15. HEISTERBERGK on June 6th at 8 a.m. took 10 drops in about 6 parts of water and found no effect. Pulse remained normal, 67 to 70. On 10th raised dose to 20 drops, and 1 1/2 h. later noticed trifling heaviness of head; pulse as on 6th. 11th. – 30 drops taken at 8 o’clock caused after an hour’s time feeling of heaviness in head. “This heaviness lasting 2 h. was not actual pain, but resembled that which occurs at the commencement of a coryza or after a debauch.” On 15th rose to 35 drops, and after it felt indisposed as on 11th. On 19th, 15 m. after a dose of 50 drops taken at 6 p.m., became smaller and slower (60 to 63), and above-mentioned feeling of heaviness in head came on 15 m. later. Although not worse than on previous day it spread, especially towards forehead, and lasted till 10 p.m. 20th. – 60 drops taken at 8 a.m.; pulse after a while smaller and slower (59 to 63), but not irregular; 1/2 h. later heaviness in head came on again, especially in anterior part, accompanied with moderate pressure in orbits as if eyeballs were rather too large for bony cavities. At 10 a.m. pulse was again regular, and at 1 p.m. heaviness in head and pressure in orbits had vanished, a frugal dinner being meanwhile consumed with zest. On 20th, at 3 p.m. took 112 drops all at once, and perceived 10 m. later feeling of heaviness in forehead and pressure in orbits, but not worse than in former experiments; 15 m. after dose pulse was small, contracted, and slower (58 to 59). Towards 7 p.m. head was again quite free and pulse regular. June, 22nd. 80 drops taken at 8 a.m. after eating a quantity of bread and butter 1 h. previously; perceived heaviness in head, though very trifling; pressure in orbits not at all, and pulse somewhat smaller, but not slower than usual. Notwithstanding that Hbk. took drug in very large doses he testifies that no other effect had followed in his case, no headache, giddiness, tremor of limbs, or obfuscation of senses was present. (Ibid.)
16. MEURER took 5 drops at 5 p.m. on March 28th without any effect. Mar. 29th, at 9 a.m., 10 drops, followed after lapse of 5 m. by pressing headache in frontal region, lasting 1/2 h., and then vanishing gradually; pulse was somewhat slower, but remained full and regular. After dinner, eaten with zest, could not resist temptation to sleep, and slept longer than accustomed to do occasionally at other times after dinner; 1 1/2 h. later was quite well again. Mar. 30th, 8 a.m. again took 10 drops; after few minutes pressing headache appeared, attacking forehead and occiput alternately, and after 1/2 h. vanished gradually. Pulse 12 beats per m. slower. Was altogether much fatigued. 31st, 8 a.m., 15 drops taken, followed by some lessening in frequency of pulse, as also by headache, worse at one time in forehead, at another in occiput, but felt worst and most continually above orbits. To-day there came on peculiar sensation in region of stomach; he cannot call it nausea, though it resembles feeling that precedes vomiting. Was likewise again much fatigued, and remained whole day more passive than active. Ap. 1st, 8 a.m., 15 drops. Experienced above-mentioned pain in head, which ceased as long as he remained in open air (1 h.), weather being fine and cold with morning wind, but became worse in heated room, where he felt particularly bad and much fatigued; sensation of nausea in region of stomach set in; contrary to custom fell asleep at noon, and only awoke at three, although he had slept well previous n.; ate towards e., and slept well and long following n. Pulse also showed to-day above-mentioned changes. Next day still not quite well; appetite still small, felt sluggish, and incapable of work. June 6th, 8 a.m., began again with 5 drops, but observed no alternation of natural state of health. June 7th went on to 10 drops, whereupon slight transitory pressure in frontal region, and especially over orbits, came on; pulse, however, remained unaltered. Attributes weakened action of drug on this occasion to change in quality of drug or to that one remains more in the open air in June. 8th, 8 a.m. immediately after swallowing 15 drops felt same headache and in same spot, but more severe; pulse 12 beats slower; felt himself afterwards much fatigued and disposed to sleep. 9th, 8 a.m. again took 15 drops, and became indisposed as on previous day. 4 p.m. took 20 drops, and felt headache, which at once set in and became of a boring character; beyond this felt considerable fatigue, disinclination for all work, moroseness, and somnolence; so long as he remained in room sleep threatened to overcome him, but spending e. in company in open air was enabled to withstand it. Appetite remained undisturbed, and he slept following night very well; next m. found himself, however, not quite brisk. 12the 11 p.m., took 25 drops. Immediately after dose severe boring headache above orbits came on; went to bed, soon fell asleep, and slept till 5 a.m. without waking, feeling by this time quite well. 13th, 9 a.m. repeated 25 drop dose, which was soon followed by above-mentioned pain in head, slower pulse, general weariness, and inclination to sleep. 8 p.m. took once more 25 drops; headache again occurred, but pain spread over whole head and become more pressing; overcome by sleep slept 2 h., becoming thereby more inclined for work; beyond this had frequent tasteless eructations, although no other disturbances of digestion were present, and he ate his food with good appetite and in usual quantity; following n. slept very well, finding himself pretty well on 14th and quite well on 15th. 16th, 8 a.m. took 30 drops, which were soon followed by all effects of previous doses, only pressing headache spread over whole head. At 4.30 p.m., feeling still fatigued from m. dose, took 35 drops. Headache increased, but besides above-mentioned symptoms there was fatigue, retarded pulse (12 beats), disinclination for all activity, and inclination to sleep; feeling of emptiness in stomach felt to-day for first time although he had dined as usual at midday. This vanished after 1/2 h. without his having eaten anything, but headache lasted several h.; enjoyed his supper. Towards 10 p.m. before going to bed, took another 35 drops; pressing headache and retarded pulse followed. he soon fell asleep, and slept well whole n., and following d. was quite well. (Ibid.)
17. KNESCHKE gives following results:- “5 and 10 drops of aqua laurocerasi, former taken Mar. 28th, after 5 p.m. and latter Mar. 29th, at 9 a.m. had not slightest effect upon me.” “Mar. 30th, rose to 15 drops; immediately after dose noticed slight confusion in head, lasting an h. Pulse sank from 70 to 65 or 66. Noticed no other departure from normal condition. Same results followed on April 1st from 20 drops, and no raising dose on April 2nd to 20 drops, confusion in head, especially in frontal region, was not only no worse, but pulse was only 5 beats slower than normal. Effect of drug did not last quite an h.; presented no other symptoms than those above narrated.” “6th, 8 a.m., 5 drops produced no effect; same was the case from doses of 10, 15, and 20 drops, taken on 7th, 8th, and 11th respectively. June 13th, 25 drops taken; immediately afterwards perceived slight pressure in frontal region, which, without becoming worse, lasted fully 1/2 h. During this time pulse sank from 70 to 64 or 66. Same pressure, which became by degrees more acute, occurred on 15th, after 30 drops, but ceased in time mentioned above; pulse 64, otherwise nothing abnormal noticed. 18th. – 35 drops produced within 1 m. of being taken confusion in head, going on to pressive pain, especially in frontal and orbital regions; effect of drug extended over nearly an h., during which pulse beat 60 to 62.” “Doses of 40, 45 and 50 drops taken on June 20th, 22nd, and 25th respectively, produced precisely similar results; pulse, instead of 70, beat only 60, and considerable dullness of whole head, accompanied constantly in frontal region by pressive pain, was present during whole time; beyond this every bodily function was in its normal condition.” (Ibid.)
18. KUMMER, on June 6th, at 8 a.m. took 5 drops on 7th 10, 8th 15, 11th 20, and on 15th 25 drops, but could not perceive slightest ill effect. 18th, 8 a.m. took 30 drops, and perceived after dinner, towards 1 O’clock, acute pressive pain in l. frontal region, spreading by degrees over whole head; thinking and other mental occupations rendered very difficult; sleep uninfluenced, however. 19th. – On awaking same pain set in and lasted till 3 p.m. Perceived no influence upon pulse, digestion remained regular, but urine deposited thick sediment on standing. (Ibid.)
19. STROFER, after 5 drops, taken June 6th, found no effect, but after 10 drops, taken on 11th, noticed his pulse 4 or 5 beats slower. 12th, after 15 drops, found pulse 5 or 6 beats slower, and on 15th, after 20 drops, 8 to 10 beats slower; same effects followed dose of 24 drops on 17th. On 22nd, after swallowing 30 drops, effect was much increased, for beats were diminished about 12 per minute. (Ibid.)
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.