10 b. Forty day after last dose of 200 dr., M. began his second proving. Dec. 5th. – He took 10 dr. of the 3x dil., and increased the dose daily by 10 dr. until the 15th, without noting the least variation in his ordinary sensations. From 16th to 23rd, M. tried daily 10 dr., m. and evening, of 2nd dil., with a similar want of result. From the 24th to the 27th, he took twice a day 10 dr. of 1x dil. After doing 3 day in succession, the well – known itching in anus developed itself, and was especially troublesome a. m. 28th. – After twice taking 15 dr. of same dil., a slight stitch in urethra, increased urination at n., and dampness at anus. 30th. – M. took in m. 30 and in evening 15 dr. of 1x dil.; afterwards uneasiness in stomach, eructations of wind, bitter taste; in evening violent headache, lasting until 10 copious, limpid urine, itching and sweat at anus. Jan. 2nd, 1845. – He observed, after 30 dr., from time to time stitches in urethra, with urgent desire to urinate, loss of appetite, vertigo, and headache in forehead in e. From 3rd to 10th, M. took daily 30 dr. of 1x in m., and 20 in e. The constant symptoms were urgency to urinate, with stitches in urethra and itchings in anus. This very promising experiment was unfortunately broken off in consequence of the death of a person nearly connected with the zealous prover. (Ibid.)
11. I (Dr. Mayrhofer) proved the arbor vitae upon myself and on my wife.
11 a. I began the proving of T. with the 2nd dil., making no change in my manner of life. Sept. 8th 1844. – At. 3 p. m. I took 50 dr. without experiencing the slightest change in my sensations; 100 dr. taken early, fasting, on 9th, produced no further effect, nor did 150 more taken in evening of same day, or 200 dr. taken on 10th. I tried then, on 11th, at 6 a. m., 100, and in evening 200 dr. taken on 10th. I tried then, on 11th, at 6 a. m., 100, and in evening 200 dr. of 1st dil., without observing any morbid phenomena. 12th. – The want of susceptibility of my tough system to the power of the dilutions determined me to try the undiluted tincture, of which, on this day, I took 50 dr. m. and evening each, but waited in vain for any signs of life in the “tree of life.” 13th. – After 100 dr. taken early and fasting, I first perceived, during day, swelling of haemorrhoidal veins, with tenesmus, itching, and burning in anus. In evening, on repeating the 100 dr., I had 2 slight passages, ending with discharge of mucus, itching, and burning. 14th. – In m. 100, and in evening 200 dr. The itching and burning in anus increased, and were especially troublesome in evening after a stool. During n., more frequent and copious urine than formerly, and, immediately after urinating, I felt a renewed inclination, whereby a few dr. were the discharged without pain. 15th. – 200 dr., taken both m. and evening produced no new symptoms. 16th. – At 6 a. m., 300 dr. Immediately afterwards nauseous taste and confluence of much saliva in mouth. After 1/4 hours, dull headache over whole frontal region (lasting an h.). At 6 p. m., a stool, with subsequent burning in anus, and shortly after a reiterated discharge of mucus, attended with very violent stitches in rectum in direction of a line from anus to sacrum. As the stitches ceased, the itching and burning returned, and lasted until 10. 17th. – 300 dr. Itching and burning in anus remained the prominent symptom, lasting till midnight and preventing sleep. Three stools followed, ending always with discharge of mucus; urine was plainly increased, and after urination the inclination returned, attended with the voiding of a few dr. more. 18th. – At about 6 a. m., 600 dr. were taken in a glass of water, with the following result: Eructations of the drug for some hours, confluence of saliva in mouth, headache in frontal region, and in evening 3 stools, with subsequent itching and burning in anus and irritating stitches up rectum. On following day, on which I took no dose, I frequently felt flying stitches under right shoulder – blade, and in evening had 3 stools with the accustomed accompaniments. As in course of 20th, the following day, I perceived no drug affections, I took 400 dr. at about 9 p. m. Before midnight sleep was destroyed by emission of much flatulence, by itching and burning in anus, accompanied by flying stitches in rectum and by repeated urination; sleep, however, came on after midnight, and on awaking I found myself better than I would have expected after a bad n. I took no medicine on the next 3 day; regularly every evening the itching and burning in anus set in; every day also I had 2 stools ending with discharge of mucus. 23rd. – In evening, 500 dr. Increased warmth in face with dull confusion in head (effect of the alcohol); unrefreshing sleep, interrupted by terrible dreams (of the head) and by frequent urination. On following m. dull confusion in head, with general debility. Through day flying drawing pains in various parts, especially in hands, and in evening return of itching and burning in anus. From 25th to end of month I ceased to take the drug, and made the following observations: On evening of 26th, 3 round red spots size of a lentil, which itched and obliged me to scratch, appeared on inner surface of right forearm near wrist. The itching became burning when they were scratched. On following m. they had disappeared without leaving a trace; on 28th I remarked a painful tubercle of about the same size in neighborhood of anus, on raphe of perinaeum, which likewise disappeared in a couple of d. Flying drawing, now here, now there, and troublesome itching in anus, especially in evening, developed themselves every day, gradually, however, wearing off. Oct. 1st. – At 5 p. m., 500 dr., followed by nausea, eructations of the remedy and (after 1/2 h.) itching and burning in anus. During n., discharge of much flatulence and copious urine; at 6 a. m. of following day an evacuation with burning in anus; through day felt well. 2nd. – On taking 500 dr., the constant burning and itching in anus reappeared, and night’s rest was as usual disturbed by frequent urination and restless dreams. On following day, no other symptoms were perceived except debility and occasional flying stitches in rectum. 4th. – I took at about 3 p. m., another 500 dr. In evening dull confusion of head and burning in anus; on following n. abundant urine, much flatulence, and dreams. On following d. I felt pretty well again, while urinating, however, I made the unpleasant discovery that the glans penis were entirely covered with a greenish – yellow, ill – smelling secretion, and after I had cleansed it, I observed on dorsum of glans, near hinder border, 4 tubercles about size of a flaxseed, with a vesicle on their summit, and in the sulcus, near attachment of foreskin, was a small eroded spot, surrounded by a red circle, about size of a lentil. 6th. – Nevertheless, I again took 500 dr., upon which the symptoms already described again appeared, and the tubercles on the glans d increased by 2. the urine, since the large doses, had become turbid, and, in cooling, deposited a flocky, mucous cloud. Urination was performed without pain, but a sensation was often experienced, while seated, as if the glans had been bruised. 7th. – No new symptoms were developed by a fresh dose of 500 dr., except that the vesicles of the elevations before described were broken, and left behind little painless erosions, surrounded by a red margin, and yielding the secretion alluded to. urging the 3 following day no medicine was taken, and the protuberances became flatter, the areola paler, and at last the sore spots disappeared also. Pains, at one time drawing, at another tearing, were repeatedly felt, especially in extremities, for the most part while at rest, but in right tibia also while walking, so as to make me limp, 11th. – At 3 p. m., 600 dr. Besides the usual phenomena, I noticed on the following day granular, elevated red spots on the glans penis, which was uncommonly sensitive, and on 13th sebaceous glands of prepuce appeared swollen and inflamed; but, on 14th, the inflamed spots were paler again, the clustered, prominent tubercles flatten; and on 15th appearance of prepuce and glans was again natural. 16th. – At 3 p. m. I drank 1000 dr. in a pint of water. Immediately afterwards, nausea with vomiturition and confluence of saliva in mouth. After an hours, headache in frontal region with heat in cheeks; and, 1/2 hours later, general feeling as if beaten, with chill over whole body in so remarkable a degree, that I was obliged to go to bed, although it was only 6 p. m. The n. was disturbed by many dreams and frequent urination. On the 3 following day, no medicine being taken, I felt uncommonly debilitated. I was especially annoyed by itching and burning in anus, attended by several violent stitches in rectum (particularly in e.). I also had, at times, drawing pains in hands and feet, which still continued even after 8 day, growing, however, weaker and weaker. No change was perceptible in the glans penis, but I felt a burning pain in perinaeum, raphe of which was more prominent than usual, and one inch from the anus a tubercle size of a pea appeared, which increased for 3 day, became moist, smarted in walking, and then day by day became smaller and disappeared in about 10 d.
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.