21. A man, aet. 26, blond, sanguine temp., too 20 dr. tinct. of seeds. Immediately, numbness of whole buccal cavity, especially tip of tongue, with loathing and nausea. Increased flow of saliva, burning in mouth and all down oesophagus. Teeth felt on edge, with drawing pain from apices of upper teeth to maxillary bones. IN stomach feeling of increased warmth and fulness. After 1/2 hours slight irritation to sneeze through whole nasal cavity. Salivation continues. Confusion of head with slight vertigo. Eructation, slight constriction of oesophagus. Feeling in both cheeks as if they were torn asunder. Pain at top of crown, like boring into head, the painful spot changes to different parts of sagittal suture. From nape up over occiput and in ears a dull drawing pain. After 3/4 hour, pressure and discomfort in stomach, contraction in stomach. After 1 hour, salivation still continued, the tooth and headache, the pressure and warm feeling in stomach increased, especially towards right side. In abdomen some rumbling, retching, and eructation. A disagreeable feeling in stomach which goes back to spine. Pressure and tearing in nasal cavity; pressure in nasal bones. feeling of commencing coryza in nose. After 2 hours, tearing in flexor aspect of all left forearm into elbow-joint. Paralysed feeling in all left arm, drawing from left thumb along radial aspect of forearm. On both forearms on their ulnar side itching of skin, with redness of skin there. After 5 hours feeling of weariness of whole body, feet tired and weak. After 7 hours, slight tearing in right hip-joint through thigh into knee, drawing on both calves and front part of right foot. After 8 hours, ordinary stool followed by rumbling in bowels and pressure in stomach. After 1 hour more, a soft stool with slight tenesmus. On urinating burning all through urethra and slight tenesmus. ON urinating burning all through urethra and slight contraction of neck of bladder. Dull pressure on both sides of lumbar vertebrae. In left side of chest spasmodic compression and dyspnoea for a few seconds.
21 b. A few days afterwards he took at 10 a. m. 15 dr. Immediately, copious flow of salvia, burning in oesophagus and stomach. After 20 morning, eructation, teeth on edge as if from eating much fruit, teeth seem too long, pain in them from apices of upper teeth into upper maxilla. After 3/4 hour constriction of oesophagus, pressure and discomfort in stomach, gums painful, dull pressure in occiput, feeling as if scalp from behind and before were drawn up in the middle of vertex, where there is a small painful spot as if the vertex were bored into. After 2 hours, creeping in nose, pressure in nasal and facial bones jerking tearing in temples. After 24 hours, twitching in all limbs as from electric shocks, especially in joints of left metatarsus, great prostration and weakness, disinclination for mental work. In night between 2nd and 3rd day very restless and fatiguing sleep. ON waking in morning great nausea and rumbling in bowels with painful contraction and pinching. Stool and urging with feeling of diarrhoea. On rising up in bed the symptoms always increased; after rising the nausea increases to vomiting of a little bilious bitter fluid, followed by soft stool with much urging and little evacuation. Better in open air, but the nausea and rumbling continue. Towards evening of 3rd day nausea and rumbling return for about 2 hours. IN evening fine but tiresome pain in whole frontal region, especially above eyebrows, extending to dorsum of nose. Soon afterwards feeling as if right eye were compressed, for a few seconds only, but frequently recurring. 4th day, in morning frequent transient anxiety in chest, pressure on parts, especially in left side of chest, short stitches which began in anterior thoracic wall and seem o go out at posterior wall; feeling as if sternum and spine were screwed together; from apex of left scapula to spine a tense pain increased by moving arm. At noon stiffness in left thigh, making walking difficult; in bed, night, right knee painful for a short time with feeling of lameness. 6th days, though he had never before had rheumatism, he got rheumatism in nape, the right ocularis in its whole extent so painful that he must cry out when he moves the neck; the worst pains went off after 2 days, but the movements of the neck were not quite free for 4 weeks. (UNSIN, A h. Z., lii, 82)
22. A man, aet. 25, strong and stout, took Nov. 25th, at 8:45, 10 dr. tinct. of seeds. NO effect. – 26th, 8 a. m., 16 dr. The only effect till the 29th was 2 stools instead of the usual 1 daily. – 29th, 8 a. m., 24 dr. NO effect. – 20th, 2 p. m., transient drawing – boring pains in middle of sternum towards left nipple, also here and there in right side of chest, but chiefly in left side; the pains relieved during deep inspiration. Later, feeling of tightness all over chest, as if a heavy weight lay in it. 5 p. m., discharge of very fetid flatus, urging to stool, followed in 1/4 hour by loose stool, with cessation of chest pains but persistence of tightness. – Dec. 2nd, 6:30 a. m., 30 dr. 8 a. m., great uneasiness in abdomen, considerable rumbling and urging to stool. 9 a. m., easy liquid stool without pain, and with relief of uneasiness in bowels. Feeling of emptiness and sinking in stomach, also after breakfast. 10 a. m., jerking tearing from right elbow to wrist, often repeated, but only momentary; later, the same pain from wrist to finger – joints. Noon, no appetite. The above pain in chest recur, are more severe, and last longer. – 34d. Tearing returns, chest tight, sometimes boring pain in left side of chest. – 4th, 10 p. m., in bed, pains became so violent, and tightness so great, that he had difficulty of breathing and anxiety. Frequent constriction of chest, shooting and boring pains in whole chest, worst below left nipple. – 5th. Appetite returned; chest better but not quite free; pinching pains in abdomen. The chest symptoms lasted a long time, sometimes better, sometimes more severe; they only finally ceased at the end of a fortnight. (Ibid., 89)
23. A strong girl, aet. 20, phlegmatic, took 5 dr. tinct. After 5 morning, eructations and feeling of flying heat in hands and feet with tearing through whole left foot; toothache, teeth seemed too long; pressive pain in frontal region; stitches in left side of chest about 8th rib; feeling of weakness and prostration in limbs; deep shooting above left eyebrow, it seems to be drawn up; arms heavy; constant drawing in hands to fingers; her hands seem so powerless than she thinks she must let even light things which she lifts fall out of them; stomach full as though she had eaten too much; great roaring in right ear; tearing in head especially forehead; tearing in arms with very paralytic feeling; tearing in legs as though they were lame; stitches in left cheek; pressure in frontal region as though all would come out there; pinching in belly; after 1 hour a normal stool. In evening epistaxis, next day several loose stools without pain. (Ibid., i 90.)
24. B – took on April 15th, 10 a. m., 1 dr. tinct., which caused heaviness of tongue, increased flow of saliva, feeling of enlargement of tongue, he would like to extrude it over the teeth; p. m., great thirst. – 16th, 7 a. m., 2 dr. Bitter taste, drawing and cold feeling in lower incisors;. 1 p. m., stool followed by tenesmus. – 18th. 2 dr., coffee aggravates; p. m., slimy stool with fatiguing pressure and straining; sleep restless, unrefreshing, limbs in morning as if fatigued; later, pressive pain in right then in left frontal region; dryness of eyes. -20th, 7 a. m., 5 dr. After 1/2 hours eructation with burning in stomach (Ibid., 90.)
25. After taking the extract and tinct. of colch. the following symptoms were observed: – Immediately after each dose the mouth became filled with saliva of a flat taste that provoked nausea, the mucous membranes secreted a viscid substance, and there occurred eructations seldom accompanied by vomiting and diarrhoea; there was a general feeling of malaise, slight attacks of colic and flatulence. After this state had lasted 2 hours there was sleep for 1 or 2 hours. After 5 to 6 hours this sickness ceased, but instead there was great feeling of emptiness in head, with confused ideas, difficulty of thinking, and intoxicated feeling; objects appear to whirl round and to have an altered colour; roaring in ears, every noise causes disagreeable sensations with involuntary starting; all part of the body experience a prickling discomfort; the breathing is difficult, often some palpitation of heat, pulse sometimes slow, sometimes quick, but always small and weak; colic, the attacks of which are very severe but generally without stool. After 12 to 15 hours the cerebral symptoms decline, but the eructation recommences vomiting often ensues, chiefly of mucus, seldom of bile; the abdomen is sometimes distended, the attacks of colic increase anxiety and dyspnoea continue, there is sometimes general dry heat, sometimes more or less profuse sweat; urging to urinate more frequent. The colic is chiefly in colon and is accompanied by pains in lumbar region and a feeling of pressure about pelvis. Then stools commence, at first of usual appearance, then soft, yellowish, of pitch-like stickiness, with a peculiar fetid odour; they cause heat of anus, then pain, and then the most tiresome tenesmus; later they diminish in frequency, become watery and colourless. If the dose was rather large the bladder becomes involved, the urging to urinate increases, symptoms resembling those caused by cantharides come on, the urine has often a muddy sediment consisting of the epithelium of he vesical m. m. All the pelvic organs are in an irritated state, especially the genitals; erections and even very exhausting seminal emissions occur. The last symptoms observed are general intolerable itching, especially around large joints, great prominence of the cutaneous papillae, easy detachment of epidermis which makes the whole integument dry and rough, and disappearance of these symptoms after profuse fetid perspiration. (These last symptoms Goupil does not consider as the effect of the colch.; why, he does not say.) After large doses, e.g. 9 grammes of the tinct. in 6 doses at 2 hours. interval, the symptoms after profuse fetid perspiration. (These last symptoms Goupil does not consider as the effect of the colch.; why, he does not say.) After large doses, e.g. 9 grammes of the tinct. in 6 doses at 2 hour interval, the symptoms do not occur so regularly. About 1 hour after the ingestion there occurs vomiting of mucus, seldom of bile, every 1/4 hour for 24 to 48 hour. The cerebral functions are quite disturbed, there is extreme empty feeling in head, confused ideas, difficulty of thinking, and painful intoxicated feeling; an object cannot be looked at fixedly with out causing vertigo, all objects seem to whirl round and change colour, they generally appear yellow and sometimes with iridescent borders. The hearing is affected, sometimes there is roaring in ears, sometimes the hearing is extremely acute; every movements of the head causes inclination to vomit and faintness. General malaise, accompanied by formication all over the body, breathing short and difficult, often palpitation of heart and intermitting pulse. After 12 to 15 hours the mouth is filled with bad-tasting saliva, the eructations increase and are often followed by vomiting of a viscid, tasteless fluid. Dry heat of skin, after more or less profuse sweat. The most dangerous symptoms are: – The patient cannot think connectedly, he has confused sensations, all objected whirl round him in a chaotic manner, he does not move his head for fear of vomiting or fainting; hallucinations of the strangest sort fatigue his sight; the most extraordinary noises distress his ear. At the same time the attacks of colic are often but slight, sometimes severe, attended with spasms; the perspiration is clammy and cold. These symptoms cease after stools, but then the pains in the pelvic organs become most severe. (GOUPIL, Froriep’s Not., 1861, iv, 18.)
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.