Sulphate of Quinine. (C20H24N2O2)2 H2SO4 15H2O. Trituration.
Clinical
Angina pectoris. Asthma. *Brow ague. Cancerous ulcers. Cholera. Delirium. Diarrhoea. Dropsy. Dysmenorrhoea. *Ear affections. Gangrenous and fetid suppurations. *Gravel. Haematuria. Hemoglobinuria. Haemorrhages. *Headache. *Intermittent fever. *Meniere’s disease. *Neuralgia. *Noises in the head. Parotitis. Pruritus vulvae. Puerperal convulsions. *Pyaemia. Rectum, prolapse of. *Remittent fever. *Rheumatism. Scarlatina. Spinal irritation. Spleen, enlarged. *Typhus fever. Urticaria. Varicose, veins. *Variola.
Characteristics
*Sulphuric acid and *Sulphur are themselves in the first rank of periodic remedies, and combined with the chief alkaloid of *China they enhance the powerful periodic properties of that drug. In old-school practice the Sulphate of Quinine has almost entirely taken the place of the crude Bark as a remedy. *China *sul. closely resembles *China in its effects, but as it has been proved separately, and as observations of the effects of over- dosing have supplied many additional symptoms, the homoeopathist has plenty of guidance in the selection of one in preference to the other. *Chi. *sul. is even more powerful as an antiseptic than *China, and it is probable that it is in virtue of its property of antagonizing the malarial poison that it *suppresses intermittent fever when it does not cure. It only cures when the fever corresponds to its own type. When a fever is “suppressed” there is generally an unholy alliance between disease-force and drug-force, which is expended on some part of the organism, resulting at times in lifelong ill-health. The “Quinine cachexia” is well known-sallow complexion, emaciation, deafness and singing in the ears, enlarged spleen, disposition to shiver, and great debility. Periodicity is extremely well marked, the attacks returning at the same hour each day. In intermittents the onset may anticipate. Skin flaccid and sensitive to touch. Red rash over whole body, with severe stinging, followed by desquamation. Other prominent symptoms are: Headache extending from occiput to forehead. Whirling in the head like a mill-wheel. Twitching of left eyelid, worse in the evening. Aphthae in weakly people. Tartar on teeth. Hunger at night. Prolapse of rectum, especially in children. Hematuria and hemoglobinuria. (“Black-water fever” has been developed through administering *Chi. *sul. in intermittents. Koch deserves much credit for showing that the worst features of African fevers are due to over-dosing with Quinine and not to the disease). ***E. W. Sawyer (*Medorrhinum *Advance, 1887) relates this instructive history: He learned from his cook that her brother (age 16) could not take a particle of Quinine without causing a profuse flow of blood with the urine, sometimes within half an hour, always without pain. This had followed every time his doctors had tried to “break his ague” with Quinine. A year later a farmer’s wife, age 60, came to Dr. Sawyer to be treated for bloody urine unattended with pain or uneasiness. She attributed it to strain from walking two miles on a slippery road. She had been for months under Hygienist treatment without benefit, and was alarmingly weak from loss of blood. *Rhus 200, *Hamamelis IX, *Erig. IX, *Chi. IX, *Ferrum *mur. 2X were given in succession in vain. At last, calling to mind the case of the youth, he gave *Chi. *sul. in 1/16 gr. doses three times a day, and a prompt cure was effected. *Chi. *sul. causes painfulness and swelling of varicose veins during a chill. (Julius E. Schmitz cured a case on this last indication.) Great sensitiveness to external influences. All discharges debilitating. Weak and nervous, a little exercise causes sweat from least exertion. Head gradually breaks into sweat when perfectly quiet. *Chi. *sul. is one of the medicines which have the ‘sinking sensation.” Tyrrell had a patient in whom in any potency it caused her to become “deathly sick and faint, thought she would die, could not raise her head, *felt she would sink through the bed.” *Sacch. *alb. produced in her the same symptoms, and she accused the doctor of having given her Quinine. (*Arsen. has “sinking sensation,” “as if bed had gone from under her and she had alighted on the floor.” *Belladonna, *Dulcamara, *Rhus, *Lachesis, have “sinking through the bed.”) Palpitation. Touch worse, pressure better. Wants to lie down. Motion causes chilliness. Stooping causes giddiness. Bending forward better. Sleeplessness and over-stimulation of nervous system.
Relations.
See China. It is *antidoted by: Arnica, Arsenicum, Carb-v., Ferrum, Hepar, Lachesis, and especially Natrum mur., which antidotes effects of over-dosing with Quinine, Pulsatilla *Compare: Cinchon sul., Apis. (chill 3 p-m.), Arsenicum (pyaemia, spinal irritation, periodically returning neuralgias), Bryonia (sweat from least exertion), Carb-an. (all discharges debilitating), Eup-per. (sweat relieves all symptoms but headache), Nux-v. (blue lips and nails with chill), Pulsatilla (rheumatic erratic pains), Stann. (supraorbital neuralgia), Staphysagria (head gradually breaks into sweat while perfectly quiet). In headache from before backward (Gelsemium, Lac-c., Sanguinaria, Silicea).
SYMPTOMS.
Mind
Fits of anxiety, great anguish, sometimes in the morning while in bed, obliging the patient to get up sooner than he would otherwise wish, or soon after midnight, with cries, and a necessity for getting up. Great moral depression, speechless melancholy, discouragement, inclination to weep and to despair. Moroseness and ill-humour, with yawning and extreme dislike to labour. Great indolence with lassitude. Excitement like that which follows taking coffee, or wine. Great liveliness. Feeble apprehension, with weakness which induces falling, great heat of the skin, dryness of the mouth and of the throat, and constipation. Inability to pronounce substantives, and slowness of reflection.
Head
Sensation of emptiness in the head, with heat in the face, thirst, or tinkling in the ears, head confused, with humming in the interior, with a feeling of intoxication and dulness, stupor with cephalalgia in left side of the forehead, a sort of furor in the head, almost preventing walking, with loss of power to guide the limbs. Delirium. Great exaltation, with a kind of dementia. Vertigo: on stooping, whirling, as if the head were falling backwards, aggravated by motion, least felt when lying down, as if intoxicated, with buzzing in the ear, heat of the skin and accelerated pulse, with cephalalgia and giddiness. Cephalalgia, especially in the evening, or else on walking in the sunshine, with lassitude, yawning, drowsiness, and moroseness. Dull pain, with deafness, anguish, sweating, trembling of the limbs, and slowness of pulse, on left side especially, with pulsation of the temporal arteries. Great bodily excitement, paleness of face, violent thirst, nausea, weakness of the feet, and general perspiration in left temple, with necessity for lying down, and amelioration on pressing the head against cold things. Frontal cephalalgia: in the morning on awaking, especially in the evening, in the afternoon, with heaviness of the head, and heat in the face, with tingling in the ears, and general heat, or else on the left side, with vertigo, increase of appetite, thirst, nausea, flatulency, and great lassitude. Aching of the head, in the occiput, on awaking in the night, and disappearing on getting up, in the forehead and orbits, worse on turning the head or the eyes, from morning till evening, with heat in the forehead. Expansive pain, especially in the temporal region, worse by motion and in the open air, as well as at night, with disturbed sleep. Pulsation in the head. Bubbling towards the head in the evening, especially with pulsation of the arteries. Pain as though the head were bursting. Heat in the face. Vertigo, tinkling, and buzzing in the ears. Hardness of hearing. Sparks before the eyes. Pulse quickened and rapid. Sleep disturbed and full of dreams, and escape of wind above and below. Sensitiveness of the scalp.
Eyes
Sensibility of the eyes, with lachrymation. Sight dimmed as by a fog, with dryness of the eyes. Sparks before the eyes, black spots, sometimes only one side of an object is seen. Obscuration of the sight, especially when looking fixedly at an object. Transient amaurosis.
Ears
Tinkling in the ears. Buzzing, especially in left ear, sometimes occasioning deafness on that side. Hardness of hearing, sometimes with violent headache.
Nose
Frequent bleeding at the nose. Frequent sneezing.
Face
Pale colour, sickly look, air of suffering, with sunken eyes. Earth-coloured face. The white of the eyes discoloured and eyes dull. Complexion icteric. Redness of the face, sometimes with heat round the eyes, and lachrymation on looking at the light. Heat of the face, especially in the evening, also after taking coffee. Bluish-coloured lips. Eruption on the upper lip.
Mouth
Dryness, with heat, thirst, flesh-like smell in the mouth, and sensation of constriction in the oesophagus, of the mouth and gullet, with constipation and weakness of intellect. Great paleness of the buccal cavity. Erosion of the gums, and of the wall of the buccal cavity, with violent pain and gangrenous crusts. Accumulation of mucous in the mouth, with nocturnal angina, augmented secretion of saliva. Salivation. Tongue coated with white mucous. Yellow mucous at the posterior part. Thick coating of a yellowish white. Yellowish coating, especially at the root, or else with dryness of tongue.
