1 b. Administered by the mouth, the same preparation, in the same dose, produced in this dog a frothy and very abundant salivation, which lasted 3/4 h.; there were two vomitings, the contractions were much less marked. (GUILLEMOT, op. cit.)
2. VIBORG administered an infusion to horses, and found that in moderate doses it increased action of heart, flow of urine, and warmth of skin, and that these effects were accompanied and followed by full pulse, muscular tremors, and depression. In larger doses it produced similar effects in a more marked degree. When injected into their veins it occasioned flow of saliva, heat of skin, general tremulousness, with roughness of coat, laboured breathing, and full pulse. To these symptoms succeeded general depression, with drooping head and closed eyes. The animal could scarcely stand, and finally lay down quite insensible to all external irritants. Within 2 hours he perfectly recovered. Effects entirely similar, but of larger duration, were observed in a cow. (STILLE, op. cit., sub voce.).
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.