These provings or experiment were conducted under the direction of Dr.R.F.Rabe, secretary of the American Institute of Drug Proving, at the New York Homoeopathic Medical College and Flower Hospital, and under the immediate supervision of Dr.F.H.Hirschland, of the department of Pathology, to whom full credit is due for the results of these experiments. Herewith appended is the report, as submitted by Dr.Hirschland:
“It was in the early part of December, 1919, when Dr. Rabe suggested these Drug – Provings which I began in January on small laboratory animals and later with students of this institution, and as well as with nurses of Flower Hospital. I wish to express my deep appreciation of the spirit of co – operation, as well as for the assistance Dr.Rabe has given me throughout these last four months. Both the students and nurses faithfully persevered in the work, and I wish to thank them also.
“The first two drugs used in the proving were Kali bichromicum, and the homoeopathic tincture of Iodine. The test animals were guinea – pigs of an average weight of 350 grams. The Kali bichromicum was used in the 2x, 3x, 6x, 12x, 30x potencies, and one animal was kept as control. The first of the guinea – pigs to die was the one which was fed on the 30x potency. (The drug was given in tablet form with the food.) The animal showed signs of restlessness at the eighth day of the proving; it had for two days a watery discharge from the nose, did not take any food for about 36 hours, and died on the 11th day. An autopsy was performed 6 hours after death; the gross – pathological findings were: Septic peritonitis, dilatation of the stomach with acute gastritis and acute parenchymatous nephritis. The organism isolated from the peritoneal exudate was the streptococcus pyogenes.
The source of this infection could not be found. Microscopic examination of the diseased organs confirmed the gross – pathological findings. The four remaining animals showed a distinct gain in weight of about 50 grams on the average, after 21 days. Then the animal receiving the 6x showed a rapid loss, which amounted to 65 grams in 5 days, when the animal died. Autopsy was performed immediately and the findings were: Congestion and oedema of both lungs, a cloudy swelling of the kidneys and an acute degeneration of the spleen. The doses of the drugs were increased after this to twice the former amount of 6 tablets a day.
The three remaining animals were weighed again, showing an increase which amounted to 25 grams on the average. The next guinea – pig which became sick, was the one which was fed on the 12x. The animal did not eat well for about 6 days, losing 75 grams of its weight, finally refused all food and died on the ninth day. The autopsy, held the same day, showed a lobar pneumonia of the right lung, congestion and oedema of the left lung, acute gastritis with dilatation of the stomach and a cloudy swelling of the kidney. The two animals which received the 2x and 3x doses together with the control animal, remained unaffected.
Great care was taken that the animals were not exposed to cold, that they were not overfed, that they were given the proper kind of food, and that they were in a good condition before the drug – proving was begun. It may be safely said that at least the lesions, produced in the stomach and kidneys and partly those in the lungs, can be ascribed to the drug. Further proofs of this, however, must be collected by subjecting other sets of animals to the same test, under the same conditions, as near as possible.
“The homoeopathic tincture of Iodine was given per mouth to three guinea – pigs, in amounts of 2, 3 and 4 drugs, which dose was increased later two weeks to 4, 6 and 8 drops, respectively. At first the animals gained weight, probably due to the alcoholic stimulus, but after a while the 6 and 8 drops animals lost what they had gained and in addition, 50 grams. They both died about the 21st day. Both had an intense inflammation of the gastto – intestinal tract; both had an oedema of the lungs and a parenchymatous inflammation of the kidneys. These organs seemed to be the ones most affected by the drug. The animal which was on a three – times – a – day – 4 – drop – dose remained alive. The dose was apparently too small to have a sufficient toxic effect.
“The third drug was given to three guinea – pigs, to three students (male) and to three nurses (female) – the name and nature of the drug was withheld from the provers, but it was Benzol. One student was used as a control. The drug was given to the animals in the fluid form, 2, 4 and 6 drops, three times a day. A strong male rabbit was also subjected to the test and was given 10 drops twice a day. The animal remained absolutely unaffected, as far as we could see. The 4 drops guinea – pig showed signs of paralysis of one leg at about the 6th day and became completely paralyzed in both hind legs on the tenth day. It died on the 12th day. The autopsy showed infarct formation in the liver, kidneys and one lung; the cause of death was oedema of the lung.