17 c. 1845, Jan. – After a pause of 5 weeks, W. on 27th, 29th, and 30th, took each day, about 6 p. m., 2 table – spoonfuls of 12th dil. of Thuja, and on 10th Feb., at about 5 p. m., he took 3iij of same dil. The dils. were prepared with distilled water. 30th. – He first perceived, soon after taking drug, feeling of dryness in throat, lasting 2 hours; in evening, drawing in right thumb and forearm, then in left thumb and in upper teeth of right jaw. The increased secretion of mucus obliged him frequently to blow his nose. 31st. – In m., frequent sneezing, stoppage of right nostril, alternating with running. This catarrh lasted 2 hours, then suddenly vanished; it appeared again for a little while in evening, and ceased suddenly as if cut off. Feb. 1st. – The same symptoms. 10th. – Immediately after dose, feeling of dryness in throat, which lasted all day 11th. – Feeling of dryness in throat whole evening; pressing in left side of chest, particularly troublesome in region of ribs; several times, drawing in lower incisors, and in 1st joint of right index finger; violent itching in lower part of sacral region; at n., sticking from right velum palati into internal ear; secretion from Schneiderian membrane increased. 27th. – As a closing experiment, W. drank 3iij of 30th dil. (prepared with distilled water) at a draught. This was at about 5 p. m.; he perceived no result whatever.
18. Dr. F. ZEINER, 42 years old, of delicate constitution and phlegmatico – sanguineous temperament, healthy from childhood (except the usual diseases of that period), for the last two years frequently troubled with haemorrhoidal affections, instituted four experiments upon himself with Thuja. (It was his first essay with drugs.)
18 a. 1844, Nov. 7th. – Without making any alteration in his ordinary mode of life, Z. took, at 9 a. m. (2 hours after cafe au lait), 1 dr. of the tinct. in water. Immediately after dose he experienced vertigo, soon disappearing, scraping in throat, slight griping above navel, sticking in right temple, numbness of left foot, and feeling of weakness in it in walking up and down room; feeling of coldness over whole body. 1 hour after, the griping drew from umbilical region towards right groin, and occasioned there transient, often – returning pressing. The vertigo, scraping in throat, and lame feeling in left foot still continued. 2 hours after having taken dose the vertigo and griping in abdomen disappeared in open air, but single stitches were repeatedly felt in right groin and between sacrum and anus. Frequent urination in course of d. At 6 p. m., inflation of abdomen for 1 hour, which disappeared by eructations. 1 hour afterwards (10 hours after taking drug) single stitches were perceived in anus, alternating with burning in prepuce. At about 9 p. m., the prover’s odour was exceedingly, almost intolerably, increased, so as to become perceptible to those about him. The night’s rest was good; but soon after waking the stitches in anus came on, and the biting in prepuce also was troublesome for 1 hour 8th. – At 9 a. m. Z. took another dr. in water; some m. after, griping above navel, and burning 1st hours single stitches in right frontal eminence, scraping in chest forcing him to cough, quivering in upper eyelid, pressing pain in right side of forehead, biting on upper surface of glans and in prepuce, feeling of weariness in left leg when seated. At 10 a. m. another dr. Soon after, he felt shivering in back; the feeling of weariness in left leg, the sticking in right side of forehead, and the griping in abdomen continued. Towards 11, drawing in left testicle and frequent eructations of wind. At 2 p. m. (4 hours after dose) the itching on prepuce became almost intolerable. Z. also observed during day frequent urgency to urinate, with passage of copious urine. Stools regular on both day 9th. – At 9 a. m. Z. took 4 dr. on sugar; soon after, slight vertigo, griping about navel, itchings on prepuce, scraping in trachea, obliging him to cough; with quivering of right upper eyelid, burning in left eye near internal canthus, compelling him to rub it, weakness of eyes, single fine stitches in temples, feeling of weakness in left secretion of sweet saliva (lasting 5 h.), drawing in left testicle, urgency to urinate, with copious urine, swelling of cervical glands, pains in sacrum. On following day, on which nothing was taken, he felt in forenoon the pains in sacrum, quivering in right eyelid, and feeling of weakness in left leg; in evening, burning in orifice of urethra an frequent stitches in anus. 11th. – 8 dr. of tinct. Soon after taking dose, quivering again in right upper eyelid, feeling of coldness with numbness of left foot, solitary stitches in shoulders, and frequent chills over whole body. At 3 p. m. a general chill; drawing in left testicle, in left thumb, in occiput; sticking in temples, in right side of forehead, and in left knee; pressing in sacral region. 12th. – Z. took nothing. In evening, sticking now in left knee, now in head, now in elbow and finger – joints; then general debility, with such weakness in legs that he thought he should fall. On following day he observed a red spot on inner surface of prepuce, which itched violently and disappeared after 24 h.
18 b. Nov. 25th. – After omitting drug for 14 day, Z. commenced again at 9 a. m. by taking 4 dr. of 3rd dil. on sugar. Soon after, he perceived griping about navel, itching on right knee, on left shoulder, scrotum, and divers others places, and burning on inner surface of prepuce. After 1 hours violent drawing in testicles; vertigo; greatly increased secretion of saliva (of metallic taste), lasting 2 hours, with swelling of salivary glands. At 4 – 5 p. m., sticking pains in glands of groin. During whole day slight chills in warm room; increased urgency to urinate. 27th. – At 9 a. m., 8 dr. of 3rd. After 1/4 hours, itching on prepuce, griping about navel, sticking in left side of forehead, pressure on right shoulder; weakness of eyes, particularly observable when writing. After 1.1/2 hours, renewed increase of saliva (of acid taste) during 2 hours; sticking in anus and violent stitches in left side of chest, which frequently returned throughout day; continual slight chills and increased secretion of urine. 28th. – The symptoms of preceding day were repeated after taking 12 dr. of same dil.
18 c. Dec. 17. – Z. ceased taking drug for 18 day, and commenced again by taking 15 dr. of the undiluted tinct., whereupon, in course of day, he observed following symptoms: Pressing in forehead, frequent stitches in frontal eminences, sticking, at one time in right, at another in left side of chest, griping about navel; scraping in throat, intolerable 18th. – 20 dr. Soon after dose: staggering while walking in air; pressing in middle of forehead; sticking in both frontal eminences (lasting whole day and continually increasing); general debility and weakness in legs; sticking in shoulders and in right knee; stitches in region of groins, often repeated during day, with feeling as if inguinal glands were swollen; intolerable itching in anus, lasting almost entire day; the urgency to urinate, with copious urine. 19th. – No medicine. On awaking, sticking pain in left frontal eminence, as well as violent pressing between shoulders, which feeling had entirely disappeared 8 day before; frequent twitching in middle finger of right hand. The itching in anus appeared but seldom. 20th. – After 25 dr. dull confusion in head, weakness in legs when walking; stitching in forehead and in different parts of body especially in shoulders, arms, and legs; in evening, spitting of much saliva. The itching in anus is almost gone, tongue and palate are very sore. On the following 3 day no dose. 21st. – On awaking, sticking in left shoulder, and in course of day flying stitches in glans; there was also an increased secretion of saliva. 22nd and 23rd. – The whole of the symptoms gradually disappeared, and prover no longer perceived the troublesome itching in the anus which had so much annoyed him during whole continuance of experiment. In my case this itching in the anus was the most durable symptom, and disappeared only after the lapse of several weeks.–Mayrhofer. 24th. – Z. took 30 dr. During the two succeeding hours burning and itching in anus, griping about navel, painful constriction in hypogastrium, weakness in legs, cracking in knee – joints, drawing in right groin, and pressing in renal region. At 6 p. m. pressing in forehead, sticking in left frontal eminence, acid taste with increased secretion of saliva, swelling of one of the cervical glands.
18 d. 1844, Jan. 4th. – After having rested 10d., Z. took 10 dr. of 12th dil. During first 2 hours he observed during rest: transient griping about navel, repeated stitches about anus, which continued to increase in violence during day, eructations of wind, sticking in left side of chest, on left scapula and right temple, failure of eyes when reading, transitory chill over whole body with cold hands in a heated room, pressing, at one time in right, at another in left arm, drawing in fingers, pain in nape of neck, stitches in left side of forehead, numbness of left foot while sitting, crawling in toes, extraordinary weakness in left leg when going out, slight reeling, pains in small of back, and increased secretion of saliva. At 4 p. m. drawing in left testicle with feeling of weight in it, urgency to urinate with copious passing of water. During the 3 following day, no medicine being taken, frequent pressing in forehead, sticking pains in frontal eminences and temples, pressing between shoulders. 8th. – 15 dr. of 12th. During first 2 hours pressing and sticking in forehead, sticking in shoulders, stitches in anus, numbness of left leg, drawing in left testicle, feeling in testicles as if they moved, drawing in fingers and pressing in left upper arm. All these symptoms disappeared while walking in the open air. 9th. – No dose. Frequent itching on glans and prepuce, alternating with stitches in anus, and the urgency to urinate was frequent and hasty. 12th. – the proving was concluded by taking 25 dr. Thereupon he observed pressing in middle of forehead, sticking pain in right axilla, increased salivary secretion, which lasted all day, stitches in inguinal glands, itching in anus, flying stitches in anus, weakness of eyes when reading, pressing between shoulders and crawling in toes of left foot, which were painful in treading. In afternoon, while seated, feeling of lameness in left leg. At 7 p. m., when walking, uncommonly violent stitch between coccyx and anus. 13th. – After waking, sticking in left side of chest, lasting all d. On discontinuing drug, all abnormal manifestations disappeared. Dr. Zeiner accompanies his beautiful and instructive proving with the remark, that during its whole period the sexual desire was completely asleep; and he further made the observation, in accordance with the experience of other provers, that the greater part of the drug – symptoms were most clearly developed during rest. (Ibid.) 19. The boldest and most indefatigable prover of Thuja was Prof. von ZLATAROVICH, who took, in 155 day, 42,260 dr. of tinct. in large doses.
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.