General Action
With its active principle, Muscarine, presents a very complex physiological study.
Poisonous doses produce violent vomiting and diarrhoea with numerous nervous phenomena; tonic contractions of smooth muscle fiber everywhere, increased glandular and mucous secretions, persistent anaemia of nerve centres from spasm of arterioles, et cetera.
Its symptomatology offers a large field; most useful are the chorea-like spasms; vertigo and general intolerance of the sun; a heavy weight in occiput; a very irritable and sensitive spine; asthenopia with flickerings, twitching of eyes and lids; (especially valuable for near-sighted people); gastro-enteric inflammation with excessive flatulence, inodorous; irritable bladder; a host of neuralgic pains everywhere, mostly splinter- like, burning and shooting. Particularly valuable in burning of the skin as from a frost-bite, especially on the ears and feet.
Generalities
Chorea-like twitchings of various fibrillae and even groups of muscles. Tremblings, external and internal. Flesh feels bruised, or as if frost-bitten, sensitive to touch, and to cold air. General aggravation from walking in the open air, ameliorated when warm in bed. Pains in the limbs may disappear on motion, and returns during rest. Symptoms often appear crosswise, as in right arm and left leg, etc. Shooting, splinter-like pains everywhere.
Mind
Delirium; attempts to escape. Incoherent talking. Aversion to mental work.
Head
Confusion and vertigo, aggravated by heat of sun. Drawing in bones of forehead, to the root of the nose. Shooting pains, mostly in the sides of the head. or in small spots. Feeling of icy coldness on the head.
Eyes
Twitching of lids and eye-balls. Margins of lids red, agglutinating. Vision dim on attempting to use the eyes. Flickering. Type wavers with itching and burning.
Ears
External ear burns and itches as if it had been frozen. Twitchings of the auricular muscles. Numerous ringing and other noises within the ear.
Nose
Clear water runs from the nose, without inflammatory symptoms.
Face
Pale. Twitching of the muscles. Pains lancinating, tearing in the cheek.
Lips
Upper lip chapped, smarting; dry, with burning vesicles. Lips twitch. Splinter-like pains through the jaws.
Mouth
Dryness on salivation. Taste sweet. Toothache, neuralgic, aggravated by open air. Splinter-like pains in the tongue.
Throat
Stitches extend through right Eustachian tube to ear. General dryness. Contractions. Feels swollen externally, hands feel tight.
Stomach
Unnatural hunger, evenings. Eructations, empty. Numerous sensations (pain, gnawings, boring, cramp, fulness, etc.), with spasmodic contractions, irritable spine, etc.
Abdomen
Flatulent distention, rumblings, cutting, griping, stitches, tension, etc.
Rectum and Anus
Burning. Piles.
Stool
Emission of much inodorous gas. Watery diarrhoea. Constipation.
Urinary Organs
Irritable bladder. Burning on urinating. Stitches. Discharge of sticky mucus. Urine lemon colored. Not profuse (as a rule).
Sexual Organs
Sexual desire without erections. In women, violent pressing- tearing pains in back and abdomen with the menses. Pruritus pudendi.
Respiratory Organs
Constriction of larynx. Convulsive paroxysms of cough, sudden, end with repeated sneezing. Expectoration (rare) of balls of mucus. Respiration difficult as if chest were full; deep and sighing; noisy at night.
Chest
Numerous pains, tearing, pinching, tensive, stinging, burning. Constriction. Oppression. Heaviness. Rawness. (Compare back.).
Heart
Palpitation. Tumultuous action. Irregular, intermittent pulse. Ameliorated by coffee.
Neck and Back
Stiffness of nape. Bruised and strained feelings. Deep stitches, burning, itching along spine and limbs. Spine sore to the touch and on stooping. Extreme pain and soreness in lower dorsal regions, becoming a pulsating on motion. Numerous and severe pains in the spine, boring, stitching, drawing, soreness, etc. Mostly in lower dorsal region. These sensations extend to nape and into the limbs. Aggravated by walking in open air.
Extremities
Trembling. Twitching. Shooting pains, shifting. Limbs weary and heavy. (Pains often ameliorated by motion.).
Skin
Jaundice. Redness, stinging, burning as if frost-bitten. Itching. White nodular elevations, with intense itching and burning.
Sleep
General sleepiness, especially after eating.
Fever
Chilliness on motion, in the air, or on lifting the clothes. Burning heat on different spots (mostly local). Profuse inodorous sweat, often localized; chest. Sweat oily.
Born in 1837in Westminster, Vermont. . He was an orthodox doctor who converted to homeopathy
Dr. Allen compiled the Encyclopedia of Pure Materia Medica over the course of 10 years.
In 1881 Allen published A Critical Revision of the Encyclopedia of Pure Materia Medica.