14. MARIE E -, housekeeper for Dr. Reiss, is 24 years of age, vaccinated, brown hair with block eyes, bright complexion, choleric temperament, active mind, strong constitution, m menstruated in her thirteenth year. Through suppression of the catamenial flow by a cold bath she became chlorotic and affected with leucorrhoea, which disease continued up to her 18th year. From that time till now she has been perfectly healthy. During the proving she has not made the least alternation in her mode of living. She took slat only from 13th to 26th Jan., and always about 10 p. m.; 3j on 13th and 3ij on 14th, 18th, 20th, 21st, 24th, 25th, and 26th. The following symptoms are given in her own language.
14a. “13th. – Soon after taking dose much thirst. 14th. – M., after rising pinching in belly, as if looseness would come on; a few m. after twitching and quivering of right upper eyelid; much emission of flatus whole day; uneasy sleep full of drams; frequent micturition during n. 15th. – M., heaviness and dull feeling in head, as if she were downright sleepy; strong shooting in right temple towards front; feeling as if upper right eyelid would fall down; heaviness and weakness of arms; in right wrist joint, when attempting to grasp anything tightly, shooting; sometimes she cannot grasp firmly on account of weakness of hand; weakness of the legs; much emission of flatus, whole forenoon. After a breakfast of coffee, pains in belly, as if a double – edged knife were being worked about there, continuing 1/4 hours; towards evening chilliness over back; later much thirst. 16th. – M., after rising, heaviness of head, though less than yesterday. After a breakfast of coffee cutting pain in belly and two loose stood; feeling of weakness in hands and legs. When she stands her legs double under wear, so that she would fall. Frequent micturition, in forenoon. After dinner all the symptoms were relieved. 17th. – After drinking coffee cutting pain in belly and two loose stools; less emission of flatus than yesterday; frequent micturition, forenoon. evening, feeling of weakness in whole body; the longer she remains up, the weaker she becomes. 18th. – M., after drinking coffee pains in belly without looseness; frequent micturition, forenoon; urine turbid, with strong smell, – it seems acrid. 19th. – Uneasy anxious sleep; frequent waking, with dread of something which she cannot describe; after rising no desire for coffee. – After coffee cutting pain in belly with straining and stool, frequently recurring during forenoon. – Afternoon, cutting in belly, not so violent as in forenoon; in left foot above and around ankle pain, as if sore; weakness in hands and feet. 20th. – M., after coffee, violent cutting in belly. This is repeated frequently during day, but not so violently as in m. 21st. – M., on rising much thirst, also during whole day 3 p. m., cutting pain in whole head. In right side it abates somewhat at intervals, though not entirely; then each time it is worse in left side (increased in open air). On left side pain extends like drawing from forehead over left eye, from zygoma down as far as angle of inferior maxilla, lasting only a few m. (This pain, unlike the former, comes each time she enters a room from the open air). evening, before taking dose trembling over whole body. There is a flush of heat up to head, with anxiety and feeling of nausea till she becomes unconscious. The objects around her appear quite different. The vertigo is relieved by keeping still. After taking the dose uneasy sleep. 22nd. – On awaking, in bed, shooting pains in whole belly, especially in hepatic region below last ribs on right side; at same time chilliness over whole body lasting 1/2 h. After drinking coffee pain in belly, not violent. At 10 a. m. weakness in hands, more marked in feet. The pain in hepatic region comes on frequently throughout day, as well as the nausea and vertigo. About 3 p. m. same cutting pain, to and fro, in head as yesterday, but only in right half and not lasting so long. 23rd. – My, after rising, cutting pain in belly, especially below ribs on right side, lasting 1/4 hours, also after drinking coffee, yet shorter and slighter in character; at same time urging to stool, without result. After dinner cutting pains in whole belly, more violent in m., lasting an hours; bitter taste in mouth and inclination to vomit. After 5 p. m. sleepiness so that she could not sit upright. She fell asleep while sitting. After 1/2 hours sleep she felt better. 24th. – Pain in hepatic region in walking; it goes through liver from before backwards, is relieved by bending body forwards and to right and lasts several h. No evacuation; urine since 8 day turbid; for some day lately melancholy hour, she likes best to be alone. Pale, faded look. She is notably thinner. evening, after taking dose, chilliness. 25th. – On waking and subsequently shooting pain in right side below last ribs, continuing whose forenoon, improved after dinner. Evening, it returned on going out; on coming home again it disappeared. Stool with exertion, hard; headache, undefined, through whole day, at same time, although she was in a bad humour the whole day, yet she felt obliged to hum and sing to herself, she had scarcely left off when she had to begin again. (Never sings otherwise.) evening, in bed, 5 m. after taking medicine, violent cutting pains in belly, frequently returning, round about navel. She fell asleep and was awakened. After awaking, in bed, much thirst. On rising she had no pains; as she got into bed pains returned. She again fell asleep and was again awakened. On getting up she felt well, only she had much thirst. As she again got into bed she became giddy, had pains in belly, with nausea. She was awakened once more, and had again much thirst on rising. As she again got into bed pains around navel directly returned. She was unable to sleep soundly any more. 26th. – In m. on rising hot twitching (?) on back of both hands and passing out by tips of all toes, with weakness of the feet, less of the hands. After rising very violent cutting in belly continuing for 1/4 hour as if everything were being drawn from behind forwards towards navel, with anxiety. The cutting was renewed after drinking coffee, after dinner, and in e. She had very little relish for the coffee. Much thirst throughout whole day, neither for water not beer, but only for wine; loose stool in forenoon; frequent micturition whole day; urine turbid and dark; much appetite at dinner; dulness of head whole day, as if too heavy. She does not see so distinctly as usual; the eyes seem all day as if veiled. in afternoon great appetite for cold things (ices). Between 6 and 7 p. m. chilliness over whole body; sleepiness during chilliness, she had to force herself to remain awake. The sleepiness was kept off by rising and walking about. She talks more and more pleasantly than usual, yet does not like it when she is spoken to. If she has nothing to say she is pensive and melancholy. Of late she has become remarkably thinner and looks pale and sunken, particularly in. and after dinner. In evening directly after taking medicine (to – day she took the last dose) chilliness, which lasted until she fell asleep. 27th. – She was unable to sleep any more after 5 a. m. She was anxious. When she fell into a slumber, she dreamed, and was soon awoke again. At same time she felt heat in The head internally and pains in belly, as if looseness would come on. In rising cutting in belly; thereupon great looseness, without straining. After the looseness violent cutting pains in whole body, especially around navel and in hepatic region. About 10 a. m. heaviness and dulness of head with vertigo in stooping; there appears to be a thick fog before eyes, lasting till 3 p. m. 5 p. m,, hot twitching (?) in whole body, alternating with chilliness. She was hot all over and yet she felt started. Yawning during chill. After 7 p. m. she was better, only legs were still heavy, so that she believed she could not rise. After lying down, chilliness. She slept well, but had a heavy dream. 28th. – M., after rising nausea with vertigo and empty eructations; heaviness in head; pressive pain in forehead. She can scarcely open her eyes from heaviness of the lids. Difficulty in breathing; quick breathing whilst standing still more in walking; appetite for coffee; surely and ill – humoured, particularly when she addresses anyone; melancholy; whatever she looks at puts her in a bad humour. Thinking becomes difficult to her. When she exerts herself to think, or when she must talk much, she has sensation on both sides of forehead directly above arch of eyebrows, as if one beat with the finger on the part. On scalp where hair is parted, itching, also so much itching in both eyebrows that she was compelled to scratch these places the whole day, but chiefly in m. Taste in mouth as if she had eaten trallo; all kinds of food appear to her bitter. In first upper molar, right side, twitching pain as if one pulled something sharp in and out. In forenoon pain in same tooth. Frequent micturition; When she presses corresponding part of check opposite tooth with finger, it seems as if something cutting shot through root of tooth. Frequent micturition; urine pale. Difficulty in breathing less than on previous days. Afternoon, on going out, chilliness over whole body (she is, however, not cold to touch) lasting an h. During the chilliness pulse seemed to her to beat quicker; at same time ill – humour and indisposition to talk, even with her lover. She did not relish the beer she drank (only 1/2 pint). Loss of appetite; fulness in belly, as if blown up, as if she had eaten and drunk a good deal; lazy, weak, and sleepy. Evening, sees things as if through a veil. Pulse 92 to 10 p. m. The last week in going upstairs palpitation of heart; uneasiness in feet, she was obliged to move them constantly, on walking it was relieved. She sent to bed early; slept, however, uneasily. 11 p. m., was awake with vertigo, nausea, weakness, trembling of limbs, and relaxation of all nerves. At 12 it drove her out of bed. In rising she became giddy as if she would fall, with inclination to vomit. She returned to bed again. In a few m. after, in bed, vertigo with unconsciousness and three times vomiting of food. What was vomited tasted like red wine (claret). After vomiting chilliness over whole body. She fell asleep about 2, dreamed much, and disputed and quarreled in her dreams. 29th. – Awoke at 5 a. m. with pain in belly below ribs on left side, as if she would be loose in her bowels. At same time vertigo with nausea. The vertigo was relieved by lying higher. it returned on rising, particularly unbending forwards. It lasted, although relieved by applying cold bandages, through whole d. In afternoon it was so bad that she nearly fell from her seat. Loss of appetite; no desire for coffee, but, on the contrary, for wine – soup; emptiness in stomach; obtuse pain in head whole day; shooting pain in both halves of forehead directly above eyebrows. Forenoon, urging to stool; stool with exertion, although it was quite normal; much emission or flatus and frequent micturition; urine dark. Good appetite at dinner. Between 4 and 6 p. m. slight chilliness; at same time itching on skin, especially in left breast, on head, arms, throat and thigh. On latter there came at times during day sensation as if flesh were being scraped off bones. Difficulty of breathing, especially great between 5 and 7 p. m., even when she kept quiet. Pulse appears to beat more rapidly. Weakness in hands and feet. At 7 she lay down in bed. She was awakened twice. In rising strong chill over whole body. When alone to – day, she felt as if she could always cry; she did not, however, know why. If anyone were with her, she was disposed to quarrel. Moreover she was ill – humoured the whole day (particularly in e.), laconic, sensitive and sleepy. 30th. – Awoke early. She fell giddy, even when in bed. The giddiness became worse after rising, but was relieved by applying cold bandages. Heat of head internally, especially in front; no desire for coffee. When, in spite of this, she had drunk coffee, cutting pain on left side in region of spleen. Trembling in whole body, especially in hands and feet. In going upstairs feeling as if someone struck her in the bend of thickness. Trembling of knees when she puts her foot on a stair. (This trembling lasts whole d.). Difficulty of breathing whole day, aggravated by walking Good appetite at dinner. Afternoon, so weak that she could not carry a basket of wood. itching whole day in the nostrils; paleness of face; sorrowful humour. Latterly dislike to men. From 4:30 till 7 p. m. great chilliness, especially in warm room. When she went into open air she did not feel chilly. At 11 p. m. she was awakened out of sleep. On rising trembling of hands and feet; she cannot hold anything steadily from weakness in hands. As she got into bed again a chill went through whole body (except head). At same time heat in head, and skin all over warm to trough. Soon after burning heat in hands, less in feet. it was an hours before she fall as sleep again, was obliged to turn over and over in bed, and slept at last very uneasily with constant dreaming of quarrels and contentions. 31st. – M., in waking, pinching pain in belly, as if before looseness of the bowels. She had hunger, and coffee was agreeable. After a while contractive pain in belly with urging to stool; hard and painful stool. forenoon micturated 6 times; urine pale. After dinner shooting pain in left half of forehead immediately above arch of eyebrows. lasting until e. About 6 p. m. when she looked at an object for a long time, particularly in sewing, it became suddenly dark before her eyes, and she saw nothing until she fixed the eyes on another object; at same time sleepiness. She went out. On returning home shooting pain in. side below last ribs, with frequent yawning. When she goes into open air her cheeks become very red, so that people speak to her about it. At home she is pale. General weakness, yet less than usual, as is also the trembling of hands and feet; cheerful humour. Uneasy sleep with much dreaming; frequent waking; she is obliged constantly to turn over and stretch herself
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.