2. STAPF, from 30th dil. Lively without any cause; lively, social, and unusually communicative, even with disagreeable feeling of fulness; very easily frightened, with sensitiveness of brain; extremely irritable; at times can only think of some fancied worry; peevishness (transient); breaks into a rage about trifles; need of being very busy, without the slightest perseverance; gladly sits in meditation; longing for amusement without, however, experiencing ennui, with lively fancies about which he himself laughs; ennui with trembling of whole body; aversion to work; must force himself to attend to business (later action); inability for abstract thought, not the least persistence; very distracted, while reading, without interesting trains of thought; weakness of memory, so that it was difficult to pay attention to what was said to him; it became extreme; y difficult to listen to others, though his hearing was not impaired the words just spoken seemed obliterated; complete loss of consciousness at times, with cold feet, it returned as soon as feet became warm. Drawing, jerking, tensive sensation in bones of skull and cheeks, also in lower jaw; rush of blood to head, with painful pressure under whole skull, he was conscious of every diseased tooth, though they were not painful, blowing of bright red blood from nose, with drawing sensation in nose and frontal sinuses and under whole skull as if water had been injected into it; deep internal headache; pressive sensation beneath skull as form taking cold after going out, associated with nausea, it comes and goes, very much aggravated by stooping, the pain alternates with heat; heavy spot in middle of head,. that goes back and forth as he moves head; pressive sticking pain in right side of head; heaviness like lead in occiput, can scarcely raise it form pillow in m. after waking, with vertigo; numbness and crawling on left side of head, as in whole of left side,-e. and next m.; round painful spot in centre of head. feeling of numbness in concha with good hearing, without roaring, and op pressure it is also felt in inner parts, afterwards followed by habitual painful pressure and heat; extremely sensitive to noises; roaring in ears, usually associated with cold feet, very often. Drawing sensation in nose and frontal sinuses and beneath whole skull. He has extremely suffering look, face sunken, and as if he had been up nights, till fourth week. itching drawing in some teeth of left side; transient stitches in front teeth; burning on tongue form ordinary water as precursor of hoarseness and rawness in throat. Slight swelling of throat, soon disappearing (later); hawking of mucus with rawness in throat after nap in daytime; pressing feeling low down in throat which causes salivation if he thinks of it; throat raw as if sore, in trachea by sternum there seems to be inflamed painful lump, this feeling disappearing after violent hawking of mucus. Food is relished without real hunger, it is hastily swallowed; a certain aversion to food with hunger; longing for wine without feeling of exhaustion; stomach almost always digests well, but meat fried in butter causes acid and bitter risings; painful pressure in stomach, immediately afterwards clawing in anus extending inward; flatulence first 14 day, not afterwards; pain in abdomen coming from small of back; fulness in abdomen, especially during first 14 day; fulness in abdomen in m. on waking; painful hemorrhoidal drawings form anus to umbilicus; painful constriction of anus; painful transient drawings, now in one, now in other side of anus; pressure in anus both painful and painless. Apparent necessity for stool, without result, during first period; stool soft, pasty, never slimy. Burning urine, with hard stool (later action); red sediment in urine, it is never burning and never very turbid. Red spots on glans penis, margin is congested in two places; red pimple with itching beneath margin of glans penis (4th d.); profuse secretion beneath prepuce; frequent transient amorous thoughts, without slightest physical excitement; emission at n. (4th, 5th, and 6th d.) with vivid and somewhat disagreeable dreams, but without any unnatural admixture of imagery, with complete waking, and weakness following only after some h. Hoarseness and rough throat, preceded by burning on tongue; tickling cough, tickling is at one time in larynx, at another in chest, at another apparently in cardiac orifice of stomach, mucus is at one time round and grey, at another tenacious and yellow, it another watery, almost never at n., always associated with secretion of mucus from nose, cannot get rid of it for 3 weeks; every contact with open air causes violent tickling cough accompanied by expectoration of mucus, it lasts from 5 m. to I hours (later action). Oppression of chest, suddenly disappearing; oppression of chest in evening during sleep, alternating with clawing in anus, with cold feet. After stooping he could with difficulty become erect. Stretching of all limbs; weary pain in all limbs, commencing in knees and elbows; painful drawing in knee and elbow, extending downward; fixed pain as from sprain in. knee and elbow which does not disappear; pain in elbow as if bruised; hands feel dead on rubbing them (on dorsa), from 6th day, while washing them rapidly after eating, it goes off during 3rd week, but again shows itself a few times in 5th; pain in all joints of left hand, as after violent exertion on waking; extremely painful tearing like a forcible extension of muscles of right hand, it refuses its service on attempting to hold anything; fingers, first of right then of left hand, also in 5th week, without cessation, especially violent in m. stiffness of joints, cannot bend them except very slowly, afterwards movements are frequently rapid and active, often uncertain and clumsy; creaking in left knee; cramp in knees on waking; intolerable drawings in legs lasting a long time; drawing in left ankle from leg; numbness and crawling in right toes; pain in few toes, as after walking all day, with heat of them, preceded by cold feet. Muscular laxity, exhausted by motion and the most moderate exertion; motion is very exhausting throughout proving; he is obliged to do everything very rapidly, bolts his food, and afterwards is unable to remain sitting; aversion to motion; decided sensation of weakness in m. in sleep, on awaking general sick feeling, vertigo, feeling of lead in occiput can scarcely raise head form pillow, all the joints seem sprained, pressure in small of back and fulness in abdomen, after 1/2 hours everything disappeared, afterwards repeated in less degree; feeling as if paralysed, cannot bend feet or close hands, at times only on left side; p slight touch is intolerable, almost puts him into a rage. Crawling in fingers and calves; crawling in right shoulder, upper arm, and beneath shoulder; crawling and pricking in left hand and toes, especially violent in latter, at times in whole left side from vertex to toes. Overpowering sleepiness before and after eating; frequent inclination to sleep at midday (after first week), during first week, sleep in forenoon; necessity of sleeping before dinner, at times quite irresistible, this sleep did him good (during first 3 weeks); sleep sound and refreshing, even if he wakes with bad feelings; was several times unable to fall asleep, during 3rd week; restless sleep, heavy m. sleep, gets up unwillingly; dreamt that a person very dear to him had died, he awoke seeping, looked about him with conviction that he would see his ghost, without experiencing fear. Cold calves and knees, at times only on left side; coldness of feet every day, at times painfully cold, after which heat sometimes follows; crawling in left calf, with cold feet and icy cold ankles; febrile heat, fulness of head, drawing in some teeth and in bones of face, eyes glistening, indicating exhaustion, with pain in knees as if sprained, next day febrile heat with same symptoms, and in addition irritability, extremely restless and uncomfortable symptoms as in a kind of grippe (influenza), during the attack expectoration consisted of tenacious grey mucus, the day following some catarrh with fever; orgasm of blood, restlessness, anxiety, pressure upon chest, violent, quarrelsome, morose, for several day he involuntarily speaks louder and more distinctly than usual, thinks clearly and expresses himself well, but has no memory, does not hear or understand what others say to him (later action); disagreeable news cause the most violent orgasm of blood, still he is at last master of it; heat in ears; perspiration on feet; moderate sweat of feet, toes are quite wet in m. in bed; sweat of feet very much diminished, feet are warm, but not unpleasantly so (later action). (Ibid.)
3. BUTE, from 30th dil. Dilatory, he cannot accomplish his business as usual; cannot perform anything in an orderly manner; unusual confusion as to time, dated everything the 26th, when it was only the 6th, and on Wednesday he asked whether it was Saturday; makes more mistakes than usual in writing. Vertigo in evening; vertigo, with reeling and attacks of loss of consciousness, as if he would be attacked by apoplexy, 2 evening in succession; pressive headache with nausea, and with sleepiness; pressive heavy sensation in forehead, with nauseous vertigo, after drinking wine; violent throbbing above left eye. Eyes feel stiff; feeling as though dust had got into eyes; inability to open eyes, with heaviness in forehead. left nostril is internally somewhat swollen and painful, worse on repeating dose, at last a scab on painful spot; catarrh, with unusually great stoppage of nose; bleeding of nose, thick, dark red blood. Feeling as if gums were swollen; salivation, with burning in throat. Unusual longing for oysters, and they agree well, for several evening; eructations of air (soon); violent pressure in stomach after eating, with feeling of weakness in knees. Pains in hepatic region; much flatulence. Two stools in m., after the stool weakness, with continued desire for another stool, without result (Ist d.). Pressure in bladder and penis, with frequent need to urinate; constant pressure in region of bladder and in urethra; constant sticking cutting in forepart of urethra; sticking in urethra; sticking pains shoot from place to place, from small of back to liver (perhaps also to kidneys), and thence downward to urethra; sore pain in urethra, in forepart of penis, in 3 persons. During the heat as of orgasm of blood, he is obliged to loosen the clothes about the neck, there is a sensation as though they hindered the circulation of the blood, with kind of suffocative feeling. cramp like pain in precordial region, causing palpitation, with anxiety; palpitation causing anxiety (soon after a dose). Sticking in upper back; constant pressive pain between scapulae and in chest; sticking between scapulae; constant simple pain in sacrum and coccyx. Stretching of all limbs; painfulness of all limbs, feeling as if beat on motion; gnawing pain in all limbs. Pains in hip and thigh, lasting into n., with pressive heaviness in forehead, so that he is unable to open eyes; pain in muscle of right thigh, as after a blow or bruise, after drinking wine, and also renewed thereby; feeling of weakness in Knees after eating, with pressure in stomach; stitches in knees when walking. Weakness after breakfast; feeling as though body were overwhelmed by a disintegrating tendency, with sinking of all the forces; he is in a suffering, emaciated condition, very weak and prostrate, and constantly inclined to rest; tremulous sensation over whole body as from anxiety, without real anxiety. Sleep prevented by itching; sleepiness after breakfast; unusual sleepiness in m. after breakfast, with great prostration, stretching, and much spitting of salvia. General sensation of coldness, with actual coldness and longing for fire. (Ibid.)
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.