3 e. April 22nd. – After all the symptoms of Thuja had ceased and the carious teeth had become entirely free from pain, F. took 80 dr. of the tinct. before breakfast, after which he swallowed a glass of water. No effects were observed either this or the next d. On 24th and 26th he took 100 dr. each d. On the latter day prover experienced considerable dulness of head and mistiness of sight; on dorsum of right foot a small blotch was discovered with a red areola, which rendered walking in boots difficult. 28th. – Another 100 dr. The blotch is diminishing, and nothing remains of it except a dark red, somewhat elevated spot with a lighter areola, still impeding walking. General weariness during day as if he had not slept all n. these symptoms are accompanied by dulness of head, sad mood, dulness of taste, indistinct sight, and bad, sunken appearance. Nevertheless, on 30th F. took another 100 dr. In forenoon: dullness of head, with vanishing of objects when attempting in fix them. In afternoon: painful stiffness of nape of neck when moving head, bruised sensation in chest, dulness of taste and very gloomy mood. The efflorescence on the dorsum of the foot began to subside. May 2nd. – Another 100 dr. elicited no new symptoms. No medicine was taken on 3rd and 4th; during this period F. observed the following symptoms: Dulness and feeling of fulness in head, with ill – humour and drowsiness; after a siesta of 3/4 hours, vertigo so that he could scarcely walk without holding on to something; great sensitiveness of skin to cool air. 5th. – F. took the last 100 dr. Result: sticking tearing in tarsal joint in forenoon, while walking. Another little blotch makes its appearance in the still existing red spot on the dorsum of the right foot, impeding walking very much. 6th. – In m., in bed. sticking beating in right hand extending as far as tips of fingers, and in anterior part of right foot. Towards noon, pressive headache with pressure in both eyes, accompanied with gastric uneasiness and reddened urine. F. had to lie down on account of increasing debility, and was not able to go to sleep for several hours 7th. – He felt a general debility as from fatigue; feeling of fulness in head; a paralytic burning sensation, which had been felt already for some day past in all muscles of forearm, and which extended as far as tips of fingers, was particularly troublesome (coming on when moving arm, going off in rest). In the afternoon and e.: feeling of coldness through back, with debility and stiffness in all the limbs; dulness of head; sticking pain in left patella when going up stairs; great debility in sacrum and legs, and feeling of weakness in chest. 8th. – After having spent a n. full of dreams, F. woke greatly improved; head continued dull, and he was attacked with turns of vertigo after talking long; at noon he felt chilly all over, especially on extremities; he was ill – humoured and restless, and had canine hunger without thirst. A small quantity of wine which he took at an unrelished dinner aggravated headache very much, and smoking increased it to vertigo. As the use of wine was beneficial previously, this aggravation seems to be rather attributable to the effects of a meal eaten with canine appetite.–Mayrhofer. At 8 p. m.: aching pain, especially in frontal eminences and temples; vertigo when walking; bruised pain in shoulder – joints and upper arms; weak feeling in chest with pressure under sternum and difficulty of breathing, especially while going upstairs. 9th. – F. felt better in every respect, and all the symptoms disappeared within a few day, except the weak feeling in chest and difficulty of breathing in going upstairs, which did not entirely leave him until the end of the month.
3 f. May 21st. – F. swallowed before breakfast a table – spoonful of recently expressed juice, obtained by crushing the twigs of Thuja and pouring upon them a mixture of equal quantities of distilled water and alcohol. Of this nauseous juice F. took one table – spoonful on the 1st and 2nd of June, and two table – spoonfuls on the 3rd. On the last day he experienced in forenoon frequent paroxysms of tearing and sticking in both hands, which became so violent in middle of right ulna while he was writing that he had to give it up. P. m., while driving in a carriage, he experienced very violent tearing in left forearm, which wa especially violent in anterior tuberosity of humerus, that region becoming very sensitive to touch. Moreover, prickings in fingers of same hand. These symptoms continued while driving, and did not abate until F. got into a profuse perspiration in evening while in a crowded theater. Upon moving hand quickly and strongly he felt burning pain in all muscles of forearm. 4th. – F. again took two table – spoonfuls of juice, which did not produce any new symptoms. The tearing pain in anterior tuberosity of left humerus continued, was increased by motion, and was heightened to a burning pain by contact, especially after the painful spot on the arm had been knocked against something, though only slightly. The red spot on dorsum of foot impeded his walking very much. Under sternum he experienced oppression, with bruised sensation in chest. These symptoms were accompanied by frequent hawking of mucus, dulness of taste with great appetite, and swelling of haemorrhoidal veins. 5th. – The following symptoms were observed: Sensitiveness of anterior tuberosity of left upper arm, especially when touched; in afternoon, feeling of fulness in head with drawing pain in nape; feeling of weakness in chest; painful stiffness in left forearm extending as far as fingers, and impeding motion; pressing sensation in the turgid haemorrhoidal veins; sticking burning pain in external tuberosity of left tibia (coming on when sitting and increased by pressure).
All these symptoms disappeared gradually on the following days except the great sensitiveness in the tuberosity of the humerus, which seemed to become more and more circumscribed every day, but which only entirely disappeared in the course of a week. The last to yield was the haemorrhoidal congestion, to remedy which he used several bottles of a mineral water. (Ibid.)
4.A Caroline P -, aet. 45, took 10 pellets, moistened with 3rd dil., No. 12th, 1844, before breakfast. Two hours after, she experienced drawing from left axilla as far as elbow-joint; afterwards drawing along vertebral column and in calves, with feeling of weakness in legs. 13th. – Prover again took 10 pellets, which elicited following symptoms: Drawing from right wrist as far as tips of fingers, and from right calf as far as malleoli, with sensation as if foot were lame; afterwards drawing from right elbow as far as wrist; then transient paralytic feeling in both thighs as far as knees. 14th. – After another 10 pellets she experienced weakness in knees and decrease of appetite. No medicine was taken on 15th, 16th, and 17th; during first two day above symptoms were yet slightly felt. From 18th to 23rd, Caroline took 10 pellets every d, and observed following symptoms: Drawing sticking in right upper arm as far as elbow, and in right thigh as far as knee; sticking in right forearm as far as finger-joints; drawing in both scapulae in direction of nape of neck, in both legs from knees to malleoli, and at same time in both forearms from elbows to wrist. These symptoms generally appeared 3 or 4 hours after taking drug, and lasted from 10 to 16 h. Prover discontinued medicine until 26th Nov., when she took another 10 pellets. On that day she experienced sticking in left thigh as far as knee, single stitches in left tarsal joint and in evening drawing in both thighs. 27th, 28th. – She again took to pellets each time, after which she experienced tearing in left upper arm, afterwards in left leg; sticking in left wrist extending as far as tip of index finger; drawing in left calf, afterwards in right forearm from elbow as far as writ. Dec. 5th, 6th, and 10th. – She took 10 pellets each time without experiencing any new symptoms. Same drawing and sticking was experienced in various parts of limbs. On inner surface of left forearm a red, round, itching spot was observed, with white vesicles raised upon it, which burst, poured out clear lymph, and left a yellowish crust behind.
4 b. Dec. 12th. – Before breakfast, F. gave prover 10 pellets of 202nd dil., without her knowing that preparation was different from what she had previously taken. Results: drawing in both hands and feet, afterwards only in forearms as far as wrists, and sticking in both sides of chest. 13th. – She took another 10 pellets, with same result. 19th, 20th. – She took usual number of pellets, and observed, besides symptoms mentioned above, drawing in both hips from without inward, and from above downward toward genital parts. After an interval of 12 day prove took 10 pellets of same on 2nd, 3rd, 4th, 6th, 7th, and 9th Jan., 1845. After every dose she experienced tearing, drawing or sticking sensations, accompanied with repeated attacks of vertigo, and feeling of stiffness in legs and back, as far as nape of neck. Prover having taken cold, in consequence of which she was attacked with toothache and swelling of the cheek, the experiments were concluded.
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.