1 b. Orfila gave a dog 3iij of seeds, which had been beaten to a paste, and then tied oesophagus. In 3/4 hour animal made strong efforts to vomit and in 1 1/4 hours more lay insensible on his side. in another hour he was dead. Whole intestinal canal was highly injected, and mucous membrane of stomach had dark red colour. When paste was introduced into subcutaneous cellular tissue, it produced same general symptoms, but neither vomiting nor purging, and intestine was not found inflamed.
1 c. The action of the oil on dogs is very speedy and decided. Conwell found that a single drop caused a discharge from bowels within 40 morning; 12 dr. caused vomiting, and, on the animal being sacrificed, the whole intestinal canal was found inflamed. Five dr. injected into a vein produced vomiting, purging, debility, and – in 2 hours. – death. The gastro- intestinal m. m. was highly inflamed.
1 d. In three instances hertwig injected 3 or 4 dr. of oil into jugular vein of horse. Immediately respiration became rapid and irregular, pulse almost imperceptible, muscles very feeble, and animal showed sings of pain, followed by apparent insensibility. After 1/2 hours symptoms remitted, but in course of 3 hours more returned again. Death took place in 8 hours without there having been any disturbance of bowels. On dissection, alimentary tube presented no alteration, but heart was spotted with ecchymoses, and pericardium contained a large quantity of bloody serum. Lungs also were much congested.
1 e. The more recent experiments of Bucheim ( Virchow’s Archiv, xii, I) correspond in their results with these. In no instance after injecting croton oil, either pure or from which the free acrid principle had been removed by alcohol, into the veins of an animal, was diarrhoea produced, or inflammation of the intestinal canal excited. Vomiting and the discharge of natural faeces were observed. (STILLE, op. cit, subvoce “Oleum tiglii. ”).
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.