3 c. Very different was effect of small doses beam july 4th. epigastrium remained free; appetite continued good; general feeling was not affect; heart and chest continued free-pulse only fell; on 7th it was 63. On the other hand, there occurred on 6th, in evening, every troublesome tenesmus vesicae, commencing with tickling in navicular fossa, and compelling him to pass water very frequently, – on 6th, 16 times, each time 3j – 3ij, in all 3xxvj. This symptoms attained a great height, and became exceedingly troublesome; it was conjoined with accompanying tenesmus recti, latter lasting only 4 days. On 7th he had go to stool 3 times; on 8th, 5 times; on 9th and 10th, 6 times, – never leaving quite satisfied. Faeces consisted chiefly of small hard lumps, evacuated with much effort; a more copious and softer evacuation occurred once a day. On 10th call to urinate reached its climax, and he had to pass water every 5 or 10 morning. This
symptoms always ceased completely at night; it continued almost uninterruptedly from 8 a. m., to 5 p. m.; was somewhat relieved by constant sitting and by lying; when he was out walking and resisted inclination it ceased at length almost entirely. This symptom persisted through 11th and 12th, though no medicine was taken. From 13th to 14th he now took 20 dr. 3 times a day, without remarking any change save slight increased of mucus in urine. After leaving off medicine symptoms rapidly declined; after 3 days urine was again clear, and formed no sediment. But 14 days elapsed before all traces of vesical tenesmus disappeared; its form, however, was sensibly altered, for it showed itself more distinctly as a neuralgic affection. Twice a day, generally 8 -9 a. m., and 6 – 7 p. m. there suddenly occurred feeling of tickling and heat in glans, accompanied immediately by irresistible desire to make water; if he yielded to it, as soon as urine reached glans, there occurred very disagreeable pulsation therein, with increased tenesmus. This pulsation continued usually some morning after evacuation of urine. The attack could be removed by quickly drinking a large quantity of water, and strongly corporessing glans with finger. Its last attack was on August 2nd.
3 d. Pulse, normally 76, fell during first 8 day to 62. Inspite of great exercise and the hot weather, it became slower, but fuller and more tense. During cessation of medicine, it soon got up to 73, but remained tense; on resuming medicine it sank in 3 days to 63. From July 7th it increased in rapidity, perhaps owing to the urinary tenesmus. Urine in fist period rose in sp. gr. from 1005 – 10 up to 1025, and colour changed from straw yellow to reddish (Ibid.)
4. a. C. KOST.aet. 25, strong, ruddy, took July 1st -15th 3j of sol. beginning with 2 and ending with 26th dr. 4 times a day. Following are analyses of his blood June 29th and July 16th respectively. Serum 381.6 454.1 Dry residuum 60.5 42.3 Ashes 7.0 7.5 Coagulum 583.8 505.8 Dry residuum 291.9 185.4 Ashes 25.5 27.8 Red sediment 34.6 30.1 Fibrine 2.03 1.89 Water 701.9 763.4 Dry residuum 296.0 234.7 Fat 1.7 3.9 Salts soluble in water 11.3 12.0 Oxide of iron 1.3 0.8 Phosphate of lime 0.7 0.6 Before taking iron blood was bright red, with moderately coloured red corpuscles and few colourless ones; it coagulated in 5′ 38”; serum was yellowish, clear, alkaline; clot rather soft. After taking iron bold had dark red colour, and besides the deep- coloured red corpuscles many colourless ones were observed; it coagulated in 5′ 30”; serum was yellowish clear alkaline; clot soft.
4 b. During first 3 days of taking med. feelings were not altered save for increase of appetite; on 4th day occurred section of tickling in urethra, beginning during passing of urine and lasting some seconds after emptying bladder. Along with this, which increased day by day, and gradually involved whole urethra, there occurred urgent desire to pass water causing frequent micturition, but without it diuresis or change in sp. gr. of urine, which was reddish yellow, acid, and clear. Bowels were moved only every 2 – 3 days during proving; on other day there were repeated fruitless calls to evacuation; faeces after 5th day were always dry and dark green; 3 days after last dose again soft and brown. On 7th days, after 2nd dose, very uncomfortable pressive feeling in abdomen, especially in region of stomach; touching place caused pain. This symptoms generally disappeared 1/2 hour after taking med., but occurred after every new dose; it was especially severe in evening, when it was accompanied by embarrassment of head; taking a walk immediately after ingestion prevented or curtailed it. Save perceptible diminution in brilliancy of complexion, no other change occurred in this prover’s health. (Ibid.)
5. a. R. STURN, aet. 21, thin, pale, took June 29th July 23rd 3ij of Liquor Ferrum Acet. beginning with 5 and increasing to 50 dr. per dose. Blood drawn June 25th and July 3rd showed following:- Serum 448.2 435.2 Dry residuum 64.6 40.2 Ashes 6.6 6.7 Coagulum 519.4 524.5 Dry residuum 231.4 174.7 Ashes 17.4 28.3 Red sediment 32.4 40.3 Fibrine 2.4 1.7 Water 756.1 778.0 Dry residuum 241.5 220.3 Fat 1.9 1.8 Salts soluble in water 185.5 23.5 Oxide of iron 2.5 1.4 Phosphate of lime 1.0 0.9 Before taking iron blood was bright red; colour of red corpuscles light; few but extremely large colourless ones; observed coagulation in 7′ 50”; serum yellowish, clear, alkaline, clot pretty firm. After, bold still unusually light; red corpuscles strongly coloured; few and small colorless ones; coagulation in 8’20”; serum as before; clot firm and elastic.
5 b. No urinary symptoms were observed by this prover, and in head occurred only occasional slight confusion. There occurred in digestive organs only occasional feeling of increased warmth in abdomen, especially in stomach, along with pressure, tension, and pricking which always went off on, or was prevented by, motion immediately after taking med. During last 2 days of proving pricking in abdomen came on at times during day. During first 4 day after leaving off med. he was tormented by colicky pain, with very few intervals of case; its severity was variable; movement had very little influence on it; on satisfying the call to stool that occurred some relief was obtained; taking food increased pain. It did not disturb rest at night, and came on only after rising. Abdomen was not swollen or sensitive to touch. Tongue was latterly furred white; appetite not impaired. On 3rd day of taking med faeces became greenish, then greenish black, at length quite black, and at same time firmer – so hard indeed that whole force of abdominal muscles was required to expel them. On exceeding 26th dr. per dose they again became loose, indeed at length quite soft. On July 3rd, and again on 16th, hoarseness with feeling of roughness in larynx ensued; the first time it lasted 3 days, the second time 8 days. The first fortnight mental and bodily energy was increased; but during latter half of proving there occurred feeling of weakness, laziness, disinclination for bodily and mental activity, fatigue on least exertion, especially walking. On last day of taking med., and for 4 days after leaving it off, he had almost insuperable inclination to sleep under all circumstance and at all times. Pulse repeatedly sank from normal 70 – 72 to 62 – 68; and in second period, even for some day after second venesection, was extraordinarily full and tense.
6. a HERZER, aet.20, stout and strong-limbed, pasty complexion, perspires easily, tendency to rheumatic and catarrhal affections; at this time well, save for a slight chronic bronchial catarrh. He took, July 10th – 26th, 3iss of sol., rising from 5 dr. to 40 per dose. Blood drawn on 6th and 26th July showed following composition.
Serum 397.1 379.2 Dry residuum 46.2 37.3 Ashes 7.9 4.6 Coagulum. 569.3 562.0 Dry residuum 225.6 168.6 Ashes 32.8 32.9 Red sediment 36.6 58.8 Fibrine 2.8 2.1 Water 747.3 789.1 Dry residuum 249.8 208.8 Fat 1.02 1.32 Salts soluble in water 11.0 13.5 Oxide of iron 1.0 1.0 Phosphate of lime 0.5 0.6 Before taking iron blood was bright red, with light-coloured red corpuscles and few colourless ones; coagulation in 6’75”; serum yellow, clear, alkaline; clot firm, elastic, deeply cupped, with thin buffy coat. After, blood deep-red; red corpuscles deeply coloured, and very many colourless ones; coagulation in 6’4′; serum and clot as above.
6 b. Soon after taking first dose occurred tension and rumbling in stomach, increasing on 2nd day, but decreasing on 3rd and going off entirely on 4th. But on 9th day these symptoms increased to pressure and weight with pinching, extending from stomach all over abdomen. These symptoms were worst in morning and evening, and sometimes accompanied with inclination to vomit. They attained their maximum on 12th day (112 dr. per diem). Although after this still larger quantities were taken, they gradually went off save for a slight feeling of tension in stomach. Appetite notwithstanding was increased; digestion excellent; no constipation, only transient tenesmus recti felt once or twice. In urinary apparatus there was only occasionally transient urgent call to micturate and frequent passing, not worth mentioning. The prover’s vascular system is very excitable, but not much difference was observed in the frequency of the pulse; and only after taking the iron 10 days was a grater tension of it noticed, and an increase of the heart’s beats. During the first days of the proving he had increased feeling of health and of mental an bodily energy; but on 4th day a feeling of weakness and weight in the limbs ensued. Along with this there was remarkable alteration of the disposition, – ill humored, he felt inclined for nothing was indifferent even to things that on other occasions interested him; every appeared on the dark side, he could nor be cheered up; memory seemed to fail him. This alteration of the disposition seemed to be independent of the abdominal affection; and the head, remained all the time free from pain. On the 3rd day after leaving off the medicine there occurred sediment in the urine, and a peculiar odour of the perspiration. His face lost in fitness and roundness, but it also lost its pasty bloated appearance, and looked firms and fresher. (Ibid.)
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.