8 b. July 2nd, 8 a.m., after taking tincture and smaller doses of infusion without result, took 3 oz. of infusion (=1/2 drachm) and felt soon after dose slight scraping along gullet. 3 p.m., perceived transient stitch in umbilical region which appeared to have its seat in small intestines, and lasted 1/4 h. 3rd, 8 a.m., took 4 oz. (=1 drachm); after 1/2 h. dull pain came on in frontal region and lasted until towards evening; at 6 next m. was attacked by pressing pain in r. hypochondriac region, which came and went, appearing to have its seat in liver or duodenum, and vanished at noon. (Ibid.)
9 a. JORG, after doses varying from 3 to 20 grs. obtained following results: Peculiar slight burning or scraping biting in throat extending through esophagus to stomach, somewhat like heartburn, and lasting 1/4 and 1/2 h. Soon after repeated belchings, at first with taste of drug. accumulation of saliva in mouth, and inclination to vomit without nausea, accompanied by feeling as if pharynx were swollen and prevented swallowing; these three symptoms vanish and reappear several times during next few h. About 1 h. after taking drug cramp-like constrictive pain begins in stomach, causing pain generally, but mostly in posterior wall of stomach, as if this were being pressed against spinal column and as if latter were made sore at same time above and below situation of stomach. Two or three h. after dose slight cutting pain in small intestines comes on, followed in 1/2 h. or 1 h. by distension and swelling of small intestines with frequent urging to stool, relieved at times by diarrheic evacuations, at other times by passage of small and touch faeces with much wind. Final effects are pressure in head, confusion of same, usually one-sided rheumatic headache, and vertigo lasting 1 or 3, 4 or even 5 h. Pain at stomach frequently changes, after 1, 2 or 3 h., into ravenous hunger, although appetite and digestion remain diminished.
9 b. June 30th, 8 a.m., after 3ij of infusion (=2 1/2 grs.) felt slight fullness in stomach and slight belching up of flatus, followed at 11 by slight dullness in head, which resolved itself at mid-day into general weariness, lassitude and somnolence; although these passed off after dinner, felt between 3 and 6 p.m. fatigued and disinclined for mental exertion. (July Ist, 10 a.m., 1/2 oz. of infusion (=5 grs.); felt immediately some scraping in throat, later on fullness on stomach and distension of abdomen, with frequent passage of flatus and urging to stool, although more constipated than usual; 3 to 6 p.m., again felt confusion of head and distaste to work. Next m. at 5 a.m. on sitting down to my work-table was surprised by severe pain in spinal column, such as would be felt by suddenly standing upright after long stooping: this cramp-like pain was not situated in the muscles of the back, but in the inner soft parts of spinal column, appearing at times as if posterior wall of stomach were pressed forcibly against anterior surface of spine. Two h. later pain was concentrated more in upper part of spinal column, between shoulder-blades; by mid-day all effects had passed off. On repeating dose 2 d. later same symptoms were produced, pain in spinal column lasting this time 2 h. and proceeding apparently from stomach. (Ibid.)
10 b. FRAU CH. took 1/2 oz. (=2 1/2 grs.); no scraping was produced, but moderate burning feeling in throat, less nausea and sinking, more pressure at stomach than from infusion of flowers. With this pressure at stomach was coupled at times feeling of emptiness and ravenous hunger, although there was complete loss of appetite and disinclination for all good. In afternoon she suffered from pressive headache, especially in forehead. Pressure at stomach was repeated from time to time, accompanied by unpleasant feeling of fullness, although stomach was empty, and also frequent acrid feeling in oral cavity lasting till 3rd day after taking drug. (Ibid.)
11 b. L-after similar dose noticed no symptoms in digestive tract, but from 11 a.m. till 10 p.m. felt confusion of head with frequently recurring inclination to sleep and distaste for active exertion. (Ibid.)
12. Eight members of the Vienna Society of Physicians proved A. in form of ext. of flowers, of which gr. j-xij were taken daily. Phenomena observed from its use were:
12 a. In digestive organs, flying pains in abdomen, epigastrium, and r. hypochondrium; eructation, disgust, yawning; dryness of mouth and throat; burning of tongue and palate; oppression of stomach; increased appetite; flatulence; firmer and less frequent evacuations.
12 b. In vascular system, stronger beat of heart; frequent blowing nose with traces of blood; slight epistaxis; swelling of hemorrhoidal vessels.
12 c. In nervous system, confusion and fullness of head; slight pressure; partial headache; vision of sparks; itching of skin and eyes; comfortable feeling or exhaustion; restless sleep, vivid agreeable dreams. (Wiener Zeitschr., Dec. 1844.)
13. SCHNELLER, one of the above, reports that he took doses increasing by 1 gr. daily for 11 d., in which therefore he took 78 grs. Up to dose of 6 grs. nothing particular was noticed save a bitter, rather disgusting taste, and increased flatus; sleep was also diminished and rather restless. Symptoms produced by doses of 7-10 grs. were, besides the foregoing, sensation of burning in tongue and soft palate, as if from pepper or from swallowing a hot liquid, which set in particular 3 h. after taking medicine and was confined to ant. third of tongue, on which nothing abnormal was visible; appetite unaffected. During doses of 11 and 12 grs. burning diminished and was only felt on point of tongue; in middle of lower lip several vesicles appeared containing a clear fluid and soon drying into scabs. In evening slight epistaxis. Nights restless, dreams very vivid. (Ibid, March, 1846.)
14. A. von SZONTAGH, et. 31, never ill since childhood, except ague 10 years ago, and whooping-cough 1 year ago. Always took the medicine about 11 a.m. either on sugar or mixed with water. Observed himself carefully for several weeks before proving.
14 a. From Oct. 20th took daily 3 drops of 3x. For some day pain in r. side of neck where the external carotid comes from under sterno-cleido-mastoideus muscle, as if a lymphatic gland were swollen there. The pain is distinctly felt on suddenly turning head to left, on applying strong pressure on the spot, and when the carotids beat more strongly. This pain never felt before the proving, and since then has frequently recurred during the last 10 or 11 months. -22nd and 23rd. On blowing nose in m. some drops of bright blood came from nose. -24th. Unusually sleepy in forenoon.
14 b. From 24th 1 drop daily of /0. -25th. Afternoon when sitting, slight cracking and feeling of sprain in right wrist on moving hand. -24th and 25th. Unusually early waking in m. with inability to go to sleep again. -26th. 3 drops 0/; nothing unusual. -28th. 5 drops /o. In afternoon some violent stitches in glans penis. -29th. Several times aching pain in first phalanges or 3 last fingers of l. hand. All afternoon confusion of head with slight singing in r. ear; evening, aching pain in l. eye extending to l. half of forehead, followed by eructation and inclination to vomit. -30th. Slight singing all day in r. ear, and similar but slighter headache or r. side without nausea. – 31st. 10 drops. Before taking it frequent empty eructation. 2nd Nov., 15 drops. Before taking it toothache in a sound l. lower molar. After taking it frequent eructation of air, smelling of arnica. Afternoon, slight squeezing pain in lower angle of l. scapula. E., in larynx feeling of obstruction, like swelling, inclining him to cough and hawk, which sometimes brings away some thick phlegm but without relief. -4th. On waking confusion of head, in the forenoon passing into pressive r. side headache. At 11 a.m. 20 drops 0/. After 1/2 h. urgent call to urinate and evacuation of a large quantity of watery urine. Headache lasts with intermissions all the afternoon. -5th. Afternoon, suddenly a violent tearing and burning in outer border of left foot for 1 m. -6th. 30 drops 0/. After 1 1/2 h. pressive squeezing pain in inner half of r. eyeball, going off gradually when walking in open air. The afternoon urine has a darker colour, acid reaction, and higher sp. gr. than usual. This and next day uncommonly frequent noises in ears, even when quite quiet. -8th. 40 drops 0/. Twitching pain in l. side of chest for some., recurring later. -9th. Forenoon, while walking for some m., each time he raises his l. foot, and also when moving l. ankle-joint, but not when moving knee, a creeping sensation in outer half of l. sole, as if a nerve were pinched. From forenoon till evening similar left -sided headache as on the 29th. The l. eye seemed more prominent and sensitive to pressure. -10h. On waking and rising pressive pain in inner half of right eyeball and corresponding part of forehead, going off towards noon. The creeping sensation in left sole came on under the same circumstances and at the same time as yesterday, lasted longer and occurred also in afternoon sometimes. At 11 a.m. 50 drops 0/. Towards evening in distal phalanx of right finger when pressed acute pain as after a bruise for more than 1 h. Slight singing in r. ear when at rest all d. The urine passed between 2 and 6 p.m. is dark yellow, very acid, of high sp. gr., becomes opalescent when boiled, but clear on adding nitr. ac. The unboiled urine left to stand forms next day a slight sediment which continually gets thicker, and after 62 hours when it is foetid shows many crystals of triple phosphates or urates under microscope. The urine passed before and after this is normal. -11th. Wakes early. In the n. and m. passes much odourless flatus. In m. in bed when lying on back tension in region of stomach. The sensitiveness to pressure of the phalanx of the r. ring finger recurs several times in the forenoon and afternoon, but slighter and shorter, and in evening turns into tiresome aching pain. -12th. 60 drops 0/. The urine, except in m., when it is normal, shows the same characters as on the 10th. -13th. In afternoon for 1 h. pressive squeezing pain limited to the inner half of r. eyeball. The urine passed in forenoon is sulphur yellow, turbid, very frothy, reaction neutral, and on standing a short time deposits a thick sediment. When boiled becomes still more turbid, but is cleared by nitr. ac., but becomes again turbid on the addition of ammonia. Left to stand it becomes fetid on the 3rd d. and deposits a large quantity of triple phosphates. -14. All d. striking decrease of quantity of urine without increase of its sp. gr. In the forenoon urine the phosphates, in the afternoon urine the urates, were somewhat increased. -15th. 75 drops 0/. E., suddenly a violent pressive tearing pain on ulnar side of distal phalanx of r. ring finger for some m. At n. when asleep breathes with open mouth (contrary to custom), whereby his mouth becomes quite dry. Urine in forenoon as on 10th, afterwards as on 13th, then normal. – 16th. Afternoon and evening, transient tension in l. buttock and knee. Towards e. till n. drawing and tearing in r. ring finger, especially in distal phalanx sometimes also in little finger and along ulnar border of forearm. In the forenoon and afternoon urine the phosphates are sometimes more, sometimes less, but always increased. E., urine normal. -17th. Urine as yesterday. – 18th. 100 drops 0/. When swallowing great burning in throat, which goes off after 1/2 h. Afternoon, unusually cheerful. Towards evening pressure and tension in spinal process of last cervical and first dorsal vertebra for a short time. Little sexual appetite. The urine passed from 3 to 6 p.m. very acid, turbid, deposits on standing a copious, brownish sediment; after standing longer there appear in it single lumps, which show under microscope many cells. After 3 d. it becomes foetid, but is still acid, the sediment more a kind of turbidity; when boiled the turbidity increases and settles at the bottom of the tube. On adding 2 drops nit. ac. it is completely dissolved with evolution of gas. -19th. Stool thinner and darker than usual. A small rapidly suppurating ache-pustule forms under the right angle of mouth with burning pain. The urine passed in m. and after breakfast normal; that passed in forenoon and afternoon turbid. – 20th. Afternoon, violent twitching pain from l. shoulder-joint to middle finger. -21st. In m. on waking, violent drawing tearing pain on ulnar side of back of r. hand for some m. This pain recurs noon, afternoon, and evening -23rd. In m. when walking, tearing pain in r. hip, ankle, and dorsum of foot. Later, when at rest, tearing jerking pain on ulnar side of back of l. hand. – 24th. All day, pressive headache in r. eye, forehead, and temple. -25th. In m. in bed, drawing pain in skin of back of l. little finger. Soon afterwards pressive pain in joints of r. ring and little fingers. Afternoon, right -sided. headache. The forenoon urine turbid when passed. -26th. Early in bed, drawing in skin of l. little finger. -24th, 25th, 26th. The above-described creeping in l. sole when walking. Next day, drawing pains in limited places of the hands and r. foot, soon going off. -30th. All day the well-known l. -sided headache; on Ist Dec. the same pain on right side. (N. Seitsch. f. hom. Klinik, vii, 9, 20.)
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.