11 b. On October 7th, at 1 a. m., took 100 dr. of an attenuation of 5 to 95. Great nausea and disposition to vomit for 2 hours after taking it. Very sleepy during forepart of evening. Slept well till 3 a. m., thenceforward very restless; at 6, headache came on as after former dose, with great dizziness, constant yawning, occasional shooting pains in sides of head, pulse rather quick, appetite poor, feeling of fatigue of limbs and general prostration, forehead dry and hot. Pains in head were partially relieved by throwing head backward. At times very chilly over entire body, continual stretching and yawning, great uneasiness and oppression in stomach and epigastrium; on attempting to read he immediately goes to sleep. Rather melancholy and disposed to get angry easily. These symptoms nearly all subsided by 2 p. m. In evening great pain in hypogastrium and fulness of abdomen, with sensation as though diarrhoea would come on; very bitter and disagreeable taste in mouth; very drowsy. Slept well till 3 a. m., after that hour very restless; this happened every morning for 2 weeks, and for 3 days there was with it hypogastric pain and diarrhoea as before. Pain in head gradually subsided by 5th days. Upper lip much swollen and inflamed for 8 days; skin cracked and came off. A small ulcer on each cheek, near centre, very much inflamed for several days bleeding almost constantly Eruptions, on hands and wrists principally, resembling mosquito – bites. (ALLEN’S Encyclopedia, x, 468.)
12. Mr. B -, aet. 24. On September 29th, 1852, took 20 dr. of tinct. at 9 a. m. In 1 hour fluent coryza with violent tickling in nares, exciting sneezing; going off in about 1/2 hour. Great drowsiness after dinner. Unnatural heat in feet, followed by weakness of knees and whole lower limbs; when walking, has to proceed very cautiously for fear of falling. General feeling of intoxication. Dull, heavy, rheumatic pains in upper posterior region of neck. Tearing in centre of vertex, in spot about size of silver dollar. Jerking in muscles of left thigh, more particularly at lower third. Cold feeling of left thigh and knee, as though cold breeze were blowing on them. Stitching pain as from fine needles in region of heart, with slight twitching in external muscles of that region and slight palpitation. Sleep imperfect; waking at midnight. General burning and itching of skin after rising in morning continuing 1/2 hour ( Ibid.)
13. Mr. E. P.G. -, aet. 18, Took 20dr. of tinct. at 10 a. m. Soon after, burning in stomach and excessively bitter taste in
mouth; in 1/2 hour sense of rawness in throat; in 1 hour dull pain in forehead and ears. On 3rd day, early in morning, pain in bowels, with thin light – brown diarrhoea, which came on in like manner for 3 or 4 days. Eruption on skin like mosquito – bites. ( Ibid.)
14. Provings made by Prof. B. L. HILL and Prof. J. S. DOUGLASS, of the Western Hom. College, Cleveland, Ohio, upon some 40 male and 6 female medical students, who were entirely ignorant of what they were taking. In at least ten different instances, the provings were so nearly alike that one would have supposed that they were all copied from one but from the fact that the style of expression was different in all.
14a. Mind and Sensorium. – Not disposed to fix attention. Vertigo, impaired vision, dizziness, dulness, with fulness and aching in vertex. A sort of delirium, with inclination to run over subject on which he was reading. Mind clear as a first effect. Miserable, dejected feeling; mind dull and heavy. Feels grieved and troubled, with sighing; next day, feeling of tremulous joy, with mirthfulness, playfulness and clear intellect.
14b. Head and Eyes. – Heaviness, dulness, fulness, slight dull pain. Acute pain over left eye, in forehead, occiput, vertex, & c., in paroxysms. Pain relieved by open air. Headache through temples; head aches as if it would burst. In 1/2 hour, half intoxicated feeling with swimming of head. Sense of fulness and heaviness of head; soon after, dull pain of forehead, heat of face and slight sweat; pain in left temple. Awoke at 2 a. m. with excruciating though dull pain in forehead, extending to temples, with coldness of forehead and pain in eyeballs; after 1 hour aching pain and soreness of vertex, increasing to great severity, after 2 or 3 hours passing to front part of the head, continuing all night and depriving him of sleep. Feeling of fulness with headache; fulness on left side; full feeling in upper part of brain with dull feeling. Head feels too large. Dull pressive pain in left side of head. Severe pain just over right side eye. Dull sensation throughout head as though he had been on a “spree” and was getting over effects. Dull headache on getting up in morning. Head in front part of head. Brain felt too large for cranium; brain feels compressed. After 1 hour, feeling of pressure in head, and heat in the head and face. Pressure in front part of head and eyes. Pain in front and top of head. Redness of face and eyes; eyes feel as if swollen; black specks before eyes. Myopia increased. During headache eyes were so congested as to attract attention of everyone, although there was no disagreeable feeling in them. Dull pain in region of moral organs; a pressing outward and upward, as if there were not room enough for upper portion of cerebrum; pain was very oppressive and almost intolerable; it began about 5 p. m., after taking 2nd dose, and continued unabated till morning; when it was relieved in 30 minutes by single dose of bryonia. Heaviness; pain in eyeballs; stinging and inflammation in lids.
14 c. Nose. – At first dry, stuffed condition of nostril, which was soon followed by open, moist condition, with great sensitiveness to cold air, as if base of brain were laid bare, and every inhalation brought cold air in contact without. This is exactly similar to that produced by a sudden change of weather in winter, from cold and dry to damp thawing. Sneezing; fluent coryza, copious, watery. Very profuse greenish and slightly sanguinous coryza.
14 d. Face, Jaws, and Teeth. – Severe pain in left jaw. Heat on left side of face, with lassitude all over. Very severe pains in face, more in under jaw, lower teeth, and articulation of lower jaw. pains in head and face constant and very severe. Pain in right superior maxillary bone and teeth.
14 e. Mouth, Throat, and Pharynx. – Hoarseness, roughness and scraping in throat. Roughness and dryness of throat, with thirst. Hoarseness. Dry pharynx; fulness of pharynx and inclination to swallow. Sore – throat when swallowing. Fulness of throat and vertex, and stiffness of neck. Sensation of rawness of throat; hoarseness, more towards night. Palate and uvula red and inflamed. Dryness of lips and mouth. Sensation as if throat were partly filled, as low as top of sternum. spitting of thick saliva, which seemed to stick to mouth and throat, and to be detached with difficulty. Mouth dry in morning. Swelling of back part of tongue. Dryness and soreness of throat on swallowing and on pressure, worse on left side. Increased flow of saliva, immediately. Roots of tongue and fauces swollen; throat dry. Offensive breath. Dry, sore lips; ulcer on inner surface of lower lip. Unpleasant taste; thick mucus on teeth.
14 f. Taste, Appetite, Stomach, etc. Thirst, but no desire to drink. Distension of stomach and upper part of abdomen. Violent eructations, but no relief; violent retching. In 10 minutes slight nausea, which increased with sickening pain in duodenum; 1/2 hour afterwards, flatulence, eructations and more nausea; a 2nd dose increased symptoms, with general feeling of illness; supper abated bad feelings, but nausea returned soon after. Slight nausea, and burning of the stomach. All foregoing stomach symptoms were produced on women; the drug producing no disturbance in the stomach of men.
14 g. Abdomen and Stools – Flatus. Rumbling in lower abdomen; fulness, pressure. acute cutting pains at umbilicus. Flatulence; dull heavy pains in abdomen. Constipation; faces hard and dry. Dull pain in the region of the liver Periodic colic, with inclination to bend forward; relief after stool. Griping pains in bowels, from umbilicus down. After second dose, large pappescent stool, with general indisposition; after fourth, scanty diarrhoea, with tenesmus. Evacuations natural during provings, but alternate constipation and tendency to diarrhoea for a month after. Disposition to diarrhoea. Wandering pains in bowels, slight pain in left iliac region; afterwards severe pains in bowels, mostly below umbilicus, with weight and pain in lumbar and sacral regions. soreness of abdominal muscles, on taking full inspiration. Dull griping twisting at umbilical region, more towards left. Urging to stool, inclined to diarrhoea. Pain in left hypochondriac region, worse on motion, and on taking deep inspiration. One or two copious pappescent stools in morning.
14 h. Urine. – Disposition to frequent urination; increased secretion. Retention of urine for 18 hours, followed by frequent micturition. Profuse flow of clear, watery urine. Violent stitches in urethra in morning.
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.