Throat
Dryness of back of throat (after fifty minutes). During the forenoon my throat felt dry and inflamed; everything swallowed caused a scraping sensation; in the afternoon the inflammation increased; the tonsils were slightly swollen and the jaws a little stiff; this soreness lasted for two days (seventh day). Quite a sore throat, smarting pain; headache, dull pain, mostly on the left side; breathing hurried; the sore throat and headache lasted all day and evening till I went to bed (twelfth day); the next morning the headache had gone, but my throat felt so sore that for a time I seriously feared an attack of diphtheria; it gradually wore off, however, during the day, and the next day I was quite well. External Throat. Moderate swelling of the submaxillary glands (after twelve and twenty four hours). Pain in the submaxillary glands (second day).
Stomach
Appetite. When I took the drug I felt quite hungry, but soon after taking it the hunger left me, and on sitting down to breakfast I could not eat; about two hours afterwards became very hungry (fifteenth day). Thirst. Urgent thirst (after three hours and thirty five minutes). Eructations and Hiccough. Eructations and vomiting. Hiccough. Nausea and Vomiting. Felt squeamish, although I was able to attend to business (second day). Sickness (in both cases). Sickness of the stomach (after three hours and a half). Was sick and vomited a quantity of saliva which I had swallowed (after one hour and a half); putting my finger into my mouth vomiting was further excited, until a portion of the Jaborandi returned. They were a little sick, faint, and prostrate. Vomited half an hour after eating supper. In some cases vomiting is produced, either at the beginning or end of the effect. The lad who failed to perspire vomited; the vomiting came on suddenly and was not repeated. Stomach. Distress at the stomach (which may be owing to the alcohol in the tincture, ore than to the jaborandi); it is a burning pain, not that dyspeptic ache experienced yesterday (fifth day). Considerable distress, both in the stomach and lower half of oesophagus, especially the latter feels constricted, aching heavily (took Pulsatilla 1st, at 3 P. M., which completely controlled the dyspeptic distress), (thirteenth day). Dull, heavy distress in the pyloric portion of the stomach, as though some hard indigestible substance was lying there, relieved by eating a full meal, at dinner time (fourth day). Constrictive feeling in the stomach, as though the rugae were puckered up (probably owing to the alcohol of the tincture, as it was taken clear), (seventh day).
Abdomen
Empty, gone feeling in the bowels (twelfth day).
Stool
Diarrhoea. Stool at 6. 30 A.M. very loose, came with a gush; stool at 7. 30 A.M., stool at 8 A.M., all thin, watery, yellow, and came with a gush; at 9. 30 A.M., another stool; at 10. 30 A.M. another; at 11. 30 A.M., another; at 1 P. M.; the eighth stool; has felt a goneness, an emptiness, from the diarrhoea, but no pain whatever; at 3. 25 P. M., another stool, which came with a gush, yellow, watery, undigested, no pains; at 5. 25, stool like the last; at 6 P. M., stool; felt a little weak at night, having had eleven copious, watery, undigested stools since 7 A.M. (twelfth day). Continues to have from five to ten stools a day, of a yellow color, and watery, painless. (Took two small doses of Gummi gutt., 3D trit., which cured the diarrhoea), (sixteenth day). Five painless stools during the day yellow, thin, watery, better digested (fourteenth day). Three stools during the day (his usual number); the last one, at 8. 30 P. M., somewhat harder, constipated (second day). Two stools during the day (eighth day). Two movements during the day, more papescent (seventh day). Two stools only during the day, the first at 7 A.M., more papescent than three days before; the second at 9 A.M., thin and yellow (tenth day). Stool at 7 A.M., papescent and very large (ninth day). Stool thin, better digested, with more control over sphincter ani, at 9 P. M. (twelfth day). Stool yellow, better digested, but came with a gush, at 2 P. M. (thirteenth day). Bowels moved at 7. 30 A.M., with this difference, the discharges were less papescent than heretofore; the first portion of the evacuation was 5/8 of an inch in diameter and about 5 inches in length; the latter portion was papescent, color dark brown (fourth day). Constipation. Constipated; two motions in the day instead of three, as usual (fifth day). Stool at 7 A.M., and again at 7 P. M., both exceedingly difficult to evacuate, consisting of long, large, and very dark faeces (eleventh day).
Urinary organs
Burning in the urethra in two cases, with urging to urinate. Secretion of urine increased (750 c. c. during the perspiration). When administered in fractional doses, jaborandi does not produce either perspiration or salivation, but becomes a powerful diuretic. The quantity of urine diminished in a very noticeable manner on the day the remedy is administered, but on the next day there is sometimes a slight augmentation, sometimes the usual amount. Urine dark colored. The urea diminishes on the day the Jaborandi is given, increases slightly again on the next day, and then falls to the normal amount. Chlorine and the chlorides, as well as the uric acid, also undergo the same quantitative changes, and diminish on the first day only to in crease on the second. Augmentation of the bronchial secretions (after ten minutes). We noticed an increase of the bronchial secretion, indicated by a loose cough, only in the lad previously quite free from catarrhal symptoms, on whom two observations were made, and in whom but a slight increase of salivary secretion occurred; the bronchial secretion was much abundant in the first than in the second observation; indeed, in the second there was very little cough. Hurried breathing (after two hours, nineteenth day). Breathing hurried, during the soreness of throat (twelfth day).
Chest
Pains in chest and around the heart (forty fifth day). Could not get to sleep for two hours after going to bed, on account of anxious and oppressed feeling in the chest (eleventh day). Pressure on chest, and great anxiety, with palpitation of heart, and pain in region of heart (twenty fourth day). Sense of heavy pressure on the chest, hurried beating, and great prostration; symptoms became so bad that I was obliged to go to bed; for half an hour after going to bed could only breathe with great difficulty (forty fifth day). Pains in chest, of a stitching character (after two hours, thirty seventh day).
Heart and Pulse
Precordium. Pain in region of heart (twenty fourth day). The pains about the heart were very severe, accompanied with severe palpitation; this condition lasted two hours in its severest form, then gradually abated (forty fifth day). Heart’s Action. Palpitation of heart (after two hours, nineteenth day). Pulse. Tracing No. 1 represents the normal pulse of the subject; its general aspect is rectilinear, excepting a very slight curve corresponding to a respiratory movement; the ascending line is short and somewhat oblique; the descending line nearly horizontal; the natural dicrotism is well marked. At the commencement of sweat the pulse become more rapid, and the tracing assumes a different appearance; its general outline becomes a little crooked; the rising line is larger and more upright; the descending line, therefore, more oblique, with more of the diacrotic character. At the height of the sweating period, the general outline becomes strikingly irregular; moreover, the beats are no longer isochronous, some being shorter than others. When the morbid activity of the secretory organs has passed off, the general outline becomes regular again, but the ascending line is shorter and more oblique, the descending line longer and nearly horizontal, with hardly a trace of exaggerated dicrotism. Sphygmographic tracings, taken at different stages of the administration of this drug, showed almost complete asystole, with a very noticeable diminution of vascular tension during the sweating stage. Pulsation was quickened while the action of the medicine lasted (in both cases). In each experiment the pulse became considerably quicker, the increase varying from forty to fifty minutes; the pulse reached its quickest in twenty five to eighty minutes after administration; the quickened pulse continued more than four hours; no close relation existed between the rapidity of the pulse and the fall of temperature; in one lad whose pulse was intermittent, the medicine entirely removed this irregularity. At the moment the sweat was produced, there was an increase of the pulse and of temperature; then during the period of active sweating, it was sometimes noted that these two elements remained at the same point as at the outset of the experiment; sometimes there was a slight diminution; but after sweating, a very notable lowering of the pulse and of the temperature were observed, which sometimes lasted two days after the experiment (in thirty two experiments). Pulse rose from 88 to 120. Pulse rose from 12 to 20 beats during the first few hours (the reverse of temperature), and returned to its normal rate with the return of the normal temperature, but became soft and compressible. Pulse 108 (normal 80), (half an hour after 80 drops), (seventh day). Pulse 100 (temperature normal, at 6 P. M. (twelfth day). Pulse 94 (an increase of 14 from 150 drops of the tincture taken within an hour), (ninth day). (140). Pulse 96 (when first noted), 104 (afterwards); 88 on awaking (second morning), normally 80. Pulse 90 (before taking); 104 (after forty minutes); 96 (after one hour and ten minutes); 90 (after one hour and forty minutes); 96 (after two hours and a half). Pulse 80 (before taking); 96 (after thirty five minutes); 108 (after one hour and a half); 112 (after three hours and a half); 90 (five hours and a half); 88 at 10 A.M. (second day). Pulse 78 (before taking); 84 (after fifteen minutes); 86 (after twenty two minutes); 87 (after forty minutes); 87 (after one hour and a quarter); 76 (after five hours and a half); 70 (second day). Pulse 75 (before taking); 90 (after half an hour); 108 (after one hour and a half); 100 (after two hours); 88 after two hours an a half); 80 (after three hours and a half); 78 at 10 A.M. (second day). Pulse 77 (before taking); 90 (after one hour); 93 (after one hour and a half); 94 (after two hours); 92 (after two hours and a half); 90 (after three hours); 82 (after three hours and a half); 80 (after four hours and a half). Pulse 80 (before taking); 100 (after fifteen minutes); 96 (after twenty minutes); 100 after thirty five minutes); 104 (after fifty minutes); 100 (after one hour); 96 (after one hour and ten minutes); 88 (after one hour and thirty five minutes); 90 (after one hour and fifty five minutes); 76 (after two hours and five minutes); 78 (after three hours and five minutes). Pulse 78 (before taking); 100 (after fifteen minutes); 96 (after twenty minutes); 100 (after thirty five minutes); 104 (after fifty minutes); 100 (after one hour); 96 (after one hour and ten minutes); 96 (after one hour and a quarter); 90 (after one hour and fifty five minutes); 76 (after two hours and five minutes); 78 (second day).
Born in 1837in Westminster, Vermont. . He was an orthodox doctor who converted to homeopathy
Dr. Allen compiled the Encyclopedia of Pure Materia Medica over the course of 10 years.
In 1881 Allen published A Critical Revision of the Encyclopedia of Pure Materia Medica.