11c. So early as Dec. 3rd of this year W. H – began a new series of experiments with the attenuations. From 3rd to 6th Dec. he took daily m. and evening 20 gr. of 30th trit. The result was (3rd and 4th) drawing sticking pain, frequently recurring, on palmar surface of tip of right thumb, and especially of right index, during rest; sometimes a similar pain below nails and at their roots; (5th) after same, pressing in stomach, as if from a stone, [ Remarkable is the connection between the affection of the stomach and the tip of the index finger and the thumb of the r. hand, which showed itself throughout the whole of the proving W.H.] with feeling of nausea, accompanied with an extensive stitch above the symphysis pubis towards right groin; same evening a drawing pain in region of right inferior ribs towards back, as if from a round but rough body, lasting several m.; (6th) in evening, drawing beating pain as if rom commencing suppuration in trip of right index, with frequent emission of flatulence. 7th to 9th, 30 gr. daily m. and evening of 25th. 7th. – Half an hour after evening dose fine stitches at measured intervals, occurring simultaneously with pulse deep in region of right kidney (comp. 16th and 17th Nov.); followed by drawing sticking pain, repeated at short intervals, in metacarpal joint of first phalanx of right thumb; 3 hours later great distension of epigastrium, with pressing and pain in stomach, as if from fine needle – points, which appeared to penetrate from stomach to below breast – bone in taking deep breath. 8th. – Taking of m. dose was followed 1/2 hours after by loud grumbling and rumbling in left side of breast close to stomach; subsequently drawing sticking pulsating pain in metacarpal joint of left thumb, and fine flying stitches here and there in skin, particularly in middle of anterior surface, of right thigh, like electric sparks, leaving behind unpleasant feeling of coldness (comp. Nov. 19th). 9th. – In forenoon, violent stitch in abdominal wall 1/2 in. from navel on right side; cramp – like drawing sticking on inner surface of left leg followed by a few violent stitches in first phalanx of right index along with strong electric shock of whole of right arm. During dinner he felt on inner surface of right cheek an open blister in which the warm food caused a burning pain. Afternoon, frequent prickling crawling in 3rd phalanx of right index. 10th – 12th daily, m. and evening, 30 gr. of 20th. 10th. – During whole day scratching in stomach, as if he had eaten something indigestible. 11th. – Sensation in rectum, as if a foreign body or rough hard faces were lying in it, with uninterrupted looseness of bowels. 12th. – No symptoms. 13th to 15th. – Twice daily 30 gr. of 15th. 13th. – Throughout day much accumulation of salvia in mouth. Next m. he awoke suddenly from intolerable itching in anus, which extended as far as neck of bladder and prostate gland and continued 7 – 8 m. 14th. – During day mouth unusually moist. At n. woke suddenly with violent urging to stool; it resulted in a thin pappy stool, followed by painful distension of abdomen above symphysis pubis, as if from flatulence. At same time he felt very weak; tongue was stiff and, like hard palate, uncommonly dry, pulse accelerated, small and weak. In tip of right thumb he experienced a prickling crawling sensation. In 1/4 hours he fell asleep. next m. he had another diarrhoeic stool. 15th. – Throughout whole of day scraping feeling in stomach with white – coated, dry, stiff tongue, without thirst. Toward evening cramp – like drawing in right femoral region; looseness of bowels. 16th and 17th, m. and evening, 30 gr. of 10th. 16th. – Forenoon, prickling itching in tip of right index; fine stitches in right tonsil; twitching in anus. In evening in walking stitch from horizontal ramus of pubes through right hip joint; 10 m. afterwards, sitting, similar but weaker pain in same place in left side. About 11 p. m, diarrhoeic stool. About 3 a. m. he awoke with urgent desire to go to stool; latter was yellowish brown and pappy, and smelt strong, followed by distension of abdomen, with loud grumbling and feeling of hardness. In turning over he noticed a sound proceeding from stomach resembling croaking of a frog. At same time he felt weakness and inquietude in whole body; tongue and pale late were stiff and dry. On attempting to fall asleep half right side of body was shaken as if by a violent electric shock. An hours after he quietly fell asleep. At 7 a. m. there again occurred urgent desire to stool, and diarrhoea with much flatus in long streams, grumbling and feeling of hardness in belly. 17th. – About 11 a. m. a diarrhoeic stool; after dinner pressing in stomach, dryness of mouth, frequent loud rumbling in epigastrium. 18th and 19th, m. and evening 30 gr. of 5th. 18th. – In course of day two diarrhoeic evacuations. evening, flying stitches in right spermatic cord as far as testicles. At n. again diarrhoea, followed by prickling crawling in tip of right index, alternately with itching in anus, as if an insect were creeping out; sticking in tendo Achillis first of right then of left foot; at last colicky pain in hypogastric region, as if from flatulence. 19th – Towards evening stitch in right pectoralis major, as if from an electric spark; an hours later similar pain in right nipple, followed by feeling of tightness, as from a band, in lower third of chest, with difficult breathing; tension and sensation of stiffness in left sterno – mastoid; frequent yawning; cramp – pain in metacarpal joint of right thumb; fine stitch in abdominal integument 1/2 in. to left of umbilicus, alternating with a similar one in middle of anterior surface of thigh; drawing pain in right ear. 20th. – In m. 60 gr. of 4th, in afternoon 60 gr of 3rd. In forenoon, in course of 3 hours much accumulation of salvia in mouth; pressure in stomach; distension of belly; loud grumbling in left side of abdomen; pain in hypogastric region, as with flatulent colic; frequent yawning; cracking in left ear on swallowing; sensitive stitches deep in root of nose towards right frontal sinus; stitches below nipples; drawing sticking pain in metacarpal joint of right thumb; after dinner diarrhoea. Afternoon (I hours after dose) sticking below left nipple; 1/2 hours later, fine stitches in left external canthus, as if there were sand in it; 2 hours after, diarrhoea; at last feeling of soreness in left nostril with difficulty in inhaling air through it. Throughout whole day he had sensation in tongue, as if he had eaten something astringent which blunted sensitiveness of papillae.
11d. Dec. 21st, 9:30 a. m., took 1 scruple of kitchen salt. 5 m., feeling of scraping and pressure in stomach, loud rumbling and grumbling in left side of abdomen and about stomach, with loathing and frequent yawning; 31/2 hours, frequent painless twitching in muscles of left side of chest, below axilla; 5 hours, sensation in anus, as if small air – bubbles were passing through, one at a time; 1/2 hours later, in lying, tension in cardiac region, followed by a sudden extremely violent concussion of whole left side of body; prickling and crawling in tip of right index; and such weakness in thumb, index and middle finger of right hand that he could scarcely hold the pen (lasting 10 m.). In evening great relaxation of body and mind, distraction, dull absence of thought, accompanied with pressive pain in stomach and frequently repeated fits of nausea. Slept well during n. till 4 a. m., when he had very violent contractive pain in hypogastric region, lasting several m. and returning (every 15 m.) 3 times; tingling, as if asleep, in thump, index and middle finger of left hand (they were as if dead for 5 m.); thereupon painless twitching in left pectoralis major and fine stitches below skin in hepatic region; lastly emission of stinking flatus. About 6 a. m., call to stool and evacuation of a pappy, yellowish – brown, very offensive stool, mixed with little whitish – grey lumps (almost like masses of tubercle). 22nd. – 9 a. m., another scruple. 15 m. after, grumbling in epigastrium (often during day and always returning with yawning); during whole day frequent crawling in tips of fingers and fine stitches here and there in skin. 23rd. – 9:45 a. m., 3ss. 5 m. after, tension in left groin, with rumbling in belly; 1/2 hours, gentle drawing in left tonsil, simultaneous cramp pain and roaring in left ear (for 10 m.); 2 hours, drawing tension in middle of anterior surface of left thigh, hindering walking; 2 1/2 hours, pressure in stomach and in hepatic region, with contraction of chest and frequent flow of salvia in mouth; yawning; an itching stitch in heel; 2 3/4 hours, thin, almost diarrhoeic stool, thereupon loud grumbling in belly, heartburn, and pressure in stomach (lasting several m., frequently returning at short intervals). The pressive pain extended from stomach as far as back, and caused slight contraction in pharynx; at same time head was dull and clouded, and prover was overpowered by a very peculiar irresolution even in regard to the most indifferent things. 3 3/4 hours, pressure and tension on spot size of a thaler, below right false ribs, for 3 m.; 5 1/2 hours, transient stitch from nape of neck into occiput and two very penetrating stitches in left thigh in neighbourhood of scrotum; digging pain above left eyebrow deep in brain; 6 1/4 hours, thread – like sharp stitch penetrating from below upwards in right edge of scapula (comp. Nov. 8th); 7 hours, transient stitch in left internal canthus, alternating with a similar one in the ramus of right ischium; twitching in inferior orbital ridge of right eye. In evening tension in nape; stitch in left great toe; prickling itching in orbital ridge of left eye (towards external canthus); digging pain deep in hepatic region. In sitting stickage, cutting, extremely violent and lightning – like pain shock whole body, which began behind the anterior spine of right ilium and spread partly downwards over trochanter towards anterior and external surface of thigh, partly upwards across back as far as neighbourhood of scapula; a few m. afterwards there appeared an itching and crawling in first phalanx of middle finger. In m. after waking, a similar sticking cutting pain as on previous evening shook body, which, however, proceeded from left hip; 1/4 hours later, fine sticking in back of thumb close to root of nail coming with each beat of pulse and frequently returning, Thereupon (after a very thin stool) a similar itching sticking on dorsum of left foot. 24th. – Took in m. another 3ss. Immediately after taking it, shaking, loathing, with rumbling in the belly and frequent yawning; an hours after feeling of chilliness in whole body, with frequent shivering, and accompanied with loathing and yawning; prickling itching in right ridge of lower jaw; 2 hours after burning in stomach, with oppression of chest; frequent yawning; 7 hours after stitch as if with a needle in root of nail of right great toe; 13 hours after similar stitch in right patella; spasmodic pains in left side of belly, lasting 1 – 2 m., relieved by emission of flatus, frequently returning at short intervals. On following m., 25th (without medicine), pricking crawling in tips of several fingers; violent stitch extending from left clavicle down side of breast; in course of day and even next, 26th, great sensitiveness of teeth (particularly in lower jaw) whilst inhaling air; raw place in inner surface of right cheek, causing burning pain in contact with warm food; irritability of edges of eyelids and their mucous membrane. 27th. – In m. 3j. Soon after taking it strong rumbling in left side of belly. Little appetite at noon. In afternoon stitches in left heel. In evening painful pressure in stomach with oppression of breathing and feeling as if diaphragm were pressed against lungs and thereby hindered their expansion, with frequent yawning, and rumbling in belly. 28th. – In m. 3iss. 2h. after, loathing the shuddering, which recurred repeatedly even at the thought of medicine taken; towards noon diarrhoea, with loud rumbling in epigastrium; later, pressure in stomach and hepatic region with constant rumbling in epigastrium; dull pressure in occiput and nape (1.) continuing 1/4 hours; squeezing, drawing, sticking pain in left groin; diarrhoea again in evening with subsequent strong rumbling in belly. From Dec. 29th to Jan. 13th medicine was suspended. The diarrhoea came during the next 4 day, each day a few times. On the 5th day the urine (which had hitherto been quite clear and normal) showed a dark green colour (as of an infusion of marsh mallow); during its emission it caused slight burning. The whole day prover was troubled with pressing pain in stomach and liver. The pressure was aggravated periodically, and was felt as far as the back. These symptoms increased in intensity during the 2 following d. The pressure in the liver and back close to the spinal column became very painful; the urine became as black as a saturated infusion of roasted coffee and perfectly opaque (urina ictericorus); the colour of the skin, however, showed no alternation; at night he frequently awoke on account of repeated accumulation of salvia in the mouth. Only 8 day after did the urine become again clear and of a natural colour. The hepatic symptoms were accompanied temporarily by pains in separate circumscribed parts of right side of chest.
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.