12. Dr. G. OTTO PIPER, of Dresden, July 13th, 1840, took 2 dr. at 5 a. m. fasting, and at the same time next day 4 dr. Slight retching followed the scraping, which, with constriction and elevation of pharynx, lasted 1/4 hours 26th. -6 dr. At midday severe tearing in fibula from below up to knee, on both sides. 17th, gtt. 7; 18th, gtt. 8; 20th, gtt. 10; 22nd, gtt. 16. In forenoon severe constrictive pain in left posterior iliac region, scarcely permitting of its being touched or moved. Unusual languor until towards e. Painful heaviness of genital organs. 23rd. -On awaking same condition, lasting till 9 a. m. During forenoon perfectly well. 24th. -20 dr.; the condition of genital organs came on in evening again, but less severely. 25th. -Quite well. Could not continue the experiment on account of the burning and scraping, much more severe than that from Mezereum, Ledum, Polygonum, and Euphorbia; and the nausea arising from the large doses lasted until noon, and prevented the prover from attending to his work. (Ibid.)
13. BARRALLIER’S experiments, Ist series; dose, 5 dr. in water at 8 a. m., fasting. 13a. A young man, aet. 20, in good health, pulse 72. Nothing noticed on taking the dose except sensation of pricking in the throat, lasting several m. At 10 a. m. headache, gradually increasing in severity. 11 a. m., decided sleepiness, slept until 3, and awoke with headache worse. 3:30, sharp colic, with 3 diarrhoeic stools. Headache and colic lasted a great part of the night. 13b. Healthy subject, aet. 27, pulse 74. At once piquant flavour in mouth, as from tobacco in powder; at 9 a. mn. slight sensation of constriction in thorax; normal condition rest of d.
13c. Healthy subject, aet. 20, pulse 58. During Ist hours nothing noticed. At 10 a. m. slight colic, increasing until evening, followed by 4 large liquid stools; annoying borborygmi; no appetite all day; pulse unchanged. Towards evening general malaise, with perspiration and constriction of thorax. These symptoms did not last long.
13d. Healthy subject, aet, 29, pulse 74. Piquant feeling in the throat at once. At 1 p. m. slight colic, then heavy sleep for 1 hours; on waking colic became severe, followed by 2 diarrhoeic stools, when the pulse fell to 58 per m., but remained full. All symptoms gone by 6 p. m. (Bull. Gen. de Therap., lxvi, 76.)
14. Second series. Dose, 10 dr. in water. 14a. Subject in robust health, aet. 25, pulse 76. On ingestion disagreeable piquant sensation in mouth, especially at tip of tongue and back of throat, lasting about 1/2 h. At 10 a. m., slight headache, gradually getting worse; drowsiness, pulse weaker, 60, become small and occasionally intermittent. Painful constriction in region of sternum; pupils slightly dilated. In afternoon all these symptoms disappeared except the drowsiness.
14b. Subject, aet. 28, pulse 70. At once similar sensation to previous experimenter. 9 a. m., constriction of thorax, mental inactivity, and inaptitude for work, muscular fatigue. 11, slight colic. Afternoon normal. 14c. Subject, aet. 20, pulse 72. Immediately eructations and distressing nausea, lasting 15 m.; headache and thoracic constriction in afternoon, and general weakness in e.
14d. Subject in robust health, aet. 20, pulse 70. For an hours or two only felt result of local contact of liquid and some nausea lasting about 1 h. At 10 a. m. slight dilatation of pupil and considerable sense of tightness of thoracic region, as from a tight band round chest. This tightness, which occasioned very obvious embarrassment of breathing, lasted about 20 m.; towards evening intense headache. (Ibid.)
15. Third series. Dose 20 dr. in water (2 spoonfuls).
15a. Healthy subject of good constitution, aet. 47, pulse 68. Sensation of roughness and dryness in back of throat, eructations and distressing nausea until 9 a. m. A few seconds after eructations left off a very painful constriction of thorax set in, especially at lower part; pulse fell to 56, was small and irregular. Praecordial anxiety, action of heart occasionally tumultuous. This very painful condition lasted 1/2 hours, and was accompanied with severe headache and drowsiness. Pupils dilated, anorexia all d. Stool easier than usual.
15b. Subject, aet. 27, of good constitution, pulse 72. Nausea on swallowing drug; following of weight in epigastrium, eructations, constriction in region of sternum and of larynx; dysphagia. 10 a. m., intense headache, sleepiness, dilated pupils, disturbed vision; pulse irregular, 58; no appetite. ( Ibid.)
16. Fourth series. Dose 40 dr., fasting in 2 spoonfuls water.
16a. Dr. BARRALLIER, of god constitution, aet. 47, pulse 66. Very disagreeable piquant sensation on swallowing dose, nausea and inclination to vomit difficult to repress, painful eructations, very distressing general malaise, praecordial anxiety, extreme difficulty of breathing caused by severe constriction in centre of chest hindering respiratory movements, dysphagia, hoarseness of voice; at same time vertigo, headache, disturbed vision, pupils dilated, constant nausea, walking difficult, pulse 50 per m., small and irregular. This condition of discomfort was succeeded after about 1 hours by heavy sleep, disturbed, however, by the least noise; some colic in the afternoon, with dislike for food; during n. unrefreshing sleep, interrupted by hallucinations. (Ibid.)
17. Dr. NORTON, on March 22nd, about 1 hours after breakfast, took 3ss of tinct. followed in an hours or two by slight nausea. 23rd. -Took 3j. Slight nausea only. 24th. -Took 3ij after breakfast. Nausea all m.; uneasiness or feeling of lump or weight stomach for a few movements; about noon burning pain in back as if in posterior wall of stomach; nearly all the symptoms disappeared towards evening 25th. -Took 3iiss. Eructation immediately after, repeated several times during d. Nausea and sensation of a lump or weight, as if from undigested food. A sensation of warmth or burning all over stomach; rumbling in bowels and passage of flatus downwards. No appetite for dinner; dryness of fauces; spitting at intervals. Amelioration of all symptoms towards evening; enjoyed tea. (Brit. Journ. of Hom., xvii, 464.)
18. Provings of L. syphilitica. -Dr. WILLIAMSON took 2nd dil 10 dr. twice a day for 3 d. On Ist day, 1/2 hours after first dose, pain on left side of head, over coronal suture; dryness of left half of palate; sense as of lump in upper part of oesophagus; hiccup; transient pain over left kidney, and soon afterwards in left hypochondrium; heavy pain in left radial muscles; p. m., pain in both mastoid processes, first felt and worst in right; drawing sensation under right eye; sense of dropping under left check-bone, pain in right maxillary joint and in middle of right lung; after 2nd dose, return on pain over coronal suture and in radial muscles, but of right arm. On 2nd and 3rd day acute pain along right temporo-frontal suture; smarting itching of left internal canthus; dryness of throats, with sense as if pharynx was open like a funnel; three loose stools; increased quantity of urine, with free discharge. On 4th day, awoke at 3 a. m. with violent pain in stomach, and pain and borborygmus in bowels, followed by copious watery stools, with tenesmus and soreness in anus; had four similar attacks during day, and they became so violent that he took podophyllin twice, which arrested the diarrhoea, and the pain gradually subsided during evening, but pain in stomach and distension increased, with hunger and water-brash. On 5th day felt as when suffering 13 years ago with dyspepsia, temporarily relieved by drinking cold water; jolting of an easy carriage gives pain in stomach and both hypochondria; boring pain in right orbit, and soreness of eyeballs when turning them; flushed face, with heat, when lying down; bleeding of gums with putrid taste; rheumatic pain along right clavicle, and over right inner ankle; stiffness of nape from looking up; sense of coldness with aching in both knees through d. On 6th day, headache after dinner with face, drowsiness and lassitude, and inability to sleep when lying down, -somewhat better on going into open air; drawing pain in right cheek-bone; morning hoarseness and cough; pain under left breast; sore pain in joints of left big toe; at n. restless sleep with frequent wakings, and headache continuing till daylight. (HERING’S provings, Hahn. Monthly, vi, 520)
19. Dr. JEANES took 5 dr. of 2nd dil. Immediately pain in region of left tonsil. During Ist hours, in this order, pain about junction of 6th right rib with sternal cartilage; continued itching in left ear; constrictive feeling of mouth and tongue, especially at left commissure of jaws; pain in region of left kidney; confused feeling, with slight aching, in head, and frequent mistakes in writing and spelling; very considerable aching of right shoulder and fingers whilst writing; itching of left internal canthus; pain in both hips occasionally (also after several hours); coldness of hands and heat of forehead; sinking feeling in stomach, followed by borborygmi; stitching-drawing pain in left anterior lumbar region; aching in cartilage of sixth left rib;pain in fleshy part of last phalanx of left great toe; pain in left chest near axilla, with aching in left shoulder and arm; stiff numb feeling in right palm; stitching pain in left temple; burning in right eye; stitching pain in right renal region; itching in left external canthus; pain in left ear; soreness of right eyelid; great soreness, rawness, pricking, dryness of palate, extending forwards through whole mouth; feeling as of foreign body under right upper lid, with smarting and burning; itching and smarting in fore part of urethra; stitching pain in left tibia; flashes of heat in back shoulders, and face, with burning of ears; slight pain in region of pylorus; pain between shoulders and neck, both sides; stitching pain in right back, passing from 8th rib downward; pain, acute and sticking, in 8th dorsal vertebra. After 60 m. thick mucous secretion in throat, with diminution of the very unpleasant feeling of constriction, rawness, dryness and soreness (which, however, had not gone off 11 hours after). In 65 m. pain in lower part of right tibia and in right ankle. In 2 hours, perfect dryness of lips, and feeling of dryness and sensitiveness of nostrils, so that inhalation of air (at about 60 Degree) creates a painful feeling; pain in left heel. After 7 hours pain in cardiac region, severe about sunset. After 10 hours pain in inner edge of left scapula. On 2nd day, painful irritation within nose, which is sensitive to cool air; frequent sneezing, with severe and painful faring in breast and larynx, latter feeling as if stretched almost to bursting, with copious discharge of thick mucus from both nostrils; renewed secretion of thick mucus in throat, with snuffing and hawking, still further diminishing soreness; borborygmi just below epigastrium for hours, most after dinner; pains in abdomen, most below umbilicus, followed by diarrhoeic stools in afternoon and evening; a small quantity of urine, which he is compelled to retain for some time, causes pain in bladder, when evacuated it is of deep amber colour; much tickling about top of larynx, with disposition to hacking cough. (Ibid.)
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.