20. PIENITZ, on May 4th, 1824, at 8 a.m. took 3 drops, and beyond two transitory stitches in occiput 5 m. after dose noticed no ill effect. 5th, at same time, took 5 drops, which caused after 5 m. dull pressive pain in forehead and confusion in head, both lasting 1 h.; pulse smaller and quicker than normal. 20th. – 20 drops, taken at 8 a.m. caused within few m. previously noticed pressure in forehead and confusion in head, with smaller and quickened pulse, which symptom vanished, however, after 1/4 h. May 21st, 8 a.m. A few m. after 30 drops noticed somewhat greater confusion in head, giving place at 9 o’ clock to pressive pain in forehead, which lasted only 1/4 h., pulse meanwhile smaller and quicker than usual. After 35 drops, taken same day at 3 p.m. same effects followed, only that confusion in head was worse and lasted longer. After last 3 doses faeces were drier and harder than usual, otherwise appetite, sleep, and other bodily functions remained normal. (Ibid.)
21. SEYFFERT took 4, 8, and 12 drops without any effect. May 15th, after 20 drops, taken at 8 a.m. felt transitory nausea and passing giddiness, which he thought would perhaps have lasted longer if he had not moved about in open air. On reaching home great inclination to sleep was present, which he was obliged to yield to for at least 1/4 h. Before and after sleep pulse beat 68, instead of 70 as usual. By midday, when he ate his dinner, all unpleasantness seemed to have vanished. 35 drops taken on 18th caused only slight transitory giddiness, followed by drowsiness, but without preceding nausea. Pulse during following h. beat 69 per m. (Ibid.)
22. SIEBENHAAR tried 3, 4, 5 and 8 drops without effect. May 10th, 8 a.m. took 10 drops: dull and tolerably severe pressive headache followed, lasting until afternoon; pulse meanwhile beat somewhat less in m. A somewhat severe cold obliged him to discontinue his experiments. May 19th, at usual time, took 12 drops, and after lapse of about 1/2 h. noticed confusion of whole head, changing by degrees into genuine dull headache, felt chiefly in temporal regions and forehead. Pulse meanwhile somewhat slower and weaker. By midday all these symptoms had vanished; he ate his dinner with good appetite, and during afternoon felt perfectly well. 20th. – 14 drops caused same effects. 21st, 8 a.m. 20 drops; noticed soon after, confusion, especially of forehead; pulse beat more slowly and lost all energy; felt considerably fatigued over whole body, and towards 11 a.m. so overcome with sleep that he was obliged to lie down on sofa, where he slept 1/4 h., although in a somewhat uncomfortable position; on awaking found himself incapable of standing upright and moving about. At midday normal frequency and force of pulse returned, as also his accustomed energy, headache also vanished. Whilst above-named effects lasted, raw feeling in throat and hoarseness were present, but disappeared after dinner. (Ibid.)
23. JORG took 6 drops mixed with 1 oz. water at 8 a.m. on May 14th, 1824. Some scraping in throat and tickling in larynx as from threatened cold followed, and lasted till 11 a.m. 15th, 8 a.m. 8 drops mixed with 1 oz. water caused slight confusion in head, lasting 1/2 h. scraping in larynx, and increased thirst, both lasting whole forenoon, and for about an h. slowing of pulse by 3 or 4 beats. Same effects followed 10 drops taken on 17th and 12 drops on 18th. On 19th, at 8 a.m. took 14 drops in 1 oz. spring water; soon experienced shooting pains in l. temple, confusion of head as if an acute coryza were about to come on, with feeling particularly as if brain at upper and anterior part of cranium were pressed, most of all in frontal region, with very sensible pressure towards orbits as if water would be pressed out of eyes (later in day increased lachrymation followed), scraping in larynx, with commencing hoarseness and increased secretion of mucus in larynx, and frequent inclination to cough, all lasting till midday. For about an h. pulse beat 1 to 6 less in minute. Towards evening was much fatigued, had hard and dry evacuation of bowels, same being very unusual, and longed for bed, where he fell asleep at once, and awoke with difficulty in m. 20th. – Experimented with 16 drops, and after taking drug at 8 a.m. in 1 oz. water obtained following effect:- “All symptoms of previous day and of 14-drop dose came on within 15 m., only confusion of head spread to-day over whole body so that common sensation was thereby considerably lowered; could neither thoroughly realise my own condition nor was able to feel things round me with usual clearness. This condition of general confusion, similar to that which comes on after drinking several glasses of wine rapidly one after another, was not accompanied, however, by the feeling of warmth or heat in whole body, and especially in head, as in tipsy condition after drinking wine quickly, but appeared, on the contrary, without slightest trace of accompanying heat. After this dose also irritation and scraping in throat, and especially in larynx, soon began; 10 m. after taking drug I was hoarse, and frequently obliged to cough towards midday, and during whole afternoon much tough mucus was secreted in windpipe, especially in upper part. Towards noon confusion of head and of whole body disappeared, natural sensation returned, but I had to endure during afternoon and until e. constant transient stitches, sometimes in occiput, sometimes in forehead. Towards, e. was much fatigued, and was inclined for bed by great disposition to sleep. Enjoyed dinner and supper, but this may be explained by fact that during experiments with aqua laurocerasi I ate nothing in and during forenoon, only drinking two cups of coffee with milk. After this dose pulse remained for about 2 h. 5 or 6 beats slower than usual, and later on did not become quicker (than usual), but emerged from slower to normal rhythm. On this occasion also constipation was not absent faeces being hard and dry. Felt each time lighter in fresh air, heavier in room.” (Ibid.)
24. TRINKS took unknown quantity of juice of cherries. [ Christison states that the pulp of the cherries is innocuous] In 1 h. became fretful; in 1 1/2 h. sad, joyless and depressed, with anxious feeling in head, and heat external and internal – in forehead, going off in open air. (HEARTLAUB and TRINKS, Arzneimittellehre, i, art. Kirschlorbeer.)
25. HARTLAUB (a) from same; had anxiety in chest immediately, pain there in 5 m.; in 1/2 h. squeezing pain in occiput, with sleepiness, of short duration and little severity; in 1 h. similar but longer lasting pain in forehead, sleepiness continuing; at 8.30 p.m. excessive thirst with dryness in mouth, without heat; in evening in bed, great anxiety about trifles, was unable to fall asleep; sleep uneasy, with frequent waking, and serious, anxious dreams; felt much relaxed in m. Next d. from another dose had in 1/2 h. violent colic lasting 20 m., without alteration of pulse; at 4 p.m. recurrence of thirst and dryness of mouth, with shooting here and there in head; later a kind of shooting and crawling in brain, violent and long-lasting. There followed complete constipation for 8 d. (Ibid.)
25 b. At another time, H. took aqua laurocerasi (in unknown dose). Violent throbbing headache in forehead came on immediately; in 1 h. dull pain in throat, cavity of chest, region of heart and stomach, and scapula on r. side only; in 3-4 h. pain in r. temporal bone; in 5-6 h. pain in stomach with qualmishness. At 4 p.m. had pressive pain in r. temple. Other symptoms were pain in r. side of forehead and in l. elbow; weariness in shoulders; and a kind of oppression causing anxiety, he is unable to work, must leave room and go into open air, but heaviness does not leave him for whole day. (Ibid.)
26. NENNING proved laurocerasus in his usual way, viz. on his wife’s work-women, who received a consideration for the same. [ See Brit. Journ. of Hom., xxxv, 106]. [He reports every trifling deviation from health observed by these while taking the drug, and so loads his symptom-lists with a number of shootings and itchings here and there, rumbling in abdomen, variations in stool, and such like, which are obviously non-medicinal, and incident to everyone’s normal condition. Hahnemann would do no more than make extracts from this surgeon’s contributions, and we correspondingly and still more rigidly restrict our use of them.- Eds.]
As effects of expressed juice and distilled water of laurocerasus [ Symptoms from distelled water are italicised] Nenning reports – predominantly gay mood, with tendency to forgetfulness; vertigo, somewhat prolonged; heaviness, dullness, and fullness of head; some heat in forehead; feeling as if ice lay on vertex, afterwards also on forehead, then in nape of neck, last in sacrum, whereupon previous head troubles disappeared (2 1/2 h.); violent aching round eyes, especially l., constantly increasing till 9th d.; violent bruised pain in whole lower jaw lasting 1/2 h.; some salivation; rawness in throat, with hacking; frequent shooting and burning in r. hypochondrium, so that spot became painful even to touch (3 h.); awakened at 2 a.m. by terrible cutting and contractive pain in whole abdomen, lasting 2 h., followed by two purgings, and cessation of pain; diarrhoea consisting of thin greenish mucus, with contraction in groins, 4 times in 2 h., without relief; urine in one case acrid, making pudenda sore; catamenia in three cases 8 d. too early, in two more profuse than natural; hoarse and deep voice; weak, prostrate feeling (1 1/2 h.); in one person, redness and some vesicles, with violent itching, between index, middle, and ring fingers of both hands, for 4 d.; subsequently rawness and roughness there, with burning on wetting hands. Chills, followed by heat, seem to have occurred in several provers. (Ibid.)
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.