2. Mr. Procter administered a grain of lobelina (alkaloid of L.) in solution to a cat. In less than 2 m. it occasioned violent emesis and much prostration, from which the animal fully recovered in 3 h. Again, 1 gr. in 3j of water was introduced into the stomach of a cat by means of a tube. Immediate and total prostration was the consequence, which in 1/2 hours rendered the animal almost motionless; its pupils were much dilated. It gradually recovered its strength, but the effects of the poison were evident for 15 hours afterwards. No emetic or cathartic operation was produced. (STILLE, op. cit.)
3. According to the investigations of Ott, left in moderate doses first increases the blood-pressure by acting an an excitant on the peripheral vaso-motor nervous system. This primary effect is not of long duration, a fall in the blood-pressure soon occurs, the peripheral circulation is so embarrassed from weakened power of the heart and obstructed pulmonary circulation that oxygenation of the tissues is rapidly impaired, and a marked reduction of temperature takes place. (BARTHOLOW, Mat. Medorrhinum and Theridion, sub voce).
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.