13 c. As was to have been expected, no results followed an experiment instituted by right with the first twelve dilutions (1:99). He began with 100 dr. of the first dilution, and took daily the same quantity of the succeeding dilutions in regular order, closing his resultless experiment with 100 dr. of the twelfth. He had now taken some 25,000 dr. of the Thuja tinct., and was well weary of it, but not ill. (Ibid.)
14. Dr STERZ made two short experiments with Thuja.
14 a. 1844, Oct. 13th. – He took tinct. every forenoon between 10 and 11, upon a lump of sugar. He began on 13th Oct., 1844, with 5 dr., took 10 on 14th, and increased dose each day by 10 dr., until, on 19th, he took 60 dr., but perceived not the slightest effects. 20th. – An hours after taking 80 dr., a sensation of roughness in throat came on and lasted until midnight. 21st. – 100 dr. Immediately after dose, feeling of roughness on tongue, hard palate, and in throat; at noon sensitiveness of gums of molars; at 7 p. m., colic – like pain in hypogastrium and moving in the bowels as if preceding a diarrhoea, which, indeed, came on very violently at 8:30 with severe bellyache: the pains then remitted, but the hypogastrium remained tender for several h. His sleep was quiet after midnight, and towards m. much flatulence was discharged; the throat was still rough and fauces dry. He was frequently obliged to hawk and throw off white, tough mucus. After 10 a. m. he took a fresh 100 dr., upon which, frequent eructations with nausea; at noon, dull confusion in forehead, which disappeared at midnight; in evening a copious evacuation, with discharge of much flatulence. All the morbid sensations had vanished on next day after a quiet night’s sleep.
14 b. Dec. 7th, 8th, 9th, and 10th. – No effects were perceived from 200 dr. of the 15th dil. The dilutions were all decimal (the dilutions were prepared with one part of alcohol and four of distilled water) taken daily, nor from the same quantity of 12th dil. taken on 11th. 12th. – S. took m. and evening 200 dr. of 12th. At noon feeling of dryness on palate, and next day drawing in both thumbs on awaking. 13th. – 400 dr. of 12th. Thereupon roughness of palate and drawing in right thumb, which last continued all day 14th. – Nothing new was developed by 400 dr. of 8th dil. The drawing in right thumb extended into the wrist – joint. On 15th no dose was taken, and except dryness of the throat no symptoms appeared. 16th. – 400 dr. of 6th dil., which were repeated on 19th; after which, scraping and roughness in throat, and drawing in right knee. After a pause of 28 day, S. also experimented with the 4th and 2nd dil. 1845 Jan. 16th, 18th, 19th, and 21st, he took 400 dr. of 2nd. The following slight symptoms appeared: Feeling of dryness in throat, with frequent hawking and spitting of a tough white mucus and confluence of much saliva into mouth; the taste was injured by it, and food tasted as if it had not salt enough. (Ibid.)
15. WACHTEL proved Thuja in the dilutions only.
15 a. 1844, Dec. 10th. – Our associate, so remarkably sensitive to the effects of this drug, began his proving by taking 30 dr. of the 3x dil. about an hour before breakfast. He observed, in forenoon, a sudden thrust from before backwards in right half of chest; at noon, complete loss of appetite; in afternoon, itching and biting in prepuce; afterwards, tearing pressing in upper part of right thigh and left arm, which greatly resembled the effects of bryonia, with this difference, that the pain produced by Thuja seized the middle of the affected member, was confined to a small spot, and was mostly in the muscles, while that produced by bryonia seemed to prefer the joints and tendons. In evening he felt maddening twitching in right frontal eminence. An hours later this pain attacked the right eyeball much more violently, but shortly disappeared, leaving behind a sensibility of the eye to touch of hand, which remained a long while. Sleep of following n. was good; but immediately on waking the same pain re – established itself in right eye. 11th. – 10 dr. of same dil., producing return of chest – pain of day before, but this time in left half. Afterwards, an unsatisfactory, hard stool, with subsequent itching and biting in anus. P. m., drawing through whole length of the outer surface of thigh; in evening, pressing pain in frontal and occipital regions; itching in corona glandis when walking (for 1/2 h.). His sleep was good and comfortable, with lively and pleasant dreams. Feeling of health on awaking, except weariness and lameness in legs. On 12th, no striking symptoms followed repetition of dose; W. only remarked in middle of left parietal bone a spot, size of a sixpence, sensitive to touch, and a drawing from crest of right iliac bone to upper part of thigh. 13th. – Pressing in occiput was only symptom after taking 10 dr. On 14th, after a similar dose, pressing in forehead, lasting all d. W. now discontinued the Thuja from the 15th Dec., 1844, until 7th Jan., 1845, in order to see how long the effects of the drug would continue; and acknowledges his astonishment at the duration of its action. During this time he observed the following symptoms: 15th. – Violent drawing and pressing a sacral region for 2 hours in forenoon. On 16th, while writing, drawing pressing in right thumb (for 5 or 6 m.); then in index; later in middle, an finally in little finger. In afternoon same sort of pain appeared in left arm, shifted then to upper part of thigh of same side, soon after appeared in both mastoid processes, then in frontal eminences, where the pain took more of a digging – twitching character, and finally reappeared in extremities. This wandering about of the pains continued through following d. On 18th, for several hours in forenoon, the pain remained in neighborhood of left wrist; and, during whole afternoon, in upper part of left thigh. 19th. – While lying down, the pressing in sacrum was fixed in same spot for a whole h. It diminished and disappeared on motion; but afterwards appeared while lying in bed in lower part of left thigh, in the same spot where it had already appeared once before. The prover remarked this day, on edge of upper lip, two small, dark red, burning spots, size of a lentil; on which, during the 3 following day, little elevations were developed, which dried up and fell off. Later two new spots appeared, which ran same course. He observed, in addition, feeling of stiffness on side of the nape of the neck, which had been already perceived during the first days of the experiment, but had been attributed from the beginning, by the prover, to an uncomfortable position in bed. 24th and 25th. – W. was often tormented by a very painful tearing drawing in left chest, in neighborhood of fifth and sixth ribs. This pain appeared when standing and sitting, disappeared when moving, and was rather diminished than increased by a deep inspiration. 26th. – Crawling drawing in left zygoma, which let behind for a long time a feeling of deadness. This symptom appeared again on 27th, on same, and afterwards on right side. In evening, drawing tearing in mastoid process of left temporal bone, and then in both eyeballs, when the pain ceased. 28th. – Prover was annoyed through whole day with a crawling pressing pain in left side of sternum, which was confined to a spot about size of a thaler, remained the same in rest or motion, and finally left the feeling as though spot was sore. After 3 weeks isolated symptoms were still perceived. The pains were, for the most part, drawing, tearing, or crawling, seldom pressing, and least of all sticking. They were mostly confined to a small spot, seldom continued long, frequently changed their location, and came on distinctly when at rest as well as during motion.
15 b. 1845, Jan. 8th. – After W. had almost ceased to perceive the symptoms produced by the proving of the 3rd dil., he took, at 7 a. m. this day, 3 oz. of the 12x dil. In 1.1/2 hours afterwards appeared (weakly marked) the characteristic tearing drawing pains, sometimes in frontal eminences and occipital protuberances, sometimes in middle of left arm and thigh (only when at rest). The crawling and drawing in both zygomata, and i left upper maxillary bone, came on instantaneously, and disappeared again as rapidly as it had appeared. 9th. – Rather violent drawing in right shoulder, and later, without the slightest cause, cutting and griping in left side of abdomen. 10th. – No abnormal sensation was perceived, but on 11th extraordinary violent tearing in left concha, and soon after in left eye, which ended with a darting stitch through middle of eyeball. Copious urination also came on. 12th. – Prover remarked in region of heart a small spot, sensitive to touch, with pain as if it were sore, and on following day a similar spot upon vertex, on which skin was somewhat reddened. At 10 o’clock he went to bed in good health, but after 1/2 hours was suddenly seized with anxiety, after which a slight perspiration broke out; whereupon he fell asleep, but continually started up again. Finally, drawing pains in arms and legs, and especially in sacrum, came on. These having ceased, he had quiet sleep till m. 14th. – W. found himself tolerably well; only general weakness and frequent accesses of drawing pain in different parts of body annoyed him. In evening the general debility increased, and he was obliged to go to bed at 7 o’clock. After some m. his feet became as cold as ice, whereupon he became again anxious. It was a very striking symptom that in no position of the body, whether sitting or lying, could he feel the pulsation of his heart. Slight shiverings, which spread themselves by little and little over whole body, came on. At last, after 1/4 hours, he experienced a trembling of the heart, after which a general sweat broke out, so that in the course of a m. whole body was wet. This was followed by dozing for an hour, unrefreshing, and disturbed by frequent starting and horrible images. When he awoke from this he was tormented with drawing and tearing pains in hands and feet, and when these last suddenly disappeared, the anxiety and heart – trembling returned. It was only after 1/4 hours that his heart again beat regularly; but then drawing tearing pains in epigastrium, in hypochondria, on chest, but worst in sacrum, came on, ending in a slight perspiration, and finally in sleep. On awaking, W. was very weak, however, was free rom pain; the weariness, too, nearly disappeared head, however, was free from pain; the weariness too, nearly disappeared in course of day 15th. – He went to bed later than usual. After he had lain quietly for a 1/4 hours his feet began again to grow cold, anxiety again came on, and in an instant, in place of the regular beat, he felt a trembling of the heart. The sweat that then broke out was interrupted by the prover’s being called to a patient: on his return, at the expiration of an hours, he slept tolerably well until m. 16th. – During day drawing pains, now here, now there; weariness, with apparent loss of sensation in limbs; in evening, after lying down, cold feet again, with anxiety and palpitation, but less in amount and of shorter duration. Isolated symptoms, but less in amount and of shorter duration. Isolated symptoms were still remarked by the observant prover six weeks after the 3 ounces of the 12th dil. had been taken. The following were daily visitors, – the drawing pains in hands and feet, in sacral region, and between the shoulders. The crawling drawing in zygomata and the tearing in occipital protuberances and in petrous portion of temporal bone were among the oftenest perceived. No chest or abdominal symptoms appeared, but wart-like excrescences frequently appeared on back of right hand, on chin, and other places. A furunculus behind right ear especially continued a long while, and formed a scab, from which exuded a glutinous moisture. This soon dried and fell off, when another formed; it was sensitive to touch, and lasted 4 whole weeks.
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.