6 b. Next d. dissolved 1 gr. ant. t. in 100 drops water, and took 6 drops three times a d. Very ill after second dose, sinciput confused, tension in crown, peculiar pressure on eyes as if eyeballs were quite heavy. Anxious pressive feeling in precordia, bitter eructation, pasty bitter taste and loathing were the precursors of violent nausea. With third dose had great flow of watery saliva into mouth, frequent hiccup and eructation, urging in throat and violent retching, always increasing until vomiting occurred with great effort; phlegm and water were vomited. After a short time retching again came on and he vomited viscid phlegm and bile; matter vomited acid, and smelt sour. The attendant symptoms were general sweat upon chest, secretion of much bright-coloured urine, and later two liquid slimy bilious stools, with rumbling and urging in belly. Pulse small and contracted, respiration lively, and thirst great. At n. much tough phlegm secreted in throat causing cough, breathing oppressed, slight stitches in left thorax on inspiration. N. very restless, full of dreams. Woke in m. with dull heavy head and great discomfort. Yesterday’s urine was of bright yellow colour, clear, without sediment, acid, sp. gr. 1018; contained earthy phosphates in considerable quantity, sulphates increased, chl. of sodium normal, phosphate of soda copious. It contained traces of sulph. of ant. The n. urine was dark red, clear, without sediment, acid, sp. gr. 1020, uric acid and urea pretty copious. No traces of ant. Next m. urine dark yellow, rather turbid, acid, sp. gr. 1025; contained a very small quantity of albumen, uric acid and urea diminished. The thin liquid slimy stools of yesterday contained much biliary colouring matter, but very slight traces of ant. The matter vomited consisted of water, stomach mucus, and biliary colouring matter, was acid, and contained traces of sulph. of ant.
Felt for some day a peculiar weakness of limbs, deranged digestion, and confused head, increased secretion of viscid mucous fluid from bronchi, and catarrhal symptoms. In abdomen slight cutting pains with semifluid, rather pappy stools. After some day felt tiresome itching in various parts of skin, especially on inner surfaces of thighs, where small pimples appeared. Urine remained for some day copious. It gradually returned to its normal condition. Only once could traces of albumen be discovered.
6 c. Several weeks after this he took 1 gr. of crystallized ant. tart. at once in 1 oz. distilled water. In 10 m. felt pressure and heaviness in scrob. cordis, anxious breathing, and nausea; in 15 m. confused sinciput with sudden congestion of head, flow of water and saliva into mouth, quickened fuller breathing with full quick pulse, anxiety, loss of hearing and sight, weakness and weariness of limbs; after 1/2 h. violent sickness, cold coming over him, pale face, loathing, frequent retching, constriction of throat, and finally, after great straining of chest and abdomen with sweat of anxiety, vomiting of watery viscid slime, then of pappy masses of food, and finally of a slimy bilious-coloured bitter fluid. The vomited matter smelt and reacted acid. Then passed much pale urine. After some h. two semi-liquid stools. After this felt very weak and prostrated, fell asleep tired out and awoke in profuse perspiration. The ejected matter contained ant. The urine passed after vomiting was of bright yellow colour and sp. gr. 1016, but showed nothing abnormal. The urine passed next. m. was very dark yellow, sp. gr. 1020, and resembled inflammatory urine. (Heller’s Archiv. f. phys. u. path. Chemie u. Mikroscopie, III Jahrgang, 1846, pp. III-124.) 7. Dr. DE MOOR took gr. 1/4, and experienced flow of tasteless, clear water into mouth, out in great quantity, with retching and straining that brought up nothing beyond a little clear mucus; eructations, sometimes tasteless, sometimes nauseous; indescribable malaise in region of stomach and abdomen, on touching parts gently pain increases in stomach but in abdomen is relieved; dull belly-ache, with slight horripilation and goose-skin; easy expectoration of a good deal of sweetish, transparent mucus; frequent yawning; slight chills, with drowsiness and weakness. (Allen’s Encyclopedia, vol. i, from Rev. de la Mat. Medorrhinum Spec., v, 436.) 8 a. -Following the example of Dr. Mayerhofer, I began, Sept. Ist, 1866, with I milligramme at 8 a.m., pulse being 73. No effect. At 3:15, pulse 71, took 2 mlgrms. After about 3/4 h. felt rather uncomfortable for 10 m., pulse rose to 72 and 73, after subsiding of discomfort returning to 71. On 2nd, at 8 a.m. took 3 mlgrms. After 45 m. some discomfort, disappearing after 12 m. On 3rd, took at same h. 4 mlgrms.; pulse 72. After 40 m. slight headache, nausea, and very acute sticking pain in epigastrium, disappearing in 1/4 h. Pulse 74; in 1/2 h. 70, in another 1/2 h. 68. Appetite at noon diminished. At 3 p.m., pulse 73, injected 1/4 c. cm. of a strong solution (1/2 cgm.) into left thigh, pulse 73. After 5 m. vivid redness and burning pain at point of injection, relieved by cold compresses; pulse 75. 10 m. after violent heat, headache, nausea, weakness, gradually increasing, till after 10 m. more sweat broke out; pulse 79. Much exhausted; felt great need of rest. Pulse after 15 m. 72, after another 1/4 h. 67. In evening took very little food, and then felt constant burning in throat, swallowing also was difficult, anorexia, increased thirst, sleep broken. 4th. -On waking slight headache in vertex, and little appetite for breakfast. Took about 8 mlgrms. of ant. tart.; pulse 71. After 38 m. came first symptoms of discomfort, soon disappearing, but 10 m. later returning with increased violence. Very disagreeable pressure with anxiety in scrob. cordis, which was distended, and very sensitive to touch, which caused a shooting; constant recurrence of yawnings, eructations, and rumbling in abdomen; alternations of chill and heat; feeling of coldness in hands and feet; pulse 74. After 15 m. this condition entirely disappeared, and gave place to weakness, weariness, and prostration of limbs, so that he could hardly rise from his chair; pulse 70. Nausea continued all day, with disagreeable taste in mouth and copious secretion of saliva. Ate scarcely anything all d. Persisting weakness sent him to bed earlier than usual. 5th. -Rose with confused head and weakness of limbs, otherwise well. At 8 took 1 centigramme of ant. t.; pulse 70. After 1/2 h. nausea, yawning, eructations, rumbling, pain and pressure in epigastric region, accelerated respiration (20), headache, burning in throat, dysphagia, accumulation of saliva in mouth, chilliness, weakness, and retching; pulse 75. These symptoms gradually diminished, and in 1/2 hour only dulness of head and weakness remained; pulse 69. There was great aversion to all kinds of food, and scarcely had some soup (swallowing of which was very painful) been taken at noon when most violent retching came on, but without vomiting. A disagreeable taste in mouth obliged him to drink much cold water all day, which afforded some relief to this and to dysphagia. Weariness caused early retirement, and sleep was good. Next day not much appetite, epigastric region felt painful; headache persisted, but only to slight degree. Dysphagia considerably relieved.
8 b. On 8th, feeling perfectly well, took 1 cgrm. at 8 a.m.; pulse 74. After 30 minutes felt first indications of nausea; pulse 79. With increasing nausea pulse rose to 84: there was violent retching, chilliness, perspiration, and vomiting of some of his breakfast; pulse 88. With increasing weakness and diminution of nausea pulse fell to 71, and 1/2 hour later to 67. At noon most intense aversion to food, sight of which causes qualmishness. During day weakness, headache, and pain in abdomen, latter increased in severity by slightest movement. At night slept little and very uneasily. 9th. -Woke with confused head and burning in esophagus; at breakfast little appetite; pulse 69. Took 12 mlgrms. After 34 m. nausea, epigastric region swollen and very painful; pulse 72. These symptoms disappeared, but returned in greater violence after 5 minutes, with metallic taste, salivation, burning in throat, coldness of extremities, retching, chilliness, sweat; pulse 77. Drank cold water; pulse fell to 72, but soon rose to 79. Symptoms disappeared after 1 1/2 hour; pulse 72; only weakness, confusion of head, and pain in esophagus remained. After 1 1/4 hour counted 65 weak beats of heart. Through day copious saliva and no appetite. On following days weak and prostrated; eyes surrounded by blue rings, and sunken; headache absent only for short periods; pulse 69 and 70.
8 c. Dec. 12th, injected 1 cgm. in solution into a superficial vein in left forearm. He had scarcely emptied syringe when he experienced raging headache, saw sparks of fire, had burning heat in face and considerable pressure in brain; at same time violent precordial anxiety. Dyspnoea followed, all became black before eyes, he was so giddy that he was obliged to sit down; vomited green masses with great effort. Very free hemorrhage from seat of injection, requiring persistent compression to stop it. Through day felt weak, as from severe illness, 13th. -Headache and pain in stomach continued; took 7 mlgrms., after which there was nausea but no vomiting. Pulse rose within 34 m. from 75 to 79, and 1 hour later fell to 70. Little appetite; slight diarrheic stools.
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.