12 b. April 22nd, 1874, commenced taking 3 dr. tinct. at 1 and 6 p. m. and 1 and 6 a. m., 12 dr. per day 22nd. – E., after 2 doses, felt indefinite disturbance in bowels, increasing to slight pain, with some flatulence; after midnight, having taken three doses, pain in both temples as from external pressure, not severe; very slight vertigo. 23rd. – Noticed no abnormal sensations before noon, when what I can only describe as a bilious or fever and – ague head returns; same as experienced in last proving, only less in degree as yet; abdominal disturbance increased, with distinct but not troublesome pain, and greater degree of flatulence. 24th. – Have experienced no noticeable symptoms up to noon to – day except general unpleasant feeling in head. 25th. – Increased dose to 4 dr. No effect save occasional slight vertigo. 26th. – 4 dr. doses continued with no effect. Bad taste in mouth after sleep, tongue covered with whitish coating; this last has occurred from the first. On 27th dose increased to 5 dr., and on 28th to 6 dr., with no effect. (Ibid.)
13. Mrs. Whitcomb proved solution of 2 dr. of tinct. to 100 of alcohol, taking from April 8th 1 dr. m. and evening 9th. – Constriction, with stinging pain, in region of heart, lasting but a moment, about noon (unusual). About 5 p. m. feeling of suffocation, lasting but a short time, but occurring several times for an hours or more. Mind clear, but inclined to irritability. 10th. – Darting pains in muscles of the legs, above knees and about hips. Nervous. The same feeling of suffocation and slight palpitation. 11th. – In m. between 8 and 9, quite a severe pain in muscles of left leg, above knee. Nervous irritability; pain about vagina and uterus, with a good deal of yellowish discharge (unusual). 12th. – Quite severe pain, a. m., through thighs and muscles of limbs, extending to small of back, a feeling as though about to menstruate (although not expected). The same nervous irritability, and occasional suffocation; for a moment a stitching pain in right side, in region of right heart (I should think). (Ibid.)
14. Mary L. Swain, April 16th, just before breakfast, took 1 dr. of tinct. in teaspoonful of water. 8:30, sense of great pressure through temples, which continued about 10 m. Throat during day felt furred, constant irritation there during p. m. Repeated dose at n. 17th. – Same dose upon rising in the m. In about 1 hours a fit of sneezing. Peculiar feeling in throat continued. Watery discharge from nose when walking out of doors to – day. Discharge from head through passages of throat, having consistency but no colour. Sneezed several times during p. m. A pain in right lung during afternoon, situated just to right of sternum, a throb coming at intervals. Repeated dose at n. 18th. – Awoke to find throat somewhat inflamed. Discharge from head, white and pale yellow. Sneeze immediately after morning dose. Latter part of day pain as of heavy pressure in chest over sternum, for space about size of hand, similar to feeling caused by clothing that binds tightly; it produced an extreme sense of nervousness. Sneezed several times during day; some unpleasant feelings in head at times. 19th. – Quite long fit of sneezing before rising in m. Cold in the head. Consistency but no colour in what passed from nostrils. Continued pressure in chest, producing great nervousness, so that I was unable to sit in one position long at a time. Sneezing continued through day at intervals. (Ibid.)
15. a. Mr. H. H. Cushing. (Died of tuberculosis 2 years later, but was apparently well at time of proving.) Took 3 dr. of tinct. In 10 m. cold creeping and pressure over fissure of Sylvius. In 15 m. tendency to eructate; feeling in head continues. In 34 m. constriction in left side of frontal bone and around eye, followed by pain in malar bone. Took 7 dr. In 7 m. flush of heat in left scalp, followed by pressure and constriction at end of sternum. In 17 m. empty eructation. In 20 m. faintness and empty feeling at stomach. In 30 m. burning in stomach and bowels. Took 10 dr. In 7 m. twitches and burning in muscles of cheek. Strong pressure over whole head. In 9 m. tendency to eructate. In 15 m. creeping over left head. In 22 m. burning in scalp (l.) and general uneasiness. In 24 m. burning in stomach; continued burning and griping in abdomen; eructation. In 30 m. tensive cutting pains in abdomen and around stomach. In 40 m. constriction over heart and laboured breathing. Took 12 dr. In 7 m. constriction at end of sternum; tendency to eructate; laboured breathing; hard griping in abdomen. In 12 m. creeping over top of head; hands hot and dry; pain in sternum, worse on walking. Took 20 dr. In 5 m. burning over whole abdomen. In 8 m. heavy laboured breathing; heat in head. In 30 m. severe cutting headache, left side, with contractive pain in left eyeball. In 35 m. heat in left temple.
15 b. Took 1 dr. In 10 m. slight pressure on top of head and slight eructation. In 15 m. distending pain of abdomen. Again, after taking 1 dr., in 5 m. congestion of blood to head, with oppression on chest; and, in 20 m., short, sharp pain at pit of stomach, repeated at intervals. The head symptoms were varied by cold creeping over the fissura Sylvii, left side; by headache in left temple; and cutting and crawling and pressing ache in left side of frontal bone. Took 2 dr. Pressure as before, coming in 4 m.; feeling as if left parietal bone were pressing on brain. In 10 m. cold creeping sensation in same place. Took 3 dr. In 3 m. prickling in left hand, not very decided, nor repeated. Some contraction of eye – ball, and pressure on forehead. In 8 m. pressure on left side of head near top, as of a blunt instrument. In 12 m. the pressure extended as if there were an indented line made in the bone. Took 4 dr. In 3 m. pain in left groin. In 7 m. contraction of eyelids; sharp, cutting pain left side of head. Took 5 dr. In 6 m. darting pain in right temple. Took 6 dr. In 10 m. pressure on top of head, with pain over left eye. In 17 m. continued swallowing. In 20 m. eructation, and feeling of emptiness – as of faintness from hunger – in stomach. Cold creeping in head. Took 8 dr. In 3 m. stitch in right side of sternum. Took 10 dr. In 8 m. contractive pain in left side near 7th rib, and at end of sternum. Pressure on top of head. In 10 m. pain over heart and at costo – sternal articulation on walking. In 18 m. shooting weakening pain in outer side of leg, just below knee. Took 12 dr. In 10 m. contractive pains about 1.7th rib. Rather laboured breathing. Pulse slow and irregular. In 12 m. pressing pain in middle of sternum. In 15 m. crawling pain in temporal bone, front of left ear. (Ibid.)
CAFFEINUM (see vol.ii, p.313)
II. 3. A single woman of 30, being exceedingly nervous from loss of sleep and somewhat immoderate use of stimulants, was advised to take a 2 gr. powder of citrate of C. By mistake she took 3 gr., and impatiently repeated the dose several times, so that within 1 1/2 hours she had taken 18 gr. (She took also – getting no relief – a 1/4 gr. morphia pill before she began to feel the effects of the C.; but it does not seem to have played any material part in the phenomena that ensured.) She passed a restless, wakeful, and almost delirious n. Respiration and heart’s action were hurried and irregular. Reflex excitability was marked for a time, when general muscular weakness supervened; and towards m. she fell into a state of stupor, in which Dr. Liell found her. Extremities were cold; there was clammy perspiration, anaesthesia, and slight paresis of muscles of hands and feet. Temp. was normal; pulse 55, and somewhat irregular; resp. 16 and slightly irregular; pupils but slightly contracted, responding readily to light. There was persistent contraction of flexor muscles of fingers and toes, with paresis of extensors, especially of thumbs and great toes. There was some spasmodic action of muscles of calves, which, when conscious, she termed cramp – like pains. She vomited occasionally. On application of warmth, with whisky by mouth and atropine (two 1/50 gr.) hypodermically, she rallied, recovering consciousness and speech. She then complained of severe paroxysmal pains in abdomen, very like those of colic; also of dimness of vision, with a blur before eyes. At one time, becoming quite delirious, partly due to pains in abdomen, she got out of bed and endeavoured to walk across room, but, being unable to stand on her feet, reeled like one intoxicated, complaining of a sudden vertigo, with feeling of numbness in soles; and would have fallen but for an attendant close at hand. A certain tremulousness of the fingers of both hands, with tremors of tongue, was present. Thirst was excessive, with dryness of mouth and tongue, relieved by small pieces of ice. There was no headache whatever, but for a fulness in the supra – orbital region. Speech was somewhat indistinct, utterance being at times thick; and there was also some difficulty in deglutition. Heart’s action was diminished in rapidity, and its rhythm was irregular. Urination was frequent and copious. About 3/4 hours after Dr. L – ‘s arrival she complained rather suddenly of severe cramp in both calves, extending upwards and gradually implicating muscles of abdomen, chest and neck; when a sudden and severe convulsive seizure followed, of marked tetanic character, abdominal and chest muscles becoming retracted and rigid. Eyes were suffused, and facial expression was that of great pain; resp. was entirely checked, and cyanosis very prominent, with jaws quite rigid, and fingers firmly contracted. This was followed by a second convulsive seizure of the same character some 3 m. later. Chloral and k. brom. were now given, which checked the convulsions; and from this time forward patient gradually recovered. The anaesthesia, and the paresis of hands and feet, did not entirely disappear until the 5th day (N. Y. Medorrhinum Journ., Sept. 19, 1885.
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.