19 a. 1844, Sept. 6th. – Z. began his proving with 6 dr. of tinct., which, as also the succeeding doses, he took in the m. fasting. On the 3 following day he took 8, 10, 12 dr., and experienced no effect. On 10th, after taking 14 dr., he first perceived, in evening, a transient pain in vertex, as though bone were repeatedly pierced with a needle near sagittal suture. 11th. – No effect after 16 dr. 12th. – After 18 dr., in evening, pressing and burning in haemorrhoidal vessels and frequent violent sneezing, which returned on m. of 13th after 20 dr. Fr, 14th Sept. to 5th Oct. Z. increased dose daily by 2 dr., and observed the following results: Sept. 14th. – After dinner, frequent violent sneezing without catarrh (a thing very unusual with him). 15th. – In m., several times, short, dry, barking cough. 16th. – In afternoon and evening, pressing in a small spot under sternum, which gradually extended to scrobiculus. 17th. – An n., and on waking, several times short, interrupted, convulsive cough, excited by an irritation in larynx, and leaving an unpleasant dryness in it. At noon, moderate appetite, head somewhat confused, especially in forehead, throat dry and rough, and some difficulty in swallowing. In evening he felt very weak and unwell, with heaviness and tension in legs, so that walking was painful head ached in that part of anterior half which was covered with hair, as though compressed; nevertheless a very good n. succeeded. 18th. – Of the catarrhal symptoms, nothing is left except a little roughness in throat. This also disappeared by noon, and he felt well again. Until this point in the experiment the sexual impulse had been much exalted. 19th. – A good night’s rest was followed by a day destitute of symptoms. 20th. – On rising, inconsiderable cough and roughness in throat, disappearing by noon. In its place appeared troublesome dryness and sensitiveness of nose, as at commencement of catarrh. This sensation extended by degrees into frontal sinuses, and eyes also became sensitive. These catarrhal symptoms disappeared again during after noon. At commencement of dinner a jerking constrictive pain was felt in hairy portion of head, and in afternoon painful tension in right popliteal space. 21st. – In forenoon dull confusion of head; slight burning in stomach, and in left external canthus. At 2 p. m., violent burning in eyes and eyelids; frequent sneezing. Roots of hair of left eyebrow are sensitive when passing hand over them. At dinner, burning tearing in whole left side of the face, apparently in periosteum. After dinner, general uneasiness for 2 h. In evening burning pressing pains in left eye, on whole upper surface of globe, aggravated by touch; sensitiveness of left temple; slight drawing in nape, and repeated sticking from nape to right ear and axilla. After supper, dull confusion in head for an h. On lying down, right leg was so painful that he was obliged to place himself on left side, contrary to his usual habit, and so to lie during whole n. For several day the skin on vertex has been sensitive to touch, and shines so clearly through the hair that the prover has afraid he was becoming bald. 22nd. – On awaking, some headache in forehead; after rising, same feeling in left nostril and right frontal sinus came on that had been experienced 2 day before; but now right nostril was entirely free from it. At noon, frequent blowing of thick mucus from nose. Whole right leg was painful. Repeated urgency to urinate, even when there was but little water in bladder. In evening, all morbid symptoms had vanished, except that a little spot upon the vertex still remained sensitive to the touch. 23rd. – No symptoms; two liquid stools which were evacuated soon after taking the dose seem to have prevented their appearance. 24th. – He had no other symptoms to – day than slight burning in haemorrhoidal vessels, and copious secretion of mucus from nose. 25th. – In m., oppression in head, especially in region of forehead and temples, which an hours after began to increase and extended over vertex, but subsequently entirely disappeared; slight burning in canthi. After dinner, general weariness with slight headache in forehead. In evening, tension in extensor muscles of extremities and trunk, now here, now there; subsequently heat. 26th. – Normal feelings during d. In evening, drawing and sensation of weariness in limbs, especially in upper arm, and forearm near wrist; oppression in the head, especially in forehead. Intellectual exertion soon fatigues; tobacco smoke is not as agreeable as at other times; frequent yawning. 27th. – P. m., slight dulness in head; no other symptom. 28th. – In n., frequent cough with raising of thick mucus. After dinner, general uneasiness, restlessness, swelling of abdomen, feeling as if beaten in upper arms. In evening, good health. The cough ceased in day 29th. – On awaking, glans is very sensitive, drawing back prepuce causes pain; frequent dry hacking cough. Soon after dose, general uneasiness and stretching of limbs. In evening, frequent violent sneezing and ticking in the nose. 30th. – In m. frequent sneezing again, with increased secretion of mucus, accompanied by frequent dry hacking cough. Soon after dose, general uneasiness and stretching of limbs. In evening, frequent violent sneezing and tickling in the nose. 30th. In m. frequent sneezing again, with increased secretion of mucus, accompanied by frequent dry hacking cough. Oct. 1st. – During day, frequent dry hacking cough; in forenoon, when walking, some itching in haemorrhoidal vessels; after dinner, strong inflation of abdomen. 2nd. – In forenoon, violent itching and pressing in the haemorrhoids. 3rd. – In forenoon, on upper lip, an elevated, red, violently itching spot, which compelled him to scratch, but was gone without a trace at expiration of an hours 4th. – In m., frequent violent sneezing, which in a short time ends with dulness of head; after dinner, extraordinary distension of the abdomen, which seriously embarrassed respiration. 5th. – No symptoms after taking 64 dr. 6th. – 70 dr. At night, much flatulence was discharged. In m., sneezing; burning in skin of right lower leg. After breakfast, frequent eructations with the taste of Thuja; frequent short, dry, interrupted cough; slight chill. In evening, sudden cramp – like twitching of under lip, and here and there in circumscribed spots on skin. From the 7th to the last of Oct. he increased dose daily by 5 dr., so that on the first day took 75, and on the last 195 dr. The following were the results: 7th. – No symptoms. 8th. – An hours after dose, squeezing in the haemorrhoids. 9th. – No symptoms. 10th. – Discharge of bloody slime from anus, as well by day as an night; frequent discharges of flatulence, which were always accompanied by some moisture. Towards evening, uncommonly strong appetite, which must be appeased; subsequently, pressing in the haemorrhoids when seated. 11th. – No symptom worthy of mention appeared during whole day, but in evening, after much conversation in company, a pressing headache began in forehead, extended gradually towards the vertex, and slowly disappeared. 12th. – 100 dr. Slight drawing behind right ear, and some constriction in ear; ache in forehead, which, after an hours, merged in sensation as if a wedge were driven into temple. Sneezing did not aggravate headache, but motion of head and swallowing had that effect. At same time, cheerful disposition and inclination to intellectual exertion. In n. very good sleep. 13th. – Uncommonly comfortable and easy. 14th. – In m., transitory burning in anus. At noon, tension in whole right leg while walking. After dinner, slight sensitiveness in skin under hair on forehead, where the cool air at the open window was exclusively felt. 15th. – At noon, frequent violent sneezing. 16th and 17th. – No symptoms. 18th. – P. m., burning and pressing in stomach, lasting several hours 19th. – Several small, painless tubercles appeared upon head. The hair comes off on the vertex. 20th. – In m., raising of tough mucus; in forenoon, itching in perinaeum when seated; slight drawing over left eyebrow. 21st. – At noon, great dullness of head; drawing in both thighs. In evening, pressing in forehead and in right temple. 22nd. – On waking, ache in forehead, which disappeared again after 1/2 h. After a normal evacuation, burning and drawing in of anus. At noon, drawing in lumbar muscles while walking. 23rd. – At noon, drawing again in loins. Lumbar vertebrae are somewhat painful when leaning forward in sitting; feeling of soreness in perinaeum. 24th. – No symptom during whole day 25th. – In m., on rising, drawing from loins towards nates. After dinner, very violent itching in anus. 26th. – At n., increased secretion of mucus in larynx and trachea. 27th. – Slight pressure in the hemorrhoids; in evening, slight drawing in left upper arm. 28th. – Drawing, now here, now there, but worst on left side of body; burning in external canthi. 29th. – In m., slight heat and redness, with burning, on upper lip; drawing in left arm. 30th. – On awaking, frequent violent sneezing with tickling in nose and burning in eyes, as though a catarrh were coming on; drawing in right forearm. 31st. – in forenoon, itching and burning in haemorrhoidal vessels when walking; internal shuddering and feeling of cold whole afternoon, with dull confusion in head. In sulcus inter nates, clammy moisture is secreted. Nov. 1st. – Dose was omitted; drawing in limbs, particularly in right forearm, aggravated by movement of limb; coldness in hands and feet; drawing in whole right leg; pressing in left side of chest. 2nd. – 200 dr. In m., roughness in throat with continual inclination to hawk, and with deeper tone of voice, which disappeared again after breakfast. At noon, burning and feeling of soreness in anus. 3rd. – 205 dr. In forenoon, drawing in right elbow – joint, and squeezing in haemorrhoidal vessels. 4th. – No dose. At noon, violent itching and squeezing in haemorrhoids; tension in the extensors of right arm when writing. P. m., normal state. In evening renewal of violent squeezing and pressing in anus; very earnest frame of mind, in spite of the cheerfulness of those around him; a small suppurating boil on back. 5th. – 210 dr. At noon, drawing in right lower leg, especially on outside towards ankle, and in right hand, particularly in thumb. From 4 to 6 p. m. severe burning and pressing in stomach. 6th. – 210 dr. A.m., burning in the stomach for an h. At noon, flying stitches on right side near sternum for 1/4 h. These stitches had the peculiarity that instead of being aggravated they disappeared on taking a deep inspiration, and returned again only on the succeeding expiration. In addition, slight tension in extensors of right hand, and drawing in dorsum of right ring finger. 7th. – 225 dr.; and he daily increased dose by 5 dr. until 16th Nov., when he took 270 dr. In m., discharge of copious, inodorous flatulence, and hard unsatisfactory stool; tension in bend of right elbow when writing. 8th. – In forenoon, pressing and burning in stomach for an h. At noon he perceived a sensation as if lower part of thorax were surrounded with a bandage, which sensation disappeared p. m. In evening, very disagreeable pressing in region of heart, confined to a small spot. 9th. – Immediately after dose, rolling and rumbling in intestines; afterwards, frequent dry hacking cough; tension in right hand, especially in thumb; the same in outside of right thigh, extending into knee, particularly when walking and bending. In forenoon, right knee – joint was painful when seated, but pain soon disappeared, and was succeeded by feeling of cold in knee. A transitory pressing and tension in heart the came on, and on its ceasing, the coldness in knee was again perceived, but in less degree. All these symptoms were gone at noon. At 1:30, on closing eyes, a feeling of vertigo. The power of thought was increased, but rather for analytical than synthetical reasoning. 10th. – In 1/2 hours after dose, rumbling in intestines, with slight griping; frequent coughing up of mucus. 11th. – In m. roughness in throat, and frequent hacking cough. Upper lip somewhat swollen, and burns. After a loose stool, burning in anus. After dinner, dull confusion of head; burning and dryness in right nostril, up as high as frontal sinuses; slight burning in right eye; oppression in lower part of thorax; frequent, short, dry, hacking cough. He feels much better in open air than in room; the indefinite feeling of uneasiness, however, cannot be exactly described. In evening knees were painful while walking, as though bruised. weight of body seems to him to be too great for legs. 13th. – At n. he urinated more than usual. In m., after rising, frequent raising of mucus, leaving behind feeling of sensitiveness in larynx; discharge of copious inodorous flatulence. After dinner, drawing behind right ear, with single stitches in mastoid process of temporal bone. When this symptom had disappeared, as it soon did, short accesses of crawling and creeping on left side of occipital bone came on; also, burning and pressing in both eyes. 14th. – On waking, aching in forehead, which disappeared by degrees after rising, but returned at about 9:30, became heavy and pressing, and only vanished after 4 hours, after which, pressure on vertex, as if a weight lay there. To these were added, weariness and uneasiness in whole body, coolness and flying shuddering over back. At noon his food had a disagreeable bitter -sharp after-taste, which was salt, especially at root of tongue and in fauces. The uneasiness became less after dinner, but even black coffee left behind an unpleasant after-taste. 15th. – Soon after dose, constriction about navel and slight pressing in lower border of right orbit, soon going off; but orbital edge remained sensitive to touch and to closing of eye for 1/4 h. Afterwards, tension in right ankle while walking. Respiration is not altogether free; thorax is raised during inspiration with somewhat more difficulty than usual, and a short, dry hacking cough frequently comes on; a violently itching tubercle makes its appearance upon upper lip, near right corner of mouth. 16th. – An hours after dose, oppression of chest, troublesome breathing, drawing between shoulders, burning and pressing in stomach increased by movement and by speaking. Constriction of anus after two papescent stools. Also heaviness and lameness in right arm, and slight drawing in right masseter, with confluence of saliva in mouth. From the 17th to the 29th he ceased to take the Thuja, and observed the following symptoms: 17th. – In n., drawing in right upper arm, axilla, and shoulder, preventing his lying on that side. In m. these pains became intolerable, but by warmly wrapping up painful parts, they gradually diminished, and finally entirely disappeared, leaving behind feeling of lameness in arm. At about 9:30, tearing in shoulders and upper arm returned in frequent short attacks. After dinner, general weariness and universal feeling of discomfort. In evening he feels generally better, but pain in shoulder is again very violent, and in right arm, especially in forearm, there is a condition bordering upon paralysis, with feeling of coldness. Before going to sleep, very gloomy frame of mind. 18th. – At 10 a. m. pain in arm came on in short accesses, was sensibly felt until noon, but was milder than the day before, and ceased entirely p. m. Mind became more cheerful again. 19th. – The pain in arm is entirely gone, and Z. felt well all day 20th. – At noon, slight drawing in sacrum, drawing in left groin, and frequently dry hacking cough. No trace of pain in arm. 21st. – Burning in whole nose which seems to feel as if swollen, with increased sensitiveness on septum, on which several vesicles are to be seen. Upper lip is likewise sensitive. P. m. these symptoms have disappeared again, and vesicles on nose are dried up. On the two following day no drug symptoms were observed. 24th. – In evening of 24th and whole forenoon of 25th an exceedingly troublesome headache came on, which wa seated in upper surface of the vertex, was heavy and pressing, an from time to time came in single stitches and thrusts. Brain was apparently unaffected, but head externally wa somewhat sensitive to touch, as were also eyes. Cool air diminished the pain; when it was at the worst he supported his face in the concavity of his hand, and for some time rubbed his forehead, eyes and face, whereupon the pain entirely disappeared, and in evening his head was wholly free, except a slight crawling and creeping on the places before indicated. On the 4 following day, no symptoms.
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.