2c. Sept. 7th., 1844, m., took 30 dr., 1st dec. dil. tinct. of leaves, the same 9th and 11th. Flatulence, eructations, distension and hardness of abdomen, copious secretion of urine. – 13th, 15th, 17th. 20 dr. tinct., same symptoms. On 17th observed a swelling on left cheek and upper lip. (During the last two years had suffered severely from toothache and gumboils in left upper incisors, though the teeth were sound.) Now on the same place there came on swelling without toothache, and after 5 days the cheek over this part commenced to swell. – 24th. On left cheek a hard, red, very painful swelling, in the centre of which, 1 1/2 in. from ala nasi, was a normal, sharply – defined circular depression, dark red, soft, and yielding. Suppuration outwards being threatened, the tooth was extracted, and a large quantity of pus was discharged through the hole thus made. In a few days the swelling and redness were gone. (Ibid., 79.)
3. Dr. M.Muller. aet. 58, of lively, irascible temperament, quite healthy, took, Dec.6th, 1842, 8:30 a. m., 10 dr. of tinct, of hulls. After 1/2 hours slight pain in bowel above navel. After I hours urging to urinate. After 2 hours scanty discharge of clear urine. After 2 1/2 hours rheumatic pain in interior of knee – joint for I m. rendering walking difficult. After 4 hours, contrary to custom, is calm and comfortable, intellectual laziness, no inclination for speaking or quarreling. After 3 1/2 hours no inclination to drink during or after dinner, he feels a kind of pleasure in keeping his mouth dry. After 6 hours less urine than usual. After 6 1/2 hours cannot have his usual siesta, though he felt disposed for it earlier than usual; electric shocks in both forearms and hands woke him up as soon as he began to sleep. Urinates at 4, 6, and 8 p. m., each time but little urine forms. At supper still without thirst, does not relish his wine, is inattentive when reading, pulse quicker and fuller than usual. (Ibid., 84.) 4. EDWARD BEGAND, surgeon, aet. 25, of robust constitution, and lazy apathetic mind, took, Sept. 5th, 1844, 5 dr. tinct. of hulls. No symptoms. – 6th. 40 dr., eructations, flatulence, distended abdomen, great appetite, hard stool. During day frequent short stitches as if in both lungs, not affected by breathing or moving. – 8th. 20 dr. tinct. of leaves caused eructations and flatulence. – 11th. 60 dr., after 1/2 hour violent eructations and rumbling in abdomen; evening, pressive pain in head, especially forehead. Frequent erections day and n. – 12th. 60 dr., eructations and flatulence, restless sleep at n. on account of itching of skin in various places; many dreams and erections. – 13th. 80 dr., eructation, rumbling in belly, transient stitches in chest and discharge of much flatus; 8 or 10 erections during day – From 14th to 20th, when he took no med., eruption of small red papules, some of which were larger and contained a viscid fluid (a kind of acne), appeared on neck, face, shoulder, and back. Frequent erections day and n., restless sleep and frightful dreams. (Ibid., 85.)
5. OTTO KESSLER, Divinity student, aet. 23, of scrofulous habitus, took, Oct. 7th, 1842, 10 dr. of tinct of hulls. Frequent eructation, distension of abdomen, rumbling, and flatus, a fluid stool. – 8th. 20 dr., abdomen tympanitically distended, 2 liquid stools, head confused and heavy, hawked up much mucus, and must urinate frequently and copiously. – 9th. 40 dr., abdominal distension so great that in spite of good appetite he dared not eat much on account of the feeling of fulness, no stool, violent headache (to which he was accustomed). – 10th. 50 dr., increase of yesterday’s symptoms, stool after much straining, urine about double the usual quantity, though thirst was not increased. – 11th. Stool hard, urine still copious, abdominal distension less. (Ibid., 86.)
6. Dr. KUCHENMEISTER, aet. 26, Sept. 4th, 1844, took 20 dr. tinct. of hulls. Soon, great eructation, and in afternoon a frequently recurring itching on sternum, compelling scratching. – 5th. 20 dr., eructation, oppression of chest, frequent itching of hands, and uncommonly good appetite. – 6th, 7 a. m., 30 dr. Forenoon, shooting in left hypochondrium under lowest ribs for some m., continual eructations. About noon, pain interfering with walking in right patella. During dinner sudden call to stool, with extreme fulness in abdomen, and on the way home shooting and hindrance to walking, as if in inner side of condyle of tibia at knee – joint, for 10 m. Then stool, broken up but not hard, and another at 2:45 p. m. – 8th. 45 dr., besides eructations, fulness of abdomen, pain in leg similar to that of 6th, very transient. – 9th. Dull tearing toothache in carious teeth, worse in warmth of bed, and going off towards m. – 10th. 50 dr., forenoon, a hitherto unknown megrim in a spot on left parietal region, the size of crown, lasting some hours, and becoming at one time so severe when speaking that he had to cease; went off after 2 hours – 12th, 14th, 16th. Took each day 40 dr. Observed the following gastric symptoms: hiccup, especially after greasy food, to a very violent degree; fulness causing necessity to go to stool; stool m. and generally again between 1 and 3 p. m., one afternoon 2 stools, never very copious; flatus that came away chiefly when lying; appetite only once affected, then, though hungry, he did not relish his dinner. Thirst increased, drank much. An old eczema which he had for years on dorsal aspect of thumb, the size of a sixpence, which had almost disappeared under mezereum, commenced to itch and got red and sore. (Ibid., 86.) 7. PAUL RADELLI, cabinet – maker, aet. 21, of robust frame. – Oct. 18th, 1842, m., 10 dr. tinct. of hulls. Eructation and flatus. – 19th. 20 dr., sickness and inclination to vomit, soon followed by pressive pain in epigastrium, and distension of abdomen. 11 p. m, woke suddenly from sleep, and vomited the food he had taken 3 hours before. – 20th. 40 dr., nausea rumbling in abdomen, flatus, stool with much straining; copious discharge of urine. – 21st. After 50 dr. violent pain all through abdomen, somewhat relieved by eructation or discharge of flatus; urine so much increased that he had to pass it 7 times, whereas his usual number was 3. Two stools. – 22nd. 31 dr., much flatus, profuse flow of urine. – 26th. 71 dr., could not button clothes, the distension of abdomen was so great, at same time violent pressure in stomach till noon, urinated 8 times in course of forenoon. Appetite very great, 2 stools with great straining. – 27th and 28th. Still shooting pains in hypogastric region when moving and stooping; urine very profuse. (Ibid., 88.) 8. A. KURTZEL, aet. 33, robust, nervous, bilious temperament, took Sept. 26th, 1842, m., 10 dr. tinct of hulls. Great appetite. – 27th. 10 dr., thin stool, confusion of head, distension of abdomen, frequent eructation. – 28th. 30 dr., 10 a. m., soft stool, heaviness and dull pain in head. 3 p. m., a second thin stool, occasional accumulation of saliva in mouth. From noon, burning, hot hands and quick pulse (9 p. m. 108.) evening, perspiration all over. – 29th. 40 dr., confusion of head, 2 liquid stools before noon, good appetite. 4 p. m., another liquid stool with full, hard abdomen, and much flatus. evening, heat in whole body, pulse 86. – From 30th till Oct. 3rd no med. Stools regular. – 4th. 50 dr., 5 liquid stools with rumbling and pinching in bowels, but constant good appetite. – 5th. 55 dr., 3 diarrhoeic stools with rumbling. – 6th. 60 dr., a diarrhoeic stools, tongue white, bitter taste, anorexia and headache. (Ibid., 89.) 9. CARL TENZLER, medical student, aet. 19, strong, healthy, Oct. 17th, 1842, took 10 dr. tinct. of hulls. No symptoms. – 18th. 20 dr., in evening dull headache after exertion. Stool normal, urine very scanty. – 19th. 30 dr., after dinner abdomen full and distended, urine scanty. – 20th. 40 dr., abdomen very tense and full; after dinner dull headache. Stools always normal, urine always scanty. (Ibid., 90.) 10. TO. S -, housemaid, aet. 26, menses since 16 always regular. – Oct. 21st, m., 10 dr. of tinct of leaves. Slight nausea, and disagreeable feeling of fulness of abdomen. – 22nd. 20 dr., drawing pains in abdomen, nausea and retching. – 23rd. 30 dr., violent pains in whole lower part of abdomen and nausea all day with short intervals. – 24th. 40 dr., abdominal pains very severe, pressing and drawing, aggravated by movement, menses came on 15 day too early, whereupon the pains moderated. For the next 8 day the menstrual discharge was profuse and blackish, often large lumps came away, the discharge used only to last 3 d. She also complained of general weakness and anorexia. – Nov.2nd. 30 dr., 2 stools, preceded by pinching. – 3rd. 40 dr., 4 liquid stools with pressive pains in belly. – 4th. 50 dr., 4 diarrhoeic stools with pinching. Urine not increased. The three next day the stools were normal, no pain in bowels. – 8th. 60 dr., distension of abdomen, with frequent discharge of flatus, rumbling in bowels, and pressive pains in epigastrium; 4 diarrhoeic stools. – 9th. 70 dr., same abdominal symptoms, only more violent, pressive pains in forehead. Appetite good. – 10th. 80 dr., diarrhoea and frontal headache, and pains in abdomen continued for some days ( Ibid., 91.) 11a. Oct. 1st. 1869, I procured a walnut, and after bruising it, hull and all, prepared a tincture with 95 per cent alcohol. On 28th of same month, at 10 a. m., I took 5 dr. of this tinct. in 45 dr. of water, which was followed in 1/2 hours by eructations tasting of the drug; at 12 took 10 dr.; eructations tasting as after eating fat, and considerable yawning. 29th, 9 a. m., 20 dr. 3:30 p. m. 25 dr.; no new symptoms. Bowels confined since commencing proving. 30th. – Had evacuation from bowels; urine increased at least one half in quantity. At 12 took 30 dr., and at 4 35 dr., followed by eructations and flatulence. 31st. – At 10 took 40 dr. At 1 took 50 dr., which was followed in 1/2 hours by throbbing in both temples, and a sharp pain in front part of head, relieved by going into open air, and returning on entering the warm room. Nov. 1st. – Headache continues; increased flow of urine; bowels confined. At 10 took 60 dr.; at 12 80 dr. Had quite natural evacuation from the bowels. The increased urination, eructations, and flatulence were now becoming rather annoying. At 3 took 90 dr., and at 8 had sharp cutting pains in right hypogastric region, lasting a few m. At 9 took 100 dr. Slept well during n., and all next day had frontal headache, with yawning, and great desire to sleep. 4th. – Headache, and flushed face; no evacuation of bowels; urine diminished in quantity. 6th. – My right ear aching, with feeling of fulness, and on 8th my left ear commenced in same way. I then had a discharge of pus from both ears until Dec.10th. External part of right ear was very much inflamed, and had two large and painful sores on it, similar to those I had seen on children who had eaten freely of the nuts.
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.