6. Experiments on dogs showed that (1) Injected into veins near the heart in sufficient quantity, it arrests the heart’s beats, causing instantaneous death by syncope owing to destruction of the contractile power of the heart. P. M. shows left side of heart and aorta full of scarlet blood; the lungs without the slightest trace of congestion, of pink colour. (2) In similar quantities than required to produce instantaneous death, the effects of quinine are seen for at least 24 hours, as shown by the diminution of the blood-pressure (tested by Poiseuille’s haemadynamometer.). given by the stomach it increased the proportion of fibrin in the blood, and diminished the amount of blood – corpuscles, and slightly increased the quantity of serum of blood. (BRIQUET, Traite therap. due Quinguina.)
7. From numerous experiments on dogs J. concludes: (1) that in small and medium doses C. causes increased quickness of heart’s beats, before death a slowing is sometimes observed. (2) This increased velocity of heart’s movements is partly owing to excitation of excito- motor centre and partly to paralysis of heart-regulating apparatus. (3) The force of the heart’s contractions and the height of blood-pressure is at first increased, then much diminished in spite of the accelerated pulse. This is owing to excitation of the cardiac ganglia, paralysis of nervi vagi, and affection of vascular centre; the last is first excited, afterwards paralysed. Toxic and frequently repeated medium doses cause a rapid paralysis of all vaso – motor centres and momentary stoppage of heart which cannot be removed by any irritant. (4) The respiration is always increased in rapidity; large doses cause quick, labored, interrupted, rattling breathing, and asphyxia. This action is explained by the affection of the respiratory centres. The occurrence of pulmonary congestion and haemoptysis is owing to pulmonary hyperaemia caused by paralysis of the vascular system. (5) C. does not always lower the temperature. In most cases the temperature is lowered to an inconsiderable degree, but not rarely it is raised and fluctuates about the normal limits. He concludes that C. lowers the temperature by altering the changes of matter. It excites the heart-centres and by means of the trophic nerves influences the changes of matter in the tissues. Large doses cause the temperature to rise by paralysing centres. (6) The rapidity of the circulation is diminished by C., by the contraction of the vessels in the primary action of the drug, or else by their subsequent dilatation. This is cased by the relation of the alkaloid to the vascular centre, the peripheral vessels, the vagi nerves, and the weakening of emigrations in inflammation. (8) C. diminishes the size of the spleen plexus linealis or the spinal cord]. (JERUSALIMSKY, op. cit.)
8. In 1867 Prof. Binz announced the fact that quinia added to human blood in the proportion of 1 part to 4000 immediately checks and in a short time arrests the amoeboid movements of the white blood cells. Conformation of this has been furnished by Scharrenbroich, by Kerner, and by Geltowsky. [* Although Ch. possesses the power to stop the movements of the colourless globules, yet this action perhaps can only be obtained on the slide of the microscope. On injecting into the blood doses which cause the death of the animals Ch. has no influence on the colours blood-corpuscles”(GELTOWSKY, Pract., viii, 334). Schwabe has obtained similar results. His investigations also appear to show that the alkaloid lessens the ozonizing power of the blood; and also (confirmed by Schulte) that it checks the development of acid in the blood after it is drawn from the body. Both these operations appear to be oxidations; and Binz has demonstrated that quinia checks them by acting on the red corpuscles.”Drs. Culler and Bradford find that Ch. diminishes the red and increases relatively the quantity of the white corpuscles of the blood”(RINGER). (H. C.WOOD.).
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.