8 c. At 10.5 a.m., I swallowed 4 grms. of another; pulse 80, conjunctiva slightly red 10:40 ate as usual. At 11 felt effect beginning. Disposed to speak and laugh, but resisted, In 10 m. I was quite under its influence. I left the house tottering as I went, felt great tension about head, heat in eyes. Legs very heavy; feet felt dislocated and turning now inwards, now outward. Heart palpitated. 11:30 pulse too rapid to count conjunctiva very red, eyelids half closed. Have feeling of intense bewilderment, tremblings in wrists, can hardly write. 11:40, head very heavy tendency to immobility, sensation of undulating flames before eyes, conjunctiva very red, pupils strongly dilated, Eyelids are seat of sensation of heat and pricking at ext. angle; pulse 130, small, compressible, very irregular palpitation, beatings at nape of neck, tongue dry, no thirst. 12.5, same state of eyes, they seen to me swollen, feel spasmodic closing of jaws, pressure at temples; pulse 130. 12:10 undulating feeling in whole body, sight dim, leaden continuance, sensation of pressure at mastoid processes, and of hissing in ears. 12.18, great weight of head, eyes painful, pupils dilated, sensation of flames before eyes, great dryness of mouth and nose, tongue dry, covered with white dried mucus, pulse 140. I feel in a world which is no longer the same. 12:35, want to urinate, but find great difficulty. Eyes same; very tired; I go to bed. At 1:15 I get up, I seem to have lain a long time. Numerous ideas have rolled like torrent over my brain, but I can recall none. Head very heavy, can hardly see to write, nausea, mouth very dry; when I bend over the paper I have difficulty to combat inclination to immobility. I press my pen tightly; cold extremities, no warmth at skin, frequent want to urinate; seem to have been long thus. 1:30, mouth always very dry, tongue covered with white lines, dryness of pharynx. 2, pulse 130, weight at epigastrium 3, face very pale, same redness of eyes, greater muscular weakness. A friend comes, who continues observation for me. 3:30, breathing frequent, heart-beats weak. Patient complains of palpitation pulse 130, small, compressible, face pale, like one affected with acute disease of brain, eyes injected, very bright. Digestion retarded, 3:40, pulse 110, he hardly answers questions, 5, went out, was bewildered all the time, 5:30 took some soup. 7, loud hissing in ears, palpitation, general stiffness. Symptoms increase. 9:15, can hardly stand, have pains top of head, right side; pain at bottom of spine, and in coxo-femoral joints; very tired; pulse 140, downcast look. 10, to bed. Became very stiff, moved arms with difficulty, lost sensation of anything in contact with me, my body seemed transformed into solid mass. Very frightened at this state, which went away and often returned. I could hear an intense noise, a great bell. Slept at 11.30, woken often during n. Next m. thought I was cured; no headache, pulse slow, but head heavy as soon as I got up, and mind troubled. Ate little, tension in head increased. This was repeated for 9 d., viz. feeling well on waking, but head heavy on rising and mind clouded and unfit or intellectual work. Constipation remained for some time after. (PROSPER ALBERT, Obs. sur le Chanvre indigene, Strasbourg, 1859.)
9. Mdlle. X -, aet. 25, nervous temperament, impressionable, weak constitution and health, took 2 grms. of 2nd extract 15 m. before food. While eating she became first of all very preoccupied, then began to eat gluttonously, which was contrary to her habits. Towards end of meal she looks at people at table with astonished air and strange expression, then bursts into ceaseless laughter interspersed with harsh cries. I called to her loudly to make her stop; she did stop, got up, and began to go about room with preoccupied air, sometimes stopping, turning round on her heel, and then going on again. Pulse very frequent, though small; mouth dry, eyes red, palpebral circle narrowed. Began then to walk in grotesque manner and laugh loudly, then advanced majestically towards a person and bowed repeatedly to her, then burst out laughing. Walked on again mumbling something unintelligible, suddenly sat down, became very pale and fainted. Breathing became difficult, pulse very frequent, very small, so much so that I could no longer feel it. Muscular relaxation complete. In a short time she called in low voice, saying she could not see, and that she was dying; pupil’s very dilated, eyelids drooping, could not move, but limbs were not stiff. Gave her a cup of tea, which made her vomit a good deal; she was put to bed and remained in comatose state, rarely answering questions. Pulse increased a little, second cup of tea made her vomit again, and prostration followed these attacks, which had lasted 4h. Next day was quite well. (Ibid.)
10 A. M. L. -, 5.5 p.m., pulse 80, regular; state normal; after 2 1/2 grms, of 3rd ext., sits down to eat at 5:10 At. 5.25 face became animated, blood to head, becomes talkative. 5.30, inclines head to left and r. Pulse 100. 5:40, falls on one of his comrades with loud burst of laughter. 5:50 we took him away with us; on way he spoke with volubility, ran, dragging people whose arm he had. When he got to his room, 6,40, pulse 100, still talks, but has calm moments. 7 p.m., almost in normal state again, only slight heaviness of head. 7.15, pulse 80, quite well again.
10 b. At 4:15 p.m., 2 grms; at 6, dined with much appetite. Up to 8 p.m., he was only excited, making him speak much, but spoke sensibly. Pulse 90, breathing regular. From 8 to 9:30 he felt fatigued; pulse 80. Nothing noteworthy, but at 9.30 he had strong sensation of heat, breathing more frequent, eyes became injected, great lassitude came on; pulse 120. At same time had such feeling of well – being that he would not be disturbed. Weakness persisted; he fell asleep; pulse 100.
10 c. Took (next d.) at 9:50 a.m., 6 grms. extra. fasting. Pulse was 75, breathing regular. Began to eat at 10:35. At 10:50 effect began; look is undecided, eyes begin to inject; pulse 100, small, breathing frequent. At 11, he becomes very loquacious, leans to right and left, wanders. Begins phrases which he cannot end; pulse 120, eyes and face congested, cold extremities. 11:10, agitated and wanders still; will not have pulse felt, and laughs loudly. 11:15, face is the seat of partial contractions; does not speak any more, looks sad, and inclines his head: pulse 110. 11:20, wanders again, cries out, very agitated; he notices himself that he is talking nonsense; face has look of stupor; breathing frequent and impeded; eyes very congested, haggard. 11:25, same wanderings, is joyous, rallies, and seems to be quarreling with an Invisible being, who he thinks wants to harm, him. Gets up and sits elsewhere. 11:30, begs people to excuse the “negligence” of his dress with very sad look: sighs and goes with contrite air to lie down full length on sofa. Cold extremities: noisy breathing: pulse 140, irregular, small; mouth very dry; however, he spits constantly; drinks much. 11.40, he shuts his eyes, does not move, nor answer questions. A child passes singing in the street; he says he hears an harmonious voice. 11:55 pulse 110, same state. At 12, same torpor; the clock strikes at cathedral, at the first beats he complains that they have been ringing very long, complains thus at each stroke of the clock. 12:15, same injection of eyes, haggard look; pulse 110, same wandering, nausea, pupil is not contracted and remains sensible to light. 12.15, same state of pulse, nausea, sight vomiting,, falls into state of torpor and then complains of headache. He does not feel returning to normal state. Intellect still hampered, head heavy, he feels great weakness. 12:35, falls asleep, breathing regular. 1:30 I awoke him; head still heavy; has not dreamed during sleep, intellect still clouded, and same feeling of no strength. At 3 p.m., he still had tension in head, but intellect was clear. All rest of d. he had heaviness of head and headache. After dinner at 6, he had an attack again which looked like drunkenness. Felt very tired and went to bed early; agitated sleep, but well next day (Ibid.).
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.