3e. Analysis shows that the composition of the bones of the animals fed with Ph. does not differ materially from that of normal bones. (Ibid). [I have been in a position to prove the perfect analogy with the above of the processes in the human subject, though only in their earlier stages, in a child that had been treated during 2.1/2 mo. with small doses of Ph. for bad development of the osseous system, and of whose body performed an autopsy.]
4. A young brown dog, after being kept for some day without food, got from May 10th to 16th several doses of alcoh. phosphoras., on 16th about 3ij. From 16th to 23rd no med., and as he seemed quite lively and ate with appetite, he got on 23rd 3ij ol. phos. Soon, restlessness. After 1 hour slimy saliva in clear viscid drops came from mouth and fauces. 10 a. m., froth came out of mouth, and he vomited with much retching a little yellow slime like poppy – seed oil. – 24th. Seemed pretty well. He then got at 7 a. m. another dose of ol. ph. Soon clear saliva dropped from fauces and viscid slimy froth hung about his mouth. 8 a. m., frequent ineffectual retching and then a thin, pappy, bright yellow slimy stool; 10 m. thereafter vomited twice much white mucus with pieces of bread, this was very acid, and fumed and smelt of Ph. His belly contracted regularly and rapidly, with occasional pressing on the rectum. Pressure on belly caused him to moan a little. He ran about, fell, had short convulsions, got up again and again fell down, and after a few convulsions with dilated pupils he died. – P. m., 5 hours after death. No cadaveric rigidity. The salivary glands of one side showed strongly injected blood – vessels, as also the anterior surface of epiglottis. The brain and upper part of spinal cord showed distended blood – vessels. Trachea and bronchial tubes filled with froth, no reddening of m. m. Lungs had brownish – red and bright red spots, and dilated air – cells protruding on lower lobes; when cut into frothy fluid exuded. Right side of heart and large veins filled with dark coagulated blood. Liver large, reddish – brown. Spleen of consistence and colour of leather. Kidneys, especially left, showed under their peritoneal covering a number of white, millet – seed sized granules, looking under microscope like fat on the red brown cortical substance, which was traversed by visible vessels. The 2 lower thirds of m. m. of oesophagus were bright red. The m. m. of fundus of stomach was gathered into many folds and bright red, not so the cardiac and pyloric parts. The stomach contained white viscid mucus. The m. m. of intestines, as far as caecum, slightly red in parts. From there to anus m. m. throughout injected bright red. (SORGE, OP. cit.,44.)
5. Similar experiments were performed on several other dogs, which gave similar results. In some there appeared to be a kind of paresis of the hind legs. In one the rectum appeared to be distinctly inflamed. Exhaustion appeared in some, not to be wondered at as they could not eat. In some the liver had a gamboge yellow colour; the duodenum had pushed itself into the pylorus to the extent of half an inch. The convulsions that attacked a good many in one case assumed the character of opisthotonos. The urine in a few contained albumen. In one the small intestine was much connected, arborescent blood – vessels showing in the m. m., which was partly covered with bloody mucus; on washing off this there appeared a whitish or grayish – yellow layer, which could be scraped off with the finger and displayed the congested blood – vessels. In several many of the blood – corpuscles were irregularly shaped. (Ibid.)
6. A number of experiments on rabbits showed much the same phenomena. In one the largest part of the right middle and left upper lung was brown and hyperemic, but not airless, as it swam in water. In this case the liver was nutmeg – coloured, the left kidney blackish – blue, but yet showed no hyperaemia under the microscope. In one the convulsions were so strong as to jerk the body, as it lay on its back, a few inches from the ground. In this case the pupils were contracted. In most of the other animals they were dilated. In this one the spinal cord was softer than normal, and about the level of the middle dorsal vertebra there was dark blood – stain of about 1 in. on the anterior wall of the spinal canal under the dura mater. In another case both brain and spinal cord seemed softer than normal. In this case there were hepatized spots in the lungs, which felt and cut like flesh and sank in water. Yet another case showed softening of the spinal cord. One rabbit showed on surface of brain and cerebellum many bright blood – spots the size of a pin’s head, and at the posterior border of the right lobe of cerebrum a large black firm blood – clot the size of half a bean. This rabbit also had hepatized spots in lungs, and both kidneys were dark blackish brown and hepatized. The urine showed, besides bladder and kidney epithelium, a good many dark fibrinous cylinders, which were granular on their surface. (Ibid.)
7a. LIEDBECK applied to a wound in a dog’s neck, 3ss of granulated Ph. The animal showed great distress and exhaustion, had dilated pupils, refused food, and died on 8th d. Animals poisoned in this manner are stated to have the blood darker and more fluid than natural, the liver studded with minute specks of a lighter colour than the rest of the organ, and the kidneys firmer and yellower than usual. Ramier placed fragments of Ph. beneath the skin of frogs, rabbits, and guinea – pigs. No local inflammation was excited, but in the case of the frogs at least, which did not die for 2 – 3 weeks, liver and kidneys were found to have undergone fatty degeneration. [ The fatty degeneration produced by Ph. appears to depend on a more rapid splitting up of albuminous tissues, along with deficient oxidation. This was shown by Vomit and Bauer, who produced fatty degeneration of the organs by the administration of Ph. to dogs absolutely deprived of food, where the fat found after death could neither have come from food nor from fat deposited in other parts of the body, fore have been formed in situ from the decomposition of albuminous substances, and these were shown to have split up more quickly than usual by the amount of urea in the urine being increased, while oxidation was shown to have diminished by the amount of oxygen absorbed and carbonic acid given off being lessened”. (BRUNTON, op. cit. The investigations of Lebert and Wyss, Panum and Storch, gave similar results.]
7b. Pelletier and Godman have seen unmistakable evidence or the aphrodisiac power of Ph., – a drake, a bitch, and a boar being the subjects of experiment. plus [Several other facts of the same kind are given or cited by SORGE (op.cit.) (STILLE, op. cit.)
8. Fatty degeneration was found by Munk and Leyden in the tissues of frogs and rabbits within 2 or 3 day after giving Ph. In Tamassi’s experiments it was still more rapidly induced. He injected 3 – 6 gr. into the rectum of 4 animals (dogs or rabbits); toxic symptoms occurred in about 5 m., death in 8 hours – the temp. falling 8 deg. F. In all 4th kidneys, and in 2 of them the liver also, were in a state of fatty degeneration. (PHILIPS, op. cit.)
2. In the livers of young rabbits the glycogen disappears in 1 1/2 d. after the giving of 0.02-0.03 grm. of Ph. (Nothnagel und Ross BACH, Op, cit).
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.