1c. From 30th. – Depression of spirits, with chilliness depressed and anxious, with shortness of breath; becomes easily peevish and mistrustful, believes himself intentionally injured by all about him, and attaches the most hateful significance to the most innocent occurrences; he sits up late at n. at mental work, with great activity; he is impelled to productive work in evening, although he had been much fatigued during day he sits up all n., without slightest sleepiness or exhaustion, writes with greatest freedom and increased vigour about everything that he knows, new things constantly throng on his mind, – also next day, after very little sleep, he is just as excited, it only gradually diminishes without subsequent reaction of mind (recurring in repeated proving); constantly obliged to pay attention to his spelling, in a language in which he is usually fluent; forgetful and indifferent. Confusion of head; vertigo after rising; vertigo as soon as he goes into street; vertigo so that he must hold on to something, especially after stooping; tensive pain in head, as if string were drawn from nape of neck above ear internally to eyes, on coughing; rush of blood to head, with flickering before eyes; rush of blood to head, with beating – roaring in ear; headache extending into root of nose; headache, with vertigo in evening; deep internal headache; headache in left frontal eminence, deep internally, as if connected with ear, it is also painful externally on pressure, as if bruised, in morning; transient drawing from left temple to forehead; stitches in left temple and side of head; very painful drawing form one spot above right ear to vertex, recurring 5 times with intervals of some seconds, an hours after eating; sticking in vertex and temples, as with knives and forks, extending through whole head, with catarrh and stiffness of nape; headache on vertex as if beaten internally, worse on external pressure; left scalp painful to touch. Blue rings under eyes, in morning; pain in both inner canthi. Pain in small spot, when touched, in petrous bone behind ear; during toothache ear is cold, and whole head feels so to him, though it is warm, – external heat is pleasant; contractive pain deep within left ear, on interesting ear – spoon it is painful as if swollen; tearing extending form zygoma into ear; itching in ears; can bear no wind in ear. Sneezing, together with mucus in throat; thin water from nose, in morning; nasal catarrh comes on in afternoon and is fully developed by evening, with much sneezing; many symptoms end with coryza; coryza with soreness of edges and tip of nostrils, which latter continues some time; short – lasting, fluent catarrh (in one who had not had one for years), at first for only few m. in m., then in evening lasting longer, whereby all the headache, lachrymation, and stoppage of ears disappeared, and he felt free from trouble; inability to have a real catarrh (yet has a constant or very frequent incomplete catarrh); bleeding of nose (in man of 45, for first time in his life); some drops of blood form nose; a few drops of blood form left nostril, after boring in with finger; blowing of blood from nose, and bloody streaks in mucus; in m. nose is very much stopped (disappearing after blowing out membranous pieces, but afterwards returning violently), in evening stoppage was less; itching in nose on sitting down to eat. Accumulation of water in mouth; water runs form mouth during violent cough; most dreadful taste in mouth, quite intolerable, which makes her makes her think of acrid poison, though she had never taken poison, somewhat coppery, makes teeth dull, causes nausea, more in forepart of tongue, which there seems thicker and worse during eructations (in hysterical woman); salty taste f mucus hawked up. Tenacious mucus in throat that he could scarcely raise; hawking of mucus only in evening after tea, instead of in m., and o much that it seems as though abscess had broken; hawking of mucus, and extremely disagreeable taste, almost like saltpetre; dryness in throat without thirst, – at n. on waking sticking as with a thousand needless, that threatens to suffocate her; dress in throat that impedes swallowing; pain in right side of throat, always extending to ear; pain in left side of throat, extending to root of tongue, jaw, hyoid bone, and into ear, so violent in m. after breakfast, that he was beside himself, there with tongue was sore on left side, with sticking here and there, gum was inflamed, all teeth painful, left side of face and lower jaw swollen and sensitive to touch, pricking and sticking at small spots in thighs and legs, disagreeable taste, loss of appetite, and bad sleep; throat and larynx are painful, even on bending head backward; burning in left side of throat and pit of throat; throat seems somewhat swollen, as if two lumps as large as the fists came together, only on empty swallowing, not on eating, which latter, on account of this sensation, seemed to do good. soreness of throat, and also somewhat in pit of throat; soreness internally on both sides of throat in morning; sensitiveness of throat as if sore, as often after taking cold, with pain in left side, worse in evening; feeling of great rawness in throat after exerting it; eating relieved pain in throat, causing an agreeable tickling; bubbling in throat, above right clavicle, also in right foot, near great toe; difficulty of swallowing salvia, not of food; swallowing prevented by dryness of throat; if in evening, on lying down, anything touches throat or larynx, it seems as though he would suffocate, and the pain is much worse. Feeling as when obliged to wait very long for food, without real hunger; longing for something, he knows not what, he took at last a swallow of water; though he has very good relish for food, yet takes very little, it seems as though he did not need more; longing for neither food, wine, nor tobacco for a week, he was accustomed to wine and tobacco daily; at times very good appetite, at times none; eructations and rising of food after eating; such eructations after dinner that he almost suffocated, they occurred as often as 50 times, followed by great relief; nausea in morning; nausea by paroxysms, for 5 or 10 m., in forenoon and afternoon; nausea after dinner; feeling in stomach as if obliged to wait long time for food; burning in stomach and hepatic region, stomach distended, with itching in epigastric region, abdomen distended, hard as if from eating much, while walking was obliged to stand still, feeling as though a stone were in upper abdomen and in pit of stomach, which draw downward as if it would break away, so that he was obliged to step carefully, – feet became swollen while sitting, and were cold though burning, therewith offensive odour from mouth, which he did not notice himself; pressure as of great load in stomach after eating, relieved by eructations and emission of flatus, but the pressure continues; pain, slight, but very disagreeable, when pressing upon pit of stomach. Painfulness in left side, near pit of stomach; clothes around hypochondria are very annoying; much rumbling in abdomen, colic and emission of flatus, after eating, in evening; very much flatulence; much flatus with loud noise, therewith anus seemed closed, so that she was obliged to press it out; eviscerated feeling in abdomen; pain in abdomen in afternoon; burning and cutting in abdomen, with pressure to urinate; fulness in abdomen, after eating; contraction in abdomen. Protrusion of rectum after stool; protrusion of rectum, which is thick and proportionately swollen, without great pains, – after it is, with difficulty, reduced, the anus is spasmodically contracted; determination of blood to anus, with haemorrhoids, diarrhoea – like stool, and increased itching in anus; burning discharge form anus, 4 times a day, preceded by cutting colic and urging to stool; he constantly feels flatus at anus, though he presses out only small, short emissions from time to time; burning in anus during a stool, also after stool; spasmodic pains in anus and rectum internally, followed by natural stool; urging to stool with the fever. Acids, even fruit, after Lachesis easily cause diarrhoea; stools more frequent than usual (in one inclined to constipation); pasty stool every forenoon; no stool, only a somewhat thin, watery evacuation (2nd d.); some mucus, so acrid that it is painfully discharged from rectum, with voluntary pressure; intolerable odour to the stool, which, as usual, was somewhat hard, the odour was scarcely endurable, like asafoetida, but much worse (like putrefying snakes); the first dose caused constipation, the second an evacuation; [Occurring in very many cases when given in various diseases] stool delayed every day; scanty, pasty stool, in m., then omitting I day; no stool for several day, with very good appetite, on account of which abdomen became hard and distended; no stool for 3 day (immediately). Much and frequent micturition, urine frothy. Unusual erections during day; want of sexual desire and inability for coition, or very late emission of semen, erections too feeble, for several weeks; emission during the midday nap; difficult emission of semen; semen possesses a penetrating odour. Diminished secretion of mucus in larynx; it seems as though something should be hawked up, which cannot be loosened; larynx and whole throat tender to touch; a feeling as if something were swollen in pit of throat and would suffocate him, it cannot be swallowed, with soreness in throat; something hinders speech, is hoarse, must hawk constantly; cough while drinking, or after drinking; cough worse after every sleep (in patient with mucous phthisis); pressure on larynx caused cough; short hacking cough; dry hacking cough caused by touching throat, also occurring in m. after n. sleep, and from smoking with a stopped catarrh, with blowing of nose and sneezing without relief; a kind of rattling seemed to be low down in larynx at n. during sleep, in only few paroxysms, followed again by ordinary breathing, in turn followed by similar paroxysms, so loud that it awoke his wife, who aroused him similar paroxysms, so loud that it awoke his wife, who a\roused him whenever it was repeated; shortness of breath and great prostration; respiration constricted, after eating a little. It seems as though wind rose up into chest, and became fixed there, relieved by eructations; burning in chest at n., with pains in sternum; pressure upon chest, as if it were full of wind; heavy dull pressure in whole of chest; oppression of chest during sleep; whole chest seems sore, as in violent catarrh, extending top between shoulders, especially after eating; pains in left side beneath breast. Palpitation. Tensive sensation as if tendons in left arm were too short on stretching it out straight, extending through whole arm to middle finger, in which it is most perceptible; stitches externally beneath right axilla; jerking in left hand and leg in afternoon while sitting; visible pulsation in large portion of ball of left thumb, very disagreeable, afterwards with slight jerking in whole thumb, frequently recurring and lasting a long time, and continuing to recur for a long time; violent cramp in the calves at n. towards m., so that it woke him; sensitiveness of balls of feet on stepping upon them; painful surging back and forth in toes; crawling and heat in toes of one side. Sudden jerking together of whole body, starting from below, while sitting; always after sleep, so stiff that he could scarcely stir or move, rubbing and stroking by another person did him good, and soon entirely removed feeling; indolence and heaviness after eating; weary, sick, dejected, with fulness after eating; great weariness on going out in evening, the accustomed walk seems endless; at meal – time, while walking in street, so weary that he could scarcely proceed, yet he ate but little; weakness after supper; suddenly, towards evening, deathly weak, with insatiable thirst, dry mouth, became pale and distressed as if about to be attacked by a violent fever; physical, not mental exhaustion; physical exhaustion and weariness, with mental excitement; great physical and mental exhaustion, especially in m., transient faintness, with nausea, vertigo even to falling down, and vanishing of sight for 2 or 3 m. during breakfast, during day frequent attacks as if it would return; great inclination to lie down, especially after eating; became very sick after drinking wine, also after strong beer; faint – like sensation of trembling; feels bruised all day; always after sleep, m. or n., bruised or stiff; weary, bruised feeling, it catarrh, cough, sore – throat, m. nausea, rumbling in upper abdomen, &c., and often in warm spring weather; great longing to go into open air. Sore spots became fungoid, dark red to brownish, with whitish spots, burning on wiping; red burning spot on thumb, followed by a large hard vesicle; itching on lower legs, obliging him to scratch, red wheals appear; after incessant itching there appears a round, red, very hard lump on back of middle finger, lasting long time without vesicles and without suppuration, there slowly forms a small deep point of pus, of which very little exudes, only on allowing hand to hang down there is a sticking pain – 6 weeks later, after a blow on the lump (which had almost entirely disappeared), it bleed unusually profuse; a large number of small flat warts suddenly appear on hands (of one who already had several large ones), which do not disappear; small pimples on face; small pimple on outer portion of right thigh, round which for some distance it is extremely painful; eruption like nettle – rash over whole face (26th d.), it disappeared and returned; itching hives on legs; erysipelatoid eruption beneath left eye, which first itched at n., when she was wakened with fright about trifles, in m. the skin began to redden and swell, and became worse after mid – day nap, next m. very thick and red, with incessant itching scarcely to be endured, whole lower lid was swollen, red, and itching preceded and followed by beating headache on stooping (rhus relieved); itching – burning and vesicles on hands and fingers; small clear vesicles on right fourth finger; violent itching on right heel, afterwards on both heels, then on right hand and fingers, on top of foot, and toes, always worse and burning after scorching, followed by small, hard, white deeply seated vesicles; small itching vesicles on backs of both feet; groups of deep hard itch vesicles on right hand; a large boil on heel, with violent shaking chill on formation of matter, caused by very slight rubbing of shoe, in one who had never before had anything like it (after 8 weeks); ulceration of a nail after a bruise; a slightly brownish – red areola about an ulcer became blackish blue; old ulcer scars reopened, after a blow the epidermis easily loosened and would not again heal, suppurated, then vesicles formed and epidermis loosened all about, the open spots were dark red, looking like flat sponge, here and there whitish, burning after sipping; bleeding of ulcers which then became cleaner; pain in and about a scar remaining from a fistula on the thigh healed the year previous; burning in ulcers at n., so that he was obliged to rise and wash them with cold water; itching in face and hands. Spasmodic yawning in m., sleepy in evening, immediately after supper, with much weariness; so sleepy after dinner that he could scarcely keep up in spite of pressing business, contrary to his bit he slept for I hours, afterwards the troubles in abdomen were the troubles in abdomen were worse; she could sleep while walking and standing;she lies constantly slumbering, as if stupefied, after pains have passed off; difficult falling asleep for a week; partial sleep full of dreams; wakes very early in m. feeling well; dreams with reflection and thought, and of the many occurrences of the day; in his dreams he possesses an intriguing character (which while awake was in no wish the case); troubles increased after each sleep. Chilly, indolent, and prostrated, was obliged to lie down flat on the ground near fireplace, which made him feel better; shivering during the heat; single paroxysms of shivering; it seems too hot at n., sleep very restless; first much thirst, then after some shivering, lingering heat without thirst, during which he desires to be covered, several such attacks in m. and during day, especially in evening, at times transient perspiration (after several weeks china relieved); every evening feverish, hot palms and hotter nape, during which the rubbing of other people is extremely beneficial; feeling of glowing warmth in skin of chest; sweats too easily; sweat too easy and too profuse. (Wikungen des Schlangengiftes, 1837.)
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.