11. GUNTZ, after 1 gr. of powdered leaves, felt, after 1/4 hour, slight frontal headache lasting 1 hour. On repeating same dose, one morning, besides the above symptoms, had increased secretion of weary urine with frequent desire to pass during afternoon. Took 2 gr. After 10 morning, slight vertigo set in and lasted 20 morning. Urination became frequent urine was weary and clear and total quantity more than he was accustomed to pass in same time. Pulse after both doses remained unaffected. (Ibid.)
12. HEISTERBERGK, after 1 gr. of powdered leaves taken in 1/2 oz. of water, felt trifling pressure in vertex. Pulse was unaffected. On repeating same dose one morning at 9 a. m., in addition to above symptoms noticed at 10:30 pressing feeling in right parietal bone lasting 1/2 hour. After drinking 16 oz. of beer at midday passed during 1 hours about 32 oz. of dark-colours urine. Next day all effects had vanished. After dose of 1 1/2 gr had some belching, but unaccompanied by nausea or inclination to vomit. Towards midday became venous. Between 1 and 11 p.. bowels acted twice, faeces being thin. Pulse and urine were unaffected. Next day bowels acted only once, but faeces were still thin. November 24th, 1823, at 9 a. m., took 2 gr. and noticed following symptoms: Between 9 and 9:30, belched wind 10 or 12 times; towards 11 slight headache in vertex lasting 1/2 hour; at noon ravenous men, and at 5 p. m. evacuation of thin faeces. Urine was unaffected. Pulse between 11 a. m. and noon beat small and soft but not more slowly than usual. Next day had another loose stool. Four day later, also at 9 a. m., took 2 1/2 gr. Belching was again present, but without headache. Towards 11 a. m. much rumbling in bowels, and at 11:30 feeling of ravenous hung, both symptoms accompanied by small but not slow pulse. During next 24 hours two loose motions occurred. (Ibid.)
13. a. KNESCHKE on November 12th, 1823, at 9 a. m., took 3/4 gr.; a few minutes later had feeling of pressure in occiput going from right to left and spreading upwards towards vertex; slight confusion of head and traces of vertigo were present until about 1 p. m. Urination during p. m. somewhat increased in frequency, especially-between 3 and 6, urine being pale yellow in colour. After dose of 1 gr. experienced same effects, only that head- symptoms lasted 2 hours longer and urine remained unaffected until following day, when he was obliged to empty bladder every hour, urine being weary and copious. On repeating same dose same effects followed, but the-symptoms lasted until evening; increased flow of urine also occurred during afternoon of same day. Pulse during afternoon was smaller than usual, but normal in frequency. on November 24th, at 9 a. m., took 1.1/2 gr. of powdered herb in water. Head – symptoms came on at once, increasing at noon to acute stabbing pain, chiefly in occiput and vertex and to less degree in forehead (received a letter containing unpleasant news at midday). During p. m., especially from 2 till 7, urine was more abundant, light coloured and dilute; pulse was meanwhile smaller r than usual. After dose of 2 gr. same effects followed except that headache did not reach frontal region, and no stabbing was noticed; pulse was also unaffected.
13 b. a 2 dr. dose of infusion (gr. xx to 3iv) caused only confusion of head; after 1/2 oz. same effects; during p. m., from 2 till 6, was obliged to passes water every hour, urine each time big copious and watery. On repeating same dose experienced same acute head-symptoms as after large doses of powder, urine being also in this case voided every hour; pulse was unaffected. After 25 drops of tincture (1 to 6) felt from 1 p. m. till evening severe pressure in right half of occiput, and from 2 p. m. till evening increased secretion of urine. (Ibid.)
14. SEYFFERT, after taking 1/4 gr. fasting, felt immediately slight transient vertigo; 1/2 gr. caused, in addition, increased secretion of urine lasting till next day. After 3/4 gr. felt, soon, confusion of head, somewhat like feeling of intoxication, and soon passing off, with increased voiding of urine lasting 24 hours. Pulse during p. m. was smaller, but not slower than usual. Infusion (3j to 3 iv) in dose of 3ss caused only slight transient giddiness, and did not affect kidneys. Of tincture (1 to 6) 12 drops taken in 1/2 oz. water caused only slight transient giddiness; 30 drops caused same symptoms, but acted more powerfully upon urinary organs, for he was obliged to pass water constantly all afternoon, quantity passed each time being small, but large in aggregate. This condition lasted, though to a less extent, during next day. (Ibid.)
15. Dr. BLACK commenced, October 21st, 1845, to prove tinct. on himself, pulse averaging in forenoon when sitting 68, and in evening 75. “At 10 p. m., after sitting quietly for an hours, felt my pulse, which was 68, and took 10 got. tinct.; continued to sit quietly reading. In 1/2 hours felt dull frontal headache; pulse 68. Headache continued increase; on going to bed felt momentary nausea. 22nd. – While dressing, took 10 gtt., sat down shortly after, and in 20 morning (9 o’clock) felt my pulse, which was 66; no headache. At 11 pulse 76, of natural strength; after walking slowly four or five times up and down my room, pulse 83; experienced uneasy sensation across chest to left side. 2 p. m., pulse 75; took 10 gtt.; dull, disagreeable sensation in region of heart. 2:30, pulse 80; feeling of slight confusion in head, especially on moving, with painful sanction of weakness in wrists and forearms. At pulse was felt by a medical friend; it was now 76; counted several times, it gave th first 1/2 morning 36, the second 40, and three beats failed to be felt. 11 p. m., have all evening been feeling dull, uneasiness in various part of head, with sensation of weakness in forearms; pulse 80 bowels moved naturally in morning and again at 9 p. m. 12, pulse 78, but weak, being strong from 12 to 20 minutes times, and then very weak for 4 to 5 times. 23rd. – Passed restless night, starting often in my sleep; woke with feeling of great lassitude and depression and languor increased; 62, small and weak; on getting up, depression and languor increased; occasional faintness,, which, on moving, was attended with nausea; appetite good; pulse in evening 72; felt very. well 24th. – Slept well and experienced no symptoms. 11 a. m., pulse 80; full and regular; took 20gtt. Quarter to 12, pulse 90, weak; 3 or 4 pulsation in the morning hardly feet. Throughout day experienced uneasiness in mammary regions, especially left, extending to left shoulder and upper part of arm; frequent griping pans in bowels; palpations of heart easily excited on going up even a slight ascent, which in health would produce no effect. 11 p. m., pulse 82, nearly natural strength, but to steadily so. 25th. – Slept well;woke with dull frontal headache and nausea 11:30 p. m., pulse 76, took 25 gtt. At noon, pulse 84; frequent griping pain in bowels, and uneasiness at heart. In evening, pulse 76, rather weak. 26th. – With exception of slight uneasiness in region of heart, experienced no symptoms. Towards evening, seized with very violent colicky pains, immediately followed by sudden evacuation of liquid stools. 27th, 10:30 a. m., pulse 72; took 30 right 11:30, pulse 88, irregular. 12:30, pulse 84, less irregular. 3, pulse 72, regular. Throughout day experienced dull frontal headache, with frequent uneasiness in region of heart. 28th, 10:30 a. m., pulse 72, regular, have felt well all day; towards evening experienced dull, disagreeable pressure outwards in chest and epigastrium, relieved by beating on chest. This lasted 3 hours. 29th. – In morning pulse 73; dull frontal headache, increased much by movement. 30th, 6.33 p. m., pulse 78. November 4th. – Having been much occupied, and suffering from the day, I suspended med. until to – day. 11 a. m., pulse 73, natural; took 25 dr. 12:30, pulse 80; 2, pulse 76;4, pulse 62. Suffered much after dinner from severe bruised pain in epigastrium and over sternum, with feeling of languor and
indigestion, going off after a little weak tea. Throughout day frequent uneasiness, amounting sometimes to pain in region of heart; occasional nausea; seldom free from dull frontal headache; feeling of great fulness in ears, as if they were suddenly stopped, attended with flush of heat over face, lasting 2 or 3 morning, recurring frequently, especially after excitement. Before going to bed took 15 dr. 5th. – In morning pulse 72. During early part of evening of 4th suffered from pains, now to be reported as being felt more on 5th, viz. bruised pain in nape of neck, between shoulders, and extending forwards over anterior part of chest, where flesh was painful when pressed, especially over sternum. These were attended with dull frontal headache, bruised pain in epigastrium, with feeling of distension in stomach. Appetite food. After dinner dull pain and distension of stomach, felt as if I had eaten too much. In evening bruised feeling over sternum and epigastrium was very distressing, preventing any mental enjoyment. 6th – Passed a wakeful night, suffering form palpation and uneasiness, especially when lying on left side, together with pulsations in ear, especially left. 11 a. m., after walking, pulse 75, a little irregular; took 36 dr. At 12 pulse 84; at 12:30, 86, slightly irregular; palpitation and uneasy feeling at heart, readily excited even by moderate exercise. IN evening took 20 dr., shortly after suffered from by moderate exercise. IN evening took 20 dr., shortly after suffered from frontal headache, with pressure on temples; pulse 100, irregular, but full; increase of bruised pain in epigastrium. 10th. – Since the 6th I have not taken D. as I continued to suffer much from uneasiness in heart, headache, and disorder of stomach; pulse was normal but easily excited. I still suffer from bruised feeling and weight in epigastrium with flatulence. These symptoms continued until about the 14th. During all the time of the experiment the condition of bowels, genital organs, and urine was not sensibly affected. (Bright. Journ. of Hom., iv, 77).
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.
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