14. Prof. WOHLER, while busied with investigations of telluric ethyl, had in his breath for some weeks the above – mentioned odour of garlic; and, it happening once during this period that in consequence of taking cold he got into a very profuse perspiration during n., the sweat gave out this offensive T. odour to so great an extent that it was hardly tolerable. He had an opportunity of observing this symptom a second time during course of his work. For similar experience see Pharm, Journ., xiv, 376; Pacific Medorrhinum and Surg. Journ., 1869(Bunsen). (Ibid.).
Experiments on animals
1. GMELIN introduced 3 gr. of an oxide into stomach of a medium-sized and lively dog, with some meat. After 22 m., vomiting of a watery mucus; the animal lost its liveliness and would not eat, but drank much water and passed much urine. After 4 hours the vomiting was repeated several times. After 8 hours appetite returned, and next day animal was quite well. (Ibid., p. 78.)
2. Same gave rabbit, which had 2 day previously taken a 4 gr. with impunity, 10 gr. made into pills with gum – arabic. Immediately after swallowing these the animal lost its liveliness for a time, but soon recovered and ate with appetite. It seemed well for remainder of this and through following day, but on 3rd m. was found dead. Intestinal canal showed externally, except distended blood-vessels, nothing particular. On opening stomach, a thick white, frothy mucus made its appearance, in which the mucous membrane – which everywhere came off with the greatest facility – seemed to be, as it were, dissolved. Inflammation proper had not occurred. Near the pylorus a quantity of black ink-like mucus was found, and the same filled all the small and large intestines as far as the rectum. It was washed off with difficulty. The rectum itself was empty and contracted. The liver was bestrewn with red inflamed spots; gall-bladder was full of green bile; ventricles of heart were filled with a polypus-like coagulum; lungs showed, save some red spots, nothing particular; serum, wherever present, was violet-coloured. Dr.Hering points out that T., prepared according to Klaproth’s method, is not free from the selenium with which it is combined in nature; and to this element some of the effects observed by Gmelin may be traced.–EDs. (Ibid.)
3. HANSEN introduced into stomach of such a dog as No. I 0.3 grm. of bitellurite of potash dissolved in water by aid of a few dr. of liquor potassae. the animal immediately lot his liveliness, seemed to be stupefied, and lay down quietly. Garlic – like odour appeared in breath after 1 m. In 20 m. vomiting set in, which was frequently repeated in course of first hours; appetite was lost. On following day animal had recovered, but still gave out strongly the odour of T. Two repetitions of the dose produced the same stupefaction and vomiting; the ejecta were black mucus, excrements were of same colour. (Ibid., p. 366.) 4. Another dog received during 4 day, in 3 doses, I grm. of tellurous acid and 1.4 grm. of bitellurite of potash, with no other results. On the 7th day 0.5 grm. of the salt, in sol., was injected into the jugular. There followed a few convulsive movements, exoneration alvi, and death in 4 m. Save for a blue-black coloration of intestinal canal and of all glands, even parotids, nothing abnormal was found; but in both eyes cataract had formed, apparently due to deposition of T., as granules – black by transmitted light – were found in lenses, and fluids of eye gave out the alliaceous odour. T. Was also found in the urine. (Ibid.).
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.