3. GUNTZ, on March 31st, 1824, took 1 gr. in pill-form at 9 a.m. On April 7th, at 9 a.m., took 5 grs., followed at 5 p.m. by pressing pain in cardiac region, as if from over-filling and distension of heart, lasting, with brief intervals, 1/2 h. and accompanied by smaller pulse; at 8 p.m. 1 loose stool. On April 9th, after 6 grs. felt occasional rumbling in bowels. Same result followed a 10 gr. dose. On April 17th, at 9 a.m., took 15 grs. Towards evening and next day in forenoon had slight nausea, as if from an empty stomach, with distaste for food. By midday both symptoms had disappeared. (JORG, op. cit.)
4. LIPPERT on March 29th, 1824, at 9 a.m., took 1 gr. Towards 10 a.m. confusion of head came on, changing gradually into heavy pain as if whole brain were pressed together; this was accompanied by giddiness, warmth of skin, and accelerated circulation. These lasted till towards 4 p.m. At 5 p.m. frequent foul-smelling eructations set in, ceasing only next m. at 9 a.m., after abundant, soft, brown, foul-smelling evacuation. On March 30th, at 9 a.m., took 2 grs. At 10 a.m. felt pressing sensation at epigastrium, at 5 p.m. slight transient giddiness. No stool passed this d. Next was seized with confusion of head, increasing gradually to actual pain, which kept coming and going periodically until late at n. On April Ist, after much straining, passed a copious hard stool. Repeated same dose on 2nd with same result, except that stool next m. was inclined to be loose. On this day too (3rd) in evening considerable headache came on. Sleep was not disturbed, but on 4th pain was still there and lasted all day with varying intensity, but never ceasing entirely. After doses of 4 and 6 grs., experienced only belching and confusion of head. After latter dose, bowels acted several times during day, but were not actually relaxed; much flatus was also evacuated. Similar results followed dose of 8 grs., except that bowels remained confined until next m., when a semi-relaxed stool was passed. After 10 grs. taken, April 10th, at 9 a.m., head remained quite clear; usual belchings occurred during afternoon, and next day two diarrheic stools were passed. Same effects followed dose of 12 grs. (Ibid.)
5. OTTO took 2 grs. on March 19th, 1824, at 9 a.m., After 1/2 h., pressing pains in occiput came on, spreading gradually over whole head, and causing sensation as of brain being surrounded and pressed together by a cloth. Whilst this symptoms increased, thorax was seized with spasmodic contraction, in consequence of which it seemed as if lungs could not expand completely, although respiration was meanwhile normal. These symptoms disappeared gradually after 1 1/2 h., first head and then chest becoming quite free. 20th, 9 a.m., took 3 grs. After 1/2 h., constrictive pain in head came on, but less than yesterday; on other hand, constriction of chest was increased so that pulse was small, contracted, and irregular, beating only 60 instead of 65 per m. After 2 h., symptoms began to pass off; pulse, however, was nearly 4 h. in resuming ordinary rate. During day, before and during micturition, drawing in glans penis was felt several times. 22nd, 9 a.m., took 4 grs. After 1/2 h., unpleasant taste, soon passing on to nausea, set in. At 10 a.m. came on gentle pressing and drawing pain in region of cardia, spreading first towards spleen and later towards liver, and aggravated by pressing diaphragm downwards, preceded by considerable rumbling in intestines and a few eructations, and accompanied also by previous contraction of chest and acceleration of respiration, although to a moderate extent; pulse meanwhile being more rapid and smaller than usual. These symptoms disappeared during afternoon, but evacuations later on were soft and yellowish, containing less bile than usual, but without any odour of drug. 23rd, 9 a.m., took 5 grs. with same results, only that bowels did not act till next day, when motion was firm, dark brown, and smelt not unlike drug. In chest only slight drawing was felt, respiration being only slightly accelerated, and pulse smaller, quicker, and more contracted than usual. Head during afternoon was confused and seized with pressing pains, as if a cord were tied tightly round brain. Towards evening, drawing in glans penis came on; urine was dark brown, easily passed, and deposited no sediment, but had rather strong and pungent smell. 24th, 8:30 a.m., took 6 grs. Rumbling in intestines, and increased warmth and pressing in gastric region soon followed; last-mentioned this time to greater extent, spreading less to left side and not at all to right, but ascending more upwards into esophagus, and causing sensation as of foreign body rising. These symptoms ceased at noon, but abdomen remained distended, although neither wind nor faeces passed this d. Contraction of chest lasted from 10 till 12, and was accompanied by quickened pulse and respiration, former being small and contracted. During afternoon drawing in glans penis was more evident than from previous doses, and kept coming and going although micturition was unaffected, except that urine had strong pungent odour. At 8 p.m., was suddenly seized with giddiness and dimness of vision. Shortly afterwards cold sweat broke out on forehead and extremities, with cutting pains in abdomen so severe as to oblige him to go to bed; here symptoms moderated, but lasted fully an h. Stool next m. was firm, dark brown, and smelt of drug. Took 8 grs. on 26th, at 9 a.m. After 2 1/2 h., nauseous taste in mouth came on, which soon changed to that of onions, lasting nearly whole day, pulse and beat of heart being meanwhile small, quick, and irregular. Chest symptoms were slighter than usual. Towards midday, rumbling in intestines came on, becoming gradually more marked, and changing during early afternoon to pressing in stomach. At same time spasmodic constriction of chest, coupled with dry irritating cough, caused by tickling in windpipe, was felt. When former had lasted 1/2 h., O-felt slight rigor reaching from last dorsal to 2nd lumbar vertebra, but not beyond this point. After rigor ceased, pressure in stomach came on, changing later to stretching pain, and spreading to right and left, and increased by pressing diaphragm downwards, or if gastric region was touched externally. Pulse as in forenoon was small and quick. When these thoracic and abdominal symptoms had lasted nearly 3 h., general malaise came on gradually. Constriction of chest increased to anguish, respiration became impeded, causing general restlessness, which compelled him to go hither and thither. Head meanwhile felt muddled, and thinking difficult. Felt also mentally restless, and unable to keep to one subject. From time to time rigors spread over whole body, but without subsequent heat. These symptoms were much relieved by an hour’s walk in open air, but had not disappeared at 10 p.m. Abdomen remained distended during afternoon and evening, because faeces nor wind were evacuated. On other hand, during evening was troubled with feeling as of substance rising from stomach through esophagus into pharynx, causing him to swallow frequently; this relieved him, but only temporarily. Urine was lighter than from previous doses, but smelt as before. Next m., on awaking, noticed head muddled, very slight constriction of thorax, with somewhat quicker cardiac and arterial pulse, gentle pressure in gastric region, becoming worse after a little time, and fulness and distension of abdomen. Bowels acted before 7 a.m., motion being small and yellowish brown, consistent at first and then pappy and soft, smelling not unlike drug. These symptoms gradually disappeared, muddled condition of head lasting longest (till e.). From this dose appetite was decidedly diminished. After 9 grs., early symptoms were much as before. Shortly after 1 p.m., chest became so constricted that it appeared as if same were squeezed by heavy body lying on sternum. Respiration and pulse were affected as before, with occasional coughing and yawning. Coupled with these thoracic symptoms felt congestion towards head, face became hot, and head began to ache. Feeling came on in eyes as of grains of sand between eyeball and lids, and as if cool wind were blowing upon eyes from without, pupils meanwhile being unusually dilated; at same time peculiar drawing developed in articulations of lower jaw, changing to moderate pain; this soon abated, but was repeated once during e. Other symptoms were same as from last experiment, but milder. After quiet n., awoke with slight pressing headache and distension of abdomen; both vanished after bowels acted at 7 a.m. After dose of 10 grs., all these symptoms were repeated with addition of scraping feeling in esophagus. At 4 p.m., abdomen became unusually distended. Bowels acted shortly afterwards, excreta being hard, dark brown, and foul smelling, and gave pain at anus in passing; after a while this relieved distension of abdomen; latter was distended from time to time, but was relieved by passage of flatus. All symptoms gradually decreased until towards 8 p.m., when all reappeared; headache spread this time from left frontal region over whole head, and pains in jaws spread to muscles of neck. Condition reached its worst at 11 p.m., then moderating rapidly, so that by 12 nearly all symptoms had ceased. After restless n., felt some confusion and pressing pain in head on awaking, with considerable distension of abdomen and very moderate feeling of constriction of chest. Soon after rising had dark brown, soft, yeasty, and foul-smelling stool. All symptoms had vanished by midday. Repetition of dose was followed by same symptoms. Next m. remarked constriction of chest, quickened respiration and pulse, and distension of abdomen. At 9 a.m., pressure in stomach came on again, and distension of abdomen became very troublesome. During m., felt drawing and tearing pains in neck, extending from occiput down neck to arms, resembling rheumatic pains. Urine has pungent and ammoniacal odour. (Ibid.)
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.