1b. The second disease is an eruption from which many suffer during the early period of their service, who are occupied with the further elaboration of the medicine. In some cases this eruption spreads all over the body, so that they have to leave off work, whereupon rapid improvement occurs; but as soon as they resume work the eruption reappears, and then nothing remains for them but to leave off their employment altogether. In a few this eruption was very serious, and the sexual organs were swollen. As a rule, however, the affair is trifling,, and disappears entirely after some time, so that intimately the work can be don without inconvenience. The eruption shows itself in every operation of the manufacture, with the exception of the grinding, – the inhaling of the dust being never followed by it but always by the fever.
1c. Our men have never suffered from diarrhoea which other manufacturers, especially in Paris, have observed among their people. (GARMS, Eroffnung eines neuen Weges Zur sichern Indic. der Arzn., 1853, p.407.)
2. A healthy man drank a considerable quantity of a strong decoction of china. there occurred headache, vertigo, chilliness, restlessness, indescribable anxiety, trembling, staggering gait, cold sweat, palpitation of heart, intermittent pulse. After enduring this for several hours he was relieved by drinking hot tea, which caused diaphoresis and diuresis, but the same symptoms occurred occasionally for a long time afterwards, especially after mental emotions, particularly the palpitation of heart and intermissions of pulse. The 9th beat was followed by an intermission, after which 3 or 4 rapid beats occurred. Physical examination showed dilatation of the right ventricle. (GOZ, Russ. Medorrhinum Z., 1851, quoted in Z. f. hom. Klin., i, 117.).
Experiments on animals.
I. Friend states that 3iss of strong decoction injected into jugular vein of dog caused in 15 m. strong palpitation and frequent spasms. On 3ss more being injected, there followed tetanus and death. the blood was found after death liquid, the left contained scarcely any. Rauschenbusch has also made experiments with C. bark. In animals to whom he had given it for some days he found stomach and alimentary canal contracted, and their coats thickened, but no traces of inflammation. Heart was firmer, lungs covered with red spots, liver yellowish, bile watery and greenish. When blood was exposed to air, it remained dark coloured longer than usual, was less coagulable, and serum separated more slowly; it appeared like that drawn in inflammation. During life pulse was stronger and fuller, and animal heat increased; but when bark had been used for a long period muscles were pale and their energy enfeebled. (PEREIRA.).
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.