b. P. M. – Labial and buccal m. m. of grey colour like lead; pharyngeal m. m. bright – red, swollen, softened, and covered with patches of exudation; bright injection of oesophagus, which is eroded in places. Posterior wall of stomach marbled with ecchymoses, but no loss of substance of gastric m. m. Intestines normal. Liver large and fatty; spleen rather large; right kidney hypertrophied and inflamed. Red hepatisation of both lower lobes of right lung. (Ibid.)
III. 5. a. Dr. KOSTER injected 7.1/2 grm. of a 5 per cent. solution into the right femoral vein of a dog weighing 10,480 grm. after a few seconds there was slight muscular trembling; after 10 grm. of same solution he became restless and whined; after 15 grm. strong trembling of all muscles, numbness of sensorium, apathy; after 35 grm. febrile rigor, the breathing occasionally changed to spasmodic, jerking contractions of single or of all muscles; the lower jaw chattered as in rigor; the reflex irritability was considerably exalted; every loud noise, every time the table was struck, produced spasmodic twitchings. The pupils would not react, moderately large, latterly slightly dilated. After 5 m. the trembling abated, then 70 grm. were injected. After every new dose the convulsions became stronger; the pupils dilated to their maximum, but soon became more contracted to moderate size; lastly the dog lay with his limbs twitching, breathing weak, a large quantity of saliva flowed from his mouth, the temperature fell continually, after 35 m. to 37.5, left evening 2less than at the commencement. The vein was now ligatured and the dog let loose; the reflex irritability seemed nearly extinct, the animal appeared to be moribund, the respiration very superficial, the pulse scarcely to be moribund, the respiration very superficial, the pulse scarcely perceptible. After 1/2 hours the symptoms diminished in intensity; after 15 m. more the dog raised his head and tried to get up on his fore legs, but always fell down powerless. At last he got up. his hind legs dragged somewhat, his gait was staggering. After 1 hours more he appeared quite lively only rather weak; after 3 hours temp. was 39.4, after 6 hours 39.6. The following m. was quite well except rather weak.
5 b. 110 gr. of same solution were injected into left femoral vein of a dog in 20 m. The effects were similar to those observed in the first case. Sensorium dulled; he barked loudly, had violent muscular trembling and convulsions, which gradually declined and the barking changed to a king of barking whining. The temp. continued to sink till death ensued. Before this occurred, the barking and trembling continuing, the pupils became insensible. After a few hours he somewhat recovered, during the night had liquid stools. Death ensued after 22 h.
5 c. 0.25 grm. was injected into connective tissue of back of a dog. The animal became very restless, the temp, before the operation was 40.9; 15 m. afterwards 41.8. After 10 m. he became quiet but lay trembling, the temp, fell to 39.7. Trembling increased and in evening temp. was 40.5 and towards m. fell again. The following day the dog was ill, ate nothing, but next day was lively. After seven day he died owing to an abscess that developed itself where the injection had been made.
5 d. A smaller dog had 3.37 grm. injected below skin of back. The temp which was at first 39.1 rose at first to 39.5 and then fell below the first degree. After 10 m. trembling which lasted 15 m. pretty severely; much saliva. Lastly he became unsteady on his limbs, fell easily. Next morning was living, but after some day he died from abscess in the back. (N. Zeitsch. f. hom. Kl., xxiv, 29.
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.