The following are without note of time:-Indescribable headache. Heaviness of head. Shooting-like electric shocks in both inner canthi and pressure in eyes. Flickering before eyes, especially on rising from seat, several times in an hours, of short duration, she seems to see through a thick veil, with vertigo (several d.). Disagreeable sensation in palate all the time. Appetite generally food, sometimes bad. Empty eructations. Great nausea with dislike to the accustomed milk and pinching in belly. Nausea, inclination to vomit after eating anything. When sitting fermentation in abdomen that changes to pinching and discharge of flatus (afternoon). The belly seems full of stones, though he has eaten nothing, and it does not feel hard to touch; a sensation like what occurs after long-continued sedentary work. The pain in abdomen causes great restlessness of body, with inclination to move some limbs or to change the position. The pain in abdomen is not violent, yet so severe as to cause great restlessness of disposition and disinclination to all work. Frequently a feeling of pulsation in abdomen. Pinching in belly with production of flatus. Sometimes the pressure in the abdomen when rising up and walking about is relieved by discharge of flatus, when standing, but returns immediately when sitting, especially in a bent-forward position. Hard stool, one day no stool. A quick peculiar burning irritation, somewhat like tickling, but not of a voluptuous character, yet extremely troublesome, relieved by nothing, extends, commencing from the region of the rectum through the urethra, to the glans penis, where the tickling is greatest (lasts uninterruptedly six or seven days and is the most annoying symptom). Violent tension in perineum, especially when walking, with great urging to urinate (several day uninterruptedly). The tips of fingers die away, feel dry and hard, several days. Feet go to sleep immediately after sitting down. The fever continues uninterruptedly in a dull way, but is much aggravated by quick and violent movement, especially on sitting down afterwards. Great laziness in limbs. Relaxation of whole body. Great prostration and laziness in body, he feels best when he sits still and does nothing. When sitting the symptoms are frequent, or they are caused by it. Constant stretching and yawning, forenoon. Restless sleep. Chilliness. Several forenoons severe chills. Afternoon, constant heat aggravated by slightest movement, it affects head chiefly (daily). Towards evening hopeless, desponding humour, with chilliness, pain in chest, and great drowsiness. All the time an uncommon, remarkable wild merriment, less noticed by herself than by others; towards evening this went off and was replaced by vexation, crossness, and anxious thoughts for the future; she thinks she shall remain permanently in this state. (Ibid.) 4. STAPF. In 1/4 hour, drowsiness, eyes closed involuntarily, he fell asleep with head erect (he was being carried), so hard to awake that he did not so when his eyes were forced open, when the pupils were found to be contracted, at same time moderately warm hands and face and tranquil breathing; occasionally retching woke him up for a few minutes. (in a child 2 years old). In 3 hours, audible movement of flatulence in stomach. Without note of time:-Slight tearing, drawing pain in left half of head from behind forwards. Head heavy and requires support behind. Occiput heavy, with anxious oppressed feeling. Slight attacks of headache in forehead. Pressive headache in middle of forehead above nose. Pressive forehead on left side of forehead, with pressure in eyes. Great pallor of face for 1 hour. Burning and smarting of inner canthus of right eye and redness of conjunctiva. Pressure in both eyes. Sudden stretching pain on upper part of right eyeball. Tearing pain on left side of root of tongue, observed when swallowing. Grey furred tongue. Salt taste in mouth. Empty eructation; it relieves pressure in stomach for a time. Great flow of water into mouth. He retches several times violently and profuse sweat comes on forehead, legs very tired, water flows out of mouth; afterwards weakness. Nausea causing a peculiarly disagreeable sensation in throat. Confusion of head with increasing nausea. Empty eructation relieves the nausea for a very short time. Excessive nausea with pressure in scrob. cordis. Nausea somewhat relieved by expulsion of flatus. As the nausea increases and slight retching comes on in throat, a spasmodic movement take place in upper abdomen. Nausea with slight pressure in scrob. cordis, then frontal headache. The anxiety becomes greater as the nausea increases, at the same time there is a slight pressure and some heat in abdomen, in which there is a rumbling of flatulence. After violent pressure in stomach, retching. On drawing in the belly shooting pain below scrob. cordis.. Up from scrob. cordis occasionally cutting sensation. Slight burning in stomach. Slight shooting tears pains on a small spot in left hypogastrium. The abdomen is distended and there is a gurgling in it, felt extremely. Transient tearing pain in left side of upper abdomen, often recurring. On drawing in abdomen a small spot in left upper abdomen is painful. Rumbling in bowels soon after taking med. The pressure in abdomen sometimes become stronger and is directed towards rectum, and then there is quietly discharged boiling hot flatus, whereupon the pressure is relieved. Bright brownish-yellow diarrhea. Before diarrhea rumbling about in abdomen, which is not distended. The diarrhea is very watery. Burning in anus after stool. Urine dark reddish brown, turbid and of fragrant odour. Urine turbid and dark at first, afterwards clearer. Slight tearing pain in anterior part of urethra. Violent tickling in middle of trachea causes short cough. Violent, rheumatic long-continued pain in whole left side, repeatedly. Short, shooting-tearing pain, especially at lower part of right side of back near right hip. Rheumatic pains in and over left hip. Just below left hip transient rheumatic pain. Slight rheumatic feeling in left pelvic bones. Rheumatic drawing in upper part of right thigh. Violent rheumatic pain between left calf and ankle, and at same time rheumatic pains in furthest back lower right molars. Rheumatic pain on outside of left calf. Cold feet. On rising, and shortly before, rheumatic and bruised feeling in limbs. Weariness in legs. He rests his eyes with his hands like one quite overpowered by sleep, and wakes up in bad humour, e.g. when anyone looks at him he begins to howl. Absence of thirst. (Ibid.) 5. No more desire for tobacco. Frequent spasmodic yawning. Desire for juicy fruit. Violent sneezing five times; then pain deep in chest and esophagus. Appetite for sour things. Stitches above pubes. Sensitiveness of the oesophagus so that unchewed morsels cause much pain. Stomach internally sensitive, he feels the morsel all through the esophagus and even in the stomach. Sour eructation. On the back of left hand when touching the little hairs fine severe pricks. Weariness in the knees. (HERING, Archiv, xiii, 2, 183. No information.) 6 a. Dr. MAYERHOFER dissolved 1 gr. crystallized tart. em. in 100 drops distilled water and took for 5 successive day 1 dr. daily in a spoonful of water before going to bed without obtaining any symptoms. 6th d. Took 1 dr. 3 times a day Sleep more dreamful than usual. Woke in m. with sinciput confused, relieved by rising. Taste dry and pasty, appetite good. 7th day Took 3 dr. 3 times a day Felt pressure in scrob. cordis and greater confusion of sinciput, taste pasty, appetite more than usual. N., sleep restless and dreamful. 8th day Same dose as yesterday. M., head much confused, pressure in frontal region, heaviness and pressure in stomach with bitter eructation. Taste bitter, pasty and appetite less. M. Urine dark yellow, clear, no sediment; a cloudy sediment of bladder mucus soon formed, and next day a voluminous sediment of pale red colour, and containing some earthy phosphates and free uric acid; acid reaction; sp. gr. 1018; got turbid by heat, but clear again on adding nitr. ac., and contained am. carb. The earthy phosphates were copious, as also phos. sod. and sulph. sod.; sod chl. rather lessened. Uric acid free, but not much increased; urea increased. After eating bitter eructation and pressure in stomach, fullness and oppression of bronchial tubes, with hard anxious breathing. Pulse somewhat excited and lively. Chilly feeling with prostration in extremities. For last 3 days constipation with distended abdomen. Sleep next n. very restless and dreamful. 9th day Took 4 dr. 3 times a day Very painful pressure in crown, and confused frontal region, at same time strong pulsation of frontal arteries, and increased heat of whole head as from congestion to head. Oppression and pressure in scrob. cordis with anxiety about heart; heart’s beats small and unequal. Tight feeling in thorax with hard full breathing, increased secretion of viscid mucus from bronchi and trachea with audible mucous rales. Towards evening sour eructation, pressure in stomach, oppression and nausea, with irritation to vomit. Increased secretion of saliva. Urine pretty copious, and also two pappy stools. Urine dark, dirty yellow, slightly turbid, no sediment, acid; sp. gr. 1018. Grew turbid when heated, which was removed by nitr. ac.; contained carb. of amm. Earthy phosphates copious, sulphates increased; sod. chl. diminished, phos. sod. copious. Uric acid free, copious; nitr. of urea increased. Next n. slept restlessly and had many dreams, confused head, tossed about much. Passed much urine. M., felt head very confused, and accompanied by obtuse pressure in frontal region. 10th d. Same dose as yesterday at three intervals. Symptoms of head, heart, and respiratory organs as yesterday. Appetite diminished, pressure in stomach and weight as if overloaded with food; bitter eructation, and after dinner constant inclination to vomit, with frequent belching of bitter bile. Taste bitter and pasty, great flow of water and saliva into mouth, appetite diminished, thirst increased. Frequently during day horripilation, with slight retching, eructation and constriction of esophagus. Sometimes a chilliness going from within outwards, starting from the dorsal vertebra, and spreading all over abdomen and upper extremities. Slight cutting pains in belly, two semifluid stools. Urine pretty copious, like that of yesterday. Following n. sleep restless, dreamful, for long spells could not sleep. 11th d. Same dose at same time. Same symptoms as previous day, only head and stomach symptoms more severe; appetite diminished, thirst increased. After dinner violent pressure in stomach increasing to nausea, when much water and saliva ran into mouth, tasting very bitter. The mucous secretion from bronchi copious. Occasionally during day recurred heat of all the body so that he broke out in profuse perspiration, which stood on chest in large drops. During day two semifluid stools, stomach and liver painful to touch, abdomen rather distended. The stools contained much bilious matter. Urine in good quantity, like yesterday. Next n. was restless and dreamful. 12th day, m., 6 dr. In 1 hour violent pressure and weight in scrob. cordis, heat and restlessness of whole body, confused heat, and nausea. Violent retching, and with great effort vomited viscid and watery phlegm after great flow of saliva and water into mouth; the vomited matter tasted bitter, and had a very acid reaction. Antimony was detected in the vomit. Taste pasty and bitter, appetite diminished, thirst increased. Urine copious, observedly little altered, sp. gr. 1016. During d. two semifluid stools of bright yellow colour and strong smell. Traces of ant. in stools. Omitted taking drug till 14th and 15th day, when he took each day 16 drops in 4 doses. Sinciput very confused, tensive pressure and weight about frontal region. In scrob. cordis boring and pressure with full feeling in stomach, bitter eructation and pasty bitter taste, tongue dirty white and furred yellow, appetite diminished, thirst increased. Towards e. abdominal integuments somewhat tense and sensitive to touch, urging tenesmus to stool, but without result, urine very copious. Tearing drawing and weight in extremities with chilly feeling all over body from within outwards, no power to get warm, combined with great malaise. Breathing in evening fuller and harder with great precordial anxiety. Pulse quick and no uniform. When lying in bed was taken with a peculiar vertigo, was often sick, and had frequent eructation, loathing, and flow of water into mouth. Urine dark yellow, slightly turbid, no sediment, sour reaction, sp. gr. 1018, otherwise much the same as before. Next n. sleep restless and dreamful, and by next m. there were catarrhal symptoms in throat, and increased secretion of saliva. Next d. two semifluid stool of strong character and dark yellow colour; trace of ant. in them. The evening urine was dark yellow, slightly turbid, no sediment, acid, sp. gr. 1021, no albumen; much uric acid and urea.
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.