After the first stage has passed, and the disease has become a secondary condition, it is a loss of time to prescribe other than the deep acting anti-miasmatics, as the superficial remedies are only palliative and prolong the case, often leading to discouragement both of physician and patient. No other fact has been more deeply and more frequently impressed upon my mind than this: Sycosis is a profoundly acting miasm; it acts upon every cell of the human organism, even to the very depths of the physical being.