10. Reinhard B-,9 months old, golden hair, appetite good, bowels regular and natural, in good flesh. His incisors are through his gums, previous to which he had suffered from diarrhoea and whooping – cough. Towards evening occasional attacks of the latter complaint still, otherwise quite healthy. On December 6th at 10 a. m., administered 10 globules of 6th At 2 p. m. there appeared on his right cheek a burning, dark red, round spot, which gradually increased till 5. Redness, heat, and swelling of scrotum. He screamed the whole night, especially on being touched; heat and perspiration on his forehead. – 7th, morning both eyes were glued together with dry mucus, left especially. Redness and heat of scrotum. Here and there, on both sides, epidermis of scrotum was raised with flat vesicles, filled with yellow fluid, from size of pin’s head to that of lentil – these were painful to touch; thin watery stool of dark yellow colour as before; he cries if left leg is moved, or left side to touched. From 2 till 6 p. m. a similar gradually increasing spot on left cheek; towards evening vesicles on scrotum burst, and red and slightly tumid skin, denuded of epidermis, discharges a little moisture. In evening another dark yellow watery stool; sleepless whole day; will neither sit nor lie, and must be carried about continually; made water 5 times through day, attended with much effort, groaning, and holding of breath-this till evening. – 8th. Slept better through night; the left eye is closed with dry mucus; scrotum is covered with dry, red, cracked thin scabs. pimple similar to cow – pox, with red margin, on right buttock; near corner of mouth, on right cheek, small vesicle with red margin; napkin stained with reddish – brown urine, which became darker when dry; slept from 1 till 6 p. m., and from 7:30 till 5 in morning; he slept only 1/4 hour in afternoon, them from 8 till 10 in evening; took some milk at 10, and then slept till 5 next morning; stool as usual – 9th. In morning a little dry mucus in left eye; skin of scrotum natural; yellow scab with red margin on pustule. – 10th. 10 globules of 6th, at 11 a. m. At end of an hour redness on left cheek, changing by degrees from bright to dark red: accelerated breathing with five eructation: after which breathing became easier. A small pimple with red margin in same place (near mouth) as on 8th; margin round small scabs on buttock is again apparent and becomes dark red; urine 3 times in 1/4 hour. After an hour redness on cheek disappeared; frequent yawning; eructations frequent till evening; after coughing, curdled milk was vomited, which had not occurred before; sleep as usual. – 11th. Cried frequently in night without awaking; increased warmth over whole body; perspiration on forehead; first motion of bowels after taking last dose occurred this morning; generally his bowels are moved at night; consistency of stool natural colour lighter; urine coloured pain a reddish yellow; dry lumps of mucus on right eyelids; red round spot on left cheek. – 12th. Quiet sleep; napkin coloured reddish by urine; stool brighter coloured than usual; both eyes closed with dry mucus on awaking, fretful; red spots alternately on both cheeks; red pimples here and there on cheeks; much thick mucus discharged from nose; urine of darker yellow than usual – 13th. Frequent screaming in night, increased on being taken up; eyelids glued together in morning. – 14th. All over right cheek numerous red round spots, with pointed pimple in the centre; eyelids glued together in morning by dry mucus. (Ibid., 139.)
11. Minna Kranke, aet. 20, was scrofulous in childhood, muscular system weak, has pains in limbs after bodily exertion, light hair, pale countenance, phlegmatic temperament; she has suffered at times form pains in her left side, also from palpitation of the heart after exerting herself; menstruation natural; healthy at time of experiment.
November 25th, 1861. – 60 dr. of tinct. at 10 a. m.; after 1/4 hour, feeling of heat throughout body; oppression and pressure in left side; difficulty of breathing; palpitation of heart; twitchings in right arm; feeling as if something solid were rising in throat, necessitating effort to swallow after which it seemed to descend; twitches in knees; dragging pain in left shoulder – blade and neck; squeezing pain in the region iliaca sinistra; twitches in calves of legs; ringing and tingling in ears; dryness and heat in mouth; thirst. Towards evening pains disappeared. – 26th. 90 dr. at 9 a. m.; in 1/4 hour oppressive pain and burning between cardiac region and navel, as well as in sternum; pain in nape of neck and back of head; tearing pain in forehead over left eye, in eye and eyelid, extending towards upper part of nose; drawing pains between shoulder – blades extending to loins; shortness of breathing and oppression as if breast were tied together and she could not breathe; shivering, and feeling of coldness over whole body till mid – day; towards evening pressing pain in forehead and back of head; alternations of heat and cold with thirst for Broihan (a kind of light effervescing beer made without hops); burning urine, with frequent during to pass it; palpitation of heat is unable to go to sleep at once, on account of drawing sensation in back, and headache; arms as if paralysed thrilling in them; shortness of breath, short cough, anxiety, nausea; pricking and ringing in left ear; in something less than an hour she fell asleep again till past 6. After getting up, weakness in limbs; great weariness; depressed spirits; pains in knees and drawing pains in calves; in evening, anxiety; tearing pain in head, over right ear; face hot; throat, tongue, and lips dry; dreamt much in night, but has no recollection of subjects of dreams. – 28th. Awoke after 4 with anxiety; stitches in left side; oppression of chest; cannot draw long breath on account of stitches; oppressive headache in forehead and occiput; face hot; gentle perspiration not thirst; soon fell asleep again till past 6; after rising headache, anxiety; paralysed feeling in arms and legs. ( Ibid., 140.)
12. L -, man of 45, sanguine temperament, pale countenance, light hair. Suffers occasionally at changes of weather from debility; eats sparingly, drinks no fermented liquors; bowels regular; perfectly well at time of experiment. – November 14th. 90 dr. at 9 a. m.; after 1/4 hour, dizziness, feeling of heat running over whole body, pain in nape of neck. At end of an hour pains in temples; particularly much dragging pain, so that whole head it affected; nausea, as if he would vomit, but relieved by eructations; uneasiness in chest; dizziness again becomes stronger; much anxiety; oppression of stomach; much eructation, after which a rigor makes its appearance. At 10:30, hollow rumbling in the abdomen; drawing towards rectum; mouth is quite dry, so that tongue almost cleaves to palate; renewed pressure in front of stomach; renewed feeling of heat over whole body; pains in front of neck which extend towards temples; from 11 till 1, horripilation through loins; renewed drawing in temples; renewed nausea, which is again relieved by repeated eructation; lassitude and paralysed feeling of limbs; renewed nausea, eructations, shivering in back and much heat in head; drawing in legs, back,
and temples; much anxiety and constriction of chest; pressure in stomach, and nausea which is again relieved by numerous eructations. At 7 p. m., cutting in bowels, so severe that whole body seemed drawn together; urgent desire to stool; three watery motions in quick succession after which cutting abated in about 1/2 hour; whole evening great discharge of wind. (Ibid., 141.)
13. Pastor G -, aet 52, of sanguino-phlegmatic temperament; suffered in youth from ischias nervosa, for which he was treated with mercury in many forms. From effects of this medicine lost his hair from forehead and crown to head, and never recovered it. Subsequently suffered from bloody piles; is sensible of changes of weather, and suffers, on taking cold, from cough and slight rheumatic pains. Appetite and digestion good. At the time free from all complaints. On January 6th, at 9 a. m., took 20 dr. of tinct. Soon after, strong discharges of wind, both upwards and downwards; urging sensations in rectum; uncomfortable feeling in bowels, as when one has had an evacuation after taking a purgative; metallic sourish taste on the tongue; unpleasant smell in nose like that of black soft soap; eructation till bedtime. – 7th, 9 a. m., 30 dr. Immediately afterwards strong discharges of wind upwards and downwards; secretion of thin mucus in throat; increased appetite; motion of bowels delayed and confined. In afternoon oppression and coldness in abdomen, which was not removed by a warm blanket; coldness over whole body, especially close under umbilical region; drawing pain in right side, from above downwards. – 8th, 8 a. m., 40 dr. Eructations and discharge of wind; greater appetite; increased secretion of mucus from throat. Natural motion of bowels, but feeling accompanied the operation as if anus were constricted, and only permitted faeces to pass with difficulty; later, another stool, soft and brighter coloured; acid taste on tongue. Towards evening drawing and pressure between shoulders, especially in right scapula, and towards right side; feeling as if larynx were swollen, especially on right side. – 9th, 8 a. m., 50 dr. Increased expectoration of mucus, and now and then running at nose; educations; much mucus in mouth; p. m., drawing between shoulders; stronger stream of urine; p. m. and evening shuddering thrill from nape to back downwards; unusual feeling of chill in bowels after drinking some water; cramp in right calf no motion of bowels throughout day. – 10th. No dose taken for fear of constipation. Evacuation of bowels; traces of blood on wiping anus; appetite not so good in morning as on day before. – 11th, about 9 a. m., 10 dr. Immediately eructation; increased expectoration of mucus; fluent coryza; feeling of chill in body on drinking water, not usual; great discharge of wind; watery eyes; confusion of head; motion of bowels lighter coloured than usual; cold shudders between shoulders; uncomfortable feeling throughout body; vertigo; evacuation of light colour and pappy consistency, followed by improvement in condition. – 12th, 9 a. m., 5 dr. Repetition feeling of great discomfort in belly with pains, relieved by a glass of wine; confusion of head again supervened; pressure on eyelids; cold feet distension and uneasiness of body, notwithstanding frequent eructations; lassitude, without ability to sleep; later, hot burning feet; next coloured than usual. 14th, 1 p. m.,2 dr. Immediately after, eructations of wind; pains in nape; expectoration of mucus; pressure in fore and back parts of head; horripilation in back; stiffness of neck on left side; pain in right shoulder, in muscles of right side of neck, and in region of right clavicle; fluent coryza; coldness of belly; shivering; next morning soft, bright – coloured stool. (Ibid., 147.)
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.