 8th. -At 6 a. m. 4 gr. 7, tearing-shooting pain in l. thigh, from hip to knee, causing lameness; at centre of left patella, in small spot, severe shooting; all day great drowsiness and lassitude. 9th. -At 5:30 a. m., 8 gr. Great drowsiness (it was thunderous weather); slight aching in r. brain; vertigo and slight stupefaction; respiration some-what oppressed. 10th. -At 6:30 a. m. 8 gr. 8, drawing between scapulae, not lasting long; lassitude. From 11th to 13th, occasional lassitude and vertigo. 17th. -At 8 a. m., gr. j of Ist trit., which was followed by oppression and eructation. P. m., slight itching in scrotum, and slight burning on micturition; urine of deep yellow colour. In evening great fulness and distension of stomach (after eating some new bread and eggs). 18th. -At 5 a. m. 4 gr. Frequent discharge of flatus; fulness; small quantity of mucus from urethra. 20th. -4 gr. Frequent emission of flatus; mucous discharge from urethra has returned. 21st-24th. -Much flatus; fulness with violent eructations. (Ibid.)
21. REICHMANN took, Nov. 27th, I gr. In 1/2 h. great drowsiness. P. m., stitches in sternum. In evening, pain in l. eye, and for a short time it appeared to be covered with a veil. Next day it was swollen, in outer canthus much mucus was found, with aching pains and considerable lachrymation. This lasted till 30th. Dec. 2nd. -At 6 a. m. again I gr. In 1/2 h. tears flowed so copiously that he could not work; this symptom, however, soon declined. At 10, violent aching pain in eye, lasting, though not so severe, till afternoon of next day (Ibid.)
22a. VULPIUS took, Nov. 21st, at 6:30 a. m., I gr. About 9, transient stitches in chest, especially right; afterwards headache, and sometimes shooting in occiput, but good, almost gay, humour. All p. m. and very violent headache, so that he was unable to work; also shooting behind ear into jaw; pulse 85; very bad humour; lassitude in limbs. 24th. -Repeated dose. Besides headache, which lasted till evening, no morbid symptom. 25th. -A third dose, without effect. 27th. -At 6:30 a. m. I gr of Ist trit. Very insipid taste some time after taking it; tongue thickly furred, yellow; shooting in l. temple and in r. occiput. 3 p. m. in l. hypochondrium. evening, headache. 28th. -Repeated dose. Slight headache; occasional shoots in r. parotid; increased saliva. Towards noon spasmodic vibrating twitching in scrob. cordis and r. thigh, lasting all 29th. 29th. -Took a third dose. Tongue somewhat furred; above vibrating twitching in scrobiculus constant. 11.30, tearing in right cheek, sometimes extending over crown of head to occiput. During last days more or less violent rheumatic pains both in head (especially jaws and ears) and in extremities. 4th. -Tearing in r. cheek and elbow; twitching in left scapula. Shortly before dinner transient belly-ache. Two motions. P. m., shooting in right thumb. 5th-Vibrating twitching in right ala nasi; sometimes shooting in right upper arm down to elbow-joint. 6th. -Very painful little ulcer in nose. 7th. – Itching in rectum, tearing in face, and previous vibrating twitching in scrob. cordis.
22b. June 8th. -At 5:30 p. m. 4 gr., without effect. 13th. – At 6 a. m. repeated dose. Soon afterwards, cramp-like twitching in extensor muscles of left upper arm; then aching in r. hypochondrium sometimes increased by breathing and then becoming shooting; almost all day insipid disagreeable taste in mouth. 14th. -At 5 a. m., same dose. Spasmodic trembling in l. upper eyelid, sometimes with slight shooting pain in eye itself. ( Ibid.)
23. WERTHER took, December 4th, at 6:30 a. m., I gr. of Ist trit. In afternoon pains before and after micturition; urine lemon-yellow, coming away in small quantity every 10 m. After a second dose following m. at 6:30, felt pain in forenoon, and move severe. After a third dose for 2 d. pains were yet more violent; then appeared pimples on face and thigh, and also at l. oral commissar. By following evening all these symptoms were gone. ( Ibid.)
24. Dr. GENZKE. of Butzow, Mecklenburg, aet. 40, of choleric temperament and strong constitution, occasionally suffers from catarrhal affection, and 7 years ago had gastric fever. He also has pityriasis versicolor on chest, back, and abdomen, which varies with treatment, but never goes away. At the time of his proving he was well except a slight cough with easy expectoration; he made no change in his diet, which was simple, except that he avoided wine and spirits and drank weak coffee in the afternoon. 24a. Dr. G-began his proving on March 25th, 1846. He took 2 gr. of the 3x trit. in m. fasting and at n. on going to bed, adding I gr. each d., so that on April 6th he took 14 gr. n. and m., -208 gr. in all. The first 3 d., no change, unless some improvement of appetite. March 28th. -Slight feeling of tension and heaviness of abdomen, with sensation as if flatulence were imprisoned, followed by restless sleep and horrible dreams, several times repeated, of fighting with wild beasts. 29th (and following d.) tension continued, usual normal stool every m. soon after rising. About 11 noticed slight pressive frontal headache (which he had previously occasionally had), coming on while writing, and lasting some h. In evening pain in back as if broken, while at work in garden, perhaps due to his being unaccustomed to the work. 30th and 31st. -Similar symptoms except headache; also feeling of roughness in trachea with somewhat increased expectoration. April Ist. -Slight shivery feeling all over with restlessness; pulse small, weak and quickened, numbering at 10 a. m. 86 while sitting, and 96 while standing (usually is 79 and 86 respectively at this hours) About 4, felt sore pain on inner side of right knee as if it were abraded; thought it was due to rubbing of the clothing. On examination skin was found normal, although the place was painful to a gentle touch with the hand. This increased during n. and to such a degree that it was impossible to bear contract of other leg when lying on side; restless sleep with dreams of same kind as before described; on one occasion when waking in a fright, noticed feeling of tension in chest. Pressure in region of stomach and some colicky pain. Towards m. peculiar sensation difficult to describe, as if sweat would break out on skin (which did not happen); pain in right knee contained and extended downwards to calf. 2nd. -On rising, momentary pricking sensation to soles of feet; in course of day pain in knee continued, but gradually lessened; except some tension in abdomen nothing else noticed. Drank a little wine in evening, slept well without dreaming. 3rd. -General feeling of well-being and of lightness, lasting all d. On 4th, 5th and 6th nothing very noteworthy, the abdominal tension occurred in less degree. In m. of 5th a pricking itching came on suddenly in bend l. knee, skin being perfectly sound; it lasted some hours; and in evening noticed indications of throbbing headache, extending from occiput to vertex. Good undisturbed sleep in n. 7th. -On rising dull pressing frontal headache, lasting all forenoon, associated with slight feeling of fatigue. Normal stool towards 8 a. m.; an hours later renewed desire for stool, followed by pappy evacuation, mixed with faecal masses and mucus. P. m., dull sticking pain in right side of back, especially on deep breathing, lasting several h. Perfect health between this date and the following experiment.
24b. April 17th, took 20 dr. tinct., m. fasting; followed only by restless sleep next n. 18th. -28 dr. m., fasting. After about I h. slight general chilly feeling, with slight frontal headache, in heated room, which came on while writing, and both of which went away later on moving. 19th. -40 dr. No change during d.; during n. somewhat restless sleep with dreams, and towards m., while still in bed, drawing pain along outer side of left ulna, lasting a short time, and followed by tenderness on pressure without there being anything to be seen. 20th. -54 dr. One h. after slight chilliness all over, lasting all d.; p. m., some abdominal disturbance with discharge of very offensive flatus. The above-mentioned drawing pain along ulna came on, but without the tenderness, a similar pain appeared also on back of l. hand. During n. restless sleep and same peculiar dreams causing feeling of anxiety like nightmare; on waking immediately after, feeling of heat over whole body and violent beating of pulse. 21st. -76 dr. Besides slight abdominal distension, a tearing pain coming on periodically in outer side of r. thigh, just above;patella, and at same time sore pain in r. nostril, worse on pressing wing of nose with finger. 22nd and 23rd. -No dose. Pappy evacuation on 22nd, soon followed by renewed desire as if diarrhoea would occur, but only a small evacuation of faeces of firmer consistence than before ensued. On both d. soreness of nose as before, and some distension of abdomen. 24th. -100 dr. taken in 2 doses m. and afternoon. Half an h. after first, violent sneezing and secretion of mucus (a not infrequent occurrence apart from the experiment); some-what later large, hard, difficult stool. About 10 pressure in abdomen and urging to stool again occurred, with evacuation of soft faces. A thin crust has formed in r. nostril where pain was. 25th and 26th. -130 and 160 dr. respectively on each d. in 2 doses. Nothing noticed beyond slight abdominal distension.
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.