12 c. 16th. -Sleep disturbed at times by anxious dreams, which awoke her. On waking, heat in head and pain in bowels; appetite poor; slight thirst; tongue coated with a thin white fur. She does not feel so well as on evening previous. Sensation as if there were an abscess under each eye; sticking and burning in eyes; margins of lids very red; photophobia; cramps of eyelids; in n. sour taste, now natural; pain of head, as if brain were pressed down by a hundredweight; pimples on forehead and chest. 5 p.m., has felt very weak all day; symptoms of head and eyes have lessened; scalp painful to touch, and hair in places matted, in places coming out on combing; face red, puffed; from time to time during d. rapid flushes of heat in face, with anxiety; lips swollen, cracked; pain in throat on swallowing; yawning and empty eructations; frequent nausea; disgust for all food, with transient desire for this or that; soreness in bowels; desire for stool, without effect; urine passed only once, scanty, dark yellow; nose stuffed as by catarrh; soreness in larynx; cough on deep inspiration and on movement; drawing from sacrum up to nucha, necessitating bending backwards; stiffness of extremities; pain in soles on walking; on movement sensation as if whole skin were harsh, and would crack; cannot go to sleep, though she feels weary; cannot endure the least noise; cannot think long of anything without fearing to lose her senses; cannot lose the thought of dying
12 d. 17th. -Uneasy sleep, troublesome dreams (of tetanus and death) alternating with anxiety; on waking knew not where she was; heavy weight in head and eyes; trembling of whole body; [ In L’Art Medical, I, 249, Dr. IMBERT-GOURBEYRE cites a number of cases of the “tremor arsenicalis.” See also ii.] faintness; disgust at food. From 3 p.m., every 5 m. attack of short, dry cough; thick yellow expectoration every hours; feverish heat; thirst; dull pain in left temple; 4 times in afternoon thin evacuations. 18th-Through n. uneasy and anxious; feverish; sleepless till 3 a.m.; before falling asleep rigor for 5 m., recurring on awaking at 6, and followed then by thirst, hoarseness, and pain in chest. At 9 voice, which had been quite lost, gradually returned, and at 10 she spoke as usual, but still with some pain in larynx. This m. voided with great straining 3ij dark yellow urine, -first time for 24 hours 19th. -N. uneasy from cough, attacks of flying heat and anxiety up to 1:30 a.m.; then urinated as before, after which quiet sleep till 6 a.m. On waking face puffed, lips swollen, two large vesicles on upper and under lip respectively; sensation as if eruption would break out on face; cough weaker, less frequent; weariness. Twice in afternoon pappy stools. In evening, some appetite; larynx on speaking still painful; cough looser; abdomen sensitive to pressure 20th. -Menses (due on 15th) have appeared; clear pale red. Upper vesicle filled with lymph, under one with pus; stiffness in legs, she cannot stretch them out for pain. 21st. -Upper vesicle purulent, under one dried up; hair still matted. About 10 a.m. set in stiff neck, with tearing pain in head, face, eye, teeth, neck and pectoralis region of left side, aggravated by slightest movement; head drawn spasmodically to l. Pain increased towards evening, and lasted all n., declining towards m.; in afternoon, flying head and thirst, sudden cold sweat; in evening chill for 2 h., then sweat without heat. Was obliged to sit all n. with head erect. 22nd. -Pains have left sensation as if left half of body were contracted; stiffness and heaviness of lower extremities. Catamenia have ceased; lasting 2 d. instead of 6, scanty and pale. At 3 p.m., headache and face ache began again, going off gradually about 11; after it very cold in hands and face. [ The reporter, writing as on morning of 23rd, adds: “At 4 O’ clock heat and sweat, without decrease of pain, till 6.” It does not appear to what period these notes of time refer. EDS] 23rd. – Pustule on face, and circular burning tetter behind right ear. Return of left -sided neuralgia at same h. -pains increased by touching sound half of face; tonic cramp in lower jaw and throat; loose feeling of teeth; flow of saliva. 24th-Sleepless till 3:30 a.m. on account of continued pain; with it, coldness of whole body, pain in right abdomen, vibration in brain as if it moved to and fro, crampy feeling in left shoulder, cannot move left arm. Pains have not yielded this m.; feels weaker than yesterday. For 1/2 h. burning and tearing in spot behind ear, during which time prosopalgia went off. Hair of left head falling out; it is matted now only on this side; at noon, sudden flow of dark blood from vagina; pinching in right hypochondrium, constraining her to bend forward; stiffness of neck, pain in back; cold feeling over whole body, most on left side, also internally, especially in stomach; bad smell from mouth, anorexia. 25th. -Sleepless again till 3:30. a.m. from the neuralgia; she ran about room, moaned and screamed, rolled herself on floor, and craved for sedatives; with it perspiration of sour odour. This m. head, neck and left shoulder feel as if paralyzed; she does not like to move or speak. Still some pain, especially in left eye; cervical vertebra pain on pressure. Pain ceased at 5 p.m., but recurred at 1 a.m. for some hours, and thence every n. till Sept. 5th. By d. she was anxious and solicitous. Great emaciation and occurred. (Hom. Vierteljahrschr., x, 119.)
13. A mother, when first seen, was sensible, and confessed to having given her children arsenic, and taken it herself. She was vomiting violently, and complained of a burning sensation at the pit of the stomach; there was constant tenesmus, with passage of mucous stools; pulse small and rapid; violent delirium soon followed, with tetanic convulsions, requiring the utmost exertions of four persons to hold her in bed; conjunctiva became intensely injected; pupils from being minutely contracted, became exceedingly dilated; eyeballs fixed upwards; mouth drawn in all directions. This state continued for some m., when calmness and repose followed, during which she expired, not more than 3 1/2 h. after having taken the poison. The autopsy presented no points of interest. (TAYLOR, op cit., p. 321.)
14. A girl swallowed 3j of A., and was in consequence attacked violently with usual symptoms of irritation in whole alimentary canal. After being ill for 24 h., she experienced several distinct remissions, and some repose, attended with fainting. In 12 h. more, she began to improve rapidly, pain subsided, strength and spirits returned, and stomach became capable of retaining liquids. Towards close of 2nd d., however, she was harassed with frightful dreams, starting from sleep, and tendency to faint; next m., with coldness along spine, giddiness, and intolerance of light; and on 4th d. with jerking of extremities and tingling of whole. These symptoms continued till close of 6th d., when she was suddenly seized with convulsions of left side, foaming at mouth, and total insensibility. Convulsions endured 2 h., insensibility during whole n. Next evening another and similar fit; a third but slighter fit on m. of 10th day; another next day at noon; and they continued to recur occasionally till 19th d. [ For similar fits, see BERRIDGE, Nos. 121, 188 (5), 219 (17), 227; and IMBERT-GOUBEYRE, L’Art Medical I, 455] For some time longer she was affected with tightness across chest and stomach complaints; but she was eventually restored to perfect health. (ROGET, Medorrhinum Chir. Trans., ii, 134.)
15 a. In beginning of May, Mrs. Wooler was attacked with pain and vomiting soon after dinner. On 8th she had sickly look; small frequent pulse; flatulence; frequent slight hacking cough, without expectoration; occasional discharge of mucus from bowels, with tenesmus and griping, of some day standing; redness of eyelids and lining membrane of nostrils; loss of appetite, and great failure of strength. In 3 or 4 d. more there was anxiety, restlessness at n., and greater weakness; increased griping, tenesmus, and mucous discharge, now also streaked with blood; dryness or tightness in throat, with hoarseness; and vomiting, which had ceased, began again. Same symptoms continued with little change, save a progressive exacerbation, till 28th, when mouth was found sore, [ Comp. BERRIDGE, Nos. 41, 52, 329] and throat so uneasy as to prevent swallowing. Two day later stools, previously bilious, assumed a fatty appearance owing to presence of pus, as proved by microscopic examination. Vomiting (only after food or medicine) and purging worse than ever. Tongue red and fiery; mouth and lips excoriated; anxiety and restlessness very great. June 4th showed further aggravation, and stethoscope revealed infiltration of both apices. Tuberculosis of chest and abdomen was suspected. On 8th, besides above symptoms, conjunctive were much injected, and anus sore. Blood-discs as well as pus-corpuscles were found in stools. On 10th, urine, which was scanty, high coloured, and high in density, was found to be albuminous, and to deposit blood-discs [ Comp. ii, 6] and casts. On 13th, face and arms presented an eruption which put on the characters of eczema. Symptoms otherwise continued much the same; and, as from the first, they presented a paroxysmal tendency in point of severity. On 23rd, still worse; restlessness and weakness extreme; pulse feeble and intermitting; edge of tongue ulcerated, and palate covered with papules or pustules; hands cold and moist; vomiting severe; diarrhea less so. To-day she first complained of a sense of stiffness, numbness, and tingling, [ Comp. BERRIDGE, Nos. 52, 93, 188 (6) ] which she had felt in arms for 2 or 3 day before. On 26th, all symptoms were worse, especially the vomiting, and the tingling and numbness of hands. Pulse 144-150, and very small and weak. In subsequent n. she was seized with paroxysms of tetanic spasm, gradually increasing in severity and duration, and at length becoming almost incessant. She died next m., in full possession of her mental faculties.
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.