b. Same took 1/2 gr. purified (solid), O., which he swallowed with 1/2 oz. water. After 10 m. confusion of head and pressing in eyes came on, latter feeling as if upper lids were being pressed downwards towards lower. Both symptoms had vanished within 4 h. Next took 1 gr. at 8 a. m. After 10 m. felt confusion of head, increasing every m., face meanwhile glowing and head sweating. Globes of both eyes felt pushed from within outwards; stabbing frontal headache alternated with drawing pains in internal ear. Head finally became so heavy that he was obliged to lie down at times or he would have fallen. Pulse beat somewhat fuller than usual. These symptoms lasted till about 11 a. m., leaving behind great lassitude and somnolence; some dulness of head and incapacity for mental exertion were noticeable until 5 p. m. Whole body perspired during p. m. Next day, except for slight lassitude, felt quite well. (JORG, Materialien.)
6. HEISTERBERGK took 1 gr. rubbed up with 3 gr. magnesia and 1/2 oz. water. After 1 hours cutting pains in abdomen set in, and lasted 10 m. First evacuation took place next m., faeces being copious and hard. Same effects followed 1 1/4 gr. After 1 1/2 gr. pains were quite colicky, and lasted 10 to 12 m., returning less violently at 2 and 4 p. m. Bowels were constipated as before. After each dose felt disinclined for serious occupation. (Ibid.)
7. a. KNESCHKE took 1/4 gr. Slight confusion of whole head and pressing frontal headache followed after 1/2 hours, lasting fully 1 h. Same effects followed after 1/2 gr. accompanied by slight giddiness. From 2 till 5 p. m. felt some lassitude, with inability to concentrate thoughts; well – known things appeared less familiar, and his speech less valuable. Slept well, but arose unrefreshed next m., and bowels did not act until evening, after which they did not act again for 36 h. Effects of drug were noticeable until evening of 3rd day, especially in shape of indifference to every thing, even to favorite occupations. After 3/4 gr. same effects followed, coupled after 2 hours with slight cutting in small intestines, lasting 2 h. Pulse during day was somewhat slower than normal. Bowels did not act for 60 hours after dose, faeces being hard, followed next m. by two liquid evacuations, and acting naturally on m. of 5th d. After 1 gr. same symptoms followed, only that pains in bowels were more colicky and lasted 4 h. Pulse was somewhat slower than normal during p. m. Towards evening frequent and troublesome yawning came on, and he was obliged to go early to bed; slept well, but arose unrefreshed. Felt lassitude all next day and bowels remained constipated. Next m. bowels acted slowly. All effects had passed off by m. of 4th d.
b. After doses of 6, 7,8, and 9 dr. of tinct., noticed only slight confusion of head, lasting but a few m.; felt also less lively p. m. Bowels regular, but faeces somewhat hard. (Ibid.) 8. a. LIPPERT took, jan. 30th, 1/4 gr. of O. After few m. felt dull gentle frontal headache, lasting all forenoon and slight aching in bowels. Same effects but more pronounced followed dose of 1/2 gr. On Feb. 3rd took 1 gr. Subsequent headache was more acute, spread over whole head, and was combined with heaviness, confusion, and buzzing in same. Colicky pains were more acute, and recurred for few m. every 1/2 hours until noon, whilst head symptoms lasted until well on into e. Bowels acted rather oftener than usual. Next day took 2 gr. After 1/2 hours head became confused and giddy, so that he could hardly stand; lassitude and weariness spread over whole body; felt at first cheerful and good – tempered, but as other symptoms increased became quiet and serious. Pulse meanwhile was large, full, and quicker than usual. Colicky pains came on after 1 hours, increased very much, and manifested themselves as tearing or cutting pains, but at longer intervals, and lasting till afternoon. Experimenter became gradually more weary and tired and very sleepy, so that he could not stand without danger of falling. Heat of skin was increased, but without sweating. These collective effective of drug increased gradually until noon, and decreased during p. m., so that by evening there was considerable abatement. After 3 gr. same effects followed, accompanied by unusually feeling of dryness in mouth, although neither mouth nor tongue were really dry, and, further, feeling ass if he would be sick, although he felt no nausea; and lastly constipation until next m.
b. After successive doses of from 1 to 9 dr. of tinct., he noticed only that evacuations were more difficult and scanty. After 12 dr. confusion of head, which also occurred after 14 dr., accompanied by quick, full, and hard pulse. Same symptoms occurred 1/2 hours after 16 dr., accompanied by giddiness so that he could scarcely stand, and head felt heavy even while sitting. The symptoms lasted nearly all d. Similar results followed 18 dr. After 24 dr., beside confusion of head felt dull pressing in same, passing on gradually to giddiness, so that thinking was rendered very difficult. Circulation was affected as before. ( Ibid.)
9. a. OTTO took 2 dr. mixed in 1/2 oz. of water. Only noticed unusual weariness and lassitude of body, indifference to everything, aversion to usual occupation, much inclination to sleep and peculiar indolence, lasting together the whole d. Slept well, but arose next m. unrefreshed. After 3 dr., besides lassitude noticed slight pressing headache, which ceased towards e. On August 6th, at 8 a. m., took 4 dr.; towards 9 became giddy, his thoughts went astray, and occipital headache came on; these head symptoms lasted 10 m. Towards noon weariness again appeared. At 4 p. m. this increased so much that he could not keep on his feet; intense giddiness was also present, face became red and head hot; sweat broke out all over body, darkness came before his eyes, and he lost consciousness. The condition, which lasted about 1/2 hours, was ushered in by nausea, eructation, and inclination to vomit. Such weakness spread over whole body that it was with utmost difficulty that he could move his limbs, and yet an inward unrest constantly urged him to sit or lie elsewhere; decided lassitude oppressed him until evening; bowels were not open during d. Appetite and sleep unaffected. Awoke next day with slight headache, which he soon lost. Soft, pappy faeces passing during p. m. Urine since taking O. was browner, and covered with an iridescent pellicle. On repeating same dose on m. of next day but on soon felt giddiness and confusion of head, lasting 15 m., then for 1/2 hours cutting pains in abdomen with urging to stool followed by evacuation of soft motion and transient weariness. At 4 p. m. pressing over whole head came on, and lasted till bedtime, accompanied by great distaste for work and indifference to everything. Next day awoke with same headache, which became worse after getting up, but gradually passed off during forenoon in open air. During p. m. passed stool.
b. O – now took 1/8 gr. of O. After 8 hours felt slight congestion of chest and head, lasting 15 m., but leaving behind slight confusion of head ceasing suddenly after 2 hours on going into open air. On July 27th at 8 a. m., took 1/4 gr. After 1 hours felt lassitude and weariness of whole body, increasing gradually until he was obliged to sit; he then passed into a reeling condition as if tipsy, everything in room appearing to him to turn round; felt at same time constriction of head as if brain were being compressed by scalp; slight pains coming and going inside head, and irritation of globe of eye, followed by diminished power of vision; next came sleepiness, manifested by frequent deep yawning and general lassitude. Pulse – beat large, full, and strong. After this group of symptoms had lasted fully 1 hours, try gradually passed off, leaving the headache and a feeling of general listlessness behind, lasting until e. Bowels did not act all day nor till noon of next day, but faeces were soft. On repeating same dose, experienced same effects, and in addition fixed tender pain in region of left mastoid process, which troubled him several hours during p. m. Bowels were affected as before. Next took 1/2 gr.; very soon felt slight giddiness, accompanied with belching up of flatus, and changing to oppression of head which here and there almost amounted to pain. Pain was also felt in abdomen, first in stomach then lower down in small intestines, changing later into general cutting, followed by copious natural action of bowels. During p. m. was troubled with lassitude and sleepiness. Slept well during n., but arose not thoroughly refreshed. Same abdominal symptoms followed 3/4 gr., but this time stool was pappy. After 15 m. from time of dose, slight giddiness came on, lasting only 15 m. and leaving no pain behind. Lassitude and weariness, especially of lower extremities, troubled him much, with sleepiness and indifference to everything, even his most important affairs. Sleep during n. was sound but unrefreshing; felt same weariness next day (Ibid.) 10. a. PIENITZ, on February 4th, at 9 a. m., took 1/2 gr. At 10 felt head confused, heavy and oppressed, pulse small and frequent, skin warmer than usual, whole body weary and unstrung, and spirits depressed; before 12 all had passed off. On 7th, took 1 gr. at 9 a. m. No symptoms occurred until 8 p. m., when there was dryness of mouth, constriction of larynx, pressing in and over both eyes reaching to vertex, increased superficial heat of whole body, and general lassitude; all passing off before 10 p. m. Next day bowels did not act until after dinner. Next took 1 1/4 gr. After 1 hours felt lassitude and weariness of whole body, followed immediately by oppression of head, and feeling as if he had been drinking spirituous liquors, trembling and weakness in extremities, moist cold skin, dryness of mouth, thirst, and great inclination to sleep, all lasting 1 hours; pulse meanwhile being weak and quickened. For next 3 hours suffered with nausea, want of appetite, belching of flatus and distension abdomen, and general weakness. Pulse during this time had became fuller and quieter. Eyes became cloudy and dark. Next day bowels acted only p. m., action being accompanied with slight colic in region of stomach. On repeating same dose, after 1/2 hours feeling of indifference came on, with tipsy feeling noticed above, confusion of head, and sensation of tension over surface of head. Later there were added, want of appetite, heaviness of rumbling in abdomen, and distension of intestinal canal, all disappearing after about 2 h. Bowels were affected as before.
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.