21. Miss E. H. Lane, aet. 29, general health excellent. Dec. 15th took (a. m.) four 10 dr. doses, with 1 hours intervening between them. Felt soon after taking first dose needle – like pain in region of bladder, which continued during d. Eyes felt injected, were painful, and it hurt to close them, as if they were inflamed. Face was very much flushed. Felt dull, and ideas were confused; when talking could not think quickly of the right word to use. Did not feel any more marked symptoms ill next evening, when she felt a sinking at pit of stomach, and a peculiar dizziness after closing eyes, as if she were revolving about herself. Next m., upon rising, was extremely dizzy; could not possibly walk straight; was nauseated and obliged to lie down again. In course of an hours rose again, but was dizzier and sicker than before; but after vomiting about a gill of bright yellow, very bitter – tasting bile, felt better; drank a cup of coffee, and went out of doors, which made her feel much better. Through day had piercing, somewhat prolonged pains in the left side of head; and in m., while vomiting, and a while after, had colicky pains in hypogastric region. (Ibid.)
22, 23. Two male students took small and large doses (up to Zij) of tinct., consuming Zj in 2 day and Zij in 4 day respectively, without the slightest effect. (Ibid.)
BARIUM (see vol.
i,519)
II. 15. I was giving B. muriat. 3x to a girl of 8 for hypertrophied tonsils, a saturated 2 gr. tablet every 2 h. After taking it for 3 day, at breakfast the child suddenly threw her plate full of food against the wall, affirming that she could not help doing so. Her mother watched her during the day, and noticed these jerkings continue and increase, while she looked ” foolish.” The medicine was stopped, and I saw her next m., when I found slight twitching of the facial muscles, and decided jerking of arms and legs; all markedly worse when she was looked at closely. The expression of her face had changed, but I should call it listless rather than foolish. The drug was not resumed, and the untoward symptoms passed on inside of 3 day (S. A. Jones, Hom. Recorder, vi, 6.)
16. A man swallowed by accident 70 or 80 dr. of a solution of the chloride (strength not stated). He had soon after profuse purging without tormina, then vomiting, and 1/2 hours after swallowing the salt excessive muscular debility, amounting to absolute paraplegia of the limbs. This state lasted about 24 hours, and then went off gradually. (Christison, op. cit.)
III. 5. a. Dr. Campbell introduced 12 gr. of the carbonate into a wound in the neck of a cat. It excited on the 3rd day languor, slow respiration, and feeble pulse; towards evening the animal became affected with convulsions of the hind – legs and with dilated pupils, and death followed not long afterwards.
5 b. In all the animals which in Dr. Campbell’s experiments were killed by the application of the muriate to wounds, the brain and its membranes were much injected with blood; and in one of them the appearances were precisely those of congestive apoplexy. (Ibid.)
6. Ten gr. of the nitrate were given to a rabbit by the mouth. It died in an h. Dilation of pupils is noted during life, and, post mortem, brain, lungs and liver congested; stomach inflamed and rotten; rectum very much congested. (Woodman and Tidy, in Jones, loc. cit.)
7. Five gr. of same were given in same manner. In 2 hours convulsions, violent purging, dilated pupils. Died in 26 h. Brain was found normal; lungs and liver congested; stomach inflamed and very rotten. No apparent change in small intestine, but rectum was very much congested. (Ibid.)
8. Thirty gr. were given to a small terrier. In 2 hours insensibility, with vomiting, purging, and convulsions, pupils dilated. Died in about 4 h. Brain was normal; lungs, liver, stomach and duodenum congested; rectum intensely so. (Ibid.)
9. Ten gr. were given to a dog. No marked symptoms for 17 hours, then violent convulsions, vomiting, and purging; and, after 28 hours, paralysis. He recovered in 4 day (Ibid.)
10. Twenty gr. were given to another. There was vomiting and purging in 3 1/2 hours, and convulsions in 6. He recovered in 2 day (Ibid.)
11. A large dog was given 60 gr. In 8 hours he had convulsions and purging, and passed a large quantity of urine. In 23 hours paralysis of hind legs occurred. He recovered in 2 day ( Ibid.)
12. To another 120 gr. were given. In 1 hours there were convulsions, purging, and vomiting. He had great thirst, and voided a large quantity of urine. Death in 2 1/2 h. Brain was normal; lungs, liver, kidneys, all the intestines, especially the rectum, were deeply congested. Bladder was empty. (Ibid.)
13. Hoppe – Seyler had found that a dog, which died 2 weeks after administration of the carbonate, presented ” numerous haemorrhagic spots in the lungs, the tissue of which was breaking down.” Onsum sought to show that the poisonous action of these salts is primarily on the lungs, the symptoms always commencing there, respiration becoming quicker and less deep and inspiratory murmur inaudible; heart’s action at same time being more frequent. Afterwards restlessness is noticed, with loss of power, which at last amounts to paralysis. The carbonate was given to a rabbit in increasing doses. When the quantity amounted to 3 gr. daily, symptoms first appeared. In 5 hours after poison was swallowed the animal was found lying motionless, with respiration much quickened. Sensation appeared to be diminished. The dyspnoea and paralysis increased; temp. fell; and in 6 hours the animal died. Small coagula were found in the branches of the pulmonary artery. Portions of the lung substance were firm, not crepitating, and redder than the normal tissue. Miliary ecchymoses were found on the surface of the lungs, and also in the stomach. (S. A. Jones, loc. cit.)
14. A solution containing 0.25 gr. of the chloride was injected into the jugular of a dog. After 12 m. arterial pressure was slightly increased, and in 1 hours action of heart was slower. 0.50 gr. was now injected. In 10 m. slight diminution of pressure, heart’s action fluttering. In 14 m. pressure had increased by 1 in. one gr. injected. 11 m., pressure diminishing, with fluttering action of heart; 14 m., pressure increased again, heart’s action slower and very irregular, two or three quick beats and then a number of slow ones. 2 gr. injected. 12 m., action of heart arrested; resp. continued irregular for 1 1/2 h. It then became intermittent, and ceased 2 3/4 hours after heart had stopped. On opening thorax auricles were contracting vigorously, and continued to do for some m. Ventricles were still, and did not contract when irritated. The left cavities contained scarlet blood. Five m. after thorax had been opened its muscles commenced contracting, and continued in motion for 15 m. (Experimenter has seen these spontaneous contractions as late as 45 m. after death from B., in the penis and scrotum of a dog.) (Blake, in Ibid.)
BELLADONNA (see vol.p.526; Vol.ii, p.728)
I. 20. A. W. W., in full health, pulse 65 and regular, took 2 dr. of tinct. in Z of water at 9 a. m. 9.5, pulse 78. 9:10, pulse 90, irregular and uneven; pulsation of carotids; fulness and throbbing in head. 9:20 heat of face without redness, afterwards flushed and swollen; sharp pains in cheek. 9:35, painful twitching in arms, soon followed by restlessness and stiff neck. 9:50, mouth dry; thirst; constant desire to swallow; after drinking pains in stomach. 10:30, throbbing headache with heat; pulse 90, hard and full. 11, palpitation while in exercise, with laboured breathing. 12:30, no desire for food; throat sore when swallowing. 2, cramp – like pain in abdomen, extending to spine; occasional sharp pains in hypochondriac region. 3:45, very sleepy, but unable to sleep because of itching; scratching causes erythema. 4, pulse 84; occasional bitter eructations. 4:30, desire to urinate, urine scant and dark, followed by slight stool and colic. 6:30, pulse 80; perspiration on upper parts; congested feeling in pelvic region, with excited sexual desire. 8, called to stool, which was watery but scant, attended with tenesmus. 8:30, overcome with sleep; slept profoundly till late in m., awoke with dull headache and languor, no appetite for breakfast. (Woodward, Trans. of Int. Hom. Convention, 1881, p. 37.)
II. 18. I was summoned in great haste to see a child of 3, who had whooping – cough, and to whom, 1 1/2 hours previously, 3 homoeopathic pilules of B. had been given. On my arrival, a few m. afterwards, I found the child comatose, pupils widely dilated (iris a mere circle), pulse scarcely perceptible, respiration gasping, and skin bathed in perspiration. Under stomach – pump, sinapisms, and gr. 1/32 of morphia hypodermically, patient so far recovered in about 1/2 hours as to be able to swallow a little beef – tea with port wine. A few m. later I observed twitching of right eyebrow, and both eyes jerking to right side; then muscles of right hand and leg became implicated, there being about 4 – 5 spasmodic contractions to the m., synchronous with the jerking of the eyes. L. side was wholly unaffected. I kept patient partially under influence of chloroform for over an hours, when spasms relaxed; I then administered a warm water enema, which brought away a large quantity of extremely offensive faeces. Child by this time was quite conscious and extremely thirsty. A second attack came on about an hours later, but was subdued by the chloroform in 1/4 h. I gave another 1/32 gr. of morphia, after which child fell asleep and remained so for 2 h. He had no return of the muscular contractions; and pupils were regaining their normal state, though eyes were occasionally turned to right side. Three day afterwards child had completely recovered save for some slight aphonia. (Brown, Lancet, March 17, 1883.)
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.