8 d. On 14th injected about 1 1/4 grms. into left forearm; pulse 68. Immediately violent burning at point of injection, which looked very red. Face became hot; violent headache in vertex and pressure in brain, and very anxious sensation in pit of stomach, nausea, retching, chilliness, and after 25 m. vomiting of green masses, with outbreak of copious perspiration. Pulse 80, very small. The whole day very weak and unfit for any effort. On two following day headache continued, with sensitiveness in epigastrium, complete loss of appetite, and diminished digestive power. 17th. -At 7:15 a.m. took 1 1/4 cgrm.; pulse 72. In 1/2 hour symptoms previously observed returned; pulse 83. Headache and weariness lasted through day Sleep at night short, restless; some diarrhea.
8 e. In spite of unpleasant remembrance of former injection into vein, he repeated it on 18th, with 3/4 cgrm. Immediately frightful headache, heat of face, vision of sparks, very anxious sensation in stomach, -in short, same symptoms as after former injection. Retching without vomiting. Inflammation of the spot where injection was performed. “On this day. I examined my urine with nitric acid and microscopically. After the acid there was slight turbidity, and the microscope showed desquamated epithelium of the uriniferous tubes. This led me to discontinue further experiments on myself.” Turbidity of urine lasted 2 days; pain in stomach and head, and dysphagia, disappeared after 3 days, and appetite returned; but even after 2 months there were frequently recurring digestive troubles. During proving N. lost 7 lb. in weight. (A. NOBILING, Zeitschrift fur Biologie, Munich, 1868, iv, 42-46.) 9 a. Being in good health, pulse 64, took at 8 a.m., fasting, 5 mlgrms. of tart. em. in water. Dose was repeated for 5 day without perceptible effect. On 6th day, at 4 p.m., respiration seemed a little less free; but feeling no other effects, and appetite continuing good, took about 9 p.m. a dose of 1 cgrm. The n. was restless, sleep interrupted by a fatiguing heat; felt necessitated to drink several times; respiration slightly impeded. On rising, general uneasiness; weariness similar to what follows a febrile fit; mouth clammy. At 8 a.m. 1 cgrm.. No appetite for breakfast. All day in same state; about 5 p.m. greater uneasiness, especially about epigastric region; nausea; desire to vomit but without result; respiration more impeded; short dry cough, pretty frequent; great thirst; heat in head; white tongue; drinks always appear too sweet; clammy mouth; two loose evacuations during day; palpitation; bruised feeling and general weariness, compelling retirement to rest at 8. Ear applied to chest gave evidence of nothing abnormal, save that respiration appeared much too rough. At 9 p.m. took 5 mlgrms. Agitated sleep, difficult respiration, feeling of pressure on chest during sleep. At 5 a.m. wakened by violent rigor, lasting 20 m., and followed by heat; pulse which had hitherto been little affected, increased to 78, was full and strong; skin hot; face red; thirst urgent; heat in head; pretty strong palpitation; slight burning at stomach, fullness, and inclination to vomit; respiration very much impeded, with feeling of pressure and constriction of chest; cough frequent, and a little moister; on auscultation, respiration appeared rougher than on previous evening, and deep inspiration was accompanied by slight pain under left nipple. N. very agitated; disagreeable dreams, even nightmare. Took no more medicine. Continued much the same till evening of 10th day, when pulse was 72; respiration somewhat less difficult; cough the same; hardly any pain in side; great thirst; much uneasiness; n. rather less restless. On 11th day, a little less roughness in breathing (on auscultation); cessation of pain; skin still hot; thirst less; uneasiness diminished; appetite in part returned; respiration still obstructed; cough a little less; n. more tranquil. The symptoms continued to diminish, so that by 18th day there remained nothing but slight cough, which persisted some time longer.
9 b. Three months later, during 8 days took each morning 5 mlgrms. without feeling anything. The 9th day, at 8 p.m., took 1 cgrm. The night was somewhat disturbed, and the respiration rather less free. A little weariness on rising next m.; took another cgrm. During day some uneasiness; mouth clammy; little appetite; breathing impeded. About 10 p.m. 5 mlgrms.; sleep very disturbed, and towards m. uneasiness, especially at epigastrium; some nausea; loss of appetite; respiration impeded; a watery stool at night; great fatigue; urgent thirst. From morning of 8th day cough appeared, and went on increasing; it is short, frequent, and painful; auscultation gave no results. At 9 a.m. 1 cgrm. In course of day rigor, lasting 1/2 hours, with burning in head and beating of heart; thirst; inclination to vomit; pulse 80, strong, skin hot; cough dry and painful; considerable difficulty of respiration; sensation of weight on chest; auscultation finds rough respiratory sounds; general bruised feeling. This state continued all day and n., latter disturbed by strange and fatiguing dreams. Two watery stools in the 24 hours. On following day symptoms declined, but more slowly than first time, so that by 25th day health was not entirely restored. (MOLIN, Des Specifiques en Medecine, Paris, 1847.)
9 c. On July 5th, 1855, began to take 2 drops of 6th morning and evening During 10 day felt nothing abnormal. From 16th onwards heat of stomach after dinner, which in 5 days more came to last all d. On 23rd increased dose to 4 drs. No difficulty in getting to sleep, sleep disturbed; mouth pasty and bitter; lively thirst, but after drinking precordial uneasiness. After bad night, had on 24th no appetite for breakfast and malaise all day, with precordial uneasiness after ingestion of either solids or liquids. After dinner, some griping below navel, followed by loose and copious stool. Similar symptoms continued up to 26th, when there was added heat at anus after greenish stool; headache; heaviness over eyes; nausea; and ineffectual effort to vomit. In evening, weight on chest and dyspnoea; also bad humour, all noise about him seeming intolerable. Pulse 68. 27th. -Was awoke this morning at 2 by colic, followed by a liquid evacuation of greenish colour; burning pain at anus during and after evacuation; stomach distended and sensitive to touch. Intense thirst. Headache is more severe and head very confused. Eyes feel larger and swollen. Breathing short, anxious, and very difficult. Now and then a little, dry cough. Pulse 72, and dull. Rose at 10; had cramps in legs, and constant desire to stretch; no appetite, but forced myself to eat. Scarcely was meal over but sickness began, increasing till I vomited. I became very pale and felt stifled; I had also gastric pains, to which I am subject. Am obliged to stop taking medicine. Same state of suffering continued all day, and I only took broth and wine now and then. Restless at n., and sleep bad. 28th. -At 4 a.m. a motion semi- liquid. I can take no breakfast on account of the sickness, which still continues. I suffer much pain in legs, and my stomach is very painful, although these are chronic pains to which I am subject. My breathing is oppressed and my face pale. I ate a little at mid-day and also in the evening, but without relish. I have great thirst, with a desire for strong liquors and acids. Slept pretty well. 29th. -Awoke feeling sick; head; confused; conjunctiva rather yellow; complexion not so pale. After breakfast bowels were relaxed. After dinner another motion, of a greenish colour. I felt very tired, and a strong inclination to go to bed. At night had troublesome dreams and nightmare. 30th. – Still feel very tired, with a great desire to stretch myself. Pulse 64. My face has resumed its natural colour. After breakfast had a semi-liquid motion. The gastralgic symptoms continue. Head and chest become comfortable. I dine with a good appetite; and I sleep well. 31st. -All symptoms are abating, and on Aug. 2nd I find myself in my usual state of health.
9 d. June 3rd. -In good health. I commence to take every day a drop of the 18th dil. morning and evening 11th. -No symptoms having occurred I double the dose (2 drops). 15th. -Sleep was rather uneasy in the n. 16th. -In m., and at noon, the bowels were relaxed. I have general uneasiness. 21st. -Nothing. I take 4 drops morning and evening 22nd. -Uneasy night; awoke frequently. I have not much appetite. Stomach feels uncomfortable, and I have some pain in bowels. For last 4 day, motions have been soft. Head a little confused. 26th. -I take 6 drops morning and evening 27th. -Did not sleep well; had several emissions of urine; Thirsty; stomach very uncomfortable; no appetite. At 12 I took breakfast, which I enjoyed. After that had pains in bowels and a sort motion. Then felt easier, and was pretty well rest of day. Had strong palpitations in night which awoke me. Head felt heavy. Was very hot; a dry heat, so disagreeable that I got up. Extreme thirst. 28th. -Head still heavy; feel fatigued. After breakfast, slight pains in bowels; head heavy; sleepy. Fell asleep in my chair, and awoke in 20 m. with palpitation. Dined without appetite and was afterwards seized with colic, followed by an abundant liquid motion, accompanied by pain in bowels and back. 29th. -Awoke at 1 a.m. with strong palpitations. Head uneasy, but not aching. Felt irritable and wished to rise. The uneasiness continued all n. In m. I greatly desired some cold drink. General lassitude; pale face; no appetite. At noon, breakfasted in pain. An hour after, I had colic and an action of the bowels. Feel fatigued; have pain in back, and a wish to stand up; also cramps in the legs. I have very great fatigue; head is still heavy; no appetite. At night uneasy, but not so much so as on the preceding one; palpitations are less violent. 30th. -After breakfast, an abundant liquid motion, but no colic. Breathing is oppressed; it requires an effort to take an inspiration. Heart beats more quickly. Very little appetite for dinner; feel sick; have great thirst. Feel so uncomfortable that I am compelled to go to bed. At midnight, I awake with palpitation; pain at base of right lung, increased by taking a long breath; respiration difficult and incomplete. Dry cough. Much thirst. Pulse 85. About 4 a.m. slept quietly and perspired profusely. July Ist. -No appetite; feel sick; pain in side is less. After soup taken at mid-day another motion with colic. Head is hot; skin dry. Pulse continues more frequent. I am ill-tempered. Could take no dinner. At 9 p.m. griping pains; also felt a want of food. Took a little wine with sugar, and two biscuits. Then I went to bed quite exhausted. 2nd. -Sleep has been disturbed. At 2 a.m., awoke with the pain in my side, which was worse; to lie on that side was so distressing that I had to change my position. The difficulty of breathing increases the pain, and respiration is imperfect. The lungs feel full (distended); dry and frequent cough. Clothes feel too tight; obliged to unbutton my shirt collar. Determination of blood to head; palpitation on left side. Skin is dry and very hot. Face much altered. Great thirst; nausea. In bed I am very uncomfortable. I leave off the medicine, but symptoms continue. I have a bitter taste and headache. At noon I eat a little. Headache is diminishing; skin not so dry. I lay down and slept 4 hours Headache then much less. For dinner, broth and meat. Afterwards, a copious stool. I am excessively fatigued, and have pain in the back. At n. I am very restless, and have much pain, but no palpitation; stomach more comfortable. 3rd. -I eat with a relish. Lungs are more free; pain in the side is less; headache is diminishing. No action of bowels to-day. A pretty good n. 4th. -When I awake I am almost free from pain; headache gone. Still some discomfort of stomach, but I eat with relish. Pain in side and breathing not yet quite right. No motion. Good night. 5th. – Stomach is all right; slight uneasiness in side. Appetite good. Bowels all right. 10th. -All the symptoms are gone; I am in perfect health.
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.